|
||||||
|
 | |
| |
| |
| Open reading frame (ORF) annotation in the exon skipping event |
| |
| 3'-UTR located exon skipping events lost miRNA binding sites |
| |
| |
| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| |
| |
|
Gene summary for CTNNA2 |
 Gene summary |
| Gene information | Gene symbol | CTNNA2 | Gene ID | 1496 |
| Gene name | catenin alpha 2 | |
| Synonyms | CAP-R|CAPR|CDCBM9|CT114|CTNR | |
| Cytomap | 2p12 | |
| Type of gene | protein-coding | |
| Description | catenin alpha-2alpha-N-cateninalpha-catenin-related proteincadherin-associated protein, relatedcancer/testis antigen 114catenin (cadherin-associated protein), alpha 2 | |
| Modification date | 20200313 | |
| UniProtAcc | A0A0A0MRI5, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
Top |
Gene structures and expression levels for CTNNA2 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
ENSG00000066032
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
 |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| STG | UP | ENST00000343114.7 | CTNNA2-201:protein_coding:CTNNA2 | 8.894778e+00 | 6.306379e+00 | 3.708926e-05 | 6.218329e-03 |
| PG | UP | ENST00000343114.7 | CTNNA2-201:protein_coding:CTNNA2 | 2.409776e+01 | 2.233470e+00 | 2.814577e-03 | 3.044724e-02 |
| CB | DOWN | ENST00000541047.5 | CTNNA2-218:protein_coding:CTNNA2 | 4.199434e+02 | -8.863958e-01 | 2.749544e-06 | 3.543057e-05 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
 |
Top |
Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CTNNA2 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
 |
| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_108091 | chr2 | 80604153:80604179:80608184:80608318:80647585:80648378 | 80608184:80608318 |
| exon_skip_116810 | chr2 | 79513151:79513207:79633698:79633840:79651552:79651658 | 79633698:79633840 |
| exon_skip_130447 | chr2 | 79197959:79198076:79312709:79312796:79373831:79374013 | 79312709:79312796 |
| exon_skip_137507 | chr2 | 79513135:79513207:79651552:79651658:79744387:79744483 | 79651552:79651658 |
| exon_skip_138807 | chr2 | 80608184:80608318:80619085:80619228:80647585:80648378 | 80619085:80619228 |
| exon_skip_152841 | chr2 | 80604074:80604179:80608184:80608318:80647585:80648378 | 80608184:80608318 |
| exon_skip_178853 | chr2 | 79651552:79651658:79744387:79744582:79858013:79858066 | 79744387:79744582 |
| exon_skip_222545 | chr2 | 80604076:80604179:80608184:80608318:80647585:80648378 | 80608184:80608318 |
| exon_skip_240154 | chr2 | 80393211:80393291:80419449:80419601:80544982:80545074 | 80419449:80419601 |
| exon_skip_251136 | chr2 | 80419449:80419601:80544982:80545074:80545907:80545986 | 80544982:80545074 |
| exon_skip_257206 | chr2 | 80608302:80608318:80619085:80619228:80647585:80648378 | 80619085:80619228 |
| exon_skip_263996 | chr2 | 79513151:79513207:79651552:79651658:79744387:79744483 | 79651552:79651658 |
| exon_skip_280673 | chr2 | 79312710:79312796:79373831:79374013:79505054:79505182 | 79373831:79374013 |
| exon_skip_287428 | chr2 | 79858013:79858179:79869816:79869935:79874076:79874342 | 79869816:79869935 |
| exon_skip_46209 | chr2 | 79312710:79312796:79319973:79320008:79339615:79339862 | 79319973:79320008 |
| exon_skip_5171 | chr2 | 79744387:79744582:79858013:79858179:79869816:79869935 | 79858013:79858179 |
| exon_skip_55137 | chr2 | 79513135:79513207:79633698:79633840:79651552:79651658 | 79633698:79633840 |
| exon_skip_59354 | chr2 | 79505054:79505182:79651552:79651658:79744387:79744483 | 79651552:79651658 |
| exon_skip_61434 | chr2 | 80555693:80555893:80574163:80574314:80581706:80581819 | 80574163:80574314 |
| exon_skip_96780 | chr2 | 80545907:80546063:80555693:80555893:80574163:80574314 | 80555693:80555893 |
| exon_skip_9824 | chr2 | 79312709:79312796:79373831:79374013:79505054:79505182 | 79373831:79374013 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
Top |
Open reading frame (ORF) annotation in the exon skipping event for CTNNA2 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000402739 | 79744387 | 79744582 | Frame-shift |
| ENST00000402739 | 79858013 | 79858179 | Frame-shift |
| ENST00000402739 | 80544982 | 80545074 | In-frame |
| ENST00000402739 | 80555693 | 80555893 | In-frame |
| ENST00000402739 | 80619085 | 80619228 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000402739 | 79744387 | 79744582 | Frame-shift |
| ENST00000402739 | 79858013 | 79858179 | Frame-shift |
| ENST00000402739 | 79869816 | 79869935 | In-frame |
| ENST00000402739 | 80619085 | 80619228 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000402739 | 79744387 | 79744582 | Frame-shift |
| ENST00000402739 | 79858013 | 79858179 | Frame-shift |
| ENST00000402739 | 80574163 | 80574314 | Frame-shift |
| ENST00000402739 | 80419449 | 80419601 | In-frame |
| ENST00000402739 | 80555693 | 80555893 | In-frame |
| ENST00000402739 | 80619085 | 80619228 | In-frame |
Top |
Infer the effects of exon skipping event on protein functional features for CTNNA2 |
p-ENSG00000066032_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000402739 | 3701 | 953 | 80544982 | 80545074 | 1297 | 1388 | 430 | 461 |
| ENST00000402739 | 3701 | 953 | 80555693 | 80555893 | 1547 | 1746 | 514 | 580 |
| ENST00000402739 | 3701 | 953 | 80619085 | 80619228 | 2437 | 2579 | 810 | 858 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000402739 | 3701 | 953 | 79869816 | 79869935 | 472 | 590 | 155 | 195 |
| ENST00000402739 | 3701 | 953 | 80619085 | 80619228 | 2437 | 2579 | 810 | 858 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000402739 | 3701 | 953 | 80419449 | 80419601 | 1144 | 1295 | 379 | 430 |
| ENST00000402739 | 3701 | 953 | 80555693 | 80555893 | 1547 | 1746 | 514 | 580 |
| ENST00000402739 | 3701 | 953 | 80619085 | 80619228 | 2437 | 2579 | 810 | 858 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P26232 | 430 | 461 | 1 | 953 | Chain | ID=PRO_0000064263;Note=Catenin alpha-2 |
| P26232 | 514 | 580 | 1 | 953 | Chain | ID=PRO_0000064263;Note=Catenin alpha-2 |
| P26232 | 810 | 858 | 766 | 858 | Alternative sequence | ID=VSP_038009;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| P26232 | 810 | 858 | 811 | 858 | Alternative sequence | ID=VSP_020337;Note=In isoform 2%2C isoform 4%2C isoform 5 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:14702039,PMID:15489 |
| P26232 | 810 | 858 | 1 | 953 | Chain | ID=PRO_0000064263;Note=Catenin alpha-2 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P26232 | 155 | 195 | 1 | 368 | Alternative sequence | ID=VSP_038008;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| P26232 | 155 | 195 | 1 | 351 | Alternative sequence | ID=VSP_038005;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 |
| P26232 | 155 | 195 | 1 | 953 | Chain | ID=PRO_0000064263;Note=Catenin alpha-2 |
| P26232 | 155 | 195 | 182 | 182 | Sequence conflict | Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P26232 | 810 | 858 | 766 | 858 | Alternative sequence | ID=VSP_038009;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| P26232 | 810 | 858 | 811 | 858 | Alternative sequence | ID=VSP_020337;Note=In isoform 2%2C isoform 4%2C isoform 5 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:14702039,PMID:15489 |
| P26232 | 810 | 858 | 1 | 953 | Chain | ID=PRO_0000064263;Note=Catenin alpha-2 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P26232 | 379 | 430 | 1 | 953 | Chain | ID=PRO_0000064263;Note=Catenin alpha-2 |
| P26232 | 514 | 580 | 1 | 953 | Chain | ID=PRO_0000064263;Note=Catenin alpha-2 |
| P26232 | 810 | 858 | 766 | 858 | Alternative sequence | ID=VSP_038009;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| P26232 | 810 | 858 | 811 | 858 | Alternative sequence | ID=VSP_020337;Note=In isoform 2%2C isoform 4%2C isoform 5 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:14702039,PMID:15489 |
| P26232 | 810 | 858 | 1 | 953 | Chain | ID=PRO_0000064263;Note=Catenin alpha-2 |
Top |
3'-UTR located exon skipping events that lost miRNA binding sites in CTNNA2 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Top |
SNVs in the skipped exons for CTNNA2 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
Top |
AD stage-associated exon skippint events for CTNNA2 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
Top |
Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CTNNA2 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
Top |
Correlation with RNA binding proteins (RBPs) for CTNNA2 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | SNRPA | exon_skip_222545 | -4.037694e-01 | 1.434835e-07 |
| CB | FUBP1 | exon_skip_222545 | -4.019458e-01 | 1.652160e-07 |
| DLPFC | RBFOX2 | exon_skip_152841 | -5.460683e-01 | 4.736288e-28 |
| DLPFC | RC3H1 | exon_skip_152841 | -4.440941e-01 | 5.206110e-18 |
| DLPFC | RALYL | exon_skip_152841 | -4.079244e-01 | 3.480356e-15 |
| DLPFC | EIF4B | exon_skip_152841 | -4.457524e-01 | 3.790524e-18 |
| FL | SRSF2 | exon_skip_152841 | -4.804411e-01 | 7.890985e-13 |
| FL | RBFOX2 | exon_skip_152841 | -4.830070e-01 | 5.726666e-13 |
| FL | FXR2 | exon_skip_152841 | -4.353468e-01 | 1.458433e-10 |
| FL | ILF2 | exon_skip_152841 | -4.919573e-01 | 1.832558e-13 |
| FL | HNRNPA0 | exon_skip_152841 | -4.564123e-01 | 1.400284e-11 |
| FL | RALYL | exon_skip_152841 | -4.485694e-01 | 3.414056e-11 |
| FL | HNRNPH2 | exon_skip_152841 | -4.389179e-01 | 9.913740e-11 |
| FL | EIF4B | exon_skip_152841 | -4.604573e-01 | 8.764069e-12 |
| IFG | RBM25 | exon_skip_152841 | 4.252965e-01 | 2.405833e-02 |
| IFG | SFPQ | exon_skip_152841 | 5.124451e-01 | 5.302459e-03 |
| IFG | SRSF11 | exon_skip_152841 | 4.995240e-01 | 6.801880e-03 |
| IFG | SAMD4A | exon_skip_152841 | 5.701963e-01 | 1.535423e-03 |
| IFG | TIA1 | exon_skip_152841 | 5.940955e-01 | 8.582005e-04 |
| IFG | RBM5 | exon_skip_152841 | 5.789750e-01 | 1.246411e-03 |
| IFG | UNK | exon_skip_152841 | 5.261910e-01 | 4.025135e-03 |
| IFG | FUBP1 | exon_skip_152841 | 6.238719e-01 | 3.889983e-04 |
| IFG | HNRNPA2B1 | exon_skip_152841 | 4.706578e-01 | 1.148104e-02 |
| IFG | SRSF1 | exon_skip_152841 | 4.035780e-01 | 3.319622e-02 |
| PCC | RBFOX2 | exon_skip_152841 | -4.868088e-01 | 3.415917e-14 |
| STG | RBFOX2 | exon_skip_152841 | -4.223299e-01 | 2.478265e-05 |
Top |
RelatedDrugs for CTNNA2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for CTNNA2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|