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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for DCTD |
 Gene summary |
| Gene information | Gene symbol | DCTD | Gene ID | 1635 |
| Gene name | dCMP deaminase | |
| Synonyms | - | |
| Cytomap | 4q35.1 | |
| Type of gene | protein-coding | |
| Description | deoxycytidylate deaminase | |
| Modification date | 20200327 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for DCTD |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000129187
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | DOWN | ENST00000500813.6 | DCTD-203:nonsense_mediated_decay:DCTD | 9.180402e+01 | -9.251108e-01 | 8.701354e-08 | 1.883720e-06 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for DCTD |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_103576 | chr4 | 182915498:182915575:182916419:182916539:182916673:182916857 | 182916419:182916539 |
| exon_skip_142971 | chr4 | 182915498:182915575:182916419:182916539:182917311:182917322 | 182916419:182916539 |
| exon_skip_145158 | chr4 | 182915498:182915575:182916419:182916539:182916673:182916722 | 182916419:182916539 |
| exon_skip_166109 | chr4 | 182915498:182915575:182916419:182916539:182917288:182917322 | 182916419:182916539 |
| exon_skip_194022 | chr4 | 182916419:182916539:182916673:182916857:182917288:182917345 | 182916673:182916857 |
| exon_skip_198064 | chr4 | 182915498:182915575:182915881:182915888:182916419:182916539 | 182915881:182915888 |
| exon_skip_200755 | chr4 | 182915498:182915575:182916419:182916539:182916673:182916725 | 182916419:182916539 |
| exon_skip_210252 | chr4 | 182894554:182894605:182914923:182915058:182915461:182915560 | 182914923:182915058 |
| exon_skip_213636 | chr4 | 182916419:182916539:182916673:182916857:182917311:182917361 | 182916673:182916857 |
| exon_skip_231922 | chr4 | 182915461:182915575:182916723:182916857:182917311:182917361 | 182916723:182916857 |
| exon_skip_236166 | chr4 | 182915498:182915575:182916419:182916539:182917311:182917361 | 182916419:182916539 |
| exon_skip_239936 | chr4 | 182915461:182915575:182915881:182915888:182916419:182916539 | 182915881:182915888 |
| exon_skip_295324 | chr4 | 182915498:182915575:182915881:182915888:182916286:182916539 | 182915881:182915888 |
| exon_skip_75629 | chr4 | 182916419:182916539:182916673:182916857:182917311:182917322 | 182916673:182916857 |
| exon_skip_85361 | chr4 | 182915498:182915575:182916419:182916539:182917288:182917345 | 182916419:182916539 |
| exon_skip_9387 | chr4 | 182893031:182893127:182894489:182894605:182914923:182915058 | 182894489:182894605 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for DCTD |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000510370 | 182916419 | 182916539 | 3UTR-3UTR |
| ENST00000438320 | 182914923 | 182915058 | Frame-shift |
| ENST00000510370 | 182914923 | 182915058 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000510370 | 182916419 | 182916539 | 3UTR-3UTR |
| ENST00000438320 | 182914923 | 182915058 | Frame-shift |
| ENST00000510370 | 182914923 | 182915058 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000510370 | 182916419 | 182916539 | 3UTR-3UTR |
| ENST00000438320 | 182914923 | 182915058 | Frame-shift |
| ENST00000510370 | 182914923 | 182915058 | Frame-shift |
| ENST00000438320 | 182894489 | 182894605 | In-frame |
| ENST00000510370 | 182894489 | 182894605 | In-frame |
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Infer the effects of exon skipping event on protein functional features for DCTD |
p-ENSG00000129187_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000438320 | 1989 | 178 | 182894489 | 182894605 | 536 | 651 | 81 | 120 |
| ENST00000510370 | 811 | 178 | 182894489 | 182894605 | 475 | 590 | 81 | 120 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P32321 | 81 | 120 | 86 | 86 | Active site | Note=Proton donor;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P32321 | 81 | 120 | 86 | 86 | Active site | Note=Proton donor;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P32321 | 81 | 120 | 102 | 107 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W4L |
| P32321 | 81 | 120 | 102 | 107 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W4L |
| P32321 | 81 | 120 | 1 | 178 | Chain | ID=PRO_0000171691;Note=Deoxycytidylate deaminase |
| P32321 | 81 | 120 | 1 | 178 | Chain | ID=PRO_0000171691;Note=Deoxycytidylate deaminase |
| P32321 | 81 | 120 | 14 | 145 | Domain | Note=CMP/dCMP-type deaminase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01083 |
| P32321 | 81 | 120 | 14 | 145 | Domain | Note=CMP/dCMP-type deaminase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01083 |
| P32321 | 81 | 120 | 85 | 91 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W4L |
| P32321 | 81 | 120 | 85 | 91 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W4L |
| P32321 | 81 | 120 | 111 | 119 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W4L |
| P32321 | 81 | 120 | 111 | 119 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W4L |
| P32321 | 81 | 120 | 84 | 84 | Metal binding | Note=Zinc%3B catalytic;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.10 |
| P32321 | 81 | 120 | 84 | 84 | Metal binding | Note=Zinc%3B catalytic;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.10 |
| P32321 | 81 | 120 | 110 | 110 | Metal binding | Note=Zinc%3B catalytic;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.10 |
| P32321 | 81 | 120 | 110 | 110 | Metal binding | Note=Zinc%3B catalytic;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.10 |
| P32321 | 81 | 120 | 113 | 113 | Metal binding | Note=Zinc%3B catalytic;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.10 |
| P32321 | 81 | 120 | 113 | 113 | Metal binding | Note=Zinc%3B catalytic;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.10 |
| P32321 | 81 | 120 | 95 | 95 | Sequence conflict | Note=S->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P32321 | 81 | 120 | 95 | 95 | Sequence conflict | Note=S->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P32321 | 81 | 120 | 79 | 81 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W4L |
| P32321 | 81 | 120 | 79 | 81 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W4L |
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3'-UTR located exon skipping events that lost miRNA binding sites in DCTD |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000510370 | 182916419 | 182916539 | hsa-miR-4632-3p | chr4:182916528-182916535 | 8mer-1a | chr4:182916515-182916535 | 154.00 | -28.46 |
| Mayo | ENST00000510370 | 182916419 | 182916539 | hsa-miR-5581-5p | chr4:182916459-182916466 | 8mer-1a | chr4:182916457-182916478 | 164.00 | -21.13 |
| Mayo | ENST00000510370 | 182916419 | 182916539 | hsa-miR-30c-1-3p | chr4:182916471-182916478 | 8mer-1a | chr4:182916463-182916488 | 159.00 | -26.46 |
| Mayo | ENST00000510370 | 182916419 | 182916539 | hsa-miR-4297 | chr4:182916459-182916466 | 8mer-1a | chr4:182916457-182916478 | 164.00 | -21.13 |
| Mayo | ENST00000510370 | 182916419 | 182916539 | hsa-miR-6788-5p | chr4:182916471-182916478 | 8mer-1a | chr4:182916463-182916488 | 159.00 | -26.46 |
| Mayo | ENST00000510370 | 182916419 | 182916539 | hsa-miR-10401-3p | chr4:182916439-182916446 | 8mer-1a | chr4:182916429-182916448 | 163.00 | -19.44 |
| Mayo | ENST00000510370 | 182916419 | 182916539 | hsa-miR-887-5p | chr4:182916472-182916479 | 8mer-1a | chr4:182916463-182916488 | 159.00 | -26.46 |
| Mayo | ENST00000510370 | 182916419 | 182916539 | hsa-miR-30c-2-3p | chr4:182916471-182916478 | 8mer-1a | chr4:182916463-182916488 | 159.00 | -26.46 |
| MSBB | ENST00000510370 | 182916419 | 182916539 | hsa-miR-4632-3p | chr4:182916528-182916535 | 8mer-1a | chr4:182916515-182916535 | 154.00 | -28.46 |
| MSBB | ENST00000510370 | 182916419 | 182916539 | hsa-miR-5581-5p | chr4:182916459-182916466 | 8mer-1a | chr4:182916457-182916478 | 164.00 | -21.13 |
| MSBB | ENST00000510370 | 182916419 | 182916539 | hsa-miR-30c-1-3p | chr4:182916471-182916478 | 8mer-1a | chr4:182916463-182916488 | 159.00 | -26.46 |
| MSBB | ENST00000510370 | 182916419 | 182916539 | hsa-miR-4297 | chr4:182916459-182916466 | 8mer-1a | chr4:182916457-182916478 | 164.00 | -21.13 |
| MSBB | ENST00000510370 | 182916419 | 182916539 | hsa-miR-6788-5p | chr4:182916471-182916478 | 8mer-1a | chr4:182916463-182916488 | 159.00 | -26.46 |
| MSBB | ENST00000510370 | 182916419 | 182916539 | hsa-miR-10401-3p | chr4:182916439-182916446 | 8mer-1a | chr4:182916429-182916448 | 163.00 | -19.44 |
| MSBB | ENST00000510370 | 182916419 | 182916539 | hsa-miR-887-5p | chr4:182916472-182916479 | 8mer-1a | chr4:182916463-182916488 | 159.00 | -26.46 |
| MSBB | ENST00000510370 | 182916419 | 182916539 | hsa-miR-30c-2-3p | chr4:182916471-182916478 | 8mer-1a | chr4:182916463-182916488 | 159.00 | -26.46 |
| ROSMAP | ENST00000510370 | 182916419 | 182916539 | hsa-miR-4632-3p | chr4:182916528-182916535 | 8mer-1a | chr4:182916515-182916535 | 154.00 | -28.46 |
| ROSMAP | ENST00000510370 | 182916419 | 182916539 | hsa-miR-5581-5p | chr4:182916459-182916466 | 8mer-1a | chr4:182916457-182916478 | 164.00 | -21.13 |
| ROSMAP | ENST00000510370 | 182916419 | 182916539 | hsa-miR-30c-1-3p | chr4:182916471-182916478 | 8mer-1a | chr4:182916463-182916488 | 159.00 | -26.46 |
| ROSMAP | ENST00000510370 | 182916419 | 182916539 | hsa-miR-4297 | chr4:182916459-182916466 | 8mer-1a | chr4:182916457-182916478 | 164.00 | -21.13 |
| ROSMAP | ENST00000510370 | 182916419 | 182916539 | hsa-miR-6788-5p | chr4:182916471-182916478 | 8mer-1a | chr4:182916463-182916488 | 159.00 | -26.46 |
| ROSMAP | ENST00000510370 | 182916419 | 182916539 | hsa-miR-10401-3p | chr4:182916439-182916446 | 8mer-1a | chr4:182916429-182916448 | 163.00 | -19.44 |
| ROSMAP | ENST00000510370 | 182916419 | 182916539 | hsa-miR-887-5p | chr4:182916472-182916479 | 8mer-1a | chr4:182916463-182916488 | 159.00 | -26.46 |
| ROSMAP | ENST00000510370 | 182916419 | 182916539 | hsa-miR-30c-2-3p | chr4:182916471-182916478 | 8mer-1a | chr4:182916463-182916488 | 159.00 | -26.46 |
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SNVs in the skipped exons for DCTD |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for DCTD |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for DCTD |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for DCTD |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| IFG | RBM3 | exon_skip_210252 | 4.626683e-01 | 1.317122e-02 |
| TC | HNRNPH2 | exon_skip_198064 | 4.545615e-01 | 1.897384e-08 |
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RelatedDrugs for DCTD |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DCTD |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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