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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for CSRP1 |
Gene summary |
Gene information | Gene symbol | CSRP1 | Gene ID | 1465 |
Gene name | cysteine and glycine rich protein 1 | |
Synonyms | CRP|CRP1|CSRP|CYRP|D1S181E|HEL-141|HEL-S-286 | |
Cytomap | 1q32.1 | |
Type of gene | protein-coding | |
Description | cysteine and glycine-rich protein 1LIM-domain proteincysteine-rich protein 1epididymis luminal protein 141epididymis secretory protein Li 286epididymis secretory sperm binding protein | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for CSRP1 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
PG | UP | ENST00000527662.5 | CSRP1-211:retained_intron:CSRP1 | 9.423106e+01 | 8.694604e-01 | 1.090296e-08 | 2.717488e-06 |
PG | UP | ENST00000526256.5 | CSRP1-207:protein_coding:CSRP1 | 1.827644e+01 | 6.458162e+00 | 3.321275e-06 | 2.212790e-04 |
TC | UP | ENST00000524951.5 | CSRP1-206:protein_coding:CSRP1 | 3.539882e+02 | 9.295725e-01 | 1.516523e-14 | 9.793745e-12 |
TC | UP | ENST00000532460.5 | CSRP1-216:protein_coding:CSRP1 | 2.264987e+02 | 8.903526e-01 | 2.209692e-13 | 1.003156e-10 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CSRP1 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_12118 | chr1 | 201488873:201488984:201490176:201490344:201496192:201496261 | 201490176:201490344 |
exon_skip_183686 | chr1 | 201484725:201484789:201485283:201485376:201496192:201496261 | 201485283:201485376 |
exon_skip_252797 | chr1 | 201490222:201490344:201496192:201496304:201507070:201507123 | 201496192:201496304 |
exon_skip_288356 | chr1 | 201490176:201490344:201496192:201496261:201507070:201507123 | 201496192:201496261 |
exon_skip_289778 | chr1 | 201490300:201490344:201496192:201496304:201507070:201507103 | 201496192:201496304 |
exon_skip_61175 | chr1 | 201490300:201490344:201496192:201496261:201507070:201507123 | 201496192:201496261 |
exon_skip_73229 | chr1 | 201490222:201490344:201496192:201496261:201507070:201507123 | 201496192:201496261 |
exon_skip_83960 | chr1 | 201484758:201484789:201485283:201485376:201496192:201496261 | 201485283:201485376 |
exon_skip_86575 | chr1 | 201484725:201484789:201485283:201485376:201496192:201496304 | 201485283:201485376 |
exon_skip_97362 | chr1 | 201490176:201490344:201496192:201496304:201507070:201507103 | 201496192:201496304 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for CSRP1 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000367306 | 201496192 | 201496304 | 3UTR-3CDS |
ENST00000340006 | 201490176 | 201490344 | Frame-shift |
ENST00000367306 | 201490176 | 201490344 | Frame-shift |
ENST00000532460 | 201490176 | 201490344 | Frame-shift |
ENST00000533432 | 201490176 | 201490344 | Frame-shift |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000367306 | 201496192 | 201496304 | 3UTR-3CDS |
ENST00000340006 | 201490176 | 201490344 | Frame-shift |
ENST00000367306 | 201490176 | 201490344 | Frame-shift |
ENST00000532460 | 201490176 | 201490344 | Frame-shift |
ENST00000533432 | 201490176 | 201490344 | Frame-shift |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000367306 | 201496192 | 201496304 | 3UTR-3CDS |
ENST00000340006 | 201490176 | 201490344 | Frame-shift |
ENST00000367306 | 201490176 | 201490344 | Frame-shift |
ENST00000532460 | 201490176 | 201490344 | Frame-shift |
ENST00000533432 | 201490176 | 201490344 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for CSRP1 |
p-ENSG00000159176_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in CSRP1 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for CSRP1 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for CSRP1 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CSRP1 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for CSRP1 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for CSRP1 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CSRP1 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |