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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for CTBP2 |
 Gene summary |
| Gene information | Gene symbol | CTBP2 | Gene ID | 1488 |
| Gene name | C-terminal binding protein 2 | |
| Synonyms | - | |
| Cytomap | 10q26.13 | |
| Type of gene | protein-coding | |
| Description | C-terminal-binding protein 2ribeye | |
| Modification date | 20200313 | |
| UniProtAcc | A0A087WYL1, P56545, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for CTBP2 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000175029
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000494626.6 | CTBP2-211:protein_coding:CTBP2 | 3.906170e+01 | 9.356598e-01 | 7.246521e-05 | 5.638270e-04 |
| CB | UP | ENST00000531469.5 | CTBP2-214:protein_coding:CTBP2 | 2.783055e+02 | 8.294441e-01 | 3.896354e-03 | 1.600680e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CTBP2 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_146061 | chr10 | 125039046:125039155:125110990:125111093:125160319:125160499 | 125110990:125111093 |
| exon_skip_252523 | chr10 | 125039046:125039155:125160319:125160520:125160827:125161026 | 125160319:125160520 |
| exon_skip_263852 | chr10 | 125039046:125039155:125088191:125088319:125110990:125111093 | 125088191:125088319 |
| exon_skip_288998 | chr10 | 125039046:125039155:125110990:125111093:125160827:125161026 | 125110990:125111093 |
| exon_skip_41372 | chr10 | 125039046:125039155:125110990:125111093:125160319:125160367 | 125110990:125111093 |
| exon_skip_50560 | chr10 | 125133516:125133612:125138007:125138104:125138211:125138250 | 125138007:125138104 |
| exon_skip_53962 | chr10 | 125039046:125039155:125133512:125133612:125160319:125160499 | 125133512:125133612 |
| exon_skip_59089 | chr10 | 125039046:125039155:125110990:125111093:125158635:125158716 | 125110990:125111093 |
| exon_skip_89323 | chr10 | 124989225:124989698:124992695:124992812:124993202:124993329 | 124992695:124992812 |
| exon_skip_97568 | chr10 | 125039046:125039155:125133512:125133612:125160319:125160367 | 125133512:125133612 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for CTBP2 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000337195 | 125110990 | 125111093 | 3UTR-3UTR |
| ENST00000411419 | 125110990 | 125111093 | 3UTR-3UTR |
| ENST00000531469 | 125110990 | 125111093 | 3UTR-3UTR |
| ENST00000494626 | 125133512 | 125133612 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000337195 | 125110990 | 125111093 | 3UTR-3UTR |
| ENST00000531469 | 125110990 | 125111093 | 3UTR-3UTR |
| ENST00000494626 | 125133512 | 125133612 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000337195 | 125110990 | 125111093 | 3UTR-3UTR |
| ENST00000411419 | 125110990 | 125111093 | 3UTR-3UTR |
| ENST00000531469 | 125110990 | 125111093 | 3UTR-3UTR |
| ENST00000494626 | 125133512 | 125133612 | 3UTR-3UTR |
| ENST00000337195 | 124992695 | 124992812 | Frame-shift |
| ENST00000411419 | 124992695 | 124992812 | Frame-shift |
| ENST00000494626 | 124992695 | 124992812 | Frame-shift |
| ENST00000531469 | 124992695 | 124992812 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for CTBP2 |
p-ENSG00000175029_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in CTBP2 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000494626 | 125133512 | 125133612 | hsa-miR-4671-5p | chr10:125133560-125133567 | 8mer-1a | chr10:125133560-125133582 | 156.00 | -22.44 |
| Mayo | ENST00000494626 | 125133512 | 125133612 | hsa-miR-1291 | chr10:125133550-125133557 | 8mer-1a | chr10:125133537-125133558 | 171.00 | -29.17 |
| Mayo | ENST00000494626 | 125133512 | 125133612 | hsa-miR-6775-3p | chr10:125133550-125133557 | 8mer-1a | chr10:125133537-125133558 | 171.00 | -29.17 |
| Mayo | ENST00000531469 | 125110990 | 125111093 | hsa-miR-522-3p | chr10:125111073-125111080 | 8mer-1a | chr10:125111055-125111080 | 149.00 | -13.18 |
| Mayo | ENST00000531469 | 125110990 | 125111093 | hsa-miR-3938 | chr10:125111047-125111054 | 8mer-1a | chr10:125111033-125111054 | 156.00 | -17.68 |
| Mayo | ENST00000494626 | 125133512 | 125133612 | hsa-miR-660-3p | chr10:125133535-125133542 | 8mer-1a | chr10:125133534-125133556 | 179.00 | -34.93 |
| Mayo | ENST00000531469 | 125110990 | 125111093 | hsa-miR-224-3p | chr10:125111073-125111080 | 8mer-1a | chr10:125111055-125111080 | 149.00 | -13.18 |
| MSBB | ENST00000494626 | 125133512 | 125133612 | hsa-miR-4671-5p | chr10:125133560-125133567 | 8mer-1a | chr10:125133560-125133582 | 156.00 | -22.44 |
| MSBB | ENST00000494626 | 125133512 | 125133612 | hsa-miR-1291 | chr10:125133550-125133557 | 8mer-1a | chr10:125133537-125133558 | 171.00 | -29.17 |
| MSBB | ENST00000494626 | 125133512 | 125133612 | hsa-miR-6775-3p | chr10:125133550-125133557 | 8mer-1a | chr10:125133537-125133558 | 171.00 | -29.17 |
| MSBB | ENST00000531469 | 125110990 | 125111093 | hsa-miR-522-3p | chr10:125111073-125111080 | 8mer-1a | chr10:125111055-125111080 | 149.00 | -13.18 |
| MSBB | ENST00000531469 | 125110990 | 125111093 | hsa-miR-3938 | chr10:125111047-125111054 | 8mer-1a | chr10:125111033-125111054 | 156.00 | -17.68 |
| MSBB | ENST00000494626 | 125133512 | 125133612 | hsa-miR-660-3p | chr10:125133535-125133542 | 8mer-1a | chr10:125133534-125133556 | 179.00 | -34.93 |
| MSBB | ENST00000531469 | 125110990 | 125111093 | hsa-miR-224-3p | chr10:125111073-125111080 | 8mer-1a | chr10:125111055-125111080 | 149.00 | -13.18 |
| ROSMAP | ENST00000494626 | 125133512 | 125133612 | hsa-miR-4671-5p | chr10:125133560-125133567 | 8mer-1a | chr10:125133560-125133582 | 156.00 | -22.44 |
| ROSMAP | ENST00000494626 | 125133512 | 125133612 | hsa-miR-1291 | chr10:125133550-125133557 | 8mer-1a | chr10:125133537-125133558 | 171.00 | -29.17 |
| ROSMAP | ENST00000494626 | 125133512 | 125133612 | hsa-miR-6775-3p | chr10:125133550-125133557 | 8mer-1a | chr10:125133537-125133558 | 171.00 | -29.17 |
| ROSMAP | ENST00000531469 | 125110990 | 125111093 | hsa-miR-522-3p | chr10:125111073-125111080 | 8mer-1a | chr10:125111055-125111080 | 149.00 | -13.18 |
| ROSMAP | ENST00000531469 | 125110990 | 125111093 | hsa-miR-3938 | chr10:125111047-125111054 | 8mer-1a | chr10:125111033-125111054 | 156.00 | -17.68 |
| ROSMAP | ENST00000494626 | 125133512 | 125133612 | hsa-miR-660-3p | chr10:125133535-125133542 | 8mer-1a | chr10:125133534-125133556 | 179.00 | -34.93 |
| ROSMAP | ENST00000531469 | 125110990 | 125111093 | hsa-miR-224-3p | chr10:125111073-125111080 | 8mer-1a | chr10:125111055-125111080 | 149.00 | -13.18 |
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SNVs in the skipped exons for CTBP2 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for CTBP2 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CTBP2 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
| HCC | exon_skip_263852 | rs1152658 | chr10:125087710 | 1.748200e-22 | 3.095472e-19 |
| HCC | exon_skip_263852 | rs17152614 | chr10:125087830 | 1.748200e-22 | 3.095472e-19 |
| HCC | exon_skip_263852 | rs1152659 | chr10:125087919 | 1.690272e-09 | 4.830969e-07 |
| HCC | exon_skip_263852 | rs1152663 | chr10:125089509 | 1.690272e-09 | 4.830969e-07 |
| HCC | exon_skip_263852 | rs1152660 | chr10:125088406 | 2.835580e-08 | 6.363181e-06 |
| HCC | exon_skip_263852 | rs1152676 | chr10:125093360 | 1.333499e-05 | 1.617244e-03 |
| HCC | exon_skip_263852 | rs7903340 | chr10:125052202 | 8.709330e-05 | 8.108334e-03 |
| HCC | exon_skip_263852 | rs998836 | chr10:125052972 | 8.709330e-05 | 8.108334e-03 |
| HCC | exon_skip_263852 | rs2938010 | chr10:125052228 | 7.547414e-04 | 4.683668e-02 |
| PCC | exon_skip_263852 | rs1152658 | chr10:125087710 | 2.678986e-12 | 3.843332e-09 |
| PCC | exon_skip_263852 | rs17152614 | chr10:125087830 | 2.678986e-12 | 3.843332e-09 |
| PCC | exon_skip_263852 | rs1152659 | chr10:125087919 | 2.438104e-07 | 1.016442e-04 |
| PCC | exon_skip_263852 | rs1152660 | chr10:125088406 | 2.438104e-07 | 1.016442e-04 |
| PCC | exon_skip_263852 | rs1152663 | chr10:125089509 | 2.438104e-07 | 1.016442e-04 |
| PCC | exon_skip_263852 | rs1152676 | chr10:125093360 | 2.873750e-04 | 3.962897e-02 |
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Correlation with RNA binding proteins (RBPs) for CTBP2 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | RBM4 | exon_skip_205771 | 4.763417e-01 | 6.487225e-08 |
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RelatedDrugs for CTBP2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CTBP2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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