ExonSkipAD: functional annotation of exon skipping event in human

Gene summary for CTSB

Gene summary

Gene information	Gene symbol	CTSB
	Gene ID	1508
	Gene name	cathepsin B
	Synonyms	APPS\|CPSB\|RECEUP
	Cytomap	8p23.1
	Type of gene	protein-coding
	Description	cathepsin BAPP secretaseamyloid precursor protein secretasecathepsin B1cysteine proteaseepididymis secretory sperm binding protein
	Modification date	20200313
	UniProtAcc	A0A024R374, E9PCB3, E9PHZ5, E9PID0, E9PIS1, E9PJ67, E9PKQ7, E9PKX0, E9PL32, E9PLY3, E9PNL5, E9PQM1, E9PR00, E9PR54, E9PS78, E9PSG5, P07858, Q8TAC7, R4GMQ5,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
CTSB	GO:0006508	proteolysis	7890620\|8811434
CTSB	GO:0030574	collagen catabolic process	22952693
CTSB	GO:0051603	proteolysis involved in cellular protein catabolic process	22952693

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Gene structures and expression levels for CTSB

Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

ENSG00000164733

Differentially expressed gene analysis across multiple brain tissues between AD and control.

Tissue type

DEG direction

Base mean exp.

log2FC(AD/control)

P-value

Adj. p-value

Differentially expressed isoform analysis across multiple brain tissues between AD and control.

Tissue type	DEG direction	ENST	Transcript info.	Base mean exp.	log2FC(AD/control)	P-value	Adjc. p-value
PG	UP	ENST00000420692.6	CTSB-203:retained_intron:CTSB	4.346705e+01	9.433070e-01	9.752786e-08	1.482454e-05
CB	DOWN	ENST00000526481.6	CTSB-211:nonsense_mediated_decay:CTSB	4.080723e+00	-1.975565e+00	2.886420e-07	5.215443e-06
CB	UP	ENST00000534510.5	CTSB-232:protein_coding:CTSB	1.566340e+01	1.530324e+00	2.483703e-03	1.103247e-02
CB	UP	ENST00000533572.5	CTSB-229:protein_coding:CTSB	1.301176e+00	1.209878e+00	1.219567e-02	4.085268e-02
TC	DOWN	ENST00000526481.6	CTSB-211:nonsense_mediated_decay:CTSB	7.333045e+00	-1.285698e+00	3.549294e-04	4.392503e-03

Landscape of isoform expressions across multiple brain tissues between AD and control.

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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CTSB

Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).

All exon skipping events in AD cohorts.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon
exon_skip_111578	chr8	11864376:11864463:11867254:11867391:11868001:11868040	11867254:11867391
exon_skip_112551	chr8	11850917:11850980:11852610:11852695:11853329:11853462	11852610:11852695
exon_skip_123095	chr8	11857858:11857940:11864376:11864463:11868001:11868040	11864376:11864463
exon_skip_136240	chr8	11861406:11861479:11864376:11864483:11868001:11868040	11864376:11864483
exon_skip_13640	chr8	11853431:11853479:11861406:11861479:11864376:11864463	11861406:11861479
exon_skip_140372	chr8	11853393:11853479:11864376:11864463:11867254:11867391	11864376:11864463
exon_skip_145015	chr8	11853393:11853479:11861406:11861479:11868001:11868040	11861406:11861479
exon_skip_161228	chr8	11853393:11853479:11861361:11861479:11868001:11868040	11861361:11861479
exon_skip_183278	chr8	11853393:11853479:11861406:11861479:11864376:11864463	11861406:11861479
exon_skip_184686	chr8	11848067:11848152:11849046:11849164:11850866:11850980	11849046:11849164
exon_skip_18893	chr8	11847117:11847168:11847679:11847822:11848067:11848152	11847679:11847822
exon_skip_189302	chr8	11853393:11853479:11864376:11864463:11868001:11868012	11864376:11864463
exon_skip_189709	chr8	11853393:11853479:11864376:11864463:11868001:11868040	11864376:11864463
exon_skip_214435	chr8	11862345:11862478:11864376:11864463:11868001:11868040	11864376:11864463
exon_skip_217469	chr8	11853393:11853479:11867254:11867391:11868001:11868040	11867254:11867391
exon_skip_221178	chr8	11853431:11853479:11864376:11864463:11868001:11868040	11864376:11864463
exon_skip_232269	chr8	11853393:11853479:11857858:11857940:11868001:11868012	11857858:11857940
exon_skip_237304	chr8	11857858:11857940:11864376:11864463:11868001:11868012	11864376:11864463
exon_skip_243393	chr8	11857858:11857940:11864376:11864463:11868001:11868106	11864376:11864463
exon_skip_25634	chr8	11853393:11853479:11862345:11862478:11864376:11864463	11862345:11862478
exon_skip_265532	chr8	11853393:11853479:11861406:11861479:11868001:11868012	11861406:11861479
exon_skip_270434	chr8	11848104:11848152:11849046:11849164:11850866:11850980	11849046:11849164
exon_skip_271026	chr8	11861406:11861479:11864376:11864483:11868001:11868012	11864376:11864483
exon_skip_280964	chr8	11864376:11864463:11867254:11867391:11868001:11868012	11867254:11867391
exon_skip_285413	chr8	11853431:11853479:11864376:11864463:11867254:11867391	11864376:11864463
exon_skip_28659	chr8	11844094:11844241:11845082:11845222:11845661:11845789	11845082:11845222
exon_skip_29994	chr8	11853393:11853479:11861361:11861479:11868001:11868012	11861361:11861479
exon_skip_4696	chr8	11853393:11853479:11857858:11857940:11868001:11868106	11857858:11857940
exon_skip_73094	chr8	11853431:11853479:11857858:11857940:11864376:11864463	11857858:11857940
exon_skip_73508	chr8	11849084:11849164:11850866:11850980:11852610:11852695	11850866:11850980
exon_skip_85770	chr8	11853393:11853479:11857858:11857940:11864376:11864463	11857858:11857940
exon_skip_88363	chr8	11853393:11853479:11857858:11857940:11868001:11868040	11857858:11857940

Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.

Exon skipping information

Tissue type

Avg(PSIs) in AD

Avg(PSIs) in control

Difference (PSI)

Adj. p-value

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Open reading frame (ORF) annotation in the exon skipping event for CTSB

Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000534510	11857858	11857940	3UTR-3UTR
ENST00000345125	11861361	11861479	3UTR-3UTR
ENST00000453527	11861406	11861479	3UTR-3UTR
ENST00000531089	11864376	11864463	3UTR-3UTR
ENST00000533455	11864376	11864463	3UTR-3UTR
ENST00000530640	11845082	11845222	5CDS-5UTR
ENST00000531089	11845082	11845222	5CDS-5UTR
ENST00000345125	11849046	11849164	Frame-shift
ENST00000353047	11849046	11849164	Frame-shift
ENST00000453527	11849046	11849164	Frame-shift
ENST00000530640	11849046	11849164	Frame-shift
ENST00000531089	11849046	11849164	Frame-shift
ENST00000533455	11849046	11849164	Frame-shift
ENST00000534510	11849046	11849164	Frame-shift
ENST00000345125	11850866	11850980	Frame-shift
ENST00000353047	11850866	11850980	Frame-shift
ENST00000453527	11850866	11850980	Frame-shift
ENST00000530640	11850866	11850980	Frame-shift
ENST00000531089	11850866	11850980	Frame-shift
ENST00000533455	11850866	11850980	Frame-shift
ENST00000534510	11850866	11850980	Frame-shift
ENST00000345125	11847679	11847822	In-frame
ENST00000353047	11847679	11847822	In-frame
ENST00000453527	11847679	11847822	In-frame
ENST00000530640	11847679	11847822	In-frame
ENST00000531089	11847679	11847822	In-frame
ENST00000533455	11847679	11847822	In-frame
ENST00000534510	11847679	11847822	In-frame

Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000534510	11857858	11857940	3UTR-3UTR
ENST00000345125	11861361	11861479	3UTR-3UTR
ENST00000453527	11861406	11861479	3UTR-3UTR
ENST00000531089	11864376	11864463	3UTR-3UTR
ENST00000533455	11864376	11864463	3UTR-3UTR
ENST00000345125	11847679	11847822	In-frame
ENST00000353047	11847679	11847822	In-frame
ENST00000453527	11847679	11847822	In-frame
ENST00000530640	11847679	11847822	In-frame
ENST00000531089	11847679	11847822	In-frame
ENST00000533455	11847679	11847822	In-frame
ENST00000534510	11847679	11847822	In-frame

Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000534510	11857858	11857940	3UTR-3UTR
ENST00000345125	11861361	11861479	3UTR-3UTR
ENST00000453527	11861406	11861479	3UTR-3UTR
ENST00000531089	11864376	11864463	3UTR-3UTR
ENST00000533455	11864376	11864463	3UTR-3UTR
ENST00000530640	11845082	11845222	5CDS-5UTR
ENST00000531089	11845082	11845222	5CDS-5UTR
ENST00000345125	11849046	11849164	Frame-shift
ENST00000353047	11849046	11849164	Frame-shift
ENST00000453527	11849046	11849164	Frame-shift
ENST00000530640	11849046	11849164	Frame-shift
ENST00000531089	11849046	11849164	Frame-shift
ENST00000533455	11849046	11849164	Frame-shift
ENST00000534510	11849046	11849164	Frame-shift
ENST00000345125	11852610	11852695	Frame-shift
ENST00000353047	11852610	11852695	Frame-shift
ENST00000453527	11852610	11852695	Frame-shift
ENST00000530640	11852610	11852695	Frame-shift
ENST00000531089	11852610	11852695	Frame-shift
ENST00000533455	11852610	11852695	Frame-shift
ENST00000534510	11852610	11852695	Frame-shift
ENST00000345125	11847679	11847822	In-frame
ENST00000353047	11847679	11847822	In-frame
ENST00000453527	11847679	11847822	In-frame
ENST00000530640	11847679	11847822	In-frame
ENST00000531089	11847679	11847822	In-frame
ENST00000533455	11847679	11847822	In-frame
ENST00000534510	11847679	11847822	In-frame

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Infer the effects of exon skipping event on protein functional features for CTSB

p-ENSG00000164733_img4.png
boxplot

Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000345125	2045	339	11847679	11847822	756	898	177	225
ENST00000353047	3892	339	11847679	11847822	787	929	177	225
ENST00000453527	2028	339	11847679	11847822	719	861	177	225
ENST00000530640	1406	339	11847679	11847822	670	812	177	225
ENST00000531089	1453	339	11847679	11847822	758	900	177	225
ENST00000533455	2026	339	11847679	11847822	752	894	177	225
ENST00000534510	2006	339	11847679	11847822	747	889	177	225

Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000345125	2045	339	11847679	11847822	756	898	177	225
ENST00000353047	3892	339	11847679	11847822	787	929	177	225
ENST00000453527	2028	339	11847679	11847822	719	861	177	225
ENST00000530640	1406	339	11847679	11847822	670	812	177	225
ENST00000531089	1453	339	11847679	11847822	758	900	177	225
ENST00000533455	2026	339	11847679	11847822	752	894	177	225
ENST00000534510	2006	339	11847679	11847822	747	889	177	225

Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000345125	2045	339	11847679	11847822	756	898	177	225
ENST00000353047	3892	339	11847679	11847822	787	929	177	225
ENST00000453527	2028	339	11847679	11847822	719	861	177	225
ENST00000530640	1406	339	11847679	11847822	670	812	177	225
ENST00000531089	1453	339	11847679	11847822	758	900	177	225
ENST00000533455	2026	339	11847679	11847822	752	894	177	225
ENST00000534510	2006	339	11847679	11847822	747	889	177	225

Lost protein functional features of individual exon skipping events in ROSMAP.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P07858	177	225	178	180	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	178	180	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	178	180	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	178	180	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	178	180	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	178	180	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	178	180	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	188	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	188	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	188	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	188	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	188	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	188	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	188	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	193	195	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2IPP
P07858	177	225	193	195	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2IPP
P07858	177	225	193	195	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2IPP
P07858	177	225	193	195	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2IPP
P07858	177	225	193	195	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2IPP
P07858	177	225	193	195	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2IPP
P07858	177	225	193	195	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2IPP
P07858	177	225	80	333	Chain	ID=PRO_0000026144;Note=Cathepsin B
P07858	177	225	80	333	Chain	ID=PRO_0000026144;Note=Cathepsin B
P07858	177	225	80	333	Chain	ID=PRO_0000026144;Note=Cathepsin B
P07858	177	225	80	333	Chain	ID=PRO_0000026144;Note=Cathepsin B
P07858	177	225	80	333	Chain	ID=PRO_0000026144;Note=Cathepsin B
P07858	177	225	80	333	Chain	ID=PRO_0000026144;Note=Cathepsin B
P07858	177	225	80	333	Chain	ID=PRO_0000026144;Note=Cathepsin B
P07858	177	225	129	333	Chain	ID=PRO_0000026146;Note=Cathepsin B heavy chain;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:3972105;Dbxref=PMID:3972105
P07858	177	225	129	333	Chain	ID=PRO_0000026146;Note=Cathepsin B heavy chain;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:3972105;Dbxref=PMID:3972105
P07858	177	225	129	333	Chain	ID=PRO_0000026146;Note=Cathepsin B heavy chain;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:3972105;Dbxref=PMID:3972105
P07858	177	225	129	333	Chain	ID=PRO_0000026146;Note=Cathepsin B heavy chain;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:3972105;Dbxref=PMID:3972105
P07858	177	225	129	333	Chain	ID=PRO_0000026146;Note=Cathepsin B heavy chain;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:3972105;Dbxref=PMID:3972105
P07858	177	225	129	333	Chain	ID=PRO_0000026146;Note=Cathepsin B heavy chain;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:3972105;Dbxref=PMID:3972105
P07858	177	225	129	333	Chain	ID=PRO_0000026146;Note=Cathepsin B heavy chain;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:3972105;Dbxref=PMID:3972105
P07858	177	225	141	207	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	141	207	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	141	207	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	141	207	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	141	207	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	141	207	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	141	207	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	179	211	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	179	211	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	179	211	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	179	211	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	179	211	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	179	211	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	179	211	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	187	198	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	187	198	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	187	198	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	187	198	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	187	198	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	187	198	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	187	198	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	192	192	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:3463996;Dbxref=PMID:3463996
P07858	177	225	192	192	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:3463996;Dbxref=PMID:3463996
P07858	177	225	192	192	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:3463996;Dbxref=PMID:3463996
P07858	177	225	192	192	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:3463996;Dbxref=PMID:3463996
P07858	177	225	192	192	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:3463996;Dbxref=PMID:3463996
P07858	177	225	192	192	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:3463996;Dbxref=PMID:3463996
P07858	177	225	192	192	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:3463996;Dbxref=PMID:3463996
P07858	177	225	220	222	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	220	222	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	220	222	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	220	222	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	220	222	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	220	222	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	220	222	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	220	220	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P10605
P07858	177	225	220	220	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P10605
P07858	177	225	220	220	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P10605
P07858	177	225	220	220	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P10605
P07858	177	225	220	220	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P10605
P07858	177	225	220	220	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P10605
P07858	177	225	220	220	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P10605

Lost protein functional features of individual exon skipping events in MSBB.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P07858	177	225	178	180	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	178	180	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	178	180	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	178	180	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	178	180	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	178	180	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	178	180	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	188	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	188	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	188	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	188	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	188	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	188	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	188	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	193	195	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2IPP
P07858	177	225	193	195	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2IPP
P07858	177	225	193	195	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2IPP
P07858	177	225	193	195	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2IPP
P07858	177	225	193	195	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2IPP
P07858	177	225	193	195	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2IPP
P07858	177	225	193	195	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2IPP
P07858	177	225	80	333	Chain	ID=PRO_0000026144;Note=Cathepsin B
P07858	177	225	80	333	Chain	ID=PRO_0000026144;Note=Cathepsin B
P07858	177	225	80	333	Chain	ID=PRO_0000026144;Note=Cathepsin B
P07858	177	225	80	333	Chain	ID=PRO_0000026144;Note=Cathepsin B
P07858	177	225	80	333	Chain	ID=PRO_0000026144;Note=Cathepsin B
P07858	177	225	80	333	Chain	ID=PRO_0000026144;Note=Cathepsin B
P07858	177	225	80	333	Chain	ID=PRO_0000026144;Note=Cathepsin B
P07858	177	225	129	333	Chain	ID=PRO_0000026146;Note=Cathepsin B heavy chain;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:3972105;Dbxref=PMID:3972105
P07858	177	225	129	333	Chain	ID=PRO_0000026146;Note=Cathepsin B heavy chain;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:3972105;Dbxref=PMID:3972105
P07858	177	225	129	333	Chain	ID=PRO_0000026146;Note=Cathepsin B heavy chain;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:3972105;Dbxref=PMID:3972105
P07858	177	225	129	333	Chain	ID=PRO_0000026146;Note=Cathepsin B heavy chain;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:3972105;Dbxref=PMID:3972105
P07858	177	225	129	333	Chain	ID=PRO_0000026146;Note=Cathepsin B heavy chain;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:3972105;Dbxref=PMID:3972105
P07858	177	225	129	333	Chain	ID=PRO_0000026146;Note=Cathepsin B heavy chain;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:3972105;Dbxref=PMID:3972105
P07858	177	225	129	333	Chain	ID=PRO_0000026146;Note=Cathepsin B heavy chain;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:3972105;Dbxref=PMID:3972105
P07858	177	225	141	207	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	141	207	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	141	207	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	141	207	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	141	207	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	141	207	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	141	207	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	179	211	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	179	211	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	179	211	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	179	211	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	179	211	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	179	211	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	179	211	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	187	198	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	187	198	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	187	198	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	187	198	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	187	198	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	187	198	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	187	198	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	192	192	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:3463996;Dbxref=PMID:3463996
P07858	177	225	192	192	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:3463996;Dbxref=PMID:3463996
P07858	177	225	192	192	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:3463996;Dbxref=PMID:3463996
P07858	177	225	192	192	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:3463996;Dbxref=PMID:3463996
P07858	177	225	192	192	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:3463996;Dbxref=PMID:3463996
P07858	177	225	192	192	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:3463996;Dbxref=PMID:3463996
P07858	177	225	192	192	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:3463996;Dbxref=PMID:3463996
P07858	177	225	220	222	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	220	222	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	220	222	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	220	222	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	220	222	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	220	222	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	220	222	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	220	220	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P10605
P07858	177	225	220	220	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P10605
P07858	177	225	220	220	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P10605
P07858	177	225	220	220	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P10605
P07858	177	225	220	220	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P10605
P07858	177	225	220	220	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P10605
P07858	177	225	220	220	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P10605

Lost protein functional features of individual exon skipping events in Mayo.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P07858	177	225	178	180	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	178	180	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	178	180	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	178	180	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	178	180	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	178	180	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	178	180	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	188	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	188	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	188	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	188	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	188	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	188	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	188	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	193	195	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2IPP
P07858	177	225	193	195	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2IPP
P07858	177	225	193	195	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2IPP
P07858	177	225	193	195	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2IPP
P07858	177	225	193	195	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2IPP
P07858	177	225	193	195	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2IPP
P07858	177	225	193	195	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2IPP
P07858	177	225	80	333	Chain	ID=PRO_0000026144;Note=Cathepsin B
P07858	177	225	80	333	Chain	ID=PRO_0000026144;Note=Cathepsin B
P07858	177	225	80	333	Chain	ID=PRO_0000026144;Note=Cathepsin B
P07858	177	225	80	333	Chain	ID=PRO_0000026144;Note=Cathepsin B
P07858	177	225	80	333	Chain	ID=PRO_0000026144;Note=Cathepsin B
P07858	177	225	80	333	Chain	ID=PRO_0000026144;Note=Cathepsin B
P07858	177	225	80	333	Chain	ID=PRO_0000026144;Note=Cathepsin B
P07858	177	225	129	333	Chain	ID=PRO_0000026146;Note=Cathepsin B heavy chain;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:3972105;Dbxref=PMID:3972105
P07858	177	225	129	333	Chain	ID=PRO_0000026146;Note=Cathepsin B heavy chain;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:3972105;Dbxref=PMID:3972105
P07858	177	225	129	333	Chain	ID=PRO_0000026146;Note=Cathepsin B heavy chain;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:3972105;Dbxref=PMID:3972105
P07858	177	225	129	333	Chain	ID=PRO_0000026146;Note=Cathepsin B heavy chain;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:3972105;Dbxref=PMID:3972105
P07858	177	225	129	333	Chain	ID=PRO_0000026146;Note=Cathepsin B heavy chain;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:3972105;Dbxref=PMID:3972105
P07858	177	225	129	333	Chain	ID=PRO_0000026146;Note=Cathepsin B heavy chain;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:3972105;Dbxref=PMID:3972105
P07858	177	225	129	333	Chain	ID=PRO_0000026146;Note=Cathepsin B heavy chain;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:3972105;Dbxref=PMID:3972105
P07858	177	225	141	207	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	141	207	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	141	207	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	141	207	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	141	207	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	141	207	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	141	207	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	179	211	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	179	211	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	179	211	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	179	211	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	179	211	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	179	211	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	179	211	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	187	198	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	187	198	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	187	198	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	187	198	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	187	198	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	187	198	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	187	198	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:1868826;Dbxref=PMID:1868826
P07858	177	225	192	192	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:3463996;Dbxref=PMID:3463996
P07858	177	225	192	192	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:3463996;Dbxref=PMID:3463996
P07858	177	225	192	192	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:3463996;Dbxref=PMID:3463996
P07858	177	225	192	192	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:3463996;Dbxref=PMID:3463996
P07858	177	225	192	192	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:3463996;Dbxref=PMID:3463996
P07858	177	225	192	192	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:3463996;Dbxref=PMID:3463996
P07858	177	225	192	192	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:3463996;Dbxref=PMID:3463996
P07858	177	225	220	222	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	220	222	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	220	222	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	220	222	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	220	222	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	220	222	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	220	222	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6AY2
P07858	177	225	220	220	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P10605
P07858	177	225	220	220	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P10605
P07858	177	225	220	220	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P10605
P07858	177	225	220	220	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P10605
P07858	177	225	220	220	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P10605
P07858	177	225	220	220	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P10605
P07858	177	225	220	220	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P10605

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3'-UTR located exon skipping events that lost miRNA binding sites in CTSB

3'-UTR exon skipping evnets lost miRNA binding.

Tissue type	ENST	Exon skip start	Exon skip end	microRNA	Binding site by TargetScan	Binding type by TargetScan	Bdinding site by miRanda	Score of miRanda	Energy by miRanda
Mayo	ENST00000533455	11864376	11864463	hsa-miR-4691-3p	chr8:11864418-11864425	8mer-1a	chr8:11864402-11864425	153.00	-19.93
Mayo	ENST00000533455	11864376	11864463	hsa-miR-1260b	chr8:11864391-11864398	8mer-1a	chr8:11864381-11864398	164.00	-28.60
Mayo	ENST00000345125	11861361	11861479	hsa-miR-4492	chr8:11861441-11861448	8mer-1a	chr8:11861441-11861462	168.00	-28.94
Mayo	ENST00000453527	11861406	11861479	hsa-miR-4492	chr8:11861441-11861448	8mer-1a	chr8:11861441-11861462	168.00	-28.94
Mayo	ENST00000345125	11861361	11861479	hsa-miR-4498	chr8:11861441-11861448	8mer-1a	chr8:11861441-11861462	168.00	-28.94
Mayo	ENST00000453527	11861406	11861479	hsa-miR-4498	chr8:11861441-11861448	8mer-1a	chr8:11861441-11861462	168.00	-28.94
Mayo	ENST00000533455	11864376	11864463	hsa-miR-1260a	chr8:11864391-11864398	8mer-1a	chr8:11864381-11864398	164.00	-28.60
Mayo	ENST00000534510	11857858	11857940	hsa-miR-1225-3p	chr8:11857917-11857924	8mer-1a	chr8:11857908-11857929	165.00	-26.29
Mayo	ENST00000345125	11861361	11861479	hsa-miR-762	chr8:11861441-11861448	8mer-1a	chr8:11861441-11861462	168.00	-28.94
Mayo	ENST00000453527	11861406	11861479	hsa-miR-762	chr8:11861441-11861448	8mer-1a	chr8:11861441-11861462	168.00	-28.94
Mayo	ENST00000345125	11861361	11861479	hsa-miR-4736	chr8:11861404-11861411	8mer-1a	chr8:11861395-11861412	151.00	-22.12
Mayo	ENST00000345125	11861361	11861479	hsa-miR-153-3p	chr8:11861417-11861424	8mer-1a	chr8:11861407-11861430	169.00	-21.53
Mayo	ENST00000345125	11861361	11861479	hsa-miR-5001-5p	chr8:11861441-11861448	8mer-1a	chr8:11861441-11861462	168.00	-28.94
Mayo	ENST00000453527	11861406	11861479	hsa-miR-5001-5p	chr8:11861441-11861448	8mer-1a	chr8:11861441-11861462	168.00	-28.94
Mayo	ENST00000345125	11861361	11861479	hsa-miR-6821-5p	chr8:11861446-11861453	8mer-1a	chr8:11861441-11861462	168.00	-28.94
Mayo	ENST00000453527	11861406	11861479	hsa-miR-6821-5p	chr8:11861446-11861453	8mer-1a	chr8:11861441-11861462	168.00	-28.94
Mayo	ENST00000533455	11864376	11864463	hsa-miR-143-5p	chr8:11864451-11864458	8mer-1a	chr8:11864436-11864458	163.00	-25.57
Mayo	ENST00000345125	11861361	11861479	hsa-miR-4650-5p	chr8:11861466-11861473	8mer-1a	chr8:11861463-11861479	164.00	-21.75
Mayo	ENST00000453527	11861406	11861479	hsa-miR-4650-5p	chr8:11861466-11861473	8mer-1a	chr8:11861463-11861479	164.00	-21.75
Mayo	ENST00000345125	11861361	11861479	hsa-miR-6853-5p	chr8:11861445-11861452	8mer-1a	chr8:11861441-11861462	168.00	-28.94
Mayo	ENST00000453527	11861406	11861479	hsa-miR-6853-5p	chr8:11861445-11861452	8mer-1a	chr8:11861441-11861462	168.00	-28.94
Mayo	ENST00000345125	11861361	11861479	hsa-miR-7150	chr8:11861405-11861412	8mer-1a	chr8:11861395-11861412	151.00	-22.12
Mayo	ENST00000345125	11861361	11861479	hsa-miR-2861	chr8:11861436-11861443	8mer-1a	chr8:11861428-11861449	158.00	-33.90
Mayo	ENST00000453527	11861406	11861479	hsa-miR-2861	chr8:11861436-11861443	8mer-1a	chr8:11861428-11861449	158.00	-33.90
MSBB	ENST00000533455	11864376	11864463	hsa-miR-4691-3p	chr8:11864418-11864425	8mer-1a	chr8:11864402-11864425	153.00	-19.93
MSBB	ENST00000533455	11864376	11864463	hsa-miR-1260b	chr8:11864391-11864398	8mer-1a	chr8:11864381-11864398	164.00	-28.60
MSBB	ENST00000345125	11861361	11861479	hsa-miR-4492	chr8:11861441-11861448	8mer-1a	chr8:11861441-11861462	168.00	-28.94
MSBB	ENST00000453527	11861406	11861479	hsa-miR-4492	chr8:11861441-11861448	8mer-1a	chr8:11861441-11861462	168.00	-28.94
MSBB	ENST00000345125	11861361	11861479	hsa-miR-4498	chr8:11861441-11861448	8mer-1a	chr8:11861441-11861462	168.00	-28.94
MSBB	ENST00000453527	11861406	11861479	hsa-miR-4498	chr8:11861441-11861448	8mer-1a	chr8:11861441-11861462	168.00	-28.94
MSBB	ENST00000533455	11864376	11864463	hsa-miR-1260a	chr8:11864391-11864398	8mer-1a	chr8:11864381-11864398	164.00	-28.60
MSBB	ENST00000534510	11857858	11857940	hsa-miR-1225-3p	chr8:11857917-11857924	8mer-1a	chr8:11857908-11857929	165.00	-26.29
MSBB	ENST00000345125	11861361	11861479	hsa-miR-762	chr8:11861441-11861448	8mer-1a	chr8:11861441-11861462	168.00	-28.94
MSBB	ENST00000453527	11861406	11861479	hsa-miR-762	chr8:11861441-11861448	8mer-1a	chr8:11861441-11861462	168.00	-28.94
MSBB	ENST00000345125	11861361	11861479	hsa-miR-4736	chr8:11861404-11861411	8mer-1a	chr8:11861395-11861412	151.00	-22.12
MSBB	ENST00000345125	11861361	11861479	hsa-miR-153-3p	chr8:11861417-11861424	8mer-1a	chr8:11861407-11861430	169.00	-21.53
MSBB	ENST00000345125	11861361	11861479	hsa-miR-5001-5p	chr8:11861441-11861448	8mer-1a	chr8:11861441-11861462	168.00	-28.94
MSBB	ENST00000453527	11861406	11861479	hsa-miR-5001-5p	chr8:11861441-11861448	8mer-1a	chr8:11861441-11861462	168.00	-28.94
MSBB	ENST00000345125	11861361	11861479	hsa-miR-6821-5p	chr8:11861446-11861453	8mer-1a	chr8:11861441-11861462	168.00	-28.94
MSBB	ENST00000453527	11861406	11861479	hsa-miR-6821-5p	chr8:11861446-11861453	8mer-1a	chr8:11861441-11861462	168.00	-28.94
MSBB	ENST00000533455	11864376	11864463	hsa-miR-143-5p	chr8:11864451-11864458	8mer-1a	chr8:11864436-11864458	163.00	-25.57
MSBB	ENST00000345125	11861361	11861479	hsa-miR-4650-5p	chr8:11861466-11861473	8mer-1a	chr8:11861463-11861479	164.00	-21.75
MSBB	ENST00000453527	11861406	11861479	hsa-miR-4650-5p	chr8:11861466-11861473	8mer-1a	chr8:11861463-11861479	164.00	-21.75
MSBB	ENST00000345125	11861361	11861479	hsa-miR-6853-5p	chr8:11861445-11861452	8mer-1a	chr8:11861441-11861462	168.00	-28.94
MSBB	ENST00000453527	11861406	11861479	hsa-miR-6853-5p	chr8:11861445-11861452	8mer-1a	chr8:11861441-11861462	168.00	-28.94
MSBB	ENST00000345125	11861361	11861479	hsa-miR-7150	chr8:11861405-11861412	8mer-1a	chr8:11861395-11861412	151.00	-22.12
MSBB	ENST00000345125	11861361	11861479	hsa-miR-2861	chr8:11861436-11861443	8mer-1a	chr8:11861428-11861449	158.00	-33.90
MSBB	ENST00000453527	11861406	11861479	hsa-miR-2861	chr8:11861436-11861443	8mer-1a	chr8:11861428-11861449	158.00	-33.90
ROSMAP	ENST00000533455	11864376	11864463	hsa-miR-4691-3p	chr8:11864418-11864425	8mer-1a	chr8:11864402-11864425	153.00	-19.93
ROSMAP	ENST00000533455	11864376	11864463	hsa-miR-1260b	chr8:11864391-11864398	8mer-1a	chr8:11864381-11864398	164.00	-28.60
ROSMAP	ENST00000345125	11861361	11861479	hsa-miR-4492	chr8:11861441-11861448	8mer-1a	chr8:11861441-11861462	168.00	-28.94
ROSMAP	ENST00000453527	11861406	11861479	hsa-miR-4492	chr8:11861441-11861448	8mer-1a	chr8:11861441-11861462	168.00	-28.94
ROSMAP	ENST00000345125	11861361	11861479	hsa-miR-4498	chr8:11861441-11861448	8mer-1a	chr8:11861441-11861462	168.00	-28.94
ROSMAP	ENST00000453527	11861406	11861479	hsa-miR-4498	chr8:11861441-11861448	8mer-1a	chr8:11861441-11861462	168.00	-28.94
ROSMAP	ENST00000533455	11864376	11864463	hsa-miR-1260a	chr8:11864391-11864398	8mer-1a	chr8:11864381-11864398	164.00	-28.60
ROSMAP	ENST00000534510	11857858	11857940	hsa-miR-1225-3p	chr8:11857917-11857924	8mer-1a	chr8:11857908-11857929	165.00	-26.29
ROSMAP	ENST00000345125	11861361	11861479	hsa-miR-762	chr8:11861441-11861448	8mer-1a	chr8:11861441-11861462	168.00	-28.94
ROSMAP	ENST00000453527	11861406	11861479	hsa-miR-762	chr8:11861441-11861448	8mer-1a	chr8:11861441-11861462	168.00	-28.94
ROSMAP	ENST00000345125	11861361	11861479	hsa-miR-4736	chr8:11861404-11861411	8mer-1a	chr8:11861395-11861412	151.00	-22.12
ROSMAP	ENST00000345125	11861361	11861479	hsa-miR-153-3p	chr8:11861417-11861424	8mer-1a	chr8:11861407-11861430	169.00	-21.53
ROSMAP	ENST00000345125	11861361	11861479	hsa-miR-5001-5p	chr8:11861441-11861448	8mer-1a	chr8:11861441-11861462	168.00	-28.94
ROSMAP	ENST00000453527	11861406	11861479	hsa-miR-5001-5p	chr8:11861441-11861448	8mer-1a	chr8:11861441-11861462	168.00	-28.94
ROSMAP	ENST00000345125	11861361	11861479	hsa-miR-6821-5p	chr8:11861446-11861453	8mer-1a	chr8:11861441-11861462	168.00	-28.94
ROSMAP	ENST00000453527	11861406	11861479	hsa-miR-6821-5p	chr8:11861446-11861453	8mer-1a	chr8:11861441-11861462	168.00	-28.94
ROSMAP	ENST00000533455	11864376	11864463	hsa-miR-143-5p	chr8:11864451-11864458	8mer-1a	chr8:11864436-11864458	163.00	-25.57
ROSMAP	ENST00000345125	11861361	11861479	hsa-miR-4650-5p	chr8:11861466-11861473	8mer-1a	chr8:11861463-11861479	164.00	-21.75
ROSMAP	ENST00000453527	11861406	11861479	hsa-miR-4650-5p	chr8:11861466-11861473	8mer-1a	chr8:11861463-11861479	164.00	-21.75
ROSMAP	ENST00000345125	11861361	11861479	hsa-miR-6853-5p	chr8:11861445-11861452	8mer-1a	chr8:11861441-11861462	168.00	-28.94
ROSMAP	ENST00000453527	11861406	11861479	hsa-miR-6853-5p	chr8:11861445-11861452	8mer-1a	chr8:11861441-11861462	168.00	-28.94
ROSMAP	ENST00000345125	11861361	11861479	hsa-miR-7150	chr8:11861405-11861412	8mer-1a	chr8:11861395-11861412	151.00	-22.12
ROSMAP	ENST00000345125	11861361	11861479	hsa-miR-2861	chr8:11861436-11861443	8mer-1a	chr8:11861428-11861449	158.00	-33.90
ROSMAP	ENST00000453527	11861406	11861479	hsa-miR-2861	chr8:11861436-11861443	8mer-1a	chr8:11861428-11861449	158.00	-33.90

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SNVs in the skipped exons for CTSB

- Differential PSIs between mutated versus non-mutated samples.

- Depth of Coverage in the skipped exon of the mutated samples.

- Sashimi plot in the skipped exon of the mutated samples.

- Non-synonymous mutations located in the skipped exons.

Cancer type

Sample

ESID

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

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AD stage-associated exon skippint events for CTSB

Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).

AD stage info

Cohort

Tissue

SE id

Coefficient

P-value

Chromosome

Strand

E1 start

E1 end

Skipped start

Skipped end

E2 start

E2 end

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CTSB

sQTL information located at the skipped exons.

Tissue type	Exon skip ID	SNP id	Location	P-value	FDR
CB	exon_skip_18893	rs17154027	chr8:11856343	6.825654e-08	3.430731e-05
CB	exon_skip_18893	rs2272767	chr8:11853550	1.253030e-07	5.806928e-05
CB	exon_skip_18893	rs4841601	chr8:11842221	1.393456e-06	4.777919e-04
CB	exon_skip_18893	rs1293320	chr8:11834430	2.528784e-06	7.910166e-04
CB	exon_skip_18893	rs12898	chr8:11843689	1.183728e-05	3.008322e-03
CB	exon_skip_18893	rs1293288	chr8:11861019	1.082307e-04	1.843393e-02
TC	exon_skip_189709	rs2272767	chr8:11853550	1.151541e-05	2.787932e-03
TC	exon_skip_189709	rs17154027	chr8:11856343	2.030179e-05	4.470292e-03
HCC	exon_skip_189709	rs2272767	chr8:11853550	9.020549e-07	1.487446e-04
HCC	exon_skip_189709	rs17154027	chr8:11856343	1.163836e-05	1.433929e-03
HCC	exon_skip_189709	rs6980952	chr8:11858964	1.385950e-05	1.673215e-03
HCC	exon_skip_189709	rs2294140	chr8:11848168	4.612256e-05	4.706412e-03
HCC	exon_skip_189709	rs17814426	chr8:11856796	5.208953e-05	5.224958e-03
HCC	exon_skip_189709	rs17814360	chr8:11855649	1.585952e-04	1.343017e-02
HCC	exon_skip_189709	rs962366	chr8:11826894	1.614788e-04	1.363506e-02
HCC	exon_skip_189709	rs10089520	chr8:11828580	8.153044e-04	4.972598e-02
PCC	exon_skip_221178	rs17814360	chr8:11855649	3.650121e-07	1.437483e-04
PCC	exon_skip_221178	rs10089520	chr8:11828580	7.428076e-07	2.681017e-04
PCC	exon_skip_221178	rs2272767	chr8:11853550	2.922701e-05	6.360274e-03
PCC	exon_skip_221178	rs6980952	chr8:11858964	4.006160e-05	8.240141e-03
PCC	exon_skip_221178	rs2294140	chr8:11848168	1.428236e-04	2.292699e-02
PCC	exon_skip_221178	rs1630828	chr8:11888311	1.946423e-04	2.908475e-02
DLPFC	exon_skip_189709	rs6980952	chr8:11858964	3.538066e-09	8.860706e-07
DLPFC	exon_skip_189709	rs2272767	chr8:11853550	4.809981e-09	1.185064e-06
DLPFC	exon_skip_189709	rs2294140	chr8:11848168	4.908298e-09	1.203960e-06
DLPFC	exon_skip_189709	rs962366	chr8:11826894	5.422591e-07	8.457570e-05
DLPFC	exon_skip_189709	rs1630828	chr8:11888311	8.182049e-07	1.235763e-04
DLPFC	exon_skip_189709	rs1293303	chr8:11862718	2.341432e-06	3.123961e-04
DLPFC	exon_skip_189709	rs17154027	chr8:11856343	2.805348e-06	3.649640e-04
DLPFC	exon_skip_189709	rs17814360	chr8:11855649	3.137492e-05	3.064889e-03
DLPFC	exon_skip_189709	rs1293288	chr8:11861019	6.666818e-05	5.952139e-03
DLPFC	exon_skip_189709	rs1293322	chr8:11835129	1.342474e-04	1.087541e-02
DLPFC	exon_skip_189709	rs3779663	chr8:11813853	2.141028e-04	1.624177e-02
DLPFC	exon_skip_189709	rs1293328	chr8:11837551	2.354429e-04	1.767599e-02
DLPFC	exon_skip_189709	rs10089520	chr8:11828580	2.518185e-04	1.863736e-02
DLPFC	exon_skip_189709	rs17814426	chr8:11856796	2.988205e-04	2.147843e-02
DLPFC	exon_skip_189709	rs2740592	chr8:11843744	3.247446e-04	2.293713e-02
DLPFC	exon_skip_189709	rs2645415	chr8:11864537	4.149090e-04	2.780090e-02
DLPFC	exon_skip_189709	rs1692821	chr8:11842479	5.126065e-04	3.290828e-02
DLPFC	exon_skip_189709	rs4839	chr8:11844424	8.411939e-04	4.852866e-02

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Correlation with RNA binding proteins (RBPs) for CTSB

Correlated RBP and related information.

Tissue type	RBP name	Exon skip ID	Correlation coeifficient	P-value
CB	RBM6	exon_skip_189302	-4.145900e-01	5.539941e-08

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RelatedDrugs for CTSB

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for CTSB

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	3'-UTR located exon skipping events lost miRNA binding sites
	SNVs in the skipped exons with depth of coverage
	AD stage-associated exon skipping events
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Correlation with RNA binding proteins (RBPs)
	Related drugs with this gene
	Related diseases with this gene

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