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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for GPR155 |
 Gene summary |
| Gene information | Gene symbol | GPR155 | Gene ID | 151556 |
| Gene name | G protein-coupled receptor 155 | |
| Synonyms | DEP.7|DEPDC3|PGR22 | |
| Cytomap | 2q31.1 | |
| Type of gene | protein-coding | |
| Description | integral membrane protein GPR155G-protein coupled receptor PGR22 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for GPR155 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000163328
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for GPR155 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_109918 | chr2 | 174468912:174469067:174470390:174470555:174472965:174473364 | 174470390:174470555 |
| exon_skip_156631 | chr2 | 174472965:174473364:174481497:174481987:174486873:174487000 | 174481497:174481987 |
| exon_skip_207384 | chr2 | 174446611:174446747:174453737:174453841:174459878:174460088 | 174453737:174453841 |
| exon_skip_21028 | chr2 | 174481497:174481987:174483010:174483158:174486873:174487000 | 174483010:174483158 |
| exon_skip_248964 | chr2 | 174465785:174465902:174466544:174466627:174468912:174469067 | 174466544:174466627 |
| exon_skip_250123 | chr2 | 174459878:174460088:174461402:174461492:174461588:174461672 | 174461402:174461492 |
| exon_skip_256353 | chr2 | 174461402:174461492:174461588:174461672:174465785:174465902 | 174461588:174461672 |
| exon_skip_282938 | chr2 | 174482873:174482918:174483010:174483158:174486873:174487000 | 174483010:174483158 |
| exon_skip_50580 | chr2 | 174481497:174481987:174482873:174482918:174486873:174487000 | 174482873:174482918 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for GPR155 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000392552 | 174481497 | 174481987 | 3UTR-3CDS |
| ENST00000392551 | 174482873 | 174482918 | 3UTR-3UTR |
| ENST00000295500 | 174483010 | 174483158 | 3UTR-3UTR |
| ENST00000295500 | 174461402 | 174461492 | Frame-shift |
| ENST00000392551 | 174461402 | 174461492 | Frame-shift |
| ENST00000392552 | 174461402 | 174461492 | Frame-shift |
| ENST00000295500 | 174461588 | 174461672 | Frame-shift |
| ENST00000392551 | 174461588 | 174461672 | Frame-shift |
| ENST00000392552 | 174461588 | 174461672 | Frame-shift |
| ENST00000295500 | 174470390 | 174470555 | Frame-shift |
| ENST00000392551 | 174470390 | 174470555 | Frame-shift |
| ENST00000392552 | 174470390 | 174470555 | Frame-shift |
| ENST00000295500 | 174453737 | 174453841 | In-frame |
| ENST00000392551 | 174453737 | 174453841 | In-frame |
| ENST00000392552 | 174453737 | 174453841 | In-frame |
| ENST00000295500 | 174466544 | 174466627 | In-frame |
| ENST00000392551 | 174466544 | 174466627 | In-frame |
| ENST00000392552 | 174466544 | 174466627 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000392551 | 174482873 | 174482918 | 3UTR-3UTR |
| ENST00000295500 | 174483010 | 174483158 | 3UTR-3UTR |
| ENST00000295500 | 174461588 | 174461672 | Frame-shift |
| ENST00000392551 | 174461588 | 174461672 | Frame-shift |
| ENST00000392552 | 174461588 | 174461672 | Frame-shift |
| ENST00000295500 | 174470390 | 174470555 | Frame-shift |
| ENST00000392551 | 174470390 | 174470555 | Frame-shift |
| ENST00000392552 | 174470390 | 174470555 | Frame-shift |
| ENST00000295500 | 174453737 | 174453841 | In-frame |
| ENST00000392551 | 174453737 | 174453841 | In-frame |
| ENST00000392552 | 174453737 | 174453841 | In-frame |
| ENST00000295500 | 174466544 | 174466627 | In-frame |
| ENST00000392551 | 174466544 | 174466627 | In-frame |
| ENST00000392552 | 174466544 | 174466627 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000392551 | 174482873 | 174482918 | 3UTR-3UTR |
| ENST00000295500 | 174483010 | 174483158 | 3UTR-3UTR |
| ENST00000295500 | 174461402 | 174461492 | Frame-shift |
| ENST00000392551 | 174461402 | 174461492 | Frame-shift |
| ENST00000392552 | 174461402 | 174461492 | Frame-shift |
| ENST00000295500 | 174461588 | 174461672 | Frame-shift |
| ENST00000392551 | 174461588 | 174461672 | Frame-shift |
| ENST00000392552 | 174461588 | 174461672 | Frame-shift |
| ENST00000295500 | 174470390 | 174470555 | Frame-shift |
| ENST00000392551 | 174470390 | 174470555 | Frame-shift |
| ENST00000392552 | 174470390 | 174470555 | Frame-shift |
| ENST00000295500 | 174453737 | 174453841 | In-frame |
| ENST00000392551 | 174453737 | 174453841 | In-frame |
| ENST00000392552 | 174453737 | 174453841 | In-frame |
| ENST00000295500 | 174466544 | 174466627 | In-frame |
| ENST00000392551 | 174466544 | 174466627 | In-frame |
| ENST00000392552 | 174466544 | 174466627 | In-frame |
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Infer the effects of exon skipping event on protein functional features for GPR155 |
p-ENSG00000163328_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000295500 | 3947 | 870 | 174466544 | 174466627 | 1528 | 1610 | 394 | 421 |
| ENST00000392551 | 4893 | 870 | 174466544 | 174466627 | 1482 | 1564 | 394 | 421 |
| ENST00000392552 | 6747 | 870 | 174466544 | 174466627 | 1422 | 1504 | 394 | 421 |
| ENST00000295500 | 3947 | 870 | 174453737 | 174453841 | 2117 | 2220 | 590 | 625 |
| ENST00000392551 | 4893 | 870 | 174453737 | 174453841 | 2071 | 2174 | 590 | 625 |
| ENST00000392552 | 6747 | 870 | 174453737 | 174453841 | 2011 | 2114 | 590 | 625 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000295500 | 3947 | 870 | 174466544 | 174466627 | 1528 | 1610 | 394 | 421 |
| ENST00000392551 | 4893 | 870 | 174466544 | 174466627 | 1482 | 1564 | 394 | 421 |
| ENST00000392552 | 6747 | 870 | 174466544 | 174466627 | 1422 | 1504 | 394 | 421 |
| ENST00000295500 | 3947 | 870 | 174453737 | 174453841 | 2117 | 2220 | 590 | 625 |
| ENST00000392551 | 4893 | 870 | 174453737 | 174453841 | 2071 | 2174 | 590 | 625 |
| ENST00000392552 | 6747 | 870 | 174453737 | 174453841 | 2011 | 2114 | 590 | 625 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000295500 | 3947 | 870 | 174466544 | 174466627 | 1528 | 1610 | 394 | 421 |
| ENST00000392551 | 4893 | 870 | 174466544 | 174466627 | 1482 | 1564 | 394 | 421 |
| ENST00000392552 | 6747 | 870 | 174466544 | 174466627 | 1422 | 1504 | 394 | 421 |
| ENST00000295500 | 3947 | 870 | 174453737 | 174453841 | 2117 | 2220 | 590 | 625 |
| ENST00000392551 | 4893 | 870 | 174453737 | 174453841 | 2071 | 2174 | 590 | 625 |
| ENST00000392552 | 6747 | 870 | 174453737 | 174453841 | 2011 | 2114 | 590 | 625 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q7Z3F1 | 394 | 421 | 1 | 870 | Chain | ID=PRO_0000087551;Note=Integral membrane protein GPR155 |
| Q7Z3F1 | 394 | 421 | 1 | 870 | Chain | ID=PRO_0000087551;Note=Integral membrane protein GPR155 |
| Q7Z3F1 | 394 | 421 | 1 | 870 | Chain | ID=PRO_0000087551;Note=Integral membrane protein GPR155 |
| Q7Z3F1 | 394 | 421 | 382 | 402 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q7Z3F1 | 394 | 421 | 382 | 402 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q7Z3F1 | 394 | 421 | 382 | 402 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q7Z3F1 | 394 | 421 | 415 | 435 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q7Z3F1 | 394 | 421 | 415 | 435 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q7Z3F1 | 394 | 421 | 415 | 435 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q7Z3F1 | 590 | 625 | 1 | 870 | Chain | ID=PRO_0000087551;Note=Integral membrane protein GPR155 |
| Q7Z3F1 | 590 | 625 | 1 | 870 | Chain | ID=PRO_0000087551;Note=Integral membrane protein GPR155 |
| Q7Z3F1 | 590 | 625 | 1 | 870 | Chain | ID=PRO_0000087551;Note=Integral membrane protein GPR155 |
| Q7Z3F1 | 590 | 625 | 612 | 612 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q7Z3F1 | 590 | 625 | 612 | 612 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q7Z3F1 | 590 | 625 | 612 | 612 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q7Z3F1 | 394 | 421 | 1 | 870 | Chain | ID=PRO_0000087551;Note=Integral membrane protein GPR155 |
| Q7Z3F1 | 394 | 421 | 1 | 870 | Chain | ID=PRO_0000087551;Note=Integral membrane protein GPR155 |
| Q7Z3F1 | 394 | 421 | 1 | 870 | Chain | ID=PRO_0000087551;Note=Integral membrane protein GPR155 |
| Q7Z3F1 | 394 | 421 | 382 | 402 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q7Z3F1 | 394 | 421 | 382 | 402 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q7Z3F1 | 394 | 421 | 382 | 402 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q7Z3F1 | 394 | 421 | 415 | 435 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q7Z3F1 | 394 | 421 | 415 | 435 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q7Z3F1 | 394 | 421 | 415 | 435 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q7Z3F1 | 590 | 625 | 1 | 870 | Chain | ID=PRO_0000087551;Note=Integral membrane protein GPR155 |
| Q7Z3F1 | 590 | 625 | 1 | 870 | Chain | ID=PRO_0000087551;Note=Integral membrane protein GPR155 |
| Q7Z3F1 | 590 | 625 | 1 | 870 | Chain | ID=PRO_0000087551;Note=Integral membrane protein GPR155 |
| Q7Z3F1 | 590 | 625 | 612 | 612 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q7Z3F1 | 590 | 625 | 612 | 612 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q7Z3F1 | 590 | 625 | 612 | 612 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q7Z3F1 | 394 | 421 | 1 | 870 | Chain | ID=PRO_0000087551;Note=Integral membrane protein GPR155 |
| Q7Z3F1 | 394 | 421 | 1 | 870 | Chain | ID=PRO_0000087551;Note=Integral membrane protein GPR155 |
| Q7Z3F1 | 394 | 421 | 1 | 870 | Chain | ID=PRO_0000087551;Note=Integral membrane protein GPR155 |
| Q7Z3F1 | 394 | 421 | 382 | 402 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q7Z3F1 | 394 | 421 | 382 | 402 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q7Z3F1 | 394 | 421 | 382 | 402 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q7Z3F1 | 394 | 421 | 415 | 435 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q7Z3F1 | 394 | 421 | 415 | 435 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q7Z3F1 | 394 | 421 | 415 | 435 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q7Z3F1 | 590 | 625 | 1 | 870 | Chain | ID=PRO_0000087551;Note=Integral membrane protein GPR155 |
| Q7Z3F1 | 590 | 625 | 1 | 870 | Chain | ID=PRO_0000087551;Note=Integral membrane protein GPR155 |
| Q7Z3F1 | 590 | 625 | 1 | 870 | Chain | ID=PRO_0000087551;Note=Integral membrane protein GPR155 |
| Q7Z3F1 | 590 | 625 | 612 | 612 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q7Z3F1 | 590 | 625 | 612 | 612 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q7Z3F1 | 590 | 625 | 612 | 612 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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3'-UTR located exon skipping events that lost miRNA binding sites in GPR155 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000295500 | 174483010 | 174483158 | hsa-miR-146b-3p | chr2:174483061-174483068 | 8mer-1a | chr2:174483046-174483068 | 162.00 | -29.33 |
| Mayo | ENST00000295500 | 174483010 | 174483158 | hsa-miR-6762-5p | chr2:174483041-174483048 | 8mer-1a | chr2:174483031-174483052 | 157.00 | -28.59 |
| Mayo | ENST00000295500 | 174483010 | 174483158 | hsa-miR-19a-3p | chr2:174483070-174483077 | 8mer-1a | chr2:174483050-174483077 | 154.00 | -16.64 |
| Mayo | ENST00000295500 | 174483010 | 174483158 | hsa-miR-19b-3p | chr2:174483070-174483077 | 8mer-1a | chr2:174483050-174483077 | 154.00 | -16.64 |
| Mayo | ENST00000295500 | 174483010 | 174483158 | hsa-miR-6791-5p | chr2:174483045-174483052 | 8mer-1a | chr2:174483031-174483052 | 157.00 | -28.59 |
| Mayo | ENST00000295500 | 174483010 | 174483158 | hsa-miR-8080 | chr2:174483135-174483142 | 8mer-1a | chr2:174483125-174483144 | 153.00 | -14.98 |
| Mayo | ENST00000295500 | 174483010 | 174483158 | hsa-miR-644a | chr2:174483030-174483037 | 8mer-1a | chr2:174483016-174483039 | 164.00 | -25.51 |
| Mayo | ENST00000392551 | 174482873 | 174482918 | hsa-miR-340-5p | chr2:174482905-174482912 | 8mer-1a | chr2:174482895-174482918 | 146.00 | -14.43 |
| Mayo | ENST00000392551 | 174482873 | 174482918 | hsa-miR-548u | chr2:174482902-174482909 | 8mer-1a | chr2:174482887-174482909 | 157.00 | -15.52 |
| Mayo | ENST00000392551 | 174482873 | 174482918 | hsa-miR-7161-5p | chr2:174482902-174482909 | 8mer-1a | chr2:174482887-174482909 | 157.00 | -15.52 |
| Mayo | ENST00000295500 | 174483010 | 174483158 | hsa-miR-6845-5p | chr2:174483041-174483048 | 8mer-1a | chr2:174483031-174483052 | 157.00 | -28.59 |
| Mayo | ENST00000295500 | 174483010 | 174483158 | hsa-miR-4292 | chr2:174483045-174483052 | 8mer-1a | chr2:174483031-174483052 | 157.00 | -28.59 |
| Mayo | ENST00000295500 | 174483010 | 174483158 | hsa-miR-891a-3p | chr2:174483057-174483064 | 8mer-1a | chr2:174483046-174483068 | 162.00 | -29.33 |
| Mayo | ENST00000295500 | 174483010 | 174483158 | hsa-miR-2114-5p | chr2:174483105-174483112 | 8mer-1a | chr2:174483103-174483127 | 166.00 | -16.97 |
| MSBB | ENST00000295500 | 174483010 | 174483158 | hsa-miR-146b-3p | chr2:174483061-174483068 | 8mer-1a | chr2:174483046-174483068 | 162.00 | -29.33 |
| MSBB | ENST00000295500 | 174483010 | 174483158 | hsa-miR-6762-5p | chr2:174483041-174483048 | 8mer-1a | chr2:174483031-174483052 | 157.00 | -28.59 |
| MSBB | ENST00000295500 | 174483010 | 174483158 | hsa-miR-19a-3p | chr2:174483070-174483077 | 8mer-1a | chr2:174483050-174483077 | 154.00 | -16.64 |
| MSBB | ENST00000295500 | 174483010 | 174483158 | hsa-miR-19b-3p | chr2:174483070-174483077 | 8mer-1a | chr2:174483050-174483077 | 154.00 | -16.64 |
| MSBB | ENST00000295500 | 174483010 | 174483158 | hsa-miR-6791-5p | chr2:174483045-174483052 | 8mer-1a | chr2:174483031-174483052 | 157.00 | -28.59 |
| MSBB | ENST00000295500 | 174483010 | 174483158 | hsa-miR-8080 | chr2:174483135-174483142 | 8mer-1a | chr2:174483125-174483144 | 153.00 | -14.98 |
| MSBB | ENST00000295500 | 174483010 | 174483158 | hsa-miR-644a | chr2:174483030-174483037 | 8mer-1a | chr2:174483016-174483039 | 164.00 | -25.51 |
| MSBB | ENST00000392551 | 174482873 | 174482918 | hsa-miR-340-5p | chr2:174482905-174482912 | 8mer-1a | chr2:174482895-174482918 | 146.00 | -14.43 |
| MSBB | ENST00000392551 | 174482873 | 174482918 | hsa-miR-548u | chr2:174482902-174482909 | 8mer-1a | chr2:174482887-174482909 | 157.00 | -15.52 |
| MSBB | ENST00000392551 | 174482873 | 174482918 | hsa-miR-7161-5p | chr2:174482902-174482909 | 8mer-1a | chr2:174482887-174482909 | 157.00 | -15.52 |
| MSBB | ENST00000295500 | 174483010 | 174483158 | hsa-miR-6845-5p | chr2:174483041-174483048 | 8mer-1a | chr2:174483031-174483052 | 157.00 | -28.59 |
| MSBB | ENST00000295500 | 174483010 | 174483158 | hsa-miR-4292 | chr2:174483045-174483052 | 8mer-1a | chr2:174483031-174483052 | 157.00 | -28.59 |
| MSBB | ENST00000295500 | 174483010 | 174483158 | hsa-miR-891a-3p | chr2:174483057-174483064 | 8mer-1a | chr2:174483046-174483068 | 162.00 | -29.33 |
| MSBB | ENST00000295500 | 174483010 | 174483158 | hsa-miR-2114-5p | chr2:174483105-174483112 | 8mer-1a | chr2:174483103-174483127 | 166.00 | -16.97 |
| ROSMAP | ENST00000295500 | 174483010 | 174483158 | hsa-miR-146b-3p | chr2:174483061-174483068 | 8mer-1a | chr2:174483046-174483068 | 162.00 | -29.33 |
| ROSMAP | ENST00000295500 | 174483010 | 174483158 | hsa-miR-6762-5p | chr2:174483041-174483048 | 8mer-1a | chr2:174483031-174483052 | 157.00 | -28.59 |
| ROSMAP | ENST00000295500 | 174483010 | 174483158 | hsa-miR-19a-3p | chr2:174483070-174483077 | 8mer-1a | chr2:174483050-174483077 | 154.00 | -16.64 |
| ROSMAP | ENST00000295500 | 174483010 | 174483158 | hsa-miR-19b-3p | chr2:174483070-174483077 | 8mer-1a | chr2:174483050-174483077 | 154.00 | -16.64 |
| ROSMAP | ENST00000295500 | 174483010 | 174483158 | hsa-miR-6791-5p | chr2:174483045-174483052 | 8mer-1a | chr2:174483031-174483052 | 157.00 | -28.59 |
| ROSMAP | ENST00000295500 | 174483010 | 174483158 | hsa-miR-8080 | chr2:174483135-174483142 | 8mer-1a | chr2:174483125-174483144 | 153.00 | -14.98 |
| ROSMAP | ENST00000295500 | 174483010 | 174483158 | hsa-miR-644a | chr2:174483030-174483037 | 8mer-1a | chr2:174483016-174483039 | 164.00 | -25.51 |
| ROSMAP | ENST00000392551 | 174482873 | 174482918 | hsa-miR-340-5p | chr2:174482905-174482912 | 8mer-1a | chr2:174482895-174482918 | 146.00 | -14.43 |
| ROSMAP | ENST00000392551 | 174482873 | 174482918 | hsa-miR-548u | chr2:174482902-174482909 | 8mer-1a | chr2:174482887-174482909 | 157.00 | -15.52 |
| ROSMAP | ENST00000392551 | 174482873 | 174482918 | hsa-miR-7161-5p | chr2:174482902-174482909 | 8mer-1a | chr2:174482887-174482909 | 157.00 | -15.52 |
| ROSMAP | ENST00000295500 | 174483010 | 174483158 | hsa-miR-6845-5p | chr2:174483041-174483048 | 8mer-1a | chr2:174483031-174483052 | 157.00 | -28.59 |
| ROSMAP | ENST00000295500 | 174483010 | 174483158 | hsa-miR-4292 | chr2:174483045-174483052 | 8mer-1a | chr2:174483031-174483052 | 157.00 | -28.59 |
| ROSMAP | ENST00000295500 | 174483010 | 174483158 | hsa-miR-891a-3p | chr2:174483057-174483064 | 8mer-1a | chr2:174483046-174483068 | 162.00 | -29.33 |
| ROSMAP | ENST00000295500 | 174483010 | 174483158 | hsa-miR-2114-5p | chr2:174483105-174483112 | 8mer-1a | chr2:174483103-174483127 | 166.00 | -16.97 |
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SNVs in the skipped exons for GPR155 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for GPR155 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for GPR155 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
| CB | exon_skip_50580 | rs7593976 | chr2:174489170 | 1.768356e-05 | 4.209856e-03 |
| HCC | exon_skip_50580 | rs7593976 | chr2:174489170 | 1.320985e-20 | 1.918725e-17 |
| HCC | exon_skip_50580 | rs12614738 | chr2:174482922 | 5.184724e-20 | 7.302586e-17 |
| HCC | exon_skip_50580 | rs1991602 | chr2:174496092 | 2.249686e-06 | 3.394972e-04 |
| HCC | exon_skip_50580 | rs7563578 | chr2:174495282 | 6.619292e-06 | 8.774727e-04 |
| HCC | exon_skip_50580 | rs12151707 | chr2:174466210 | 7.662710e-06 | 9.980016e-04 |
| HCC | exon_skip_50580 | rs4972666 | chr2:174474776 | 8.110374e-06 | 1.048228e-03 |
| HCC | exon_skip_50580 | rs4972661 | chr2:174414321 | 2.104967e-05 | 2.411302e-03 |
| HCC | exon_skip_50580 | rs9287975 | chr2:174522133 | 1.403854e-04 | 1.215384e-02 |
| PCC | exon_skip_50580 | rs7593976 | chr2:174489170 | 6.193066e-11 | 6.628717e-08 |
| PCC | exon_skip_50580 | rs12614738 | chr2:174482922 | 1.129740e-10 | 1.137871e-07 |
| PCC | exon_skip_50580 | rs1991602 | chr2:174496092 | 8.733034e-05 | 1.544978e-02 |
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Correlation with RNA binding proteins (RBPs) for GPR155 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| TC | ELAVL4 | exon_skip_248964 | 4.941704e-01 | 1.119560e-08 |
| TC | KHDRBS2 | exon_skip_248964 | 5.102453e-01 | 3.071480e-09 |
| TC | RALYL | exon_skip_248964 | 4.486127e-01 | 3.108287e-07 |
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RelatedDrugs for GPR155 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GPR155 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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