ExonSkipAD: functional annotation of exon skipping event in human

Gene summary for CSNK2A1

Gene summary

Gene information	Gene symbol	CSNK2A1
	Gene ID	1457
	Gene name	casein kinase 2 alpha 1
	Synonyms	CK2A1\|CKII\|Cka1\|Cka2\|OCNDS
	Cytomap	20p13
	Type of gene	protein-coding
	Description	casein kinase II subunit alphaCK2 catalytic subunit alphacasein kinase 2, alpha 1 polypeptidecasein kinase II alpha 1 polypeptide pseudogenecasein kinase II alpha 1 subunitprotein kinase CK2
	Modification date	20200327
	UniProtAcc	A0A087WY74, A0A2R8Y3W6, A0A2R8Y4D6, A0A2R8Y4H0, A0A2R8Y5A0, A0A2R8Y797, A0A2R8Y7T1, A0A2R8YCC9, A0A2R8YCK2, A0A2R8YD58, A0A2R8YDP2, A0A2R8YDY7, A0A2R8YEL7, A0A2R8YEW1, A0A2R8YF43, A0A2R8YF47, A0A2R8YFU2, B5BUH5, E7EU96, P68400, Q5U5J2, V9GY80, V9GYA2, V9GYW6,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
CSNK2A1	GO:0006468	protein phosphorylation	18548200\|20625391\|22406621
CSNK2A1	GO:0008284	positive regulation of cell proliferation	20625391
CSNK2A1	GO:0018105	peptidyl-serine phosphorylation	28031292
CSNK2A1	GO:0018107	peptidyl-threonine phosphorylation	15723517
CSNK2A1	GO:0030307	positive regulation of cell growth	20625391
CSNK2A1	GO:0045732	positive regulation of protein catabolic process	20625391

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Gene structures and expression levels for CSNK2A1

Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

ENSG00000101266

Differentially expressed gene analysis across multiple brain tissues between AD and control.

Tissue type

DEG direction

Base mean exp.

log2FC(AD/control)

P-value

Adj. p-value

Differentially expressed isoform analysis across multiple brain tissues between AD and control.

Tissue type	DEG direction	ENST	Transcript info.	Base mean exp.	log2FC(AD/control)	P-value	Adjc. p-value
CB	UP	ENST00000647155.1	CSNK2A1-247:retained_intron:CSNK2A1	9.416392e+01	1.071366e+00	1.968996e-13	3.902492e-11
CB	UP	ENST00000642689.1	CSNK2A1-213:protein_coding:CSNK2A1	1.403920e+02	1.878494e+00	6.686047e-08	1.510909e-06
CB	UP	ENST00000643600.1	CSNK2A1-214:protein_coding:CSNK2A1	3.824228e+01	8.577576e-01	1.138032e-07	2.372405e-06

Landscape of isoform expressions across multiple brain tissues between AD and control.

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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CSNK2A1

Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).

All exon skipping events in AD cohorts.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon
exon_skip_105447	chr20	497721:497780:499255:499305:499833:499934	499255:499305
exon_skip_106092	chr20	505118:505229:508451:508605:543672:543696	508451:508605
exon_skip_113639	chr20	495797:495802:497721:497780:499833:499934	497721:497780
exon_skip_118504	chr20	495719:495802:497721:497780:499833:499934	497721:497780
exon_skip_123548	chr20	508451:508660:510168:510338:543672:543729	510168:510338
exon_skip_125924	chr20	508451:508660:526696:526942:527933:528049	526696:526942
exon_skip_147737	chr20	492339:492364:495719:495802:497721:497780	495719:495802
exon_skip_15049	chr20	473337:473950:483928:484076:486376:486462	483928:484076
exon_skip_152353	chr20	487427:487575:488678:488778:489780:489881	488678:488778
exon_skip_153362	chr20	526696:526942:527933:528049:543672:543712	527933:528049
exon_skip_16122	chr20	508451:508660:510168:510338:543672:543696	510168:510338
exon_skip_171157	chr20	505118:505229:527933:528049:543672:543696	527933:528049
exon_skip_180805	chr20	505118:505229:508451:508621:543672:543727	508451:508621
exon_skip_185057	chr20	499255:499305:499525:499630:499833:499934	499525:499630
exon_skip_186790	chr20	508451:508660:527933:528049:543672:543696	527933:528049
exon_skip_193175	chr20	492254:492364:495719:495802:497721:497780	495719:495802
exon_skip_194691	chr20	508451:508660:526696:526942:543672:543696	526696:526942
exon_skip_205826	chr20	492339:492364:495719:495802:499833:499934	495719:495802
exon_skip_237478	chr20	497747:497780:499255:499934:505118:505229	499255:499934
exon_skip_245843	chr20	505118:505229:508451:508605:543672:543730	508451:508605
exon_skip_247161	chr20	505118:505229:508451:508621:543672:543696	508451:508621
exon_skip_272836	chr20	505118:505229:508451:508660:543672:543696	508451:508660
exon_skip_279502	chr20	499255:499305:499525:499573:499833:499934	499525:499573
exon_skip_284059	chr20	505118:505229:508451:508660:527933:528049	508451:508660
exon_skip_292004	chr20	489780:489881:492254:492364:495719:495802	492254:492364
exon_skip_294197	chr20	489780:489881:492254:492364:495719:495733	492254:492364
exon_skip_44828	chr20	489780:489881:492254:492364:497721:497780	492254:492364
exon_skip_58430	chr20	497747:497780:499255:499305:499833:499934	499255:499305
exon_skip_62249	chr20	497747:497780:499255:499305:499525:499573	499255:499305
exon_skip_68392	chr20	489780:489881:495719:495802:497721:497780	495719:495802
exon_skip_76267	chr20	497747:497780:499833:499934:505118:505229	499833:499934
exon_skip_78979	chr20	499924:499934:500031:500115:505118:505229	500031:500115
exon_skip_97518	chr20	526696:526942:527933:528049:543672:543696	527933:528049

Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.

Exon skipping information

Tissue type

Avg(PSIs) in AD

Avg(PSIs) in control

Difference (PSI)

Adj. p-value

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Open reading frame (ORF) annotation in the exon skipping event for CSNK2A1

Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000217244	508451	508660	3UTR-3CDS
ENST00000400217	508451	508605	3UTR-3CDS
ENST00000643660	508451	508660	3UTR-3CDS
ENST00000645623	508451	508660	3UTR-3CDS
ENST00000646561	508451	508660	3UTR-3CDS
ENST00000646305	526696	526942	3UTR-3UTR
ENST00000646814	526696	526942	3UTR-3UTR
ENST00000645623	527933	528049	3UTR-3UTR
ENST00000646305	527933	528049	3UTR-3UTR
ENST00000643660	483928	484076	5CDS-5UTR
ENST00000645623	483928	484076	5CDS-5UTR
ENST00000217244	492254	492364	In-frame
ENST00000400217	492254	492364	In-frame
ENST00000643660	492254	492364	In-frame
ENST00000645623	492254	492364	In-frame
ENST00000646305	492254	492364	In-frame
ENST00000646561	492254	492364	In-frame
ENST00000646814	492254	492364	In-frame
ENST00000647348	492254	492364	In-frame
ENST00000217244	495719	495802	In-frame
ENST00000400217	495719	495802	In-frame
ENST00000643660	495719	495802	In-frame
ENST00000645623	495719	495802	In-frame
ENST00000646305	495719	495802	In-frame
ENST00000646561	495719	495802	In-frame
ENST00000646814	495719	495802	In-frame
ENST00000647348	495719	495802	In-frame
ENST00000217244	499255	499305	In-frame
ENST00000400217	499255	499305	In-frame
ENST00000643660	499255	499305	In-frame
ENST00000645623	499255	499305	In-frame
ENST00000646305	499255	499305	In-frame
ENST00000646561	499255	499305	In-frame
ENST00000646814	499255	499305	In-frame
ENST00000647348	499255	499305	In-frame

Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000217244	508451	508660	3UTR-3CDS
ENST00000643660	508451	508660	3UTR-3CDS
ENST00000645623	508451	508660	3UTR-3CDS
ENST00000646561	508451	508660	3UTR-3CDS
ENST00000645623	527933	528049	3UTR-3UTR
ENST00000217244	499255	499305	In-frame
ENST00000400217	499255	499305	In-frame
ENST00000643660	499255	499305	In-frame
ENST00000645623	499255	499305	In-frame
ENST00000646305	499255	499305	In-frame
ENST00000646561	499255	499305	In-frame
ENST00000646814	499255	499305	In-frame
ENST00000647348	499255	499305	In-frame

Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000217244	508451	508660	3UTR-3CDS
ENST00000400217	508451	508605	3UTR-3CDS
ENST00000643660	508451	508660	3UTR-3CDS
ENST00000645623	508451	508660	3UTR-3CDS
ENST00000646561	508451	508660	3UTR-3CDS
ENST00000646305	526696	526942	3UTR-3UTR
ENST00000646814	526696	526942	3UTR-3UTR
ENST00000645623	527933	528049	3UTR-3UTR
ENST00000646305	527933	528049	3UTR-3UTR
ENST00000643660	483928	484076	5CDS-5UTR
ENST00000645623	483928	484076	5CDS-5UTR
ENST00000217244	488678	488778	Frame-shift
ENST00000400217	488678	488778	Frame-shift
ENST00000643660	488678	488778	Frame-shift
ENST00000645623	488678	488778	Frame-shift
ENST00000646305	488678	488778	Frame-shift
ENST00000646561	488678	488778	Frame-shift
ENST00000646814	488678	488778	Frame-shift
ENST00000647348	488678	488778	Frame-shift
ENST00000217244	492254	492364	In-frame
ENST00000400217	492254	492364	In-frame
ENST00000643660	492254	492364	In-frame
ENST00000645623	492254	492364	In-frame
ENST00000646305	492254	492364	In-frame
ENST00000646561	492254	492364	In-frame
ENST00000646814	492254	492364	In-frame
ENST00000647348	492254	492364	In-frame
ENST00000217244	495719	495802	In-frame
ENST00000400217	495719	495802	In-frame
ENST00000643660	495719	495802	In-frame
ENST00000645623	495719	495802	In-frame
ENST00000646305	495719	495802	In-frame
ENST00000646561	495719	495802	In-frame
ENST00000646814	495719	495802	In-frame
ENST00000647348	495719	495802	In-frame
ENST00000217244	499255	499305	In-frame
ENST00000400217	499255	499305	In-frame
ENST00000643660	499255	499305	In-frame
ENST00000645623	499255	499305	In-frame
ENST00000646305	499255	499305	In-frame
ENST00000646561	499255	499305	In-frame
ENST00000646814	499255	499305	In-frame
ENST00000647348	499255	499305	In-frame

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Infer the effects of exon skipping event on protein functional features for CSNK2A1

p-ENSG00000101266_img4.png
boxplot

Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000217244	4407	391	499255	499305	694	743	105	121
ENST00000400217	1502	391	499255	499305	429	478	105	121
ENST00000643660	2839	391	499255	499305	486	535	105	121
ENST00000645623	2209	391	499255	499305	609	658	105	121
ENST00000646305	4476	391	499255	499305	830	879	105	121
ENST00000646561	12929	391	499255	499305	589	638	105	121
ENST00000646814	2829	391	499255	499305	713	762	105	121
ENST00000647348	1798	391	499255	499305	751	800	105	121
ENST00000217244	4407	391	495719	495802	805	887	142	169
ENST00000400217	1502	391	495719	495802	540	622	142	169
ENST00000643660	2839	391	495719	495802	597	679	142	169
ENST00000645623	2209	391	495719	495802	720	802	142	169
ENST00000646305	4476	391	495719	495802	941	1023	142	169
ENST00000646561	12929	391	495719	495802	700	782	142	169
ENST00000646814	2829	391	495719	495802	824	906	142	169
ENST00000647348	1798	391	495719	495802	862	944	142	169
ENST00000217244	4407	391	492254	492364	889	998	170	206
ENST00000400217	1502	391	492254	492364	624	733	170	206
ENST00000643660	2839	391	492254	492364	681	790	170	206
ENST00000645623	2209	391	492254	492364	804	913	170	206
ENST00000646305	4476	391	492254	492364	1025	1134	170	206
ENST00000646561	12929	391	492254	492364	784	893	170	206
ENST00000646814	2829	391	492254	492364	908	1017	170	206
ENST00000647348	1798	391	492254	492364	946	1055	170	206

Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000217244	4407	391	499255	499305	694	743	105	121
ENST00000400217	1502	391	499255	499305	429	478	105	121
ENST00000643660	2839	391	499255	499305	486	535	105	121
ENST00000645623	2209	391	499255	499305	609	658	105	121
ENST00000646305	4476	391	499255	499305	830	879	105	121
ENST00000646561	12929	391	499255	499305	589	638	105	121
ENST00000646814	2829	391	499255	499305	713	762	105	121
ENST00000647348	1798	391	499255	499305	751	800	105	121

Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000217244	4407	391	499255	499305	694	743	105	121
ENST00000400217	1502	391	499255	499305	429	478	105	121
ENST00000643660	2839	391	499255	499305	486	535	105	121
ENST00000645623	2209	391	499255	499305	609	658	105	121
ENST00000646305	4476	391	499255	499305	830	879	105	121
ENST00000646561	12929	391	499255	499305	589	638	105	121
ENST00000646814	2829	391	499255	499305	713	762	105	121
ENST00000647348	1798	391	499255	499305	751	800	105	121
ENST00000217244	4407	391	495719	495802	805	887	142	169
ENST00000400217	1502	391	495719	495802	540	622	142	169
ENST00000643660	2839	391	495719	495802	597	679	142	169
ENST00000645623	2209	391	495719	495802	720	802	142	169
ENST00000646305	4476	391	495719	495802	941	1023	142	169
ENST00000646561	12929	391	495719	495802	700	782	142	169
ENST00000646814	2829	391	495719	495802	824	906	142	169
ENST00000647348	1798	391	495719	495802	862	944	142	169
ENST00000217244	4407	391	492254	492364	889	998	170	206
ENST00000400217	1502	391	492254	492364	624	733	170	206
ENST00000643660	2839	391	492254	492364	681	790	170	206
ENST00000645623	2209	391	492254	492364	804	913	170	206
ENST00000646305	4476	391	492254	492364	1025	1134	170	206
ENST00000646561	12929	391	492254	492364	784	893	170	206
ENST00000646814	2829	391	492254	492364	908	1017	170	206
ENST00000647348	1798	391	492254	492364	946	1055	170	206

Lost protein functional features of individual exon skipping events in ROSMAP.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P68400	105	121	1	136	Alternative sequence	ID=VSP_041925;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
P68400	105	121	1	136	Alternative sequence	ID=VSP_041925;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
P68400	105	121	1	136	Alternative sequence	ID=VSP_041925;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
P68400	105	121	1	136	Alternative sequence	ID=VSP_041925;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
P68400	105	121	1	136	Alternative sequence	ID=VSP_041925;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
P68400	105	121	1	136	Alternative sequence	ID=VSP_041925;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
P68400	105	121	1	136	Alternative sequence	ID=VSP_041925;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
P68400	105	121	1	136	Alternative sequence	ID=VSP_041925;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
P68400	105	121	107	114	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	107	114	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	107	114	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	107	114	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	107	114	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	107	114	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	107	114	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	107	114	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	105	121	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	105	121	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	105	121	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	105	121	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	105	121	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	105	121	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	105	121	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	105	121	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	105	121	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	105	121	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	105	121	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	105	121	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	105	121	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	105	121	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	105	121	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	105	121	121	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	121	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	121	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	121	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	121	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	121	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	121	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	121	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	104	106	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	104	106	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	104	106	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	104	106	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	104	106	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	104	106	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	104	106	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	104	106	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	118	120	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5CVG
P68400	105	121	118	120	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5CVG
P68400	105	121	118	120	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5CVG
P68400	105	121	118	120	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5CVG
P68400	105	121	118	120	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5CVG
P68400	105	121	118	120	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5CVG
P68400	105	121	118	120	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5CVG
P68400	105	121	118	120	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5CVG
P68400	142	169	156	156	Active site	Note=Proton acceptor
P68400	142	169	156	156	Active site	Note=Proton acceptor
P68400	142	169	156	156	Active site	Note=Proton acceptor
P68400	142	169	156	156	Active site	Note=Proton acceptor
P68400	142	169	156	156	Active site	Note=Proton acceptor
P68400	142	169	156	156	Active site	Note=Proton acceptor
P68400	142	169	156	156	Active site	Note=Proton acceptor
P68400	142	169	156	156	Active site	Note=Proton acceptor
P68400	142	169	162	165	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	162	165	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	162	165	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	162	165	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	162	165	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	162	165	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	162	165	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	162	165	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	142	169	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	142	169	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	142	169	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	142	169	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	142	169	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	142	169	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	142	169	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	142	169	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	142	169	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	142	169	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	142	169	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	142	169	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	142	169	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	142	169	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	142	169	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	142	169	130	149	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	130	149	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	130	149	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	130	149	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	130	149	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	130	149	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	130	149	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	130	149	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	159	161	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	159	161	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	159	161	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	159	161	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	159	161	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	159	161	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	159	161	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	159	161	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	166	168	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	166	168	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	166	168	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	166	168	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	166	168	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	166	168	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	166	168	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	166	168	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	170	173	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	170	173	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	170	173	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	170	173	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	170	173	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	170	173	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	170	173	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	170	173	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	170	206	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	170	206	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	170	206	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	170	206	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	170	206	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	170	206	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	170	206	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	170	206	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	170	206	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	170	206	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	170	206	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	170	206	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	170	206	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	170	206	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	170	206	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	170	206	176	178	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5CVG
P68400	170	206	176	178	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5CVG
P68400	170	206	176	178	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5CVG
P68400	170	206	176	178	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5CVG
P68400	170	206	176	178	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5CVG
P68400	170	206	176	178	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5CVG
P68400	170	206	176	178	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5CVG
P68400	170	206	176	178	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5CVG
P68400	170	206	195	197	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	195	197	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	195	197	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	195	197	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	195	197	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	195	197	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	195	197	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	195	197	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	200	203	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	200	203	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	200	203	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	200	203	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	200	203	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	200	203	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	200	203	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	200	203	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	175	175	Natural variant	ID=VAR_077047;Note=In OCNDS. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:27048600;Dbxref=dbSNP:rs869312848,PMID:27048600
P68400	170	206	175	175	Natural variant	ID=VAR_077047;Note=In OCNDS. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:27048600;Dbxref=dbSNP:rs869312848,PMID:27048600
P68400	170	206	175	175	Natural variant	ID=VAR_077047;Note=In OCNDS. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:27048600;Dbxref=dbSNP:rs869312848,PMID:27048600
P68400	170	206	175	175	Natural variant	ID=VAR_077047;Note=In OCNDS. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:27048600;Dbxref=dbSNP:rs869312848,PMID:27048600
P68400	170	206	175	175	Natural variant	ID=VAR_077047;Note=In OCNDS. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:27048600;Dbxref=dbSNP:rs869312848,PMID:27048600
P68400	170	206	175	175	Natural variant	ID=VAR_077047;Note=In OCNDS. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:27048600;Dbxref=dbSNP:rs869312848,PMID:27048600
P68400	170	206	175	175	Natural variant	ID=VAR_077047;Note=In OCNDS. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:27048600;Dbxref=dbSNP:rs869312848,PMID:27048600
P68400	170	206	175	175	Natural variant	ID=VAR_077047;Note=In OCNDS. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:27048600;Dbxref=dbSNP:rs869312848,PMID:27048600
P68400	170	206	198	198	Natural variant	ID=VAR_077048;Note=In OCNDS. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:27048600;Dbxref=dbSNP:rs869312840,PMID:27048600
P68400	170	206	198	198	Natural variant	ID=VAR_077048;Note=In OCNDS. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:27048600;Dbxref=dbSNP:rs869312840,PMID:27048600
P68400	170	206	198	198	Natural variant	ID=VAR_077048;Note=In OCNDS. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:27048600;Dbxref=dbSNP:rs869312840,PMID:27048600
P68400	170	206	198	198	Natural variant	ID=VAR_077048;Note=In OCNDS. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:27048600;Dbxref=dbSNP:rs869312840,PMID:27048600
P68400	170	206	198	198	Natural variant	ID=VAR_077048;Note=In OCNDS. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:27048600;Dbxref=dbSNP:rs869312840,PMID:27048600
P68400	170	206	198	198	Natural variant	ID=VAR_077048;Note=In OCNDS. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:27048600;Dbxref=dbSNP:rs869312840,PMID:27048600
P68400	170	206	198	198	Natural variant	ID=VAR_077048;Note=In OCNDS. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:27048600;Dbxref=dbSNP:rs869312840,PMID:27048600
P68400	170	206	198	198	Natural variant	ID=VAR_077048;Note=In OCNDS. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:27048600;Dbxref=dbSNP:rs869312840,PMID:27048600

Lost protein functional features of individual exon skipping events in MSBB.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P68400	105	121	1	136	Alternative sequence	ID=VSP_041925;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
P68400	105	121	1	136	Alternative sequence	ID=VSP_041925;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
P68400	105	121	1	136	Alternative sequence	ID=VSP_041925;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
P68400	105	121	1	136	Alternative sequence	ID=VSP_041925;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
P68400	105	121	1	136	Alternative sequence	ID=VSP_041925;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
P68400	105	121	1	136	Alternative sequence	ID=VSP_041925;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
P68400	105	121	1	136	Alternative sequence	ID=VSP_041925;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
P68400	105	121	1	136	Alternative sequence	ID=VSP_041925;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
P68400	105	121	107	114	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	107	114	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	107	114	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	107	114	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	107	114	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	107	114	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	107	114	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	107	114	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	105	121	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	105	121	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	105	121	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	105	121	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	105	121	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	105	121	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	105	121	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	105	121	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	105	121	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	105	121	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	105	121	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	105	121	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	105	121	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	105	121	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	105	121	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	105	121	121	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	121	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	121	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	121	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	121	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	121	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	121	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	121	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	104	106	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	104	106	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	104	106	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	104	106	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	104	106	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	104	106	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	104	106	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	104	106	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	118	120	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5CVG
P68400	105	121	118	120	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5CVG
P68400	105	121	118	120	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5CVG
P68400	105	121	118	120	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5CVG
P68400	105	121	118	120	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5CVG
P68400	105	121	118	120	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5CVG
P68400	105	121	118	120	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5CVG
P68400	105	121	118	120	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5CVG

Lost protein functional features of individual exon skipping events in Mayo.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P68400	105	121	1	136	Alternative sequence	ID=VSP_041925;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
P68400	105	121	1	136	Alternative sequence	ID=VSP_041925;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
P68400	105	121	1	136	Alternative sequence	ID=VSP_041925;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
P68400	105	121	1	136	Alternative sequence	ID=VSP_041925;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
P68400	105	121	1	136	Alternative sequence	ID=VSP_041925;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
P68400	105	121	1	136	Alternative sequence	ID=VSP_041925;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
P68400	105	121	1	136	Alternative sequence	ID=VSP_041925;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
P68400	105	121	1	136	Alternative sequence	ID=VSP_041925;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
P68400	105	121	107	114	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	107	114	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	107	114	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	107	114	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	107	114	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	107	114	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	107	114	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	107	114	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	105	121	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	105	121	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	105	121	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	105	121	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	105	121	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	105	121	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	105	121	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	105	121	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	105	121	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	105	121	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	105	121	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	105	121	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	105	121	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	105	121	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	105	121	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	105	121	121	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	121	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	121	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	121	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	121	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	121	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	121	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	121	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	104	106	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	104	106	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	104	106	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	104	106	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	104	106	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	104	106	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	104	106	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	104	106	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	105	121	118	120	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5CVG
P68400	105	121	118	120	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5CVG
P68400	105	121	118	120	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5CVG
P68400	105	121	118	120	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5CVG
P68400	105	121	118	120	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5CVG
P68400	105	121	118	120	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5CVG
P68400	105	121	118	120	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5CVG
P68400	105	121	118	120	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5CVG
P68400	142	169	156	156	Active site	Note=Proton acceptor
P68400	142	169	156	156	Active site	Note=Proton acceptor
P68400	142	169	156	156	Active site	Note=Proton acceptor
P68400	142	169	156	156	Active site	Note=Proton acceptor
P68400	142	169	156	156	Active site	Note=Proton acceptor
P68400	142	169	156	156	Active site	Note=Proton acceptor
P68400	142	169	156	156	Active site	Note=Proton acceptor
P68400	142	169	156	156	Active site	Note=Proton acceptor
P68400	142	169	162	165	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	162	165	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	162	165	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	162	165	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	162	165	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	162	165	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	162	165	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	162	165	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	142	169	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	142	169	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	142	169	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	142	169	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	142	169	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	142	169	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	142	169	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	142	169	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	142	169	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	142	169	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	142	169	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	142	169	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	142	169	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	142	169	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	142	169	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	142	169	130	149	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	130	149	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	130	149	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	130	149	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	130	149	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	130	149	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	130	149	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	130	149	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	159	161	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	159	161	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	159	161	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	159	161	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	159	161	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	159	161	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	159	161	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	159	161	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	166	168	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	166	168	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	166	168	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	166	168	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	166	168	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	166	168	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	166	168	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	142	169	166	168	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	170	173	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	170	173	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	170	173	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	170	173	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	170	173	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	170	173	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	170	173	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	170	173	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	170	206	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	170	206	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	170	206	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	170	206	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	170	206	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	170	206	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	170	206	1	391	Chain	ID=PRO_0000085883;Note=Casein kinase II subunit alpha
P68400	170	206	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	170	206	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	170	206	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	170	206	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	170	206	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	170	206	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	170	206	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	170	206	39	324	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P68400	170	206	176	178	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5CVG
P68400	170	206	176	178	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5CVG
P68400	170	206	176	178	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5CVG
P68400	170	206	176	178	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5CVG
P68400	170	206	176	178	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5CVG
P68400	170	206	176	178	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5CVG
P68400	170	206	176	178	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5CVG
P68400	170	206	176	178	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5CVG
P68400	170	206	195	197	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	195	197	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	195	197	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	195	197	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	195	197	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	195	197	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	195	197	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	195	197	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	200	203	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	200	203	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	200	203	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	200	203	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	200	203	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	200	203	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	200	203	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	200	203	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WAR
P68400	170	206	175	175	Natural variant	ID=VAR_077047;Note=In OCNDS. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:27048600;Dbxref=dbSNP:rs869312848,PMID:27048600
P68400	170	206	175	175	Natural variant	ID=VAR_077047;Note=In OCNDS. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:27048600;Dbxref=dbSNP:rs869312848,PMID:27048600
P68400	170	206	175	175	Natural variant	ID=VAR_077047;Note=In OCNDS. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:27048600;Dbxref=dbSNP:rs869312848,PMID:27048600
P68400	170	206	175	175	Natural variant	ID=VAR_077047;Note=In OCNDS. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:27048600;Dbxref=dbSNP:rs869312848,PMID:27048600
P68400	170	206	175	175	Natural variant	ID=VAR_077047;Note=In OCNDS. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:27048600;Dbxref=dbSNP:rs869312848,PMID:27048600
P68400	170	206	175	175	Natural variant	ID=VAR_077047;Note=In OCNDS. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:27048600;Dbxref=dbSNP:rs869312848,PMID:27048600
P68400	170	206	175	175	Natural variant	ID=VAR_077047;Note=In OCNDS. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:27048600;Dbxref=dbSNP:rs869312848,PMID:27048600
P68400	170	206	175	175	Natural variant	ID=VAR_077047;Note=In OCNDS. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:27048600;Dbxref=dbSNP:rs869312848,PMID:27048600
P68400	170	206	198	198	Natural variant	ID=VAR_077048;Note=In OCNDS. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:27048600;Dbxref=dbSNP:rs869312840,PMID:27048600
P68400	170	206	198	198	Natural variant	ID=VAR_077048;Note=In OCNDS. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:27048600;Dbxref=dbSNP:rs869312840,PMID:27048600
P68400	170	206	198	198	Natural variant	ID=VAR_077048;Note=In OCNDS. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:27048600;Dbxref=dbSNP:rs869312840,PMID:27048600
P68400	170	206	198	198	Natural variant	ID=VAR_077048;Note=In OCNDS. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:27048600;Dbxref=dbSNP:rs869312840,PMID:27048600
P68400	170	206	198	198	Natural variant	ID=VAR_077048;Note=In OCNDS. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:27048600;Dbxref=dbSNP:rs869312840,PMID:27048600
P68400	170	206	198	198	Natural variant	ID=VAR_077048;Note=In OCNDS. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:27048600;Dbxref=dbSNP:rs869312840,PMID:27048600
P68400	170	206	198	198	Natural variant	ID=VAR_077048;Note=In OCNDS. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:27048600;Dbxref=dbSNP:rs869312840,PMID:27048600
P68400	170	206	198	198	Natural variant	ID=VAR_077048;Note=In OCNDS. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:27048600;Dbxref=dbSNP:rs869312840,PMID:27048600

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3'-UTR located exon skipping events that lost miRNA binding sites in CSNK2A1

3'-UTR exon skipping evnets lost miRNA binding.

Tissue type	ENST	Exon skip start	Exon skip end	microRNA	Binding site by TargetScan	Binding type by TargetScan	Bdinding site by miRanda	Score of miRanda	Energy by miRanda
Mayo	ENST00000646814	526696	526942	hsa-miR-4695-3p	chr20:526901-526908	8mer-1a	chr20:526885-526908	162.00	-28.39
Mayo	ENST00000646814	526696	526942	hsa-miR-9851-3p	chr20:526817-526824	8mer-1a	chr20:526817-526845	155.00	-31.92
Mayo	ENST00000646814	526696	526942	hsa-miR-4485-5p	chr20:526726-526733	8mer-1a	chr20:526726-526748	148.00	-23.87
Mayo	ENST00000646814	526696	526942	hsa-miR-6747-3p	chr20:526852-526859	8mer-1a	chr20:526836-526859	158.00	-27.30
Mayo	ENST00000646814	526696	526942	hsa-miR-1304-3p	chr20:526933-526940	8mer-1a	chr20:526919-526940	157.00	-21.39
Mayo	ENST00000646814	526696	526942	hsa-miR-6760-3p	chr20:526931-526938	8mer-1a	chr20:526919-526940	157.00	-21.39
Mayo	ENST00000646305	527933	528049	hsa-miR-549a-5p	chr20:528017-528024	8mer-1a	chr20:528001-528024	157.00	-18.70
Mayo	ENST00000646305	527933	528049	hsa-miR-4717-3p	chr20:528011-528018	8mer-1a	chr20:528001-528024	157.00	-18.70
Mayo	ENST00000646814	526696	526942	hsa-miR-193b-5p	chr20:526776-526783	8mer-1a	chr20:526760-526784	145.00	-18.72
Mayo	ENST00000646814	526696	526942	hsa-miR-6787-3p	chr20:526898-526905	8mer-1a	chr20:526881-526905	166.00	-30.85
Mayo	ENST00000646305	527933	528049	hsa-miR-5695	chr20:527974-527981	8mer-1a	chr20:527960-527981	163.00	-18.72
Mayo	ENST00000646814	526696	526942	hsa-miR-4435	chr20:526761-526768	8mer-1a	chr20:526745-526768	146.00	-19.62
Mayo	ENST00000646814	526696	526942	hsa-miR-593-5p	chr20:526817-526824	8mer-1a	chr20:526817-526845	155.00	-31.92
Mayo	ENST00000646814	526696	526942	hsa-miR-9903	chr20:526845-526852	8mer-1a	chr20:526836-526859	158.00	-27.30
Mayo	ENST00000646814	526696	526942	hsa-miR-660-3p	chr20:526842-526849	8mer-1a	chr20:526836-526859	158.00	-27.30
Mayo	ENST00000646814	526696	526942	hsa-miR-504-3p	chr20:526916-526923	8mer-1a	chr20:526902-526923	170.00	-32.12
MSBB	ENST00000645623	527933	528049	hsa-miR-549a-5p	chr20:528017-528024	8mer-1a	chr20:528001-528024	157.00	-18.70
MSBB	ENST00000645623	527933	528049	hsa-miR-4717-3p	chr20:528011-528018	8mer-1a	chr20:528001-528024	157.00	-18.70
MSBB	ENST00000645623	527933	528049	hsa-miR-5695	chr20:527974-527981	8mer-1a	chr20:527960-527981	163.00	-18.72
ROSMAP	ENST00000646814	526696	526942	hsa-miR-4695-3p	chr20:526901-526908	8mer-1a	chr20:526885-526908	162.00	-28.39
ROSMAP	ENST00000646814	526696	526942	hsa-miR-9851-3p	chr20:526817-526824	8mer-1a	chr20:526817-526845	155.00	-31.92
ROSMAP	ENST00000646814	526696	526942	hsa-miR-4485-5p	chr20:526726-526733	8mer-1a	chr20:526726-526748	148.00	-23.87
ROSMAP	ENST00000646814	526696	526942	hsa-miR-6747-3p	chr20:526852-526859	8mer-1a	chr20:526836-526859	158.00	-27.30
ROSMAP	ENST00000646814	526696	526942	hsa-miR-1304-3p	chr20:526933-526940	8mer-1a	chr20:526919-526940	157.00	-21.39
ROSMAP	ENST00000646814	526696	526942	hsa-miR-6760-3p	chr20:526931-526938	8mer-1a	chr20:526919-526940	157.00	-21.39
ROSMAP	ENST00000646305	527933	528049	hsa-miR-549a-5p	chr20:528017-528024	8mer-1a	chr20:528001-528024	157.00	-18.70
ROSMAP	ENST00000646305	527933	528049	hsa-miR-4717-3p	chr20:528011-528018	8mer-1a	chr20:528001-528024	157.00	-18.70
ROSMAP	ENST00000646814	526696	526942	hsa-miR-193b-5p	chr20:526776-526783	8mer-1a	chr20:526760-526784	145.00	-18.72
ROSMAP	ENST00000646814	526696	526942	hsa-miR-6787-3p	chr20:526898-526905	8mer-1a	chr20:526881-526905	166.00	-30.85
ROSMAP	ENST00000646305	527933	528049	hsa-miR-5695	chr20:527974-527981	8mer-1a	chr20:527960-527981	163.00	-18.72
ROSMAP	ENST00000646814	526696	526942	hsa-miR-4435	chr20:526761-526768	8mer-1a	chr20:526745-526768	146.00	-19.62
ROSMAP	ENST00000646814	526696	526942	hsa-miR-593-5p	chr20:526817-526824	8mer-1a	chr20:526817-526845	155.00	-31.92
ROSMAP	ENST00000646814	526696	526942	hsa-miR-9903	chr20:526845-526852	8mer-1a	chr20:526836-526859	158.00	-27.30
ROSMAP	ENST00000646814	526696	526942	hsa-miR-660-3p	chr20:526842-526849	8mer-1a	chr20:526836-526859	158.00	-27.30
ROSMAP	ENST00000646814	526696	526942	hsa-miR-504-3p	chr20:526916-526923	8mer-1a	chr20:526902-526923	170.00	-32.12

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SNVs in the skipped exons for CSNK2A1

- Differential PSIs between mutated versus non-mutated samples.

- Depth of Coverage in the skipped exon of the mutated samples.

- Sashimi plot in the skipped exon of the mutated samples.

- Non-synonymous mutations located in the skipped exons.

Cancer type

Sample

ESID

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

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AD stage-associated exon skippint events for CSNK2A1

Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).

AD stage info

Cohort

Tissue

SE id

Coefficient

P-value

Chromosome

Strand

E1 start

E1 end

Skipped start

Skipped end

E2 start

E2 end

ADstage

MSBB

IFG

exon_skip_186790

5.335058e-01

3.459758e-03

chr20

508451

508660

527933

528049

543672

543696

CDR

MSBB

IFG

exon_skip_186790

5.412436e-01

2.937040e-03

chr20

508451

508660

527933

528049

543672

543696

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CSNK2A1

sQTL information located at the skipped exons.

Tissue type

Exon skip ID

SNP id

Location

P-value

FDR

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Correlation with RNA binding proteins (RBPs) for CSNK2A1

Correlated RBP and related information.

Tissue type	RBP name	Exon skip ID	Correlation coeifficient	P-value
CB	ELAVL1	exon_skip_58430	-4.871927e-01	1.480458e-10
CB	RBM6	exon_skip_58430	-4.816531e-01	2.550234e-10
CB	CNOT4	exon_skip_58430	-6.186311e-01	1.235710e-17
CB	PCBP4	exon_skip_58430	5.687019e-01	1.425179e-14

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RelatedDrugs for CSNK2A1

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
P68400	approved\|investigational	DB12010	Fostamatinib	small molecule	P68400

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RelatedDiseases for CSNK2A1

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	3'-UTR located exon skipping events lost miRNA binding sites
	SNVs in the skipped exons with depth of coverage
	AD stage-associated exon skipping events
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Correlation with RNA binding proteins (RBPs)
	Related drugs with this gene
	Related diseases with this gene

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Gene summary for CSNK2A1

Gene structures and expression levels for CSNK2A1

Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CSNK2A1

Open reading frame (ORF) annotation in the exon skipping event for CSNK2A1

Infer the effects of exon skipping event on protein functional features for CSNK2A1

3'-UTR located exon skipping events that lost miRNA binding sites in CSNK2A1

SNVs in the skipped exons for CSNK2A1

AD stage-associated exon skippint events for CSNK2A1

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CSNK2A1

Correlation with RNA binding proteins (RBPs) for CSNK2A1

RelatedDrugs for CSNK2A1

RelatedDiseases for CSNK2A1