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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for CRY2 |
 Gene summary |
| Gene information | Gene symbol | CRY2 | Gene ID | 1408 |
| Gene name | cryptochrome circadian regulator 2 | |
| Synonyms | HCRY2|PHLL2 | |
| Cytomap | 11p11.2 | |
| Type of gene | protein-coding | |
| Description | cryptochrome-2cryptochrome 2 (photolyase-like)cryptochrome circadian clock 2growth-inhibiting protein 37 | |
| Modification date | 20200329 | |
| UniProtAcc | ||
| Context | - 28317486(Abnormal Clock Gene Expression and Locomotor Activity Rhythms in Two Month-Old Female APPSwe/PS1dE9 Mice) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| CRY2 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 12397359|14672706|15147242 |
| CRY2 | GO:0000719 | photoreactive repair | 12627958 |
| CRY2 | GO:0032515 | negative regulation of phosphoprotein phosphatase activity | 9383998 |
| CRY2 | GO:0045892 | negative regulation of transcription, DNA-templated | 12397359 |
| CRY2 | GO:2000118 | regulation of sodium-dependent phosphate transport | 9753616 |
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Gene structures and expression levels for CRY2 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000121671
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CRY2 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_11496 | chr11 | 45860980:45861032:45862060:45862148:45867612:45867752 | 45862060:45862148 |
| exon_skip_195598 | chr11 | 45855982:45856090:45858731:45858873:45862060:45862115 | 45858731:45858873 |
| exon_skip_224561 | chr11 | 45870330:45870532:45870842:45870934:45872092:45872233 | 45870842:45870934 |
| exon_skip_276099 | chr11 | 45867612:45867752:45869506:45869817:45870053:45870204 | 45869506:45869817 |
| exon_skip_83674 | chr11 | 45858731:45858873:45860848:45861032:45862060:45862115 | 45860848:45861032 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for CRY2 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000616080 | 45860848 | 45861032 | Frame-shift |
| ENST00000616080 | 45862060 | 45862148 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000616080 | 45860848 | 45861032 | Frame-shift |
| ENST00000616080 | 45862060 | 45862148 | Frame-shift |
| ENST00000616080 | 45869506 | 45869817 | In-frame |
| ENST00000616080 | 45870842 | 45870934 | In-frame |
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Infer the effects of exon skipping event on protein functional features for CRY2 |
p-ENSG00000121671_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000616080 | 1953 | 593 | 45869506 | 45869817 | 900 | 1210 | 294 | 398 |
| ENST00000616080 | 1953 | 593 | 45870842 | 45870934 | 1567 | 1658 | 517 | 547 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q49AN0 | 294 | 398 | 308 | 308 | Binding site | Note=FAD;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q49AN0 | 294 | 398 | 374 | 374 | Binding site | Note=FAD;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q49AN0 | 294 | 398 | 1 | 593 | Chain | ID=PRO_0000261148;Note=Cryptochrome-2 |
| Q49AN0 | 294 | 398 | 348 | 348 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9R194 |
| Q49AN0 | 294 | 398 | 299 | 299 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P97784 |
| Q49AN0 | 294 | 398 | 390 | 489 | Region | Note=Required for inhibition of CLOCK-ARNTL-mediated transcription;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q49AN0 | 517 | 547 | 1 | 593 | Chain | ID=PRO_0000261148;Note=Cryptochrome-2 |
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3'-UTR located exon skipping events that lost miRNA binding sites in CRY2 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for CRY2 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for CRY2 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CRY2 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for CRY2 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for CRY2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CRY2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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