|
||||||
|
 | |
| |
| |
| Open reading frame (ORF) annotation in the exon skipping event |
| |
| 3'-UTR located exon skipping events lost miRNA binding sites |
| |
| |
| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| |
| |
|
Gene summary for TOR1AIP2 |
 Gene summary |
| Gene information | Gene symbol | TOR1AIP2 | Gene ID | 163590 |
| Gene name | torsin 1A interacting protein 2 | |
| Synonyms | IFRG15|LULL1|NET9 | |
| Cytomap | 1q25.2 | |
| Type of gene | protein-coding | |
| Description | torsin-1A-interacting protein 2interferon alpha responsive protein15 kDa interferon-responsive proteininterferon responsive gene 15lumenal domain like LAP1torsin A interacting protein 2 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TOR1AIP2 | GO:0032781 | positive regulation of ATPase activity | 23569223|24275647 |
| TOR1AIP2 | GO:0090435 | protein localization to nuclear envelope | 19339278 |
Top |
Gene structures and expression levels for TOR1AIP2 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
ENSG00000169905
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
 |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000609928.5 | TOR1AIP2-206:protein_coding:TOR1AIP2 | 9.248095e+01 | 1.224632e+00 | 1.065523e-05 | 1.111650e-04 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
 |
Top |
Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TOR1AIP2 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
 |
| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_110476 | chr1 | 179865436:179865854:179877239:179877373:179877693:179877772 | 179877239:179877373 |
| exon_skip_116668 | chr1 | 179865679:179865854:179877239:179877373:179877693:179877772 | 179877239:179877373 |
| exon_skip_194779 | chr1 | 179852632:179852811:179865436:179865854:179877239:179877373 | 179865436:179865854 |
| exon_skip_38402 | chr1 | 179852632:179852811:179865436:179865854:179877239:179877367 | 179865436:179865854 |
| exon_skip_45708 | chr1 | 179865571:179865854:179877239:179877373:179877693:179877772 | 179877239:179877373 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
Top |
Open reading frame (ORF) annotation in the exon skipping event for TOR1AIP2 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000609928 | 179865436 | 179865854 | 3UTR-3UTR |
| ENST00000609928 | 179877239 | 179877373 | 3UTR-3UTR |
| ENST00000482587 | 179877239 | 179877373 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000609928 | 179865436 | 179865854 | 3UTR-3UTR |
| ENST00000609928 | 179877239 | 179877373 | 3UTR-3UTR |
| ENST00000482587 | 179877239 | 179877373 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000609928 | 179865436 | 179865854 | 3UTR-3UTR |
| ENST00000609928 | 179877239 | 179877373 | 3UTR-3UTR |
| ENST00000482587 | 179877239 | 179877373 | 3UTR-3UTR |
Top |
Infer the effects of exon skipping event on protein functional features for TOR1AIP2 |
p-ENSG00000169905_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Top |
3'-UTR located exon skipping events that lost miRNA binding sites in TOR1AIP2 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000482587 | 179877239 | 179877373 | hsa-miR-186-3p | chr1:179877295-179877302 | 8mer-1a | chr1:179877295-179877316 | 154.00 | -31.06 |
| Mayo | ENST00000609928 | 179865436 | 179865854 | hsa-miR-4256 | chr1:179865719-179865726 | 8mer-1a | chr1:179865711-179865733 | 156.00 | -17.58 |
| Mayo | ENST00000609928 | 179865436 | 179865854 | hsa-miR-6736-3p | chr1:179865615-179865622 | 8mer-1a | chr1:179865602-179865622 | 157.00 | -24.78 |
| Mayo | ENST00000482587 | 179877239 | 179877373 | hsa-miR-7151-3p | chr1:179877279-179877286 | 8mer-1a | chr1:179877272-179877293 | 192.00 | -42.14 |
| Mayo | ENST00000609928 | 179865436 | 179865854 | hsa-miR-3157-5p | chr1:179865824-179865831 | 8mer-1a | chr1:179865809-179865831 | 152.00 | -20.25 |
| Mayo | ENST00000609928 | 179865436 | 179865854 | hsa-miR-8087 | chr1:179865681-179865688 | 8mer-1a | chr1:179865681-179865704 | 158.00 | -19.24 |
| Mayo | ENST00000609928 | 179865436 | 179865854 | hsa-miR-492 | chr1:179865623-179865630 | 8mer-1a | chr1:179865619-179865640 | 160.00 | -21.51 |
| Mayo | ENST00000609928 | 179865436 | 179865854 | hsa-miR-17-5p | chr1:179865697-179865704 | 8mer-1a | chr1:179865681-179865704 | 158.00 | -19.24 |
| Mayo | ENST00000609928 | 179865436 | 179865854 | hsa-miR-20a-5p | chr1:179865697-179865704 | 8mer-1a | chr1:179865681-179865704 | 158.00 | -19.24 |
| Mayo | ENST00000609928 | 179865436 | 179865854 | hsa-miR-4501 | chr1:179865846-179865853 | 8mer-1a | chr1:179865833-179865853 | 140.00 | -17.91 |
| Mayo | ENST00000482587 | 179877239 | 179877373 | hsa-miR-4713-5p | chr1:179877311-179877318 | 8mer-1a | chr1:179877298-179877318 | 166.00 | -34.30 |
| Mayo | ENST00000609928 | 179865436 | 179865854 | hsa-miR-11181-5p | chr1:179865719-179865726 | 8mer-1a | chr1:179865711-179865733 | 156.00 | -17.58 |
| Mayo | ENST00000609928 | 179865436 | 179865854 | hsa-miR-1225-5p | chr1:179865675-179865682 | 8mer-1a | chr1:179865671-179865689 | 155.00 | -16.30 |
| Mayo | ENST00000609928 | 179865436 | 179865854 | hsa-miR-142-5p | chr1:179865699-179865706 | 8mer-1a | chr1:179865686-179865706 | 150.00 | -9.51 |
| Mayo | ENST00000609928 | 179865436 | 179865854 | hsa-miR-5583-5p | chr1:179865506-179865513 | 8mer-1a | chr1:179865497-179865517 | 151.00 | -8.22 |
| Mayo | ENST00000609928 | 179865436 | 179865854 | hsa-miR-4750-3p | chr1:179865718-179865725 | 8mer-1a | chr1:179865711-179865733 | 156.00 | -17.58 |
| Mayo | ENST00000609928 | 179865436 | 179865854 | hsa-miR-526b-5p | chr1:179865478-179865485 | 8mer-1a | chr1:179865478-179865498 | 154.00 | -20.27 |
| Mayo | ENST00000609928 | 179865436 | 179865854 | hsa-miR-526b-3p | chr1:179865697-179865704 | 8mer-1a | chr1:179865681-179865704 | 158.00 | -19.24 |
| Mayo | ENST00000609928 | 179865436 | 179865854 | hsa-miR-519d-3p | chr1:179865697-179865704 | 8mer-1a | chr1:179865681-179865704 | 158.00 | -19.24 |
| Mayo | ENST00000609928 | 179865436 | 179865854 | hsa-miR-5590-3p | chr1:179865699-179865706 | 8mer-1a | chr1:179865686-179865706 | 150.00 | -9.51 |
| Mayo | ENST00000609928 | 179865436 | 179865854 | hsa-miR-3129-3p | chr1:179865506-179865513 | 8mer-1a | chr1:179865497-179865517 | 151.00 | -8.22 |
| Mayo | ENST00000609928 | 179865436 | 179865854 | hsa-miR-499a-5p | chr1:179865682-179865689 | 8mer-1a | chr1:179865681-179865704 | 158.00 | -19.24 |
| Mayo | ENST00000609928 | 179865436 | 179865854 | hsa-miR-4535 | chr1:179865624-179865631 | 8mer-1a | chr1:179865619-179865640 | 160.00 | -21.51 |
| Mayo | ENST00000482587 | 179877239 | 179877373 | hsa-miR-1224-3p | chr1:179877308-179877315 | 8mer-1a | chr1:179877298-179877318 | 166.00 | -34.30 |
| Mayo | ENST00000609928 | 179865436 | 179865854 | hsa-miR-93-5p | chr1:179865697-179865704 | 8mer-1a | chr1:179865681-179865704 | 158.00 | -19.24 |
| Mayo | ENST00000609928 | 179865436 | 179865854 | hsa-miR-106b-5p | chr1:179865697-179865704 | 8mer-1a | chr1:179865681-179865704 | 158.00 | -19.24 |
| Mayo | ENST00000482587 | 179877239 | 179877373 | hsa-miR-6843-3p | chr1:179877339-179877346 | 8mer-1a | chr1:179877327-179877346 | 152.00 | -18.79 |
| Mayo | ENST00000609928 | 179865436 | 179865854 | hsa-miR-6846-3p | chr1:179865716-179865723 | 8mer-1a | chr1:179865711-179865733 | 156.00 | -17.58 |
| Mayo | ENST00000482587 | 179877239 | 179877373 | hsa-miR-6848-3p | chr1:179877339-179877346 | 8mer-1a | chr1:179877327-179877346 | 152.00 | -18.79 |
| Mayo | ENST00000609928 | 179865436 | 179865854 | hsa-miR-32-3p | chr1:179865502-179865509 | 8mer-1a | chr1:179865497-179865517 | 151.00 | -8.22 |
| Mayo | ENST00000609928 | 179865436 | 179865854 | hsa-miR-7702 | chr1:179865499-179865506 | 8mer-1a | chr1:179865488-179865506 | 146.00 | -16.40 |
| Mayo | ENST00000482587 | 179877239 | 179877373 | hsa-miR-532-3p | chr1:179877310-179877317 | 8mer-1a | chr1:179877298-179877318 | 166.00 | -34.30 |
| Mayo | ENST00000609928 | 179865436 | 179865854 | hsa-miR-20b-5p | chr1:179865697-179865704 | 8mer-1a | chr1:179865681-179865704 | 158.00 | -19.24 |
| Mayo | ENST00000609928 | 179865436 | 179865854 | hsa-miR-106a-5p | chr1:179865697-179865704 | 8mer-1a | chr1:179865681-179865704 | 158.00 | -19.24 |
| MSBB | ENST00000482587 | 179877239 | 179877373 | hsa-miR-186-3p | chr1:179877295-179877302 | 8mer-1a | chr1:179877295-179877316 | 154.00 | -31.06 |
| MSBB | ENST00000609928 | 179865436 | 179865854 | hsa-miR-4256 | chr1:179865719-179865726 | 8mer-1a | chr1:179865711-179865733 | 156.00 | -17.58 |
| MSBB | ENST00000609928 | 179865436 | 179865854 | hsa-miR-6736-3p | chr1:179865615-179865622 | 8mer-1a | chr1:179865602-179865622 | 157.00 | -24.78 |
| MSBB | ENST00000482587 | 179877239 | 179877373 | hsa-miR-7151-3p | chr1:179877279-179877286 | 8mer-1a | chr1:179877272-179877293 | 192.00 | -42.14 |
| MSBB | ENST00000609928 | 179865436 | 179865854 | hsa-miR-3157-5p | chr1:179865824-179865831 | 8mer-1a | chr1:179865809-179865831 | 152.00 | -20.25 |
| MSBB | ENST00000609928 | 179865436 | 179865854 | hsa-miR-8087 | chr1:179865681-179865688 | 8mer-1a | chr1:179865681-179865704 | 158.00 | -19.24 |
| MSBB | ENST00000609928 | 179865436 | 179865854 | hsa-miR-492 | chr1:179865623-179865630 | 8mer-1a | chr1:179865619-179865640 | 160.00 | -21.51 |
| MSBB | ENST00000609928 | 179865436 | 179865854 | hsa-miR-17-5p | chr1:179865697-179865704 | 8mer-1a | chr1:179865681-179865704 | 158.00 | -19.24 |
| MSBB | ENST00000609928 | 179865436 | 179865854 | hsa-miR-20a-5p | chr1:179865697-179865704 | 8mer-1a | chr1:179865681-179865704 | 158.00 | -19.24 |
| MSBB | ENST00000609928 | 179865436 | 179865854 | hsa-miR-4501 | chr1:179865846-179865853 | 8mer-1a | chr1:179865833-179865853 | 140.00 | -17.91 |
| MSBB | ENST00000482587 | 179877239 | 179877373 | hsa-miR-4713-5p | chr1:179877311-179877318 | 8mer-1a | chr1:179877298-179877318 | 166.00 | -34.30 |
| MSBB | ENST00000609928 | 179865436 | 179865854 | hsa-miR-11181-5p | chr1:179865719-179865726 | 8mer-1a | chr1:179865711-179865733 | 156.00 | -17.58 |
| MSBB | ENST00000609928 | 179865436 | 179865854 | hsa-miR-1225-5p | chr1:179865675-179865682 | 8mer-1a | chr1:179865671-179865689 | 155.00 | -16.30 |
| MSBB | ENST00000609928 | 179865436 | 179865854 | hsa-miR-142-5p | chr1:179865699-179865706 | 8mer-1a | chr1:179865686-179865706 | 150.00 | -9.51 |
| MSBB | ENST00000609928 | 179865436 | 179865854 | hsa-miR-5583-5p | chr1:179865506-179865513 | 8mer-1a | chr1:179865497-179865517 | 151.00 | -8.22 |
| MSBB | ENST00000609928 | 179865436 | 179865854 | hsa-miR-4750-3p | chr1:179865718-179865725 | 8mer-1a | chr1:179865711-179865733 | 156.00 | -17.58 |
| MSBB | ENST00000609928 | 179865436 | 179865854 | hsa-miR-526b-5p | chr1:179865478-179865485 | 8mer-1a | chr1:179865478-179865498 | 154.00 | -20.27 |
| MSBB | ENST00000609928 | 179865436 | 179865854 | hsa-miR-526b-3p | chr1:179865697-179865704 | 8mer-1a | chr1:179865681-179865704 | 158.00 | -19.24 |
| MSBB | ENST00000609928 | 179865436 | 179865854 | hsa-miR-519d-3p | chr1:179865697-179865704 | 8mer-1a | chr1:179865681-179865704 | 158.00 | -19.24 |
| MSBB | ENST00000609928 | 179865436 | 179865854 | hsa-miR-5590-3p | chr1:179865699-179865706 | 8mer-1a | chr1:179865686-179865706 | 150.00 | -9.51 |
| MSBB | ENST00000609928 | 179865436 | 179865854 | hsa-miR-3129-3p | chr1:179865506-179865513 | 8mer-1a | chr1:179865497-179865517 | 151.00 | -8.22 |
| MSBB | ENST00000609928 | 179865436 | 179865854 | hsa-miR-499a-5p | chr1:179865682-179865689 | 8mer-1a | chr1:179865681-179865704 | 158.00 | -19.24 |
| MSBB | ENST00000609928 | 179865436 | 179865854 | hsa-miR-4535 | chr1:179865624-179865631 | 8mer-1a | chr1:179865619-179865640 | 160.00 | -21.51 |
| MSBB | ENST00000482587 | 179877239 | 179877373 | hsa-miR-1224-3p | chr1:179877308-179877315 | 8mer-1a | chr1:179877298-179877318 | 166.00 | -34.30 |
| MSBB | ENST00000609928 | 179865436 | 179865854 | hsa-miR-93-5p | chr1:179865697-179865704 | 8mer-1a | chr1:179865681-179865704 | 158.00 | -19.24 |
| MSBB | ENST00000609928 | 179865436 | 179865854 | hsa-miR-106b-5p | chr1:179865697-179865704 | 8mer-1a | chr1:179865681-179865704 | 158.00 | -19.24 |
| MSBB | ENST00000482587 | 179877239 | 179877373 | hsa-miR-6843-3p | chr1:179877339-179877346 | 8mer-1a | chr1:179877327-179877346 | 152.00 | -18.79 |
| MSBB | ENST00000609928 | 179865436 | 179865854 | hsa-miR-6846-3p | chr1:179865716-179865723 | 8mer-1a | chr1:179865711-179865733 | 156.00 | -17.58 |
| MSBB | ENST00000482587 | 179877239 | 179877373 | hsa-miR-6848-3p | chr1:179877339-179877346 | 8mer-1a | chr1:179877327-179877346 | 152.00 | -18.79 |
| MSBB | ENST00000609928 | 179865436 | 179865854 | hsa-miR-32-3p | chr1:179865502-179865509 | 8mer-1a | chr1:179865497-179865517 | 151.00 | -8.22 |
| MSBB | ENST00000609928 | 179865436 | 179865854 | hsa-miR-7702 | chr1:179865499-179865506 | 8mer-1a | chr1:179865488-179865506 | 146.00 | -16.40 |
| MSBB | ENST00000482587 | 179877239 | 179877373 | hsa-miR-532-3p | chr1:179877310-179877317 | 8mer-1a | chr1:179877298-179877318 | 166.00 | -34.30 |
| MSBB | ENST00000609928 | 179865436 | 179865854 | hsa-miR-20b-5p | chr1:179865697-179865704 | 8mer-1a | chr1:179865681-179865704 | 158.00 | -19.24 |
| MSBB | ENST00000609928 | 179865436 | 179865854 | hsa-miR-106a-5p | chr1:179865697-179865704 | 8mer-1a | chr1:179865681-179865704 | 158.00 | -19.24 |
| ROSMAP | ENST00000482587 | 179877239 | 179877373 | hsa-miR-186-3p | chr1:179877295-179877302 | 8mer-1a | chr1:179877295-179877316 | 154.00 | -31.06 |
| ROSMAP | ENST00000609928 | 179865436 | 179865854 | hsa-miR-4256 | chr1:179865719-179865726 | 8mer-1a | chr1:179865711-179865733 | 156.00 | -17.58 |
| ROSMAP | ENST00000609928 | 179865436 | 179865854 | hsa-miR-6736-3p | chr1:179865615-179865622 | 8mer-1a | chr1:179865602-179865622 | 157.00 | -24.78 |
| ROSMAP | ENST00000482587 | 179877239 | 179877373 | hsa-miR-7151-3p | chr1:179877279-179877286 | 8mer-1a | chr1:179877272-179877293 | 192.00 | -42.14 |
| ROSMAP | ENST00000609928 | 179865436 | 179865854 | hsa-miR-3157-5p | chr1:179865824-179865831 | 8mer-1a | chr1:179865809-179865831 | 152.00 | -20.25 |
| ROSMAP | ENST00000609928 | 179865436 | 179865854 | hsa-miR-8087 | chr1:179865681-179865688 | 8mer-1a | chr1:179865681-179865704 | 158.00 | -19.24 |
| ROSMAP | ENST00000609928 | 179865436 | 179865854 | hsa-miR-492 | chr1:179865623-179865630 | 8mer-1a | chr1:179865619-179865640 | 160.00 | -21.51 |
| ROSMAP | ENST00000609928 | 179865436 | 179865854 | hsa-miR-17-5p | chr1:179865697-179865704 | 8mer-1a | chr1:179865681-179865704 | 158.00 | -19.24 |
| ROSMAP | ENST00000609928 | 179865436 | 179865854 | hsa-miR-20a-5p | chr1:179865697-179865704 | 8mer-1a | chr1:179865681-179865704 | 158.00 | -19.24 |
| ROSMAP | ENST00000609928 | 179865436 | 179865854 | hsa-miR-4501 | chr1:179865846-179865853 | 8mer-1a | chr1:179865833-179865853 | 140.00 | -17.91 |
| ROSMAP | ENST00000482587 | 179877239 | 179877373 | hsa-miR-4713-5p | chr1:179877311-179877318 | 8mer-1a | chr1:179877298-179877318 | 166.00 | -34.30 |
| ROSMAP | ENST00000609928 | 179865436 | 179865854 | hsa-miR-11181-5p | chr1:179865719-179865726 | 8mer-1a | chr1:179865711-179865733 | 156.00 | -17.58 |
| ROSMAP | ENST00000609928 | 179865436 | 179865854 | hsa-miR-1225-5p | chr1:179865675-179865682 | 8mer-1a | chr1:179865671-179865689 | 155.00 | -16.30 |
| ROSMAP | ENST00000609928 | 179865436 | 179865854 | hsa-miR-142-5p | chr1:179865699-179865706 | 8mer-1a | chr1:179865686-179865706 | 150.00 | -9.51 |
| ROSMAP | ENST00000609928 | 179865436 | 179865854 | hsa-miR-5583-5p | chr1:179865506-179865513 | 8mer-1a | chr1:179865497-179865517 | 151.00 | -8.22 |
| ROSMAP | ENST00000609928 | 179865436 | 179865854 | hsa-miR-4750-3p | chr1:179865718-179865725 | 8mer-1a | chr1:179865711-179865733 | 156.00 | -17.58 |
| ROSMAP | ENST00000609928 | 179865436 | 179865854 | hsa-miR-526b-5p | chr1:179865478-179865485 | 8mer-1a | chr1:179865478-179865498 | 154.00 | -20.27 |
| ROSMAP | ENST00000609928 | 179865436 | 179865854 | hsa-miR-526b-3p | chr1:179865697-179865704 | 8mer-1a | chr1:179865681-179865704 | 158.00 | -19.24 |
| ROSMAP | ENST00000609928 | 179865436 | 179865854 | hsa-miR-519d-3p | chr1:179865697-179865704 | 8mer-1a | chr1:179865681-179865704 | 158.00 | -19.24 |
| ROSMAP | ENST00000609928 | 179865436 | 179865854 | hsa-miR-5590-3p | chr1:179865699-179865706 | 8mer-1a | chr1:179865686-179865706 | 150.00 | -9.51 |
| ROSMAP | ENST00000609928 | 179865436 | 179865854 | hsa-miR-3129-3p | chr1:179865506-179865513 | 8mer-1a | chr1:179865497-179865517 | 151.00 | -8.22 |
| ROSMAP | ENST00000609928 | 179865436 | 179865854 | hsa-miR-499a-5p | chr1:179865682-179865689 | 8mer-1a | chr1:179865681-179865704 | 158.00 | -19.24 |
| ROSMAP | ENST00000609928 | 179865436 | 179865854 | hsa-miR-4535 | chr1:179865624-179865631 | 8mer-1a | chr1:179865619-179865640 | 160.00 | -21.51 |
| ROSMAP | ENST00000482587 | 179877239 | 179877373 | hsa-miR-1224-3p | chr1:179877308-179877315 | 8mer-1a | chr1:179877298-179877318 | 166.00 | -34.30 |
| ROSMAP | ENST00000609928 | 179865436 | 179865854 | hsa-miR-93-5p | chr1:179865697-179865704 | 8mer-1a | chr1:179865681-179865704 | 158.00 | -19.24 |
| ROSMAP | ENST00000609928 | 179865436 | 179865854 | hsa-miR-106b-5p | chr1:179865697-179865704 | 8mer-1a | chr1:179865681-179865704 | 158.00 | -19.24 |
| ROSMAP | ENST00000482587 | 179877239 | 179877373 | hsa-miR-6843-3p | chr1:179877339-179877346 | 8mer-1a | chr1:179877327-179877346 | 152.00 | -18.79 |
| ROSMAP | ENST00000609928 | 179865436 | 179865854 | hsa-miR-6846-3p | chr1:179865716-179865723 | 8mer-1a | chr1:179865711-179865733 | 156.00 | -17.58 |
| ROSMAP | ENST00000482587 | 179877239 | 179877373 | hsa-miR-6848-3p | chr1:179877339-179877346 | 8mer-1a | chr1:179877327-179877346 | 152.00 | -18.79 |
| ROSMAP | ENST00000609928 | 179865436 | 179865854 | hsa-miR-32-3p | chr1:179865502-179865509 | 8mer-1a | chr1:179865497-179865517 | 151.00 | -8.22 |
| ROSMAP | ENST00000609928 | 179865436 | 179865854 | hsa-miR-7702 | chr1:179865499-179865506 | 8mer-1a | chr1:179865488-179865506 | 146.00 | -16.40 |
| ROSMAP | ENST00000482587 | 179877239 | 179877373 | hsa-miR-532-3p | chr1:179877310-179877317 | 8mer-1a | chr1:179877298-179877318 | 166.00 | -34.30 |
| ROSMAP | ENST00000609928 | 179865436 | 179865854 | hsa-miR-20b-5p | chr1:179865697-179865704 | 8mer-1a | chr1:179865681-179865704 | 158.00 | -19.24 |
| ROSMAP | ENST00000609928 | 179865436 | 179865854 | hsa-miR-106a-5p | chr1:179865697-179865704 | 8mer-1a | chr1:179865681-179865704 | 158.00 | -19.24 |
Top |
SNVs in the skipped exons for TOR1AIP2 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
Top |
AD stage-associated exon skippint events for TOR1AIP2 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
Top |
Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TOR1AIP2 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
Top |
Correlation with RNA binding proteins (RBPs) for TOR1AIP2 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| DLPFC | RBM6 | exon_skip_110476 | 4.745141e-01 | 5.844706e-17 |
| DLPFC | CELF1 | exon_skip_110476 | 4.148539e-01 | 6.003812e-13 |
| IFG | TARDBP | exon_skip_110476 | 4.681854e-01 | 1.198353e-02 |
| IFG | ZNF638 | exon_skip_110476 | 4.687340e-01 | 1.187049e-02 |
| IFG | RBM6 | exon_skip_110476 | 4.064738e-01 | 3.183721e-02 |
| IFG | CNOT4 | exon_skip_110476 | 5.677057e-01 | 1.627306e-03 |
| IFG | ENOX1 | exon_skip_110476 | 4.239852e-01 | 2.454438e-02 |
| IFG | KHSRP | exon_skip_110476 | 4.344498e-01 | 2.087974e-02 |
| IFG | HNRNPD | exon_skip_110476 | 4.384867e-01 | 1.959173e-02 |
| IFG | CELF1 | exon_skip_110476 | 4.895788e-01 | 8.186942e-03 |
Top |
RelatedDrugs for TOR1AIP2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for TOR1AIP2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|