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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for CSNK1A1 |
 Gene summary |
| Gene information | Gene symbol | CSNK1A1 | Gene ID | 1452 |
| Gene name | casein kinase 1 alpha 1 | |
| Synonyms | CK1|CK1a|CKIa|HEL-S-77p|HLCDGP1|PRO2975 | |
| Cytomap | 5q32 | |
| Type of gene | protein-coding | |
| Description | casein kinase I isoform alphaCKI-alphaclock regulator kinasedown-regulated in lung cancerepididymis secretory sperm binding protein Li 77p | |
| Modification date | 20200313 | |
| UniProtAcc | A0A590UJ43, A0A590UJQ7, | |
| Context | - 30644102(Potential Biomarkers to Detect Traumatic Brain Injury by the Profiling of Salivary Extracellular Vesicles) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| CSNK1A1 | GO:0006468 | protein phosphorylation | 18305108 |
| CSNK1A1 | GO:0018105 | peptidyl-serine phosphorylation | 25500533 |
| CSNK1A1 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 19364825 |
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Gene structures and expression levels for CSNK1A1 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000113712
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| STG | UP | ENST00000504676.5 | CSNK1A1-204:protein_coding:CSNK1A1 | 9.785584e+00 | 6.446674e+00 | 5.377064e-05 | 7.721675e-03 |
| PG | UP | ENST00000504676.5 | CSNK1A1-204:protein_coding:CSNK1A1 | 6.452418e+01 | 1.796051e+00 | 1.839603e-03 | 2.246898e-02 |
| CB | UP | ENST00000606826.5 | CSNK1A1-211:nonsense_mediated_decay:CSNK1A1 | 8.911829e+00 | 1.321205e+00 | 1.047737e-08 | 3.126903e-07 |
| CB | UP | ENST00000606299.2 | CSNK1A1-209:nonsense_mediated_decay:CSNK1A1 | 1.829773e+01 | 1.394981e+00 | 1.849966e-07 | 3.572093e-06 |
| CB | UP | ENST00000657706.1 | CSNK1A1-214:nonsense_mediated_decay:CSNK1A1 | 1.039799e+01 | 1.639420e+00 | 8.266317e-07 | 1.275544e-05 |
| TC | UP | ENST00000657706.1 | CSNK1A1-214:nonsense_mediated_decay:CSNK1A1 | 2.561892e+00 | 1.268920e+00 | 7.078659e-03 | 4.340534e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CSNK1A1 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_106666 | chr5 | 149515669:149515726:149517794:149517877:149520290:149520293 | 149517794:149517877 |
| exon_skip_121785 | chr5 | 149513207:149513209:149517794:149517877:149520290:149520293 | 149517794:149517877 |
| exon_skip_148217 | chr5 | 149525135:149525171:149529604:149529719:149531394:149531511 | 149529604:149529719 |
| exon_skip_20500 | chr5 | 149505483:149505595:149507027:149507133:149509879:149509953 | 149507027:149507133 |
| exon_skip_206044 | chr5 | 149513070:149513209:149515669:149515726:149517794:149517877 | 149515669:149515726 |
| exon_skip_227319 | chr5 | 149509879:149509953:149513070:149513209:149520290:149520293 | 149513070:149513209 |
| exon_skip_270741 | chr5 | 149509879:149509953:149511794:149511872:149513070:149513209 | 149511794:149511872 |
| exon_skip_32685 | chr5 | 149509879:149509953:149511066:149511158:149511794:149511872 | 149511066:149511158 |
| exon_skip_61484 | chr5 | 149520290:149520388:149525045:149525171:149550075:149550135 | 149525045:149525171 |
| exon_skip_62887 | chr5 | 149513207:149513209:149520290:149520388:149525045:149525171 | 149520290:149520388 |
| exon_skip_71756 | chr5 | 149513207:149513209:149515669:149515726:149517794:149517877 | 149515669:149515726 |
| exon_skip_77167 | chr5 | 149520290:149520388:149525045:149525171:149550075:149550181 | 149525045:149525171 |
| exon_skip_8124 | chr5 | 149509879:149509953:149511794:149511872:149513070:149513120 | 149511794:149511872 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for CSNK1A1 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000377843 | 149507027 | 149507133 | Frame-shift |
| ENST00000377843 | 149511794 | 149511872 | Frame-shift |
| ENST00000377843 | 149525045 | 149525171 | Frame-shift |
| ENST00000377843 | 149520290 | 149520388 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000377843 | 149507027 | 149507133 | Frame-shift |
| ENST00000377843 | 149511794 | 149511872 | Frame-shift |
| ENST00000377843 | 149525045 | 149525171 | Frame-shift |
| ENST00000377843 | 149520290 | 149520388 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000377843 | 149507027 | 149507133 | Frame-shift |
| ENST00000377843 | 149511794 | 149511872 | Frame-shift |
| ENST00000377843 | 149525045 | 149525171 | Frame-shift |
| ENST00000377843 | 149520290 | 149520388 | In-frame |
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Infer the effects of exon skipping event on protein functional features for CSNK1A1 |
p-ENSG00000113712_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000377843 | 2576 | 337 | 149520290 | 149520388 | 946 | 1043 | 119 | 151 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000377843 | 2576 | 337 | 149520290 | 149520388 | 946 | 1043 | 119 | 151 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000377843 | 2576 | 337 | 149520290 | 149520388 | 946 | 1043 | 119 | 151 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P48729 | 119 | 151 | 136 | 136 | Active site | Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027 |
| P48729 | 119 | 151 | 142 | 144 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FQD |
| P48729 | 119 | 151 | 2 | 337 | Chain | ID=PRO_0000192822;Note=Casein kinase I isoform alpha |
| P48729 | 119 | 151 | 17 | 285 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| P48729 | 119 | 151 | 110 | 129 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FQD |
| P48729 | 119 | 151 | 139 | 141 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FQD |
| P48729 | 119 | 151 | 147 | 149 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FQD |
| P48729 | 119 | 151 | 122 | 122 | Sequence conflict | Note=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P48729 | 119 | 151 | 129 | 129 | Sequence conflict | Note=T->TK;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P48729 | 119 | 151 | 136 | 136 | Active site | Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027 |
| P48729 | 119 | 151 | 142 | 144 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FQD |
| P48729 | 119 | 151 | 2 | 337 | Chain | ID=PRO_0000192822;Note=Casein kinase I isoform alpha |
| P48729 | 119 | 151 | 17 | 285 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| P48729 | 119 | 151 | 110 | 129 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FQD |
| P48729 | 119 | 151 | 139 | 141 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FQD |
| P48729 | 119 | 151 | 147 | 149 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FQD |
| P48729 | 119 | 151 | 122 | 122 | Sequence conflict | Note=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P48729 | 119 | 151 | 129 | 129 | Sequence conflict | Note=T->TK;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P48729 | 119 | 151 | 136 | 136 | Active site | Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027 |
| P48729 | 119 | 151 | 142 | 144 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FQD |
| P48729 | 119 | 151 | 2 | 337 | Chain | ID=PRO_0000192822;Note=Casein kinase I isoform alpha |
| P48729 | 119 | 151 | 17 | 285 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| P48729 | 119 | 151 | 110 | 129 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FQD |
| P48729 | 119 | 151 | 139 | 141 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FQD |
| P48729 | 119 | 151 | 147 | 149 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FQD |
| P48729 | 119 | 151 | 122 | 122 | Sequence conflict | Note=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P48729 | 119 | 151 | 129 | 129 | Sequence conflict | Note=T->TK;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
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3'-UTR located exon skipping events that lost miRNA binding sites in CSNK1A1 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for CSNK1A1 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for CSNK1A1 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CSNK1A1 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
| DLPFC | exon_skip_121785 | rs353291 | chr5:149431183 | 4.887901e-04 | 3.177002e-02 |
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Correlation with RNA binding proteins (RBPs) for CSNK1A1 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | DAZAP1 | exon_skip_8124 | -4.415991e-01 | 5.652008e-09 |
| CB | FUBP1 | exon_skip_8124 | -5.235913e-01 | 1.425373e-12 |
| CB | RBM3 | exon_skip_121785 | 5.121050e-01 | 5.216370e-12 |
| CB | TRA2A | exon_skip_121785 | -5.681326e-01 | 5.699639e-15 |
| CB | NUP42 | exon_skip_121785 | 5.619498e-01 | 1.289316e-14 |
| CB | PTBP1 | exon_skip_121785 | -4.626101e-01 | 8.296298e-10 |
| DLPFC | RBM3 | exon_skip_121785 | 4.928672e-01 | 3.773445e-22 |
| FL | RBM3 | exon_skip_121785 | 4.832665e-01 | 5.543160e-13 |
| FL | G3BP2 | exon_skip_121785 | 4.626188e-01 | 6.805412e-12 |
| HCC | RBM3 | exon_skip_121785 | 4.149873e-01 | 8.660561e-13 |
| HCC | PTBP1 | exon_skip_121785 | -5.263997e-01 | 7.329231e-21 |
| IFG | RBM3 | exon_skip_121785 | 4.875186e-01 | 8.501699e-03 |
| PCC | RBM3 | exon_skip_121785 | 4.774643e-01 | 1.215113e-13 |
| PCC | G3BP2 | exon_skip_121785 | 4.887569e-01 | 2.609100e-14 |
| PCC | PTBP1 | exon_skip_121785 | -5.037315e-01 | 3.102835e-15 |
| PG | RBM3 | exon_skip_121785 | 5.185023e-01 | 8.875706e-16 |
| PG | G3BP2 | exon_skip_121785 | 4.487495e-01 | 9.461685e-12 |
| PG | KHDRBS2 | exon_skip_121785 | 4.233005e-01 | 1.706907e-10 |
| PG | PUF60 | exon_skip_121785 | 4.352606e-01 | 4.516597e-11 |
| PG | RALYL | exon_skip_121785 | 4.092232e-01 | 7.645737e-10 |
| STG | RBM3 | exon_skip_121785 | 6.266422e-01 | 3.047727e-11 |
| STG | G3BP2 | exon_skip_121785 | 4.298562e-01 | 2.115992e-05 |
| TC | RBM3 | exon_skip_121785 | 6.531643e-01 | 7.944567e-21 |
| TC | ILF2 | exon_skip_121785 | 4.566545e-01 | 1.284557e-09 |
| TC | G3BP2 | exon_skip_121785 | 4.552181e-01 | 1.468181e-09 |
| TC | KHDRBS2 | exon_skip_121785 | 4.368199e-01 | 7.703728e-09 |
| TC | PUF60 | exon_skip_121785 | 4.717684e-01 | 3.031263e-10 |
| TC | NUP42 | exon_skip_121785 | 4.592768e-01 | 1.004905e-09 |
| TC | PTBP1 | exon_skip_121785 | -4.094836e-01 | 7.588982e-08 |
| TC | EWSR1 | exon_skip_121785 | 4.329691e-01 | 1.076567e-08 |
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RelatedDrugs for CSNK1A1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| P48729 | approved|investigational | DB12010 | Fostamatinib | small molecule | P48729 |
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RelatedDiseases for CSNK1A1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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