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	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	3'-UTR located exon skipping events lost miRNA binding sites
	SNVs in the skipped exons with depth of coverage
	AD stage-associated exon skipping events
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Correlation with RNA binding proteins (RBPs)
	Related drugs with this gene
	Related diseases with this gene

Gene summary for DCN

Gene summary

Gene information	Gene symbol	DCN
	Gene ID	1634
	Gene name	decorin
	Synonyms	CSCD|DSPG2|PG40|PGII|PGS2|SLRR1B
	Cytomap	12q21.33
	Type of gene	protein-coding
	Description	decorinbone proteoglycan IIdermatan sulphate proteoglycans IIproteoglycan core proteinsmall leucine-rich protein 1B
	Modification date	20200313
	UniProtAcc	A0A024RBG6, A0A0S2Z3J8, A0A0S2Z3L3, A0A0S2Z3L8, F8VNV6, F8VNW0, F8VSI3, F8VU58, F8VUF6, F8VWU0, F8VX58, F8VXZ8, H0YI87, H0YIH3, P07585, Q6FH10,
	Context	- 26784894(Network Topology Analysis of Post-Mortem Brain Microarrays Identifies More Alzheimer's Related Genes and MicroRNAs and Points to Novel Routes for Fighting with the Disease)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
DCN	GO:0010508	positive regulation of autophagy	23798385
DCN	GO:0010596	negative regulation of endothelial cell migration	23798385
DCN	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	23798385
DCN	GO:0016239	positive regulation of macroautophagy	23798385
DCN	GO:0016525	negative regulation of angiogenesis	23978385
DCN	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway	23798385

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Gene structures and expression levels for DCN

Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

ENSG00000011465

Differentially expressed gene analysis across multiple brain tissues between AD and control.

***cutpoints = c(0, 0.0001, 0.001, 0.01, 1), symbols = c("****", "***", "**", "ns")

Tissue type	DEG direction	Base mean exp.	log2FC(AD/control)	P-value	Adj. p-value
TC	UP	2.348874e+03	1.268512e+00	1.127271e-17	6.566078e-15

Differentially expressed isoform analysis across multiple brain tissues between AD and control.

Tissue type	DEG direction	ENST	Transcript info.	Base mean exp.	log2FC(AD/control)	P-value	Adjc. p-value
STG	UP	ENST00000552962.5	DCN-220:protein_coding:DCN	1.480260e+02	8.336229e-01	1.124403e-03	4.085448e-02
CB	UP	ENST00000547568.6	DCN-210:protein_coding:DCN	3.127873e+01	8.089706e-01	1.705102e-06	2.361322e-05
CB	UP	ENST00000550758.1	DCN-217:protein_coding:DCN	2.156560e+00	8.203930e-01	4.255091e-05	3.588399e-04
CB	DOWN	ENST00000425043.5	DCN-204:protein_coding:DCN	1.408379e+01	-4.998081e+00	8.298211e-05	6.327666e-04
CB	UP	ENST00000552962.5	DCN-220:protein_coding:DCN	7.607800e+01	1.331202e+00	9.270607e-04	4.845261e-03
TC	DOWN	ENST00000425043.5	DCN-204:protein_coding:DCN	1.248397e+01	-2.586194e+01	1.390970e-48	3.826725e-44
TC	UP	ENST00000547568.6	DCN-210:protein_coding:DCN	1.390952e+02	1.462794e+00	5.162180e-16	5.475987e-13
TC	UP	ENST00000552962.5	DCN-220:protein_coding:DCN	5.307413e+02	1.892845e+00	3.024766e-11	7.114128e-09
TC	UP	ENST00000393155.5	DCN-202:protein_coding:DCN	1.437553e+03	9.218246e-01	4.693851e-11	1.016799e-08
TC	UP	ENST00000550758.1	DCN-217:protein_coding:DCN	6.884306e+00	1.220399e+00	6.631554e-11	1.367631e-08
TC	UP	ENST00000550563.5	DCN-216:protein_coding:DCN	5.076069e+01	2.294734e+00	2.271302e-10	3.925015e-08
TC	UP	ENST00000551354.1	DCN-218:protein_coding:DCN	9.354008e+00	1.206808e+00	6.519933e-10	9.259258e-08
TC	UP	ENST00000552145.5	DCN-219:protein_coding:DCN	1.081495e+01	2.328040e+00	1.312381e-05	3.208779e-04
TC	UP	ENST00000546745.5	DCN-209:protein_coding:DCN	2.872176e+00	1.232845e+00	1.007556e-04	1.622137e-03
TC	UP	ENST00000549513.5	DCN-214:protein_coding:DCN	8.349544e-01	1.170418e+00	2.196282e-03	1.800320e-02
TC	UP	ENST00000547937.5	DCN-211:protein_coding:DCN	6.014626e+00	9.222300e-01	5.394178e-03	3.548719e-02
TC	UP	ENST00000548218.1	DCN-212:protein_coding:DCN	1.348376e+00	1.020245e+00	7.552198e-03	4.553764e-02

Landscape of isoform expressions across multiple brain tissues between AD and control.

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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for DCN

Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).

All exon skipping events in AD cohorts.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon
exon_skip_109978	chr12	91158476:91158509:91164605:91164717:91178342:91178552	91164605:91164717
exon_skip_198320	chr12	91178342:91178585:91179362:91179686:91182655:91182709	91179362:91179686
exon_skip_237540	chr12	91178342:91178585:91179362:91179686:91182655:91182824	91179362:91179686
exon_skip_286708	chr12	91153096:91153189:91157075:91157188:91158296:91158509	91157075:91157188
exon_skip_41843	chr12	91153096:91153189:91157075:91157188:91178342:91178552	91157075:91157188

Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.

Exon skipping information

Tissue type

Avg(PSIs) in AD

Avg(PSIs) in control

Difference (PSI)

Adj. p-value

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Open reading frame (ORF) annotation in the exon skipping event for DCN

Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000552962	91179362	91179686	3UTR-3UTR
ENST00000052754	91164605	91164717	Frame-shift
ENST00000393155	91164605	91164717	Frame-shift
ENST00000552962	91164605	91164717	Frame-shift
ENST00000052754	91157075	91157188	In-frame
ENST00000393155	91157075	91157188	In-frame
ENST00000552962	91157075	91157188	In-frame

Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000552962	91179362	91179686	3UTR-3UTR

Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000552962	91179362	91179686	3UTR-3UTR
ENST00000052754	91164605	91164717	Frame-shift
ENST00000393155	91164605	91164717	Frame-shift
ENST00000552962	91164605	91164717	Frame-shift
ENST00000052754	91157075	91157188	In-frame
ENST00000393155	91157075	91157188	In-frame
ENST00000552962	91157075	91157188	In-frame

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Infer the effects of exon skipping event on protein functional features for DCN

p-ENSG00000011465_img4.png

Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000052754	7173	359	91157075	91157188	1041	1153	179	217
ENST00000393155	2150	359	91157075	91157188	793	905	179	217
ENST00000552962	1947	359	91157075	91157188	1067	1179	179	217

Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.

ENST

Length of mRNA

Length of AA seq.

Genomic start

Genomic end

mRNA start

mRNA end

AA start

AA end

Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000052754	7173	359	91157075	91157188	1041	1153	179	217
ENST00000393155	2150	359	91157075	91157188	793	905	179	217
ENST00000552962	1947	359	91157075	91157188	1067	1179	179	217

Lost protein functional features of individual exon skipping events in ROSMAP.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P07585	179	217	71	179	Alternative sequence	ID=VSP_006172;Note=In isoform B. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
P07585	179	217	71	179	Alternative sequence	ID=VSP_006172;Note=In isoform B. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
P07585	179	217	71	179	Alternative sequence	ID=VSP_006172;Note=In isoform B. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
P07585	179	217	73	219	Alternative sequence	ID=VSP_006173;Note=In isoform C. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
P07585	179	217	73	219	Alternative sequence	ID=VSP_006173;Note=In isoform C. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
P07585	179	217	73	219	Alternative sequence	ID=VSP_006173;Note=In isoform C. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
P07585	179	217	76	359	Alternative sequence	ID=VSP_006176;Note=In isoform E. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
P07585	179	217	76	359	Alternative sequence	ID=VSP_006176;Note=In isoform E. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
P07585	179	217	76	359	Alternative sequence	ID=VSP_006176;Note=In isoform E. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
P07585	179	217	109	295	Alternative sequence	ID=VSP_006174;Note=In isoform D. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
P07585	179	217	109	295	Alternative sequence	ID=VSP_006174;Note=In isoform D. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
P07585	179	217	109	295	Alternative sequence	ID=VSP_006174;Note=In isoform D. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
P07585	179	217	31	359	Chain	ID=PRO_0000032710;Note=Decorin
P07585	179	217	31	359	Chain	ID=PRO_0000032710;Note=Decorin
P07585	179	217	31	359	Chain	ID=PRO_0000032710;Note=Decorin
P07585	179	217	211	211	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
P07585	179	217	211	211	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
P07585	179	217	211	211	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
P07585	179	217	163	186	Repeat	Note=LRR 5
P07585	179	217	163	186	Repeat	Note=LRR 5
P07585	179	217	163	186	Repeat	Note=LRR 5
P07585	179	217	187	212	Repeat	Note=LRR 6
P07585	179	217	187	212	Repeat	Note=LRR 6
P07585	179	217	187	212	Repeat	Note=LRR 6
P07585	179	217	213	233	Repeat	Note=LRR 7
P07585	179	217	213	233	Repeat	Note=LRR 7
P07585	179	217	213	233	Repeat	Note=LRR 7

Lost protein functional features of individual exon skipping events in MSBB.

UniProt acc.

Start of exon skipping (AA)

End of exon skipping (AA)

Protein feature start (AA)

Protein feature end (AA)

Category of protein feature

Description of feature

Lost protein functional features of individual exon skipping events in Mayo.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P07585	179	217	71	179	Alternative sequence	ID=VSP_006172;Note=In isoform B. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
P07585	179	217	71	179	Alternative sequence	ID=VSP_006172;Note=In isoform B. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
P07585	179	217	71	179	Alternative sequence	ID=VSP_006172;Note=In isoform B. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
P07585	179	217	73	219	Alternative sequence	ID=VSP_006173;Note=In isoform C. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
P07585	179	217	73	219	Alternative sequence	ID=VSP_006173;Note=In isoform C. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
P07585	179	217	73	219	Alternative sequence	ID=VSP_006173;Note=In isoform C. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
P07585	179	217	76	359	Alternative sequence	ID=VSP_006176;Note=In isoform E. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
P07585	179	217	76	359	Alternative sequence	ID=VSP_006176;Note=In isoform E. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
P07585	179	217	76	359	Alternative sequence	ID=VSP_006176;Note=In isoform E. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
P07585	179	217	109	295	Alternative sequence	ID=VSP_006174;Note=In isoform D. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
P07585	179	217	109	295	Alternative sequence	ID=VSP_006174;Note=In isoform D. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
P07585	179	217	109	295	Alternative sequence	ID=VSP_006174;Note=In isoform D. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
P07585	179	217	31	359	Chain	ID=PRO_0000032710;Note=Decorin
P07585	179	217	31	359	Chain	ID=PRO_0000032710;Note=Decorin
P07585	179	217	31	359	Chain	ID=PRO_0000032710;Note=Decorin
P07585	179	217	211	211	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
P07585	179	217	211	211	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
P07585	179	217	211	211	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218
P07585	179	217	163	186	Repeat	Note=LRR 5
P07585	179	217	163	186	Repeat	Note=LRR 5
P07585	179	217	163	186	Repeat	Note=LRR 5
P07585	179	217	187	212	Repeat	Note=LRR 6
P07585	179	217	187	212	Repeat	Note=LRR 6
P07585	179	217	187	212	Repeat	Note=LRR 6
P07585	179	217	213	233	Repeat	Note=LRR 7
P07585	179	217	213	233	Repeat	Note=LRR 7
P07585	179	217	213	233	Repeat	Note=LRR 7

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3'-UTR located exon skipping events that lost miRNA binding sites in DCN

3'-UTR exon skipping evnets lost miRNA binding.

Tissue type	ENST	Exon skip start	Exon skip end	microRNA	Binding site by TargetScan	Binding type by TargetScan	Bdinding site by miRanda	Score of miRanda	Energy by miRanda
Mayo	ENST00000552962	91179362	91179686	hsa-miR-3116	chr12:91179425-91179432	8mer-1a	chr12:91179424-91179448	157.00	-23.26
Mayo	ENST00000552962	91179362	91179686	hsa-miR-1255b-5p	chr12:91179421-91179428	8mer-1a	chr12:91179405-91179428	156.00	-16.60
Mayo	ENST00000552962	91179362	91179686	hsa-miR-19a-3p	chr12:91179612-91179619	8mer-1a	chr12:91179595-91179619	151.00	-16.83
Mayo	ENST00000552962	91179362	91179686	hsa-miR-19b-3p	chr12:91179612-91179619	8mer-1a	chr12:91179595-91179619	151.00	-16.83
Mayo	ENST00000552962	91179362	91179686	hsa-miR-4708-3p	chr12:91179598-91179605	8mer-1a	chr12:91179594-91179616	157.00	-15.37
Mayo	ENST00000552962	91179362	91179686	hsa-miR-95-5p	chr12:91179643-91179650	8mer-1a	chr12:91179635-91179655	147.00	-16.48
Mayo	ENST00000552962	91179362	91179686	hsa-miR-548ah-5p	chr12:91179639-91179646	8mer-1a	chr12:91179623-91179646	160.00	-13.68
Mayo	ENST00000552962	91179362	91179686	hsa-miR-8066	chr12:91179499-91179506	8mer-1a	chr12:91179486-91179506	146.00	-8.36
Mayo	ENST00000552962	91179362	91179686	hsa-miR-1255a	chr12:91179421-91179428	8mer-1a	chr12:91179405-91179428	156.00	-16.60
Mayo	ENST00000552962	91179362	91179686	hsa-miR-887-5p	chr12:91179459-91179466	8mer-1a	chr12:91179458-91179479	153.00	-21.70
Mayo	ENST00000552962	91179362	91179686	hsa-miR-148a-5p	chr12:91179491-91179498	8mer-1a	chr12:91179474-91179502	143.00	-13.34
Mayo	ENST00000552962	91179362	91179686	hsa-miR-3609	chr12:91179639-91179646	8mer-1a	chr12:91179623-91179646	160.00	-13.68
Mayo	ENST00000552962	91179362	91179686	hsa-miR-937-5p	chr12:91179624-91179631	8mer-1a	chr12:91179623-91179646	160.00	-13.68
Mayo	ENST00000552962	91179362	91179686	hsa-miR-1468-3p	chr12:91179610-91179617	8mer-1a	chr12:91179595-91179619	151.00	-16.83
MSBB	ENST00000552962	91179362	91179686	hsa-miR-3116	chr12:91179425-91179432	8mer-1a	chr12:91179424-91179448	157.00	-23.26
MSBB	ENST00000552962	91179362	91179686	hsa-miR-1255b-5p	chr12:91179421-91179428	8mer-1a	chr12:91179405-91179428	156.00	-16.60
MSBB	ENST00000552962	91179362	91179686	hsa-miR-19a-3p	chr12:91179612-91179619	8mer-1a	chr12:91179595-91179619	151.00	-16.83
MSBB	ENST00000552962	91179362	91179686	hsa-miR-19b-3p	chr12:91179612-91179619	8mer-1a	chr12:91179595-91179619	151.00	-16.83
MSBB	ENST00000552962	91179362	91179686	hsa-miR-4708-3p	chr12:91179598-91179605	8mer-1a	chr12:91179594-91179616	157.00	-15.37
MSBB	ENST00000552962	91179362	91179686	hsa-miR-95-5p	chr12:91179643-91179650	8mer-1a	chr12:91179635-91179655	147.00	-16.48
MSBB	ENST00000552962	91179362	91179686	hsa-miR-548ah-5p	chr12:91179639-91179646	8mer-1a	chr12:91179623-91179646	160.00	-13.68
MSBB	ENST00000552962	91179362	91179686	hsa-miR-8066	chr12:91179499-91179506	8mer-1a	chr12:91179486-91179506	146.00	-8.36
MSBB	ENST00000552962	91179362	91179686	hsa-miR-1255a	chr12:91179421-91179428	8mer-1a	chr12:91179405-91179428	156.00	-16.60
MSBB	ENST00000552962	91179362	91179686	hsa-miR-887-5p	chr12:91179459-91179466	8mer-1a	chr12:91179458-91179479	153.00	-21.70
MSBB	ENST00000552962	91179362	91179686	hsa-miR-148a-5p	chr12:91179491-91179498	8mer-1a	chr12:91179474-91179502	143.00	-13.34
MSBB	ENST00000552962	91179362	91179686	hsa-miR-3609	chr12:91179639-91179646	8mer-1a	chr12:91179623-91179646	160.00	-13.68
MSBB	ENST00000552962	91179362	91179686	hsa-miR-937-5p	chr12:91179624-91179631	8mer-1a	chr12:91179623-91179646	160.00	-13.68
MSBB	ENST00000552962	91179362	91179686	hsa-miR-1468-3p	chr12:91179610-91179617	8mer-1a	chr12:91179595-91179619	151.00	-16.83
ROSMAP	ENST00000552962	91179362	91179686	hsa-miR-3116	chr12:91179425-91179432	8mer-1a	chr12:91179424-91179448	157.00	-23.26
ROSMAP	ENST00000552962	91179362	91179686	hsa-miR-1255b-5p	chr12:91179421-91179428	8mer-1a	chr12:91179405-91179428	156.00	-16.60
ROSMAP	ENST00000552962	91179362	91179686	hsa-miR-19a-3p	chr12:91179612-91179619	8mer-1a	chr12:91179595-91179619	151.00	-16.83
ROSMAP	ENST00000552962	91179362	91179686	hsa-miR-19b-3p	chr12:91179612-91179619	8mer-1a	chr12:91179595-91179619	151.00	-16.83
ROSMAP	ENST00000552962	91179362	91179686	hsa-miR-4708-3p	chr12:91179598-91179605	8mer-1a	chr12:91179594-91179616	157.00	-15.37
ROSMAP	ENST00000552962	91179362	91179686	hsa-miR-95-5p	chr12:91179643-91179650	8mer-1a	chr12:91179635-91179655	147.00	-16.48
ROSMAP	ENST00000552962	91179362	91179686	hsa-miR-548ah-5p	chr12:91179639-91179646	8mer-1a	chr12:91179623-91179646	160.00	-13.68
ROSMAP	ENST00000552962	91179362	91179686	hsa-miR-8066	chr12:91179499-91179506	8mer-1a	chr12:91179486-91179506	146.00	-8.36
ROSMAP	ENST00000552962	91179362	91179686	hsa-miR-1255a	chr12:91179421-91179428	8mer-1a	chr12:91179405-91179428	156.00	-16.60
ROSMAP	ENST00000552962	91179362	91179686	hsa-miR-887-5p	chr12:91179459-91179466	8mer-1a	chr12:91179458-91179479	153.00	-21.70
ROSMAP	ENST00000552962	91179362	91179686	hsa-miR-148a-5p	chr12:91179491-91179498	8mer-1a	chr12:91179474-91179502	143.00	-13.34
ROSMAP	ENST00000552962	91179362	91179686	hsa-miR-3609	chr12:91179639-91179646	8mer-1a	chr12:91179623-91179646	160.00	-13.68
ROSMAP	ENST00000552962	91179362	91179686	hsa-miR-937-5p	chr12:91179624-91179631	8mer-1a	chr12:91179623-91179646	160.00	-13.68
ROSMAP	ENST00000552962	91179362	91179686	hsa-miR-1468-3p	chr12:91179610-91179617	8mer-1a	chr12:91179595-91179619	151.00	-16.83

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SNVs in the skipped exons for DCN

- Differential PSIs between mutated versus non-mutated samples.

- Depth of Coverage in the skipped exon of the mutated samples.

- Sashimi plot in the skipped exon of the mutated samples.

- Non-synonymous mutations located in the skipped exons.

Cancer type

Sample

ESID

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

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AD stage-associated exon skippint events for DCN

Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).

AD stage info

Cohort

Tissue

SE id

Coefficient

P-value

Chromosome

Strand

E1 start

E1 end

Skipped start

Skipped end

E2 start

E2 end

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for DCN

sQTL information located at the skipped exons.

Tissue type

Exon skip ID

SNP id

Location

P-value

FDR

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Correlation with RNA binding proteins (RBPs) for DCN

Correlated RBP and related information.

Tissue type

RBP name

Exon skip ID

Correlation coeifficient

P-value

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RelatedDrugs for DCN

Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02)

UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
P07585	approved	DB03754	Tromethamine	small molecule	P07585

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RelatedDiseases for DCN

Diseases associated with this gene. (DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

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