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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for DCC |
 Gene summary |
| Gene information | Gene symbol | DCC | Gene ID | 1630 |
| Gene name | DCC netrin 1 receptor | |
| Synonyms | CRC18|CRCR1|HGPPS2|IGDCC1|MRMV1|NTN1R1 | |
| Cytomap | 18q21.2 | |
| Type of gene | protein-coding | |
| Description | netrin receptor DCCcolorectal cancer suppressordeleted in colorectal carcinomaimmunoglobulin superfamily DCC subclass member 1putative colorectal tumor suppressortumor suppressor protein DCC | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for DCC |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000187323
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for DCC |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_167243 | chr18 | 52925234:52925370:53063305:53063459:53066046:53066166 | 53063305:53063459 |
| exon_skip_233191 | chr18 | 53157356:53157512:53178962:53179116:53205216:53205364 | 53178962:53179116 |
| exon_skip_244512 | chr18 | 53467894:53468010:53486797:53486952:53499298:53499510 | 53486797:53486952 |
| exon_skip_279553 | chr18 | 53305578:53305719:53322047:53322157:53339713:53339907 | 53322047:53322157 |
| exon_skip_55402 | chr18 | 53467894:53468010:53486797:53486958:53499298:53499510 | 53486797:53486958 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for DCC |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000442544 | 53063305 | 53063459 | Frame-shift |
| ENST00000442544 | 53178962 | 53179116 | Frame-shift |
| ENST00000442544 | 53322047 | 53322157 | In-frame |
| ENST00000442544 | 53486797 | 53486958 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000442544 | 53486797 | 53486958 | In-frame |
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Infer the effects of exon skipping event on protein functional features for DCC |
p-ENSG00000187323_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000442544 | 10223 | 1447 | 53322047 | 53322157 | 2671 | 2780 | 685 | 721 |
| ENST00000442544 | 10223 | 1447 | 53486797 | 53486958 | 4354 | 4514 | 1246 | 1299 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000442544 | 10223 | 1447 | 53486797 | 53486958 | 4354 | 4514 | 1246 | 1299 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P43146 | 685 | 721 | 691 | 694 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ED9 |
| P43146 | 685 | 721 | 696 | 699 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ED9 |
| P43146 | 685 | 721 | 711 | 714 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ED9 |
| P43146 | 685 | 721 | 716 | 719 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2EDB |
| P43146 | 685 | 721 | 26 | 1447 | Chain | ID=PRO_0000014744;Note=Netrin receptor DCC |
| P43146 | 685 | 721 | 625 | 718 | Domain | Note=Fibronectin type-III 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316 |
| P43146 | 685 | 721 | 702 | 702 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P43146 | 685 | 721 | 275 | 1447 | Natural variant | ID=VAR_079145;Note=In MRMV1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28250454;Dbxref=PMID:28250454 |
| P43146 | 685 | 721 | 691 | 691 | Natural variant | ID=VAR_079287;Note=In HGPPS2%3B unknown pathological significance. Q->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28250456;Dbxref=PMID:28250456 |
| P43146 | 685 | 721 | 26 | 1097 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P43146 | 1246 | 1299 | 26 | 1447 | Chain | ID=PRO_0000014744;Note=Netrin receptor DCC |
| P43146 | 1246 | 1299 | 1267 | 1267 | Modified residue | Note=Phosphoserine%3B by MAPK1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63155 |
| P43146 | 1246 | 1299 | 275 | 1447 | Natural variant | ID=VAR_079145;Note=In MRMV1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28250454;Dbxref=PMID:28250454 |
| P43146 | 1246 | 1299 | 1250 | 1250 | Natural variant | ID=VAR_079153;Note=In MRMV1%3B unknown pathological significance. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28250454;Dbxref=dbSNP:rs748112308,PMID:28250454 |
| P43146 | 1246 | 1299 | 1123 | 1447 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P43146 | 1246 | 1299 | 26 | 1447 | Chain | ID=PRO_0000014744;Note=Netrin receptor DCC |
| P43146 | 1246 | 1299 | 1267 | 1267 | Modified residue | Note=Phosphoserine%3B by MAPK1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63155 |
| P43146 | 1246 | 1299 | 275 | 1447 | Natural variant | ID=VAR_079145;Note=In MRMV1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28250454;Dbxref=PMID:28250454 |
| P43146 | 1246 | 1299 | 1250 | 1250 | Natural variant | ID=VAR_079153;Note=In MRMV1%3B unknown pathological significance. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28250454;Dbxref=dbSNP:rs748112308,PMID:28250454 |
| P43146 | 1246 | 1299 | 1123 | 1447 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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3'-UTR located exon skipping events that lost miRNA binding sites in DCC |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for DCC |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for DCC |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for DCC |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for DCC |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for DCC |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DCC |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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