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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for HDX |
Gene summary |
Gene information | Gene symbol | HDX | Gene ID | 139324 |
Gene name | highly divergent homeobox | |
Synonyms | CXorf43|D030011N01Rik | |
Cytomap | Xq21.1 | |
Type of gene | protein-coding | |
Description | highly divergent homeobox | |
Modification date | 20200313 | |
UniProtAcc | E2QRN0, Q7Z353, | |
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for HDX |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
TC | DOWN | ENST00000506585.6 | HDX-206:protein_coding:HDX | 1.428030e+01 | -2.481446e+00 | 3.968605e-03 | 2.815542e-02 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for HDX |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_110686 | chrX | 84500025:84500304:84501429:84501511:84502342:84502453 | 84501429:84501511 |
exon_skip_171682 | chrX | 84336801:84336880:84344250:84344457:84361466:84361612 | 84344250:84344457 |
exon_skip_197718 | chrX | 84475251:84475397:84488024:84488132:84502342:84502453 | 84488024:84488132 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for HDX |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000373177 | 84488024 | 84488132 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000373177 | 84488024 | 84488132 | 3UTR-3UTR |
ENST00000297977 | 84344250 | 84344457 | Frame-shift |
ENST00000373177 | 84344250 | 84344457 | Frame-shift |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000373177 | 84488024 | 84488132 | 3UTR-3UTR |
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Infer the effects of exon skipping event on protein functional features for HDX |
p-ENSG00000165259_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in HDX |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Mayo | ENST00000373177 | 84488024 | 84488132 | hsa-miR-3605-5p | chrX:84488054-84488061 | 8mer-1a | chrX:84488049-84488070 | 163.00 | -29.98 |
Mayo | ENST00000373177 | 84488024 | 84488132 | hsa-miR-518c-5p | chrX:84488119-84488126 | 8mer-1a | chrX:84488109-84488129 | 158.00 | -14.14 |
Mayo | ENST00000373177 | 84488024 | 84488132 | hsa-miR-4638-3p | chrX:84488117-84488124 | 8mer-1a | chrX:84488109-84488129 | 158.00 | -14.14 |
Mayo | ENST00000373177 | 84488024 | 84488132 | hsa-miR-548m | chrX:84488079-84488086 | 8mer-1a | chrX:84488066-84488088 | 160.00 | -16.01 |
MSBB | ENST00000373177 | 84488024 | 84488132 | hsa-miR-3605-5p | chrX:84488054-84488061 | 8mer-1a | chrX:84488049-84488070 | 163.00 | -29.98 |
MSBB | ENST00000373177 | 84488024 | 84488132 | hsa-miR-518c-5p | chrX:84488119-84488126 | 8mer-1a | chrX:84488109-84488129 | 158.00 | -14.14 |
MSBB | ENST00000373177 | 84488024 | 84488132 | hsa-miR-4638-3p | chrX:84488117-84488124 | 8mer-1a | chrX:84488109-84488129 | 158.00 | -14.14 |
MSBB | ENST00000373177 | 84488024 | 84488132 | hsa-miR-548m | chrX:84488079-84488086 | 8mer-1a | chrX:84488066-84488088 | 160.00 | -16.01 |
ROSMAP | ENST00000373177 | 84488024 | 84488132 | hsa-miR-3605-5p | chrX:84488054-84488061 | 8mer-1a | chrX:84488049-84488070 | 163.00 | -29.98 |
ROSMAP | ENST00000373177 | 84488024 | 84488132 | hsa-miR-518c-5p | chrX:84488119-84488126 | 8mer-1a | chrX:84488109-84488129 | 158.00 | -14.14 |
ROSMAP | ENST00000373177 | 84488024 | 84488132 | hsa-miR-4638-3p | chrX:84488117-84488124 | 8mer-1a | chrX:84488109-84488129 | 158.00 | -14.14 |
ROSMAP | ENST00000373177 | 84488024 | 84488132 | hsa-miR-548m | chrX:84488079-84488086 | 8mer-1a | chrX:84488066-84488088 | 160.00 | -16.01 |
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SNVs in the skipped exons for HDX |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for HDX |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for HDX |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for HDX |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for HDX |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HDX |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |