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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for PRUNE2 |
 Gene summary |
| Gene information | Gene symbol | PRUNE2 | Gene ID | 158471 |
| Gene name | prune homolog 2 with BCH domain | |
| Synonyms | BMCC1|BNIPXL|C9orf65|KIAA0367 | |
| Cytomap | 9q21.2 | |
| Type of gene | protein-coding | |
| Description | protein prune homolog 2BCH motif-containing molecule at the carboxyl terminal region 1BNIP2 motif containing molecule at the carboxyl terminal region 1BNIP2 motif-containing molecule at the C-terminal region 1olfaxintruncated PRUNE2 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for PRUNE2 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000106772
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
 |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PCC | UP | ENST00000466266.6 | PRUNE2-210:lncRNA:PRUNE2 | 4.950785e+01 | 1.739686e+00 | 1.179382e-07 | 5.790763e-05 |
| PG | UP | ENST00000443509.6 | PRUNE2-208:protein_coding:PRUNE2 | 9.863219e+02 | 1.239103e+00 | 4.083264e-05 | 1.409073e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for PRUNE2 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_100245 | chr9 | 76846599:76846678:76850463:76850665:76854104:76854208 | 76850463:76850665 |
| exon_skip_123731 | chr9 | 76619340:76619387:76625023:76625058:76629192:76629275 | 76625023:76625058 |
| exon_skip_124559 | chr9 | 76850463:76850665:76854104:76854208:76905928:76906041 | 76854104:76854208 |
| exon_skip_136627 | chr9 | 76624452:76624490:76629192:76629290:76636471:76636557 | 76629192:76629290 |
| exon_skip_169466 | chr9 | 76826580:76826732:76846515:76846678:76850463:76850660 | 76846515:76846678 |
| exon_skip_171621 | chr9 | 76637539:76637549:76638186:76638288:76644739:76644909 | 76638186:76638288 |
| exon_skip_18208 | chr9 | 76826580:76826732:76846515:76846678:76850463:76850665 | 76846515:76846678 |
| exon_skip_188141 | chr9 | 76614569:76614600:76619340:76619387:76625023:76625058 | 76619340:76619387 |
| exon_skip_194238 | chr9 | 76614540:76614600:76619340:76619387:76625023:76625058 | 76619340:76619387 |
| exon_skip_194903 | chr9 | 76823632:76823726:76826580:76826732:76846515:76846678 | 76826580:76826732 |
| exon_skip_201999 | chr9 | 76637539:76637549:76638186:76638288:76644739:76644900 | 76638186:76638288 |
| exon_skip_222742 | chr9 | 76713563:76713721:76823632:76823726:76826580:76826732 | 76823632:76823726 |
| exon_skip_237870 | chr9 | 76619340:76619387:76624452:76624490:76629192:76629278 | 76624452:76624490 |
| exon_skip_241455 | chr9 | 76619340:76619387:76624452:76624490:76629192:76629275 | 76624452:76624490 |
| exon_skip_243417 | chr9 | 76625023:76625058:76629192:76629290:76636471:76636557 | 76629192:76629290 |
| exon_skip_259494 | chr9 | 76638186:76638288:76641972:76641980:76644739:76644900 | 76641972:76641980 |
| exon_skip_263146 | chr9 | 76636471:76636557:76637418:76637549:76638186:76638288 | 76637418:76637549 |
| exon_skip_267384 | chr9 | 76619340:76619387:76625023:76625058:76629192:76629278 | 76625023:76625058 |
| exon_skip_281573 | chr9 | 76614450:76614600:76629192:76629290:76636471:76636557 | 76629192:76629290 |
| exon_skip_286254 | chr9 | 76619340:76619387:76624452:76624490:76629192:76629290 | 76624452:76624490 |
| exon_skip_39411 | chr9 | 76638186:76638288:76641972:76641980:76644739:76644909 | 76641972:76641980 |
| exon_skip_50760 | chr9 | 76614450:76614600:76619340:76619387:76625023:76625058 | 76619340:76619387 |
| exon_skip_8360 | chr9 | 76619340:76619387:76625023:76625058:76629192:76629290 | 76625023:76625058 |
| exon_skip_95500 | chr9 | 76614450:76614600:76619340:76619387:76624452:76624490 | 76619340:76619387 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_39411 | ROSMAP_DLPFC | 4.477202e-01 | 3.286792e-01 | 1.190410e-01 | 1.118608e-04 |
| exon_skip_39411 | MSBB_STG | 4.080645e-01 | 3.020833e-01 | 1.059812e-01 | 1.487999e-02 |
| exon_skip_39411 | MSBB_PG | 5.103623e-01 | 3.269091e-01 | 1.834532e-01 | 7.721548e-07 |
| exon_skip_60589 | Mayo_CB | 8.164634e-01 | 9.304545e-01 | -1.139911e-01 | 3.715269e-08 |
| exon_skip_208144 | Mayo_TC | 3.859756e-01 | 5.328767e-01 | -1.469011e-01 | 1.600068e-03 |
| exon_skip_158530 | Mayo_TC | 4.912195e-01 | 6.166216e-01 | -1.254021e-01 | 1.781686e-05 |
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Open reading frame (ORF) annotation in the exon skipping event for PRUNE2 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000376718 | 76638186 | 76638288 | Frame-shift |
| ENST00000376718 | 76846515 | 76846678 | Frame-shift |
| ENST00000376718 | 76850463 | 76850665 | Frame-shift |
| ENST00000376718 | 76619340 | 76619387 | In-frame |
| ENST00000376718 | 76624452 | 76624490 | In-frame |
| ENST00000376718 | 76629192 | 76629290 | In-frame |
| ENST00000376718 | 76637418 | 76637549 | In-frame |
| ENST00000376718 | 76826580 | 76826732 | In-frame |
| ENST00000376718 | 76854104 | 76854208 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000376718 | 76638186 | 76638288 | Frame-shift |
| ENST00000376718 | 76823632 | 76823726 | Frame-shift |
| ENST00000376718 | 76846515 | 76846678 | Frame-shift |
| ENST00000376718 | 76850463 | 76850665 | Frame-shift |
| ENST00000376718 | 76619340 | 76619387 | In-frame |
| ENST00000376718 | 76624452 | 76624490 | In-frame |
| ENST00000376718 | 76826580 | 76826732 | In-frame |
| ENST00000376718 | 76854104 | 76854208 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000376718 | 76638186 | 76638288 | Frame-shift |
| ENST00000376718 | 76850463 | 76850665 | Frame-shift |
| ENST00000376718 | 76619340 | 76619387 | In-frame |
| ENST00000376718 | 76624452 | 76624490 | In-frame |
| ENST00000376718 | 76629192 | 76629290 | In-frame |
| ENST00000376718 | 76826580 | 76826732 | In-frame |
| ENST00000376718 | 76854104 | 76854208 | In-frame |
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Infer the effects of exon skipping event on protein functional features for PRUNE2 |
p-ENSG00000106772_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000376718 | 12601 | 3088 | 76854104 | 76854208 | 161 | 264 | 12 | 46 |
| ENST00000376718 | 12601 | 3088 | 76826580 | 76826732 | 633 | 784 | 169 | 220 |
| ENST00000376718 | 12601 | 3088 | 76637418 | 76637549 | 8956 | 9086 | 2944 | 2987 |
| ENST00000376718 | 12601 | 3088 | 76629192 | 76629290 | 9175 | 9272 | 3017 | 3049 |
| ENST00000376718 | 12601 | 3088 | 76624452 | 76624490 | 9274 | 9311 | 3050 | 3062 |
| ENST00000376718 | 12601 | 3088 | 76619340 | 76619387 | 9313 | 9359 | 3063 | 3078 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000376718 | 12601 | 3088 | 76854104 | 76854208 | 161 | 264 | 12 | 46 |
| ENST00000376718 | 12601 | 3088 | 76826580 | 76826732 | 633 | 784 | 169 | 220 |
| ENST00000376718 | 12601 | 3088 | 76624452 | 76624490 | 9274 | 9311 | 3050 | 3062 |
| ENST00000376718 | 12601 | 3088 | 76619340 | 76619387 | 9313 | 9359 | 3063 | 3078 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000376718 | 12601 | 3088 | 76854104 | 76854208 | 161 | 264 | 12 | 46 |
| ENST00000376718 | 12601 | 3088 | 76826580 | 76826732 | 633 | 784 | 169 | 220 |
| ENST00000376718 | 12601 | 3088 | 76629192 | 76629290 | 9175 | 9272 | 3017 | 3049 |
| ENST00000376718 | 12601 | 3088 | 76624452 | 76624490 | 9274 | 9311 | 3050 | 3062 |
| ENST00000376718 | 12601 | 3088 | 76619340 | 76619387 | 9313 | 9359 | 3063 | 3078 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8WUY3 | 12 | 46 | 1 | 2736 | Alternative sequence | ID=VSP_039339;Note=In isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334 |
| Q8WUY3 | 12 | 46 | 1 | 3088 | Chain | ID=PRO_0000089701;Note=Protein prune homolog 2 |
| Q8WUY3 | 169 | 220 | 1 | 2736 | Alternative sequence | ID=VSP_039339;Note=In isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334 |
| Q8WUY3 | 169 | 220 | 1 | 3088 | Chain | ID=PRO_0000089701;Note=Protein prune homolog 2 |
| Q8WUY3 | 2944 | 2987 | 1 | 3088 | Chain | ID=PRO_0000089701;Note=Protein prune homolog 2 |
| Q8WUY3 | 2944 | 2987 | 2895 | 3056 | Domain | Note=CRAL-TRIO;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00056 |
| Q8WUY3 | 3017 | 3049 | 1 | 3088 | Chain | ID=PRO_0000089701;Note=Protein prune homolog 2 |
| Q8WUY3 | 3017 | 3049 | 2895 | 3056 | Domain | Note=CRAL-TRIO;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00056 |
| Q8WUY3 | 3050 | 3062 | 3051 | 3088 | Alternative sequence | ID=VSP_039343;Note=In isoform 4. LDEELREASEAAKTSCLYNDPEMSSMEKDIDLKLKEKP->Y;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.5 |
| Q8WUY3 | 3050 | 3062 | 1 | 3088 | Chain | ID=PRO_0000089701;Note=Protein prune homolog 2 |
| Q8WUY3 | 3050 | 3062 | 2895 | 3056 | Domain | Note=CRAL-TRIO;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00056 |
| Q8WUY3 | 3063 | 3078 | 3051 | 3088 | Alternative sequence | ID=VSP_039343;Note=In isoform 4. LDEELREASEAAKTSCLYNDPEMSSMEKDIDLKLKEKP->Y;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.5 |
| Q8WUY3 | 3063 | 3078 | 1 | 3088 | Chain | ID=PRO_0000089701;Note=Protein prune homolog 2 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8WUY3 | 12 | 46 | 1 | 2736 | Alternative sequence | ID=VSP_039339;Note=In isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334 |
| Q8WUY3 | 12 | 46 | 1 | 3088 | Chain | ID=PRO_0000089701;Note=Protein prune homolog 2 |
| Q8WUY3 | 169 | 220 | 1 | 2736 | Alternative sequence | ID=VSP_039339;Note=In isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334 |
| Q8WUY3 | 169 | 220 | 1 | 3088 | Chain | ID=PRO_0000089701;Note=Protein prune homolog 2 |
| Q8WUY3 | 3050 | 3062 | 3051 | 3088 | Alternative sequence | ID=VSP_039343;Note=In isoform 4. LDEELREASEAAKTSCLYNDPEMSSMEKDIDLKLKEKP->Y;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.5 |
| Q8WUY3 | 3050 | 3062 | 1 | 3088 | Chain | ID=PRO_0000089701;Note=Protein prune homolog 2 |
| Q8WUY3 | 3050 | 3062 | 2895 | 3056 | Domain | Note=CRAL-TRIO;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00056 |
| Q8WUY3 | 3063 | 3078 | 3051 | 3088 | Alternative sequence | ID=VSP_039343;Note=In isoform 4. LDEELREASEAAKTSCLYNDPEMSSMEKDIDLKLKEKP->Y;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.5 |
| Q8WUY3 | 3063 | 3078 | 1 | 3088 | Chain | ID=PRO_0000089701;Note=Protein prune homolog 2 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8WUY3 | 12 | 46 | 1 | 2736 | Alternative sequence | ID=VSP_039339;Note=In isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334 |
| Q8WUY3 | 12 | 46 | 1 | 3088 | Chain | ID=PRO_0000089701;Note=Protein prune homolog 2 |
| Q8WUY3 | 169 | 220 | 1 | 2736 | Alternative sequence | ID=VSP_039339;Note=In isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334 |
| Q8WUY3 | 169 | 220 | 1 | 3088 | Chain | ID=PRO_0000089701;Note=Protein prune homolog 2 |
| Q8WUY3 | 3017 | 3049 | 1 | 3088 | Chain | ID=PRO_0000089701;Note=Protein prune homolog 2 |
| Q8WUY3 | 3017 | 3049 | 2895 | 3056 | Domain | Note=CRAL-TRIO;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00056 |
| Q8WUY3 | 3050 | 3062 | 3051 | 3088 | Alternative sequence | ID=VSP_039343;Note=In isoform 4. LDEELREASEAAKTSCLYNDPEMSSMEKDIDLKLKEKP->Y;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.5 |
| Q8WUY3 | 3050 | 3062 | 1 | 3088 | Chain | ID=PRO_0000089701;Note=Protein prune homolog 2 |
| Q8WUY3 | 3050 | 3062 | 2895 | 3056 | Domain | Note=CRAL-TRIO;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00056 |
| Q8WUY3 | 3063 | 3078 | 3051 | 3088 | Alternative sequence | ID=VSP_039343;Note=In isoform 4. LDEELREASEAAKTSCLYNDPEMSSMEKDIDLKLKEKP->Y;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.5 |
| Q8WUY3 | 3063 | 3078 | 1 | 3088 | Chain | ID=PRO_0000089701;Note=Protein prune homolog 2 |
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3'-UTR located exon skipping events that lost miRNA binding sites in PRUNE2 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for PRUNE2 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for PRUNE2 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PRUNE2 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
| TC | exon_skip_95500 | rs13290974 | chr9:76549730 | 2.710438e-04 | 3.630990e-02 |
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Correlation with RNA binding proteins (RBPs) for PRUNE2 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | SRSF9 | exon_skip_50760 | 4.449907e-01 | 5.591959e-07 |
| CB | SRSF2 | exon_skip_290248 | 4.967140e-01 | 1.381933e-09 |
| CB | SRSF9 | exon_skip_290248 | 4.771426e-01 | 7.283223e-09 |
| CB | TARDBP | exon_skip_152162 | -5.020950e-01 | 2.437548e-09 |
| CB | RBM3 | exon_skip_152162 | 4.559536e-01 | 9.120130e-08 |
| CB | TRA2A | exon_skip_152162 | -5.690238e-01 | 4.406434e-12 |
| CB | TRA2A | exon_skip_237870 | -5.074304e-01 | 3.426695e-11 |
| CB | HNRNPF | exon_skip_237870 | -4.188329e-01 | 9.605731e-08 |
| CB | TARDBP | exon_skip_267384 | -4.623430e-01 | 5.033805e-08 |
| CB | RBM3 | exon_skip_267384 | 4.108019e-01 | 1.771034e-06 |
| CB | TRA2A | exon_skip_267384 | -5.016753e-01 | 2.176213e-09 |
| CB | RBM3 | exon_skip_206760 | -4.751972e-01 | 6.173202e-08 |
| CB | UNK | exon_skip_206760 | -4.367738e-01 | 8.510295e-07 |
| CB | DAZAP1 | exon_skip_210124 | -4.299849e-01 | 1.058937e-06 |
| CB | TARDBP | exon_skip_210124 | -4.213082e-01 | 1.829002e-06 |
| CB | RBM6 | exon_skip_210124 | -4.914853e-01 | 1.380630e-08 |
| CB | CNOT4 | exon_skip_210124 | -4.276198e-01 | 1.230896e-06 |
| CB | PCBP4 | exon_skip_210124 | 5.354582e-01 | 3.510861e-10 |
| CB | TRA2A | exon_skip_210124 | -5.833852e-01 | 3.345397e-12 |
| CB | FUBP3 | exon_skip_210124 | 4.950627e-01 | 1.043814e-08 |
| CB | FUBP1 | exon_skip_210124 | -4.958776e-01 | 9.789500e-09 |
| CB | DAZAP1 | exon_skip_60589 | -4.470472e-01 | 1.227664e-08 |
| CB | TARDBP | exon_skip_60589 | -5.208709e-01 | 1.149506e-11 |
| CB | RBM6 | exon_skip_60589 | -4.716337e-01 | 1.443237e-09 |
| CB | CNOT4 | exon_skip_60589 | -5.575246e-01 | 1.837083e-13 |
| CB | RBM3 | exon_skip_60589 | 4.664887e-01 | 2.291007e-09 |
| CB | PCBP1 | exon_skip_60589 | -4.324518e-01 | 4.047450e-08 |
| CB | PCBP4 | exon_skip_60589 | 6.197735e-01 | 4.523326e-17 |
| CB | TRA2A | exon_skip_60589 | -6.501971e-01 | 3.813120e-19 |
| CB | FUBP1 | exon_skip_60589 | -5.308740e-01 | 3.904433e-12 |
| CB | PTBP1 | exon_skip_60589 | -4.931919e-01 | 1.911272e-10 |
| CB | RBM4B | exon_skip_60589 | -5.139668e-01 | 2.373383e-11 |
| CB | RBM3 | exon_skip_201999 | 4.586744e-01 | 5.807463e-09 |
| CB | PTBP1 | exon_skip_201999 | -4.823102e-01 | 7.079238e-10 |
| CB | RBM4B | exon_skip_201999 | -5.194679e-01 | 1.838808e-11 |
| CB | SRSF2 | exon_skip_259494 | -4.148399e-01 | 9.744585e-08 |
| FL | SRSF9 | exon_skip_50760 | 4.257790e-01 | 1.149072e-07 |
| FL | SRSF2 | exon_skip_39411 | -4.457230e-01 | 7.379046e-11 |
| HCC | RBM5 | exon_skip_50760 | -5.803350e-01 | 2.964336e-25 |
| HCC | SRSF1 | exon_skip_50760 | -4.135449e-01 | 2.269861e-12 |
| HCC | RBM5 | exon_skip_296676 | -5.433800e-01 | 1.109350e-21 |
| HCC | RBM3 | exon_skip_92390 | 5.770909e-01 | 2.254060e-25 |
| HCC | SRSF1 | exon_skip_39411 | 4.431838e-01 | 2.037157e-14 |
| IFG | RBM5 | exon_skip_296676 | -5.944082e-01 | 2.779861e-03 |
| IFG | SRSF1 | exon_skip_296676 | -4.617676e-01 | 2.654553e-02 |
| PCC | G3BP2 | exon_skip_208144 | 6.302371e-01 | 3.315541e-23 |
| PCC | HNRNPF | exon_skip_208144 | -6.086916e-01 | 2.344304e-21 |
| PCC | RBM3 | exon_skip_98487 | 5.456824e-01 | 4.667685e-16 |
| STG | SRSF2 | exon_skip_39411 | -4.242503e-01 | 4.685236e-05 |
| STG | SRSF9 | exon_skip_39411 | -4.426529e-01 | 1.976024e-05 |
| TC | SRSF9 | exon_skip_50760 | 4.821848e-01 | 2.772848e-10 |
| TC | SRSF2 | exon_skip_34413 | 4.991144e-01 | 1.069629e-10 |
| TC | SRSF9 | exon_skip_34413 | 4.780108e-01 | 8.052537e-10 |
| TC | SRSF2 | exon_skip_208144 | 5.054407e-01 | 1.978669e-11 |
| TC | G3BP2 | exon_skip_208144 | 7.532464e-01 | 1.235905e-29 |
| TC | RBMS2 | exon_skip_158530 | -4.176101e-01 | 5.830787e-08 |
| TC | RBM3 | exon_skip_158530 | 6.484658e-01 | 5.578179e-20 |
| TC | SRSF2 | exon_skip_39411 | -4.563873e-01 | 1.484571e-09 |
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RelatedDrugs for PRUNE2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PRUNE2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
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