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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for DOCK11 |
 Gene summary |
| Gene information | Gene symbol | DOCK11 | Gene ID | 139818 |
| Gene name | dedicator of cytokinesis 11 | |
| Synonyms | ACG|ZIZ2|bB128O4.1 | |
| Cytomap | Xq24 | |
| Type of gene | protein-coding | |
| Description | dedicator of cytokinesis protein 11Activated Cdc42-associated guanine nucleotide exchange factor, ACGbB128O4.1.1 (novel protein)zizimin-2zizimin2 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for DOCK11 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000147251
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for DOCK11 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_103732 | chrX | 118618550:118618728:118624539:118624655:118627504:118627579 | 118624539:118624655 |
| exon_skip_178618 | chrX | 118615600:118615711:118616202:118616240:118618550:118618728 | 118616202:118616240 |
| exon_skip_205396 | chrX | 118599139:118599228:118605238:118605356:118608072:118608141 | 118605238:118605356 |
| exon_skip_258 | chrX | 118683103:118683217:118685520:118685537:118685688:118686139 | 118685520:118685537 |
| exon_skip_39713 | chrX | 118641190:118641305:118643457:118643594:118648945:118649127 | 118643457:118643594 |
| exon_skip_40130 | chrX | 118588137:118588321:118588413:118588478:118590210:118590302 | 118588413:118588478 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_258 | Mayo_TC | 2.313924e-01 | 3.420270e-01 | -1.106346e-01 | 5.517325e-03 |
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Open reading frame (ORF) annotation in the exon skipping event for DOCK11 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000276202 | 118605238 | 118605356 | Frame-shift |
| ENST00000276202 | 118588413 | 118588478 | In-frame |
| ENST00000276202 | 118624539 | 118624655 | In-frame |
| ENST00000276202 | 118643457 | 118643594 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000276202 | 118624539 | 118624655 | In-frame |
| ENST00000276202 | 118643457 | 118643594 | In-frame |
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Infer the effects of exon skipping event on protein functional features for DOCK11 |
p-ENSG00000147251_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000276202 | 6642 | 2073 | 118588413 | 118588478 | 2045 | 2109 | 660 | 682 |
| ENST00000276202 | 6642 | 2073 | 118624539 | 118624655 | 3536 | 3651 | 1157 | 1196 |
| ENST00000276202 | 6642 | 2073 | 118643457 | 118643594 | 4325 | 4461 | 1420 | 1466 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000276202 | 6642 | 2073 | 118624539 | 118624655 | 3536 | 3651 | 1157 | 1196 |
| ENST00000276202 | 6642 | 2073 | 118643457 | 118643594 | 4325 | 4461 | 1420 | 1466 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q5JSL3 | 660 | 682 | 1 | 2073 | Chain | ID=PRO_0000299558;Note=Dedicator of cytokinesis protein 11 |
| Q5JSL3 | 660 | 682 | 640 | 818 | Domain | Note=DHR-1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00983 |
| Q5JSL3 | 1157 | 1196 | 1 | 2073 | Chain | ID=PRO_0000299558;Note=Dedicator of cytokinesis protein 11 |
| Q5JSL3 | 1420 | 1466 | 1 | 2073 | Chain | ID=PRO_0000299558;Note=Dedicator of cytokinesis protein 11 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q5JSL3 | 1157 | 1196 | 1 | 2073 | Chain | ID=PRO_0000299558;Note=Dedicator of cytokinesis protein 11 |
| Q5JSL3 | 1420 | 1466 | 1 | 2073 | Chain | ID=PRO_0000299558;Note=Dedicator of cytokinesis protein 11 |
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3'-UTR located exon skipping events that lost miRNA binding sites in DOCK11 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for DOCK11 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for DOCK11 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for DOCK11 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for DOCK11 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| TC | SRSF2 | exon_skip_258 | 4.204686e-01 | 6.259661e-08 |
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RelatedDrugs for DOCK11 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DOCK11 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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