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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for CRYZ |
 Gene summary |
| Gene information | Gene symbol | CRYZ | Gene ID | 1429 |
| Gene name | crystallin zeta | |
| Synonyms | - | |
| Cytomap | 1p31.1 | |
| Type of gene | protein-coding | |
| Description | quinone oxidoreductaseNADPH:quinone reductasecrystallin, zeta (quinone reductase)epididymis secretory sperm binding protein | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| CRYZ | GO:0042178 | xenobiotic catabolic process | 17497241 |
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Gene structures and expression levels for CRYZ |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000116791
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000370871.7 | CRYZ-203:protein_coding:CRYZ | 1.903294e+01 | 1.908894e+00 | 2.286047e-05 | 2.119156e-04 |
| CB | UP | ENST00000417775.5 | CRYZ-205:protein_coding:CRYZ | 2.652686e+01 | 8.784597e-01 | 4.187140e-04 | 2.479697e-03 |
| TC | UP | ENST00000370871.7 | CRYZ-203:protein_coding:CRYZ | 9.700763e+00 | 1.362538e+00 | 2.557610e-04 | 3.394256e-03 |
| TC | UP | ENST00000370870.5 | CRYZ-202:protein_coding:CRYZ | 3.355982e+00 | 1.574882e+00 | 7.296661e-03 | 4.439213e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CRYZ |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_111162 | chr1 | 74710109:74710247:74714579:74714630:74723118:74723270 | 74714579:74714630 |
| exon_skip_111675 | chr1 | 74723118:74723270:74724711:74724834:74732767:74732811 | 74724711:74724834 |
| exon_skip_121344 | chr1 | 74714579:74714630:74719209:74719372:74723118:74723270 | 74719209:74719372 |
| exon_skip_134689 | chr1 | 74706899:74706994:74707103:74707204:74710098:74710247 | 74707103:74707204 |
| exon_skip_216796 | chr1 | 74714579:74714630:74719209:74719372:74723118:74723258 | 74719209:74719372 |
| exon_skip_8730 | chr1 | 74724711:74724834:74730382:74730420:74732956:74733018 | 74730382:74730420 |
| exon_skip_994 | chr1 | 74723118:74723270:74724711:74724834:74732956:74733018 | 74724711:74724834 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for CRYZ |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000340866 | 74724711 | 74724834 | 3UTR-3CDS |
| ENST00000417775 | 74730382 | 74730420 | 3UTR-3UTR |
| ENST00000340866 | 74719209 | 74719372 | Frame-shift |
| ENST00000417775 | 74719209 | 74719372 | Frame-shift |
| ENST00000340866 | 74707103 | 74707204 | In-frame |
| ENST00000417775 | 74707103 | 74707204 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000340866 | 74724711 | 74724834 | 3UTR-3CDS |
| ENST00000417775 | 74730382 | 74730420 | 3UTR-3UTR |
| ENST00000340866 | 74719209 | 74719372 | Frame-shift |
| ENST00000417775 | 74719209 | 74719372 | Frame-shift |
| ENST00000340866 | 74707103 | 74707204 | In-frame |
| ENST00000417775 | 74707103 | 74707204 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000340866 | 74724711 | 74724834 | 3UTR-3CDS |
| ENST00000417775 | 74730382 | 74730420 | 3UTR-3UTR |
| ENST00000340866 | 74719209 | 74719372 | Frame-shift |
| ENST00000417775 | 74719209 | 74719372 | Frame-shift |
| ENST00000340866 | 74707103 | 74707204 | In-frame |
| ENST00000417775 | 74707103 | 74707204 | In-frame |
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Infer the effects of exon skipping event on protein functional features for CRYZ |
p-ENSG00000116791_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000340866 | 1905 | 329 | 74707103 | 74707204 | 719 | 819 | 210 | 243 |
| ENST00000417775 | 2318 | 329 | 74707103 | 74707204 | 1136 | 1236 | 210 | 243 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000340866 | 1905 | 329 | 74707103 | 74707204 | 719 | 819 | 210 | 243 |
| ENST00000417775 | 2318 | 329 | 74707103 | 74707204 | 1136 | 1236 | 210 | 243 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000340866 | 1905 | 329 | 74707103 | 74707204 | 719 | 819 | 210 | 243 |
| ENST00000417775 | 2318 | 329 | 74707103 | 74707204 | 1136 | 1236 | 210 | 243 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q08257 | 210 | 243 | 211 | 244 | Alternative sequence | ID=VSP_046425;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q08257 | 210 | 243 | 211 | 244 | Alternative sequence | ID=VSP_046425;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q08257 | 210 | 243 | 218 | 224 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB5 |
| Q08257 | 210 | 243 | 218 | 224 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB5 |
| Q08257 | 210 | 243 | 237 | 245 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB5 |
| Q08257 | 210 | 243 | 237 | 245 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB5 |
| Q08257 | 210 | 243 | 229 | 229 | Binding site | Note=NADP;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.17 |
| Q08257 | 210 | 243 | 229 | 229 | Binding site | Note=NADP;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.17 |
| Q08257 | 210 | 243 | 2 | 329 | Chain | ID=PRO_0000160906;Note=Quinone oxidoreductase |
| Q08257 | 210 | 243 | 2 | 329 | Chain | ID=PRO_0000160906;Note=Quinone oxidoreductase |
| Q08257 | 210 | 243 | 205 | 213 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB5 |
| Q08257 | 210 | 243 | 205 | 213 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB5 |
| Q08257 | 210 | 243 | 226 | 236 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB5 |
| Q08257 | 210 | 243 | 226 | 236 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB5 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q08257 | 210 | 243 | 211 | 244 | Alternative sequence | ID=VSP_046425;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q08257 | 210 | 243 | 211 | 244 | Alternative sequence | ID=VSP_046425;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q08257 | 210 | 243 | 218 | 224 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB5 |
| Q08257 | 210 | 243 | 218 | 224 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB5 |
| Q08257 | 210 | 243 | 237 | 245 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB5 |
| Q08257 | 210 | 243 | 237 | 245 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB5 |
| Q08257 | 210 | 243 | 229 | 229 | Binding site | Note=NADP;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.17 |
| Q08257 | 210 | 243 | 229 | 229 | Binding site | Note=NADP;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.17 |
| Q08257 | 210 | 243 | 2 | 329 | Chain | ID=PRO_0000160906;Note=Quinone oxidoreductase |
| Q08257 | 210 | 243 | 2 | 329 | Chain | ID=PRO_0000160906;Note=Quinone oxidoreductase |
| Q08257 | 210 | 243 | 205 | 213 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB5 |
| Q08257 | 210 | 243 | 205 | 213 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB5 |
| Q08257 | 210 | 243 | 226 | 236 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB5 |
| Q08257 | 210 | 243 | 226 | 236 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB5 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q08257 | 210 | 243 | 211 | 244 | Alternative sequence | ID=VSP_046425;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q08257 | 210 | 243 | 211 | 244 | Alternative sequence | ID=VSP_046425;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q08257 | 210 | 243 | 218 | 224 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB5 |
| Q08257 | 210 | 243 | 218 | 224 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB5 |
| Q08257 | 210 | 243 | 237 | 245 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB5 |
| Q08257 | 210 | 243 | 237 | 245 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB5 |
| Q08257 | 210 | 243 | 229 | 229 | Binding site | Note=NADP;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.17 |
| Q08257 | 210 | 243 | 229 | 229 | Binding site | Note=NADP;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.17 |
| Q08257 | 210 | 243 | 2 | 329 | Chain | ID=PRO_0000160906;Note=Quinone oxidoreductase |
| Q08257 | 210 | 243 | 2 | 329 | Chain | ID=PRO_0000160906;Note=Quinone oxidoreductase |
| Q08257 | 210 | 243 | 205 | 213 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB5 |
| Q08257 | 210 | 243 | 205 | 213 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB5 |
| Q08257 | 210 | 243 | 226 | 236 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB5 |
| Q08257 | 210 | 243 | 226 | 236 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YB5 |
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3'-UTR located exon skipping events that lost miRNA binding sites in CRYZ |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for CRYZ |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for CRYZ |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CRYZ |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for CRYZ |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | TARDBP | exon_skip_134689 | -4.706008e-01 | 2.048684e-09 |
| CB | ZNF638 | exon_skip_134689 | -4.413160e-01 | 2.468004e-08 |
| CB | TRA2A | exon_skip_134689 | -4.671221e-01 | 2.787784e-09 |
| CB | FUBP1 | exon_skip_134689 | -4.412605e-01 | 2.479140e-08 |
| CB | NUP42 | exon_skip_134689 | 4.256693e-01 | 8.499778e-08 |
| CB | CNOT4 | exon_skip_121344 | -4.219882e-01 | 1.018266e-07 |
| CB | TRA2A | exon_skip_121344 | -4.028676e-01 | 4.217575e-07 |
| CB | CNOT4 | exon_skip_994 | -4.791370e-01 | 2.115420e-09 |
| CB | TRA2A | exon_skip_994 | -4.860257e-01 | 1.147660e-09 |
| TC | RBMS2 | exon_skip_134689 | -4.863711e-01 | 1.218278e-10 |
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RelatedDrugs for CRYZ |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Q08257 | approved | DB00266 | Dicoumarol | small molecule | Q08257 |
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RelatedDiseases for CRYZ |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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