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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for IL34 |
 Gene summary |
| Gene information | Gene symbol | IL34 | Gene ID | 146433 |
| Gene name | interleukin 34 | |
| Synonyms | C16orf77|IL-34 | |
| Cytomap | 16q22.1 | |
| Type of gene | protein-coding | |
| Description | interleukin-34 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context | - 28848420(Studies on Colony Stimulating Factor Receptor-1 and Ligands Colony Stimulating Factor-1 and Interleukin-34 in Alzheimer's Disease Brains and Human Microglia) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| IL34 | GO:0001934 | positive regulation of protein phosphorylation | 18467591 |
| IL34 | GO:0008284 | positive regulation of cell proliferation | 18467591 |
| IL34 | GO:0045651 | positive regulation of macrophage differentiation | 23409120 |
| IL34 | GO:0045657 | positive regulation of monocyte differentiation | 23409120 |
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Gene structures and expression levels for IL34 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000157368
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for IL34 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_151924 | chr16 | 70646873:70646975:70656602:70656679:70656963:70657357 | 70656602:70656679 |
| exon_skip_164386 | chr16 | 70654538:70654671:70656602:70656679:70656960:70657121 | 70656602:70656679 |
| exon_skip_35771 | chr16 | 70646873:70646975:70654538:70654671:70656602:70656671 | 70654538:70654671 |
| exon_skip_97375 | chr16 | 70656960:70657121:70659618:70659753:70659997:70660269 | 70659618:70659753 |
| exon_skip_97923 | chr16 | 70646873:70646975:70654538:70654671:70656602:70656679 | 70654538:70654671 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for IL34 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000288098 | 70654538 | 70654671 | Frame-shift |
| ENST00000429149 | 70654538 | 70654671 | Frame-shift |
| ENST00000288098 | 70659618 | 70659753 | Frame-shift |
| ENST00000429149 | 70659618 | 70659753 | Frame-shift |
| ENST00000288098 | 70656602 | 70656679 | In-frame |
| ENST00000429149 | 70656602 | 70656679 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000288098 | 70654538 | 70654671 | Frame-shift |
| ENST00000429149 | 70654538 | 70654671 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000288098 | 70654538 | 70654671 | Frame-shift |
| ENST00000429149 | 70654538 | 70654671 | Frame-shift |
| ENST00000288098 | 70656602 | 70656679 | In-frame |
| ENST00000429149 | 70656602 | 70656679 | In-frame |
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Infer the effects of exon skipping event on protein functional features for IL34 |
p-ENSG00000157368_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000288098 | 1624 | 242 | 70656602 | 70656679 | 547 | 623 | 54 | 80 |
| ENST00000429149 | 1796 | 242 | 70656602 | 70656679 | 719 | 795 | 54 | 80 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000288098 | 1624 | 242 | 70656602 | 70656679 | 547 | 623 | 54 | 80 |
| ENST00000429149 | 1796 | 242 | 70656602 | 70656679 | 719 | 795 | 54 | 80 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q6ZMJ4 | 54 | 80 | 64 | 66 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DKC |
| Q6ZMJ4 | 54 | 80 | 64 | 66 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DKC |
| Q6ZMJ4 | 54 | 80 | 21 | 242 | Chain | ID=PRO_0000294348;Note=Interleukin-34 |
| Q6ZMJ4 | 54 | 80 | 21 | 242 | Chain | ID=PRO_0000294348;Note=Interleukin-34 |
| Q6ZMJ4 | 54 | 80 | 76 | 76 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q6ZMJ4 | 54 | 80 | 76 | 76 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q6ZMJ4 | 54 | 80 | 47 | 54 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DKC |
| Q6ZMJ4 | 54 | 80 | 47 | 54 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DKC |
| Q6ZMJ4 | 54 | 80 | 68 | 70 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DKC |
| Q6ZMJ4 | 54 | 80 | 68 | 70 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DKC |
| Q6ZMJ4 | 54 | 80 | 74 | 81 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DKC |
| Q6ZMJ4 | 54 | 80 | 74 | 81 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DKC |
| Q6ZMJ4 | 54 | 80 | 55 | 57 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DKC |
| Q6ZMJ4 | 54 | 80 | 55 | 57 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DKC |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q6ZMJ4 | 54 | 80 | 64 | 66 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DKC |
| Q6ZMJ4 | 54 | 80 | 64 | 66 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DKC |
| Q6ZMJ4 | 54 | 80 | 21 | 242 | Chain | ID=PRO_0000294348;Note=Interleukin-34 |
| Q6ZMJ4 | 54 | 80 | 21 | 242 | Chain | ID=PRO_0000294348;Note=Interleukin-34 |
| Q6ZMJ4 | 54 | 80 | 76 | 76 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q6ZMJ4 | 54 | 80 | 76 | 76 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q6ZMJ4 | 54 | 80 | 47 | 54 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DKC |
| Q6ZMJ4 | 54 | 80 | 47 | 54 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DKC |
| Q6ZMJ4 | 54 | 80 | 68 | 70 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DKC |
| Q6ZMJ4 | 54 | 80 | 68 | 70 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DKC |
| Q6ZMJ4 | 54 | 80 | 74 | 81 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DKC |
| Q6ZMJ4 | 54 | 80 | 74 | 81 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DKC |
| Q6ZMJ4 | 54 | 80 | 55 | 57 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DKC |
| Q6ZMJ4 | 54 | 80 | 55 | 57 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DKC |
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3'-UTR located exon skipping events that lost miRNA binding sites in IL34 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for IL34 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for IL34 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for IL34 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for IL34 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for IL34 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for IL34 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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