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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for XRRA1 |
 Gene summary |
| Gene information | Gene symbol | XRRA1 | Gene ID | 143570 |
| Gene name | X-ray radiation resistance associated 1 | |
| Synonyms | - | |
| Cytomap | 11q13.4 | |
| Type of gene | protein-coding | |
| Description | X-ray radiation resistance-associated protein 1 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| XRRA1 | GO:0010165 | response to X-ray | 12908878 |
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Gene structures and expression levels for XRRA1 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000166435
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000531852.5 | XRRA1-216:protein_coding:XRRA1 | 1.047172e+00 | 1.544265e+00 | 2.562575e-03 | 1.132145e-02 |
| CB | UP | ENST00000524430.1 | XRRA1-204:lncRNA:XRRA1 | 1.481806e+00 | 1.648209e+00 | 1.481864e-02 | 4.779035e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for XRRA1 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_101498 | chr11 | 74907148:74907273:74921214:74921347:74936884:74936916 | 74921214:74921347 |
| exon_skip_10741 | chr11 | 74851989:74852082:74906239:74906456:74907145:74907221 | 74906239:74906456 |
| exon_skip_127133 | chr11 | 74852034:74852082:74862981:74863021:74906239:74906352 | 74862981:74863021 |
| exon_skip_165512 | chr11 | 74848125:74848462:74851088:74851203:74851989:74852064 | 74851088:74851203 |
| exon_skip_175608 | chr11 | 74930300:74930372:74933801:74933872:74936884:74936916 | 74933801:74933872 |
| exon_skip_178941 | chr11 | 74930300:74930372:74933801:74933872:74936884:74937068 | 74933801:74933872 |
| exon_skip_181185 | chr11 | 74936884:74937068:74945018:74945085:74948928:74949020 | 74945018:74945085 |
| exon_skip_191211 | chr11 | 74843441:74843453:74843854:74843959:74844168:74844283 | 74843854:74843959 |
| exon_skip_2 | chr11 | 74921275:74921347:74927391:74927488:74930300:74930372 | 74927391:74927488 |
| exon_skip_200715 | chr11 | 74936884:74937068:74940785:74940882:74945018:74945085 | 74940785:74940882 |
| exon_skip_20544 | chr11 | 74859167:74859283:74862981:74863021:74906239:74906456 | 74862981:74863021 |
| exon_skip_208264 | chr11 | 74848125:74848462:74851088:74851203:74906239:74906352 | 74851088:74851203 |
| exon_skip_21623 | chr11 | 74851989:74852082:74907145:74907273:74921214:74921299 | 74907145:74907273 |
| exon_skip_220899 | chr11 | 74930300:74930372:74933825:74933872:74936884:74937068 | 74933825:74933872 |
| exon_skip_22502 | chr11 | 74851989:74852082:74862981:74863021:74906239:74906352 | 74862981:74863021 |
| exon_skip_22593 | chr11 | 74843350:74843453:74843854:74843959:74844168:74844283 | 74843854:74843959 |
| exon_skip_243321 | chr11 | 74906353:74906456:74907145:74907273:74921214:74921299 | 74907145:74907273 |
| exon_skip_248183 | chr11 | 74851989:74852082:74906239:74906456:74907145:74907273 | 74906239:74906456 |
| exon_skip_27671 | chr11 | 74930300:74930372:74933825:74933872:74936884:74936916 | 74933825:74933872 |
| exon_skip_33843 | chr11 | 74851989:74852082:74859158:74859283:74862981:74863021 | 74859158:74859283 |
| exon_skip_35888 | chr11 | 74851088:74851203:74851989:74852082:74906239:74906352 | 74851989:74852082 |
| exon_skip_7767 | chr11 | 74843370:74843453:74843854:74843959:74844168:74844283 | 74843854:74843959 |
| exon_skip_80018 | chr11 | 74906840:74907273:74909889:74910012:74921214:74921299 | 74909889:74910012 |
| exon_skip_81637 | chr11 | 74852034:74852082:74859158:74859283:74862981:74863021 | 74859158:74859283 |
| exon_skip_84678 | chr11 | 74862981:74863021:74906239:74906456:74907145:74907221 | 74906239:74906456 |
| exon_skip_93890 | chr11 | 74936884:74937068:74940785:74940882:74948928:74949020 | 74940785:74940882 |
| exon_skip_96594 | chr11 | 74940785:74940882:74945018:74945085:74948928:74949020 | 74945018:74945085 |
| exon_skip_97099 | chr11 | 74851088:74851203:74851989:74852082:74862981:74863021 | 74851989:74852082 |
| exon_skip_98264 | chr11 | 74921275:74921347:74930300:74930372:74933801:74933872 | 74930300:74930372 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_22593 | Mayo_CB | 4.809375e-01 | 3.718033e-01 | 1.091342e-01 | 1.707619e-02 |
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Open reading frame (ORF) annotation in the exon skipping event for XRRA1 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000340360 | 74940785 | 74940882 | 3UTR-3CDS |
| ENST00000340360 | 74945018 | 74945085 | 3UTR-3UTR |
| ENST00000340360 | 74843854 | 74843959 | Frame-shift |
| ENST00000340360 | 74851088 | 74851203 | Frame-shift |
| ENST00000340360 | 74862981 | 74863021 | Frame-shift |
| ENST00000340360 | 74906239 | 74906456 | Frame-shift |
| ENST00000340360 | 74927391 | 74927488 | Frame-shift |
| ENST00000340360 | 74859158 | 74859283 | In-frame |
| ENST00000340360 | 74933825 | 74933872 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000340360 | 74940785 | 74940882 | 3UTR-3CDS |
| ENST00000340360 | 74945018 | 74945085 | 3UTR-3UTR |
| ENST00000340360 | 74843854 | 74843959 | Frame-shift |
| ENST00000340360 | 74927391 | 74927488 | Frame-shift |
| ENST00000340360 | 74859158 | 74859283 | In-frame |
| ENST00000340360 | 74933825 | 74933872 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000340360 | 74940785 | 74940882 | 3UTR-3CDS |
| ENST00000340360 | 74945018 | 74945085 | 3UTR-3UTR |
| ENST00000340360 | 74843854 | 74843959 | Frame-shift |
| ENST00000340360 | 74851088 | 74851203 | Frame-shift |
| ENST00000340360 | 74906239 | 74906456 | Frame-shift |
| ENST00000340360 | 74927391 | 74927488 | Frame-shift |
| ENST00000340360 | 74859158 | 74859283 | In-frame |
| ENST00000340360 | 74907145 | 74907273 | In-frame |
| ENST00000340360 | 74933825 | 74933872 | In-frame |
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Infer the effects of exon skipping event on protein functional features for XRRA1 |
p-ENSG00000166435_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000340360 | 5698 | 792 | 74933825 | 74933872 | 612 | 658 | 93 | 108 |
| ENST00000340360 | 5698 | 792 | 74859158 | 74859283 | 1353 | 1477 | 340 | 381 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000340360 | 5698 | 792 | 74933825 | 74933872 | 612 | 658 | 93 | 108 |
| ENST00000340360 | 5698 | 792 | 74859158 | 74859283 | 1353 | 1477 | 340 | 381 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000340360 | 5698 | 792 | 74933825 | 74933872 | 612 | 658 | 93 | 108 |
| ENST00000340360 | 5698 | 792 | 74907145 | 74907273 | 965 | 1092 | 211 | 253 |
| ENST00000340360 | 5698 | 792 | 74859158 | 74859283 | 1353 | 1477 | 340 | 381 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q6P2D8 | 93 | 108 | 1 | 233 | Alternative sequence | ID=VSP_044988;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q6P2D8 | 93 | 108 | 1 | 792 | Chain | ID=PRO_0000318130;Note=X-ray radiation resistance-associated protein 1 |
| Q6P2D8 | 93 | 108 | 104 | 125 | Repeat | Note=LRR 1 |
| Q6P2D8 | 340 | 381 | 327 | 413 | Alternative sequence | ID=VSP_052670;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q6P2D8 | 340 | 381 | 327 | 382 | Alternative sequence | ID=VSP_052671;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4 |
| Q6P2D8 | 340 | 381 | 327 | 340 | Alternative sequence | ID=VSP_052672;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12908878;Dbxref=PMID:12908878 |
| Q6P2D8 | 340 | 381 | 341 | 382 | Alternative sequence | ID=VSP_044989;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q6P2D8 | 340 | 381 | 1 | 792 | Chain | ID=PRO_0000318130;Note=X-ray radiation resistance-associated protein 1 |
| Q6P2D8 | 340 | 381 | 356 | 356 | Sequence conflict | Note=V->M;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q6P2D8 | 93 | 108 | 1 | 233 | Alternative sequence | ID=VSP_044988;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q6P2D8 | 93 | 108 | 1 | 792 | Chain | ID=PRO_0000318130;Note=X-ray radiation resistance-associated protein 1 |
| Q6P2D8 | 93 | 108 | 104 | 125 | Repeat | Note=LRR 1 |
| Q6P2D8 | 340 | 381 | 327 | 413 | Alternative sequence | ID=VSP_052670;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q6P2D8 | 340 | 381 | 327 | 382 | Alternative sequence | ID=VSP_052671;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4 |
| Q6P2D8 | 340 | 381 | 327 | 340 | Alternative sequence | ID=VSP_052672;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12908878;Dbxref=PMID:12908878 |
| Q6P2D8 | 340 | 381 | 341 | 382 | Alternative sequence | ID=VSP_044989;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q6P2D8 | 340 | 381 | 1 | 792 | Chain | ID=PRO_0000318130;Note=X-ray radiation resistance-associated protein 1 |
| Q6P2D8 | 340 | 381 | 356 | 356 | Sequence conflict | Note=V->M;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q6P2D8 | 93 | 108 | 1 | 233 | Alternative sequence | ID=VSP_044988;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q6P2D8 | 93 | 108 | 1 | 792 | Chain | ID=PRO_0000318130;Note=X-ray radiation resistance-associated protein 1 |
| Q6P2D8 | 93 | 108 | 104 | 125 | Repeat | Note=LRR 1 |
| Q6P2D8 | 211 | 253 | 1 | 233 | Alternative sequence | ID=VSP_044988;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q6P2D8 | 211 | 253 | 1 | 792 | Chain | ID=PRO_0000318130;Note=X-ray radiation resistance-associated protein 1 |
| Q6P2D8 | 211 | 253 | 229 | 250 | Repeat | Note=LRR 5 |
| Q6P2D8 | 340 | 381 | 327 | 413 | Alternative sequence | ID=VSP_052670;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q6P2D8 | 340 | 381 | 327 | 382 | Alternative sequence | ID=VSP_052671;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4 |
| Q6P2D8 | 340 | 381 | 327 | 340 | Alternative sequence | ID=VSP_052672;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12908878;Dbxref=PMID:12908878 |
| Q6P2D8 | 340 | 381 | 341 | 382 | Alternative sequence | ID=VSP_044989;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q6P2D8 | 340 | 381 | 1 | 792 | Chain | ID=PRO_0000318130;Note=X-ray radiation resistance-associated protein 1 |
| Q6P2D8 | 340 | 381 | 356 | 356 | Sequence conflict | Note=V->M;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
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3'-UTR located exon skipping events that lost miRNA binding sites in XRRA1 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for XRRA1 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for XRRA1 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for XRRA1 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for XRRA1 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for XRRA1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for XRRA1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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