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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for PRICKLE1 |
 Gene summary |
| Gene information | Gene symbol | PRICKLE1 | Gene ID | 144165 |
| Gene name | prickle planar cell polarity protein 1 | |
| Synonyms | EPM1B|RILP | |
| Cytomap | 12q12 | |
| Type of gene | protein-coding | |
| Description | prickle-like protein 1REST (RE-1 silencing transcription factor)/NRSF (neuron-restrictive silencer factor)-interacting LIM domain proteinREST/NRSF interacting LIM domain proteinREST/NRSF-interacting LIM domain protein 1prickle homolog 1prickle-like 1 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| PRICKLE1 | GO:0006606 | protein import into nucleus | 21199191 |
| PRICKLE1 | GO:0031398 | positive regulation of protein ubiquitination | 17030191 |
| PRICKLE1 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 17030191 |
| PRICKLE1 | GO:0045892 | negative regulation of transcription, DNA-templated | 17030191 |
| PRICKLE1 | GO:0090090 | negative regulation of canonical Wnt signaling pathway | 17030191 |
| PRICKLE1 | GO:2000691 | negative regulation of cardiac muscle cell myoblast differentiation | 21199191 |
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Gene structures and expression levels for PRICKLE1 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000139174
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| TC | UP | ENST00000455697.6 | PRICKLE1-203:protein_coding:PRICKLE1 | 3.586096e+01 | 9.344324e-01 | 8.538560e-03 | 4.989423e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for PRICKLE1 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_108701 | chr12 | 42466194:42466380:42468626:42468829:42469450:42469587 | 42468626:42468829 |
| exon_skip_108888 | chr12 | 42472385:42472564:42550208:42550329:42589465:42589746 | 42550208:42550329 |
| exon_skip_62193 | chr12 | 42472385:42472564:42483758:42483985:42484274:42484298 | 42483758:42483985 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for PRICKLE1 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000455697 | 42483758 | 42483985 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000455697 | 42483758 | 42483985 | 3UTR-3UTR |
| ENST00000345127 | 42468626 | 42468829 | In-frame |
| ENST00000445766 | 42468626 | 42468829 | In-frame |
| ENST00000455697 | 42468626 | 42468829 | In-frame |
| ENST00000548696 | 42468626 | 42468829 | In-frame |
| ENST00000552240 | 42468626 | 42468829 | In-frame |
| ENST00000639566 | 42468626 | 42468829 | In-frame |
| ENST00000639589 | 42468626 | 42468829 | In-frame |
| ENST00000640055 | 42468626 | 42468829 | In-frame |
| ENST00000640132 | 42468626 | 42468829 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000455697 | 42483758 | 42483985 | 3UTR-3UTR |
| ENST00000345127 | 42468626 | 42468829 | In-frame |
| ENST00000445766 | 42468626 | 42468829 | In-frame |
| ENST00000455697 | 42468626 | 42468829 | In-frame |
| ENST00000548696 | 42468626 | 42468829 | In-frame |
| ENST00000552240 | 42468626 | 42468829 | In-frame |
| ENST00000639566 | 42468626 | 42468829 | In-frame |
| ENST00000639589 | 42468626 | 42468829 | In-frame |
| ENST00000640055 | 42468626 | 42468829 | In-frame |
| ENST00000640132 | 42468626 | 42468829 | In-frame |
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Infer the effects of exon skipping event on protein functional features for PRICKLE1 |
p-ENSG00000139174_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000345127 | 5919 | 831 | 42468626 | 42468829 | 739 | 941 | 128 | 195 |
| ENST00000445766 | 4092 | 831 | 42468626 | 42468829 | 515 | 717 | 128 | 195 |
| ENST00000455697 | 4294 | 831 | 42468626 | 42468829 | 729 | 931 | 128 | 195 |
| ENST00000548696 | 3652 | 831 | 42468626 | 42468829 | 666 | 868 | 128 | 195 |
| ENST00000552240 | 3328 | 831 | 42468626 | 42468829 | 671 | 873 | 128 | 195 |
| ENST00000639566 | 3358 | 831 | 42468626 | 42468829 | 686 | 888 | 128 | 195 |
| ENST00000639589 | 5778 | 831 | 42468626 | 42468829 | 604 | 806 | 128 | 195 |
| ENST00000640055 | 3795 | 831 | 42468626 | 42468829 | 683 | 885 | 128 | 195 |
| ENST00000640132 | 4295 | 831 | 42468626 | 42468829 | 730 | 932 | 128 | 195 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000345127 | 5919 | 831 | 42468626 | 42468829 | 739 | 941 | 128 | 195 |
| ENST00000445766 | 4092 | 831 | 42468626 | 42468829 | 515 | 717 | 128 | 195 |
| ENST00000455697 | 4294 | 831 | 42468626 | 42468829 | 729 | 931 | 128 | 195 |
| ENST00000548696 | 3652 | 831 | 42468626 | 42468829 | 666 | 868 | 128 | 195 |
| ENST00000552240 | 3328 | 831 | 42468626 | 42468829 | 671 | 873 | 128 | 195 |
| ENST00000639566 | 3358 | 831 | 42468626 | 42468829 | 686 | 888 | 128 | 195 |
| ENST00000639589 | 5778 | 831 | 42468626 | 42468829 | 604 | 806 | 128 | 195 |
| ENST00000640055 | 3795 | 831 | 42468626 | 42468829 | 683 | 885 | 128 | 195 |
| ENST00000640132 | 4295 | 831 | 42468626 | 42468829 | 730 | 932 | 128 | 195 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q96MT3 | 128 | 195 | 1 | 828 | Chain | ID=PRO_0000075889;Note=Prickle-like protein 1 |
| Q96MT3 | 128 | 195 | 1 | 828 | Chain | ID=PRO_0000075889;Note=Prickle-like protein 1 |
| Q96MT3 | 128 | 195 | 1 | 828 | Chain | ID=PRO_0000075889;Note=Prickle-like protein 1 |
| Q96MT3 | 128 | 195 | 1 | 828 | Chain | ID=PRO_0000075889;Note=Prickle-like protein 1 |
| Q96MT3 | 128 | 195 | 1 | 828 | Chain | ID=PRO_0000075889;Note=Prickle-like protein 1 |
| Q96MT3 | 128 | 195 | 1 | 828 | Chain | ID=PRO_0000075889;Note=Prickle-like protein 1 |
| Q96MT3 | 128 | 195 | 1 | 828 | Chain | ID=PRO_0000075889;Note=Prickle-like protein 1 |
| Q96MT3 | 128 | 195 | 1 | 828 | Chain | ID=PRO_0000075889;Note=Prickle-like protein 1 |
| Q96MT3 | 128 | 195 | 1 | 828 | Chain | ID=PRO_0000075889;Note=Prickle-like protein 1 |
| Q96MT3 | 128 | 195 | 124 | 189 | Domain | Note=LIM zinc-binding 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125 |
| Q96MT3 | 128 | 195 | 124 | 189 | Domain | Note=LIM zinc-binding 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125 |
| Q96MT3 | 128 | 195 | 124 | 189 | Domain | Note=LIM zinc-binding 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125 |
| Q96MT3 | 128 | 195 | 124 | 189 | Domain | Note=LIM zinc-binding 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125 |
| Q96MT3 | 128 | 195 | 124 | 189 | Domain | Note=LIM zinc-binding 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125 |
| Q96MT3 | 128 | 195 | 124 | 189 | Domain | Note=LIM zinc-binding 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125 |
| Q96MT3 | 128 | 195 | 124 | 189 | Domain | Note=LIM zinc-binding 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125 |
| Q96MT3 | 128 | 195 | 124 | 189 | Domain | Note=LIM zinc-binding 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125 |
| Q96MT3 | 128 | 195 | 124 | 189 | Domain | Note=LIM zinc-binding 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125 |
| Q96MT3 | 128 | 195 | 189 | 249 | Domain | Note=LIM zinc-binding 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125 |
| Q96MT3 | 128 | 195 | 189 | 249 | Domain | Note=LIM zinc-binding 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125 |
| Q96MT3 | 128 | 195 | 189 | 249 | Domain | Note=LIM zinc-binding 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125 |
| Q96MT3 | 128 | 195 | 189 | 249 | Domain | Note=LIM zinc-binding 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125 |
| Q96MT3 | 128 | 195 | 189 | 249 | Domain | Note=LIM zinc-binding 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125 |
| Q96MT3 | 128 | 195 | 189 | 249 | Domain | Note=LIM zinc-binding 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125 |
| Q96MT3 | 128 | 195 | 189 | 249 | Domain | Note=LIM zinc-binding 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125 |
| Q96MT3 | 128 | 195 | 189 | 249 | Domain | Note=LIM zinc-binding 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125 |
| Q96MT3 | 128 | 195 | 189 | 249 | Domain | Note=LIM zinc-binding 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125 |
| Q96MT3 | 128 | 195 | 144 | 144 | Natural variant | ID=VAR_065580;Note=In EPM1B. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21276947;Dbxref=dbSNP:rs281865563,PMID:21276947 |
| Q96MT3 | 128 | 195 | 144 | 144 | Natural variant | ID=VAR_065580;Note=In EPM1B. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21276947;Dbxref=dbSNP:rs281865563,PMID:21276947 |
| Q96MT3 | 128 | 195 | 144 | 144 | Natural variant | ID=VAR_065580;Note=In EPM1B. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21276947;Dbxref=dbSNP:rs281865563,PMID:21276947 |
| Q96MT3 | 128 | 195 | 144 | 144 | Natural variant | ID=VAR_065580;Note=In EPM1B. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21276947;Dbxref=dbSNP:rs281865563,PMID:21276947 |
| Q96MT3 | 128 | 195 | 144 | 144 | Natural variant | ID=VAR_065580;Note=In EPM1B. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21276947;Dbxref=dbSNP:rs281865563,PMID:21276947 |
| Q96MT3 | 128 | 195 | 144 | 144 | Natural variant | ID=VAR_065580;Note=In EPM1B. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21276947;Dbxref=dbSNP:rs281865563,PMID:21276947 |
| Q96MT3 | 128 | 195 | 144 | 144 | Natural variant | ID=VAR_065580;Note=In EPM1B. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21276947;Dbxref=dbSNP:rs281865563,PMID:21276947 |
| Q96MT3 | 128 | 195 | 144 | 144 | Natural variant | ID=VAR_065580;Note=In EPM1B. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21276947;Dbxref=dbSNP:rs281865563,PMID:21276947 |
| Q96MT3 | 128 | 195 | 144 | 144 | Natural variant | ID=VAR_065580;Note=In EPM1B. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21276947;Dbxref=dbSNP:rs281865563,PMID:21276947 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q96MT3 | 128 | 195 | 1 | 828 | Chain | ID=PRO_0000075889;Note=Prickle-like protein 1 |
| Q96MT3 | 128 | 195 | 1 | 828 | Chain | ID=PRO_0000075889;Note=Prickle-like protein 1 |
| Q96MT3 | 128 | 195 | 1 | 828 | Chain | ID=PRO_0000075889;Note=Prickle-like protein 1 |
| Q96MT3 | 128 | 195 | 1 | 828 | Chain | ID=PRO_0000075889;Note=Prickle-like protein 1 |
| Q96MT3 | 128 | 195 | 1 | 828 | Chain | ID=PRO_0000075889;Note=Prickle-like protein 1 |
| Q96MT3 | 128 | 195 | 1 | 828 | Chain | ID=PRO_0000075889;Note=Prickle-like protein 1 |
| Q96MT3 | 128 | 195 | 1 | 828 | Chain | ID=PRO_0000075889;Note=Prickle-like protein 1 |
| Q96MT3 | 128 | 195 | 1 | 828 | Chain | ID=PRO_0000075889;Note=Prickle-like protein 1 |
| Q96MT3 | 128 | 195 | 1 | 828 | Chain | ID=PRO_0000075889;Note=Prickle-like protein 1 |
| Q96MT3 | 128 | 195 | 124 | 189 | Domain | Note=LIM zinc-binding 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125 |
| Q96MT3 | 128 | 195 | 124 | 189 | Domain | Note=LIM zinc-binding 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125 |
| Q96MT3 | 128 | 195 | 124 | 189 | Domain | Note=LIM zinc-binding 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125 |
| Q96MT3 | 128 | 195 | 124 | 189 | Domain | Note=LIM zinc-binding 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125 |
| Q96MT3 | 128 | 195 | 124 | 189 | Domain | Note=LIM zinc-binding 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125 |
| Q96MT3 | 128 | 195 | 124 | 189 | Domain | Note=LIM zinc-binding 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125 |
| Q96MT3 | 128 | 195 | 124 | 189 | Domain | Note=LIM zinc-binding 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125 |
| Q96MT3 | 128 | 195 | 124 | 189 | Domain | Note=LIM zinc-binding 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125 |
| Q96MT3 | 128 | 195 | 124 | 189 | Domain | Note=LIM zinc-binding 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125 |
| Q96MT3 | 128 | 195 | 189 | 249 | Domain | Note=LIM zinc-binding 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125 |
| Q96MT3 | 128 | 195 | 189 | 249 | Domain | Note=LIM zinc-binding 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125 |
| Q96MT3 | 128 | 195 | 189 | 249 | Domain | Note=LIM zinc-binding 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125 |
| Q96MT3 | 128 | 195 | 189 | 249 | Domain | Note=LIM zinc-binding 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125 |
| Q96MT3 | 128 | 195 | 189 | 249 | Domain | Note=LIM zinc-binding 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125 |
| Q96MT3 | 128 | 195 | 189 | 249 | Domain | Note=LIM zinc-binding 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125 |
| Q96MT3 | 128 | 195 | 189 | 249 | Domain | Note=LIM zinc-binding 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125 |
| Q96MT3 | 128 | 195 | 189 | 249 | Domain | Note=LIM zinc-binding 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125 |
| Q96MT3 | 128 | 195 | 189 | 249 | Domain | Note=LIM zinc-binding 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125 |
| Q96MT3 | 128 | 195 | 144 | 144 | Natural variant | ID=VAR_065580;Note=In EPM1B. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21276947;Dbxref=dbSNP:rs281865563,PMID:21276947 |
| Q96MT3 | 128 | 195 | 144 | 144 | Natural variant | ID=VAR_065580;Note=In EPM1B. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21276947;Dbxref=dbSNP:rs281865563,PMID:21276947 |
| Q96MT3 | 128 | 195 | 144 | 144 | Natural variant | ID=VAR_065580;Note=In EPM1B. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21276947;Dbxref=dbSNP:rs281865563,PMID:21276947 |
| Q96MT3 | 128 | 195 | 144 | 144 | Natural variant | ID=VAR_065580;Note=In EPM1B. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21276947;Dbxref=dbSNP:rs281865563,PMID:21276947 |
| Q96MT3 | 128 | 195 | 144 | 144 | Natural variant | ID=VAR_065580;Note=In EPM1B. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21276947;Dbxref=dbSNP:rs281865563,PMID:21276947 |
| Q96MT3 | 128 | 195 | 144 | 144 | Natural variant | ID=VAR_065580;Note=In EPM1B. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21276947;Dbxref=dbSNP:rs281865563,PMID:21276947 |
| Q96MT3 | 128 | 195 | 144 | 144 | Natural variant | ID=VAR_065580;Note=In EPM1B. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21276947;Dbxref=dbSNP:rs281865563,PMID:21276947 |
| Q96MT3 | 128 | 195 | 144 | 144 | Natural variant | ID=VAR_065580;Note=In EPM1B. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21276947;Dbxref=dbSNP:rs281865563,PMID:21276947 |
| Q96MT3 | 128 | 195 | 144 | 144 | Natural variant | ID=VAR_065580;Note=In EPM1B. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21276947;Dbxref=dbSNP:rs281865563,PMID:21276947 |
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3'-UTR located exon skipping events that lost miRNA binding sites in PRICKLE1 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000455697 | 42483758 | 42483985 | hsa-miR-4654 | chr12:42483787-42483794 | 8mer-1a | chr12:42483787-42483806 | 166.00 | -29.56 |
| Mayo | ENST00000455697 | 42483758 | 42483985 | hsa-miR-7154-3p | chr12:42483799-42483806 | 8mer-1a | chr12:42483787-42483806 | 166.00 | -29.56 |
| Mayo | ENST00000455697 | 42483758 | 42483985 | hsa-miR-629-3p | chr12:42483933-42483940 | 8mer-1a | chr12:42483931-42483953 | 150.00 | -20.63 |
| Mayo | ENST00000455697 | 42483758 | 42483985 | hsa-miR-4533 | chr12:42483910-42483917 | 8mer-1a | chr12:42483904-42483925 | 147.00 | -35.85 |
| Mayo | ENST00000455697 | 42483758 | 42483985 | hsa-miR-1275 | chr12:42483888-42483895 | 8mer-1a | chr12:42483887-42483909 | 156.00 | -38.71 |
| Mayo | ENST00000455697 | 42483758 | 42483985 | hsa-miR-4665-5p | chr12:42483888-42483895 | 8mer-1a | chr12:42483887-42483909 | 156.00 | -38.71 |
| Mayo | ENST00000455697 | 42483758 | 42483985 | hsa-miR-4769-5p | chr12:42483787-42483794 | 8mer-1a | chr12:42483787-42483806 | 166.00 | -29.56 |
| MSBB | ENST00000455697 | 42483758 | 42483985 | hsa-miR-4654 | chr12:42483787-42483794 | 8mer-1a | chr12:42483787-42483806 | 166.00 | -29.56 |
| MSBB | ENST00000455697 | 42483758 | 42483985 | hsa-miR-7154-3p | chr12:42483799-42483806 | 8mer-1a | chr12:42483787-42483806 | 166.00 | -29.56 |
| MSBB | ENST00000455697 | 42483758 | 42483985 | hsa-miR-629-3p | chr12:42483933-42483940 | 8mer-1a | chr12:42483931-42483953 | 150.00 | -20.63 |
| MSBB | ENST00000455697 | 42483758 | 42483985 | hsa-miR-4533 | chr12:42483910-42483917 | 8mer-1a | chr12:42483904-42483925 | 147.00 | -35.85 |
| MSBB | ENST00000455697 | 42483758 | 42483985 | hsa-miR-1275 | chr12:42483888-42483895 | 8mer-1a | chr12:42483887-42483909 | 156.00 | -38.71 |
| MSBB | ENST00000455697 | 42483758 | 42483985 | hsa-miR-4665-5p | chr12:42483888-42483895 | 8mer-1a | chr12:42483887-42483909 | 156.00 | -38.71 |
| MSBB | ENST00000455697 | 42483758 | 42483985 | hsa-miR-4769-5p | chr12:42483787-42483794 | 8mer-1a | chr12:42483787-42483806 | 166.00 | -29.56 |
| ROSMAP | ENST00000455697 | 42483758 | 42483985 | hsa-miR-4654 | chr12:42483787-42483794 | 8mer-1a | chr12:42483787-42483806 | 166.00 | -29.56 |
| ROSMAP | ENST00000455697 | 42483758 | 42483985 | hsa-miR-7154-3p | chr12:42483799-42483806 | 8mer-1a | chr12:42483787-42483806 | 166.00 | -29.56 |
| ROSMAP | ENST00000455697 | 42483758 | 42483985 | hsa-miR-629-3p | chr12:42483933-42483940 | 8mer-1a | chr12:42483931-42483953 | 150.00 | -20.63 |
| ROSMAP | ENST00000455697 | 42483758 | 42483985 | hsa-miR-4533 | chr12:42483910-42483917 | 8mer-1a | chr12:42483904-42483925 | 147.00 | -35.85 |
| ROSMAP | ENST00000455697 | 42483758 | 42483985 | hsa-miR-1275 | chr12:42483888-42483895 | 8mer-1a | chr12:42483887-42483909 | 156.00 | -38.71 |
| ROSMAP | ENST00000455697 | 42483758 | 42483985 | hsa-miR-4665-5p | chr12:42483888-42483895 | 8mer-1a | chr12:42483887-42483909 | 156.00 | -38.71 |
| ROSMAP | ENST00000455697 | 42483758 | 42483985 | hsa-miR-4769-5p | chr12:42483787-42483794 | 8mer-1a | chr12:42483787-42483806 | 166.00 | -29.56 |
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SNVs in the skipped exons for PRICKLE1 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for PRICKLE1 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PRICKLE1 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for PRICKLE1 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for PRICKLE1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PRICKLE1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
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