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![]() | Open reading frame (ORF) annotation in the exon skipping event |
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![]() | 3'-UTR located exon skipping events lost miRNA binding sites |
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![]() | Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for TEPSIN |
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Gene information | Gene symbol | TEPSIN | Gene ID | 146705 |
Gene name | TEPSIN adaptor related protein complex 4 accessory protein | |
Synonyms | C17orf56|ENTHD2 | |
Cytomap | 17q25.3 | |
Type of gene | protein-coding | |
Description | AP-4 complex accessory subunit tepsinAP-4 accessory proteinENTH domain containing 2ENTH domain-containing protein 2epsin for AP-4tetra-epsin | |
Modification date | 20200320 | |
UniProtAcc | ||
Context |
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Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for TEPSIN |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
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Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TEPSIN |
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Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_120825 | chr17 | 81231862:81232021:81232315:81232518:81233432:81233503 | 81232315:81232518 |
exon_skip_180798 | chr17 | 81237387:81237459:81237551:81237660:81238514:81238873 | 81237551:81237660 |
exon_skip_265897 | chr17 | 81231862:81232021:81233432:81233503:81233638:81233716 | 81233432:81233503 |
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Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
exon_skip_120825 | Mayo_CB | 6.062195e-01 | 7.312987e-01 | -1.250792e-01 | 2.038836e-06 |
exon_skip_120825 | Mayo_TC | 6.731707e-01 | 7.791304e-01 | -1.059597e-01 | 2.493568e-06 |
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Open reading frame (ORF) annotation in the exon skipping event for TEPSIN |
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ENST | Start of skipped exon | End of skipped exon | ORF |
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ENST | Start of skipped exon | End of skipped exon | ORF |
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ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000300714 | 81233432 | 81233503 | In-frame |
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Infer the effects of exon skipping event on protein functional features for TEPSIN |
p-ENSG00000167302_img4.png![]() |
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ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
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ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
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ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
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UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in TEPSIN |
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Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for TEPSIN |
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Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for TEPSIN |
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AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TEPSIN |
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Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for TEPSIN |
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Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
CB | RBM6 | exon_skip_120825 | -5.040303e-01 | 1.261910e-11 |
CB | SAMD4A | exon_skip_120825 | -4.890789e-01 | 6.101525e-11 |
CB | PCBP4 | exon_skip_120825 | 6.187875e-01 | 3.552071e-18 |
CB | NUP42 | exon_skip_120825 | 4.791592e-01 | 1.665719e-10 |
CB | RBM4 | exon_skip_120825 | -6.941350e-01 | 3.511355e-24 |
CB | RBM4B | exon_skip_120825 | -4.039111e-01 | 1.294344e-07 |
DLPFC | SAMD4A | exon_skip_120825 | -4.048649e-01 | 2.171016e-12 |
TC | SAMD4A | exon_skip_120825 | -4.100715e-01 | 1.704310e-07 |
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RelatedDrugs for TEPSIN |
![]() (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TEPSIN |
![]() (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |