ExonSkipAD: functional annotation of exon skipping event in human

Gene summary for ATF2

Gene summary

Gene information	Gene symbol	ATF2
	Gene ID	1386
	Gene name	activating transcription factor 2
	Synonyms	CRE-BP1\|CREB-2\|CREB2\|HB16\|TREB7
	Cytomap	2q31.1
	Type of gene	protein-coding
	Description	cyclic AMP-dependent transcription factor ATF-2activating transcription factor 2 splice variant ATF2-var2cAMP response element-binding protein CRE-BP1cAMP responsive element binding protein 2, formerlycAMP-dependent transcription factor ATF-2cyclic A
	Modification date	20200322
	UniProtAcc	A4D7U3, A4D7U7, A4D7U9, A4D7V5, B8ZZU6, C9JCI8, E9PBF9, E9PEK8, F2Z2K2, F5H629, H7C2N6, P15336,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
ATF2	GO:0006357	regulation of transcription by RNA polymerase II	19861239
ATF2	GO:0006970	response to osmotic stress	21098032
ATF2	GO:0006974	cellular response to DNA damage stimulus	22304920
ATF2	GO:0045944	positive regulation of transcription by RNA polymerase II	16300731\|18671972
ATF2	GO:0110024	positive regulation of cardiac muscle myoblast proliferation	22982025

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Gene structures and expression levels for ATF2

Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

ENSG00000115966

Differentially expressed gene analysis across multiple brain tissues between AD and control.

Tissue type

DEG direction

Base mean exp.

log2FC(AD/control)

P-value

Adj. p-value

Differentially expressed isoform analysis across multiple brain tissues between AD and control.

Tissue type	DEG direction	ENST	Transcript info.	Base mean exp.	log2FC(AD/control)	P-value	Adjc. p-value
PCC	UP	ENST00000413123.5	ATF2-208:lncRNA:ATF2	1.467058e+00	9.755186e-01	3.055159e-05	2.751190e-03
PCC	UP	ENST00000409437.5	ATF2-204:protein_coding:ATF2	2.192055e+01	2.086287e+00	1.014860e-03	2.582633e-02
STG	UP	ENST00000413123.5	ATF2-208:lncRNA:ATF2	8.006831e+00	8.138319e-01	3.060233e-04	2.085563e-02
CB	UP	ENST00000435004.6	ATF2-215:protein_coding:ATF2	1.129141e+01	1.582808e+00	2.608661e-08	6.808666e-07
CB	UP	ENST00000409833.5	ATF2-207:protein_coding:ATF2	4.672723e+00	9.957271e-01	3.484128e-06	4.330143e-05
CB	UP	ENST00000413123.5	ATF2-208:lncRNA:ATF2	3.839614e+00	8.086065e-01	3.306620e-05	2.896478e-04
CB	UP	ENST00000435231.6	ATF2-216:nonsense_mediated_decay:ATF2	2.583701e+00	2.064391e+00	1.258715e-04	9.000874e-04
CB	DOWN	ENST00000409437.5	ATF2-204:protein_coding:ATF2	6.767713e+02	-1.441848e+00	3.886021e-03	1.596946e-02
CB	UP	ENST00000437522.5	ATF2-217:protein_coding:ATF2	9.378688e+00	1.528397e+00	5.353703e-03	2.083321e-02
CB	DOWN	ENST00000435842.2	BATF2-202:protein_coding:BATF2	6.090989e+00	-1.556031e+00	1.105444e-02	3.774111e-02
TC	UP	ENST00000413123.5	ATF2-208:lncRNA:ATF2	2.934319e+00	8.414665e-01	1.546562e-05	3.667021e-04
TC	UP	ENST00000435231.6	ATF2-216:nonsense_mediated_decay:ATF2	8.483892e-01	1.721917e+00	3.087420e-03	2.332197e-02

Landscape of isoform expressions across multiple brain tissues between AD and control.

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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ATF2

Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).

All exon skipping events in AD cohorts.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon
exon_skip_102318	chr2	175074505:175074867:175075000:175075087:175080660:175080765	175075000:175075087
exon_skip_107722	chr2	175080660:175080765:175092543:175092616:175093061:175093267	175092543:175092616
exon_skip_151067	chr2	175097444:175097593:175111568:175111654:175113994:175114108	175111568:175111654
exon_skip_199879	chr2	175130138:175130207:175136412:175136486:175147946:175147980	175136412:175136486
exon_skip_201456	chr2	175114818:175114868:175118251:175118369:175130138:175130205	175118251:175118369
exon_skip_203682	chr2	175118251:175118369:175121444:175121540:175130138:175130205	175121444:175121540
exon_skip_213515	chr2	175111568:175111654:175114690:175114868:175117990:175118023	175114690:175114868
exon_skip_221933	chr2	175074651:175074835:175075000:175075087:175080660:175080765	175075000:175075087
exon_skip_23016	chr2	175074505:175074835:175075000:175075087:175080660:175080765	175075000:175075087
exon_skip_241505	chr2	175097444:175097593:175111568:175111654:175117990:175118118	175111568:175111654
exon_skip_251012	chr2	175126993:175127058:175127156:175127231:175130138:175130205	175127156:175127231
exon_skip_259922	chr2	175136412:175136486:175147946:175147980:175151060:175151082	175147946:175147980
exon_skip_273576	chr2	175074392:175074835:175080660:175080765:175093061:175093267	175080660:175080765
exon_skip_275540	chr2	175130138:175130207:175136412:175136486:175151060:175151082	175136412:175136486
exon_skip_28541	chr2	175114818:175114868:175117990:175118118:175118251:175118369	175117990:175118118
exon_skip_287633	chr2	175097444:175097593:175111568:175111654:175114690:175114766	175111568:175111654
exon_skip_33951	chr2	175111568:175111654:175114690:175114868:175117990:175118118	175114690:175114868
exon_skip_35834	chr2	175111568:175111654:175113994:175114108:175114690:175114868	175113994:175114108
exon_skip_6237	chr2	175074651:175074835:175080660:175080765:175093061:175093267	175080660:175080765
exon_skip_70749	chr2	175111647:175111654:175113994:175114108:175114690:175114766	175113994:175114108
exon_skip_88255	chr2	175097444:175097593:175111568:175111654:175113994:175114067	175111568:175111654
exon_skip_93029	chr2	175114818:175114868:175117990:175118118:175118251:175118364	175117990:175118118

Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.

Exon skipping information

Tissue type

Avg(PSIs) in AD

Avg(PSIs) in control

Difference (PSI)

Adj. p-value

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Open reading frame (ORF) annotation in the exon skipping event for ATF2

Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000264110	175136412	175136486	3UTR-3CDS
ENST00000392544	175136412	175136486	3UTR-3CDS
ENST00000392544	175147946	175147980	3UTR-3UTR
ENST00000264110	175080660	175080765	Frame-shift
ENST00000392544	175080660	175080765	Frame-shift
ENST00000264110	175113994	175114108	Frame-shift
ENST00000392544	175113994	175114108	Frame-shift
ENST00000264110	175121444	175121540	Frame-shift
ENST00000392544	175121444	175121540	Frame-shift
ENST00000264110	175111568	175111654	In-frame
ENST00000392544	175111568	175111654	In-frame
ENST00000264110	175117990	175118118	In-frame
ENST00000392544	175117990	175118118	In-frame

Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000264110	175136412	175136486	3UTR-3CDS
ENST00000392544	175147946	175147980	3UTR-3UTR
ENST00000264110	175080660	175080765	Frame-shift
ENST00000392544	175080660	175080765	Frame-shift
ENST00000264110	175121444	175121540	Frame-shift
ENST00000392544	175121444	175121540	Frame-shift
ENST00000264110	175111568	175111654	In-frame
ENST00000392544	175111568	175111654	In-frame
ENST00000264110	175117990	175118118	In-frame
ENST00000392544	175117990	175118118	In-frame

Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000264110	175136412	175136486	3UTR-3CDS
ENST00000392544	175147946	175147980	3UTR-3UTR
ENST00000264110	175080660	175080765	Frame-shift
ENST00000392544	175080660	175080765	Frame-shift
ENST00000264110	175113994	175114108	Frame-shift
ENST00000392544	175113994	175114108	Frame-shift
ENST00000264110	175121444	175121540	Frame-shift
ENST00000392544	175121444	175121540	Frame-shift
ENST00000264110	175111568	175111654	In-frame
ENST00000392544	175111568	175111654	In-frame
ENST00000264110	175117990	175118118	In-frame
ENST00000392544	175117990	175118118	In-frame

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Infer the effects of exon skipping event on protein functional features for ATF2

p-ENSG00000115966_img4.png
boxplot

Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000264110	4193	505	175117990	175118118	618	745	106	148
ENST00000392544	1936	505	175117990	175118118	616	743	106	148
ENST00000264110	4193	505	175111568	175111654	1041	1126	247	275
ENST00000392544	1936	505	175111568	175111654	1039	1124	247	275

Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000264110	4193	505	175117990	175118118	618	745	106	148
ENST00000392544	1936	505	175117990	175118118	616	743	106	148
ENST00000264110	4193	505	175111568	175111654	1041	1126	247	275
ENST00000392544	1936	505	175111568	175111654	1039	1124	247	275

Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000264110	4193	505	175117990	175118118	618	745	106	148
ENST00000392544	1936	505	175117990	175118118	616	743	106	148
ENST00000264110	4193	505	175111568	175111654	1041	1126	247	275
ENST00000392544	1936	505	175111568	175111654	1039	1124	247	275

Lost protein functional features of individual exon skipping events in ROSMAP.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P15336	106	148	1	176	Alternative sequence	ID=VSP_000587;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:9058782;Dbxref=PMID:9058782
P15336	106	148	1	176	Alternative sequence	ID=VSP_000587;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:9058782;Dbxref=PMID:9058782
P15336	106	148	34	394	Alternative sequence	ID=VSP_047593;Note=In isoform 6 and isoform 8. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:11932306,ECO:0000303\|Ref.4;Dbxref=PMID:11932306
P15336	106	148	34	394	Alternative sequence	ID=VSP_047593;Note=In isoform 6 and isoform 8. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:11932306,ECO:0000303\|Ref.4;Dbxref=PMID:11932306
P15336	106	148	1	505	Chain	ID=PRO_0000076577;Note=Cyclic AMP-dependent transcription factor ATF-2
P15336	106	148	1	505	Chain	ID=PRO_0000076577;Note=Cyclic AMP-dependent transcription factor ATF-2
P15336	106	148	112	112	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163,E
P15336	106	148	112	112	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163,E
P15336	106	148	116	116	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:20068231;Dbxref=PMID:20068231
P15336	106	148	116	116	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:20068231;Dbxref=PMID:20068231
P15336	106	148	121	121	Modified residue	Note=Phosphoserine%3B by PKC/PRKCA and PKC/PRKCB;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19176525;Dbxref=PMID:19176525
P15336	106	148	121	121	Modified residue	Note=Phosphoserine%3B by PKC/PRKCA and PKC/PRKCB;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19176525;Dbxref=PMID:19176525
P15336	106	148	136	136	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
P15336	106	148	136	136	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
P15336	106	148	121	121	Mutagenesis	Note=Reduced phosphorylation and repression of c-Jun-mediated activation of transcription. S->A
P15336	106	148	121	121	Mutagenesis	Note=Reduced phosphorylation and repression of c-Jun-mediated activation of transcription. S->A
P15336	247	275	34	394	Alternative sequence	ID=VSP_047593;Note=In isoform 6 and isoform 8. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:11932306,ECO:0000303\|Ref.4;Dbxref=PMID:11932306
P15336	247	275	34	394	Alternative sequence	ID=VSP_047593;Note=In isoform 6 and isoform 8. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:11932306,ECO:0000303\|Ref.4;Dbxref=PMID:11932306
P15336	247	275	210	505	Alternative sequence	ID=VSP_045161;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
P15336	247	275	210	505	Alternative sequence	ID=VSP_045161;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
P15336	247	275	238	505	Alternative sequence	ID=VSP_047595;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.4
P15336	247	275	238	505	Alternative sequence	ID=VSP_047595;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.4
P15336	247	275	1	505	Chain	ID=PRO_0000076577;Note=Cyclic AMP-dependent transcription factor ATF-2
P15336	247	275	1	505	Chain	ID=PRO_0000076577;Note=Cyclic AMP-dependent transcription factor ATF-2

Lost protein functional features of individual exon skipping events in MSBB.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P15336	106	148	1	176	Alternative sequence	ID=VSP_000587;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:9058782;Dbxref=PMID:9058782
P15336	106	148	1	176	Alternative sequence	ID=VSP_000587;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:9058782;Dbxref=PMID:9058782
P15336	106	148	34	394	Alternative sequence	ID=VSP_047593;Note=In isoform 6 and isoform 8. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:11932306,ECO:0000303\|Ref.4;Dbxref=PMID:11932306
P15336	106	148	34	394	Alternative sequence	ID=VSP_047593;Note=In isoform 6 and isoform 8. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:11932306,ECO:0000303\|Ref.4;Dbxref=PMID:11932306
P15336	106	148	1	505	Chain	ID=PRO_0000076577;Note=Cyclic AMP-dependent transcription factor ATF-2
P15336	106	148	1	505	Chain	ID=PRO_0000076577;Note=Cyclic AMP-dependent transcription factor ATF-2
P15336	106	148	112	112	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163,E
P15336	106	148	112	112	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163,E
P15336	106	148	116	116	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:20068231;Dbxref=PMID:20068231
P15336	106	148	116	116	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:20068231;Dbxref=PMID:20068231
P15336	106	148	121	121	Modified residue	Note=Phosphoserine%3B by PKC/PRKCA and PKC/PRKCB;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19176525;Dbxref=PMID:19176525
P15336	106	148	121	121	Modified residue	Note=Phosphoserine%3B by PKC/PRKCA and PKC/PRKCB;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19176525;Dbxref=PMID:19176525
P15336	106	148	136	136	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
P15336	106	148	136	136	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
P15336	106	148	121	121	Mutagenesis	Note=Reduced phosphorylation and repression of c-Jun-mediated activation of transcription. S->A
P15336	106	148	121	121	Mutagenesis	Note=Reduced phosphorylation and repression of c-Jun-mediated activation of transcription. S->A
P15336	247	275	34	394	Alternative sequence	ID=VSP_047593;Note=In isoform 6 and isoform 8. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:11932306,ECO:0000303\|Ref.4;Dbxref=PMID:11932306
P15336	247	275	34	394	Alternative sequence	ID=VSP_047593;Note=In isoform 6 and isoform 8. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:11932306,ECO:0000303\|Ref.4;Dbxref=PMID:11932306
P15336	247	275	210	505	Alternative sequence	ID=VSP_045161;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
P15336	247	275	210	505	Alternative sequence	ID=VSP_045161;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
P15336	247	275	238	505	Alternative sequence	ID=VSP_047595;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.4
P15336	247	275	238	505	Alternative sequence	ID=VSP_047595;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.4
P15336	247	275	1	505	Chain	ID=PRO_0000076577;Note=Cyclic AMP-dependent transcription factor ATF-2
P15336	247	275	1	505	Chain	ID=PRO_0000076577;Note=Cyclic AMP-dependent transcription factor ATF-2

Lost protein functional features of individual exon skipping events in Mayo.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P15336	106	148	1	176	Alternative sequence	ID=VSP_000587;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:9058782;Dbxref=PMID:9058782
P15336	106	148	1	176	Alternative sequence	ID=VSP_000587;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:9058782;Dbxref=PMID:9058782
P15336	106	148	34	394	Alternative sequence	ID=VSP_047593;Note=In isoform 6 and isoform 8. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:11932306,ECO:0000303\|Ref.4;Dbxref=PMID:11932306
P15336	106	148	34	394	Alternative sequence	ID=VSP_047593;Note=In isoform 6 and isoform 8. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:11932306,ECO:0000303\|Ref.4;Dbxref=PMID:11932306
P15336	106	148	1	505	Chain	ID=PRO_0000076577;Note=Cyclic AMP-dependent transcription factor ATF-2
P15336	106	148	1	505	Chain	ID=PRO_0000076577;Note=Cyclic AMP-dependent transcription factor ATF-2
P15336	106	148	112	112	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163,E
P15336	106	148	112	112	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163,E
P15336	106	148	116	116	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:20068231;Dbxref=PMID:20068231
P15336	106	148	116	116	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:20068231;Dbxref=PMID:20068231
P15336	106	148	121	121	Modified residue	Note=Phosphoserine%3B by PKC/PRKCA and PKC/PRKCB;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19176525;Dbxref=PMID:19176525
P15336	106	148	121	121	Modified residue	Note=Phosphoserine%3B by PKC/PRKCA and PKC/PRKCB;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19176525;Dbxref=PMID:19176525
P15336	106	148	136	136	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
P15336	106	148	136	136	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
P15336	106	148	121	121	Mutagenesis	Note=Reduced phosphorylation and repression of c-Jun-mediated activation of transcription. S->A
P15336	106	148	121	121	Mutagenesis	Note=Reduced phosphorylation and repression of c-Jun-mediated activation of transcription. S->A
P15336	247	275	34	394	Alternative sequence	ID=VSP_047593;Note=In isoform 6 and isoform 8. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:11932306,ECO:0000303\|Ref.4;Dbxref=PMID:11932306
P15336	247	275	34	394	Alternative sequence	ID=VSP_047593;Note=In isoform 6 and isoform 8. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:11932306,ECO:0000303\|Ref.4;Dbxref=PMID:11932306
P15336	247	275	210	505	Alternative sequence	ID=VSP_045161;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
P15336	247	275	210	505	Alternative sequence	ID=VSP_045161;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
P15336	247	275	238	505	Alternative sequence	ID=VSP_047595;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.4
P15336	247	275	238	505	Alternative sequence	ID=VSP_047595;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.4
P15336	247	275	1	505	Chain	ID=PRO_0000076577;Note=Cyclic AMP-dependent transcription factor ATF-2
P15336	247	275	1	505	Chain	ID=PRO_0000076577;Note=Cyclic AMP-dependent transcription factor ATF-2

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3'-UTR located exon skipping events that lost miRNA binding sites in ATF2

3'-UTR exon skipping evnets lost miRNA binding.

Tissue type

ENST

Exon skip start

Exon skip end

microRNA

Binding site by TargetScan

Binding type by TargetScan

Bdinding site by miRanda

Score of miRanda

Energy by miRanda

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SNVs in the skipped exons for ATF2

- Differential PSIs between mutated versus non-mutated samples.

- Depth of Coverage in the skipped exon of the mutated samples.

- Sashimi plot in the skipped exon of the mutated samples.

- Non-synonymous mutations located in the skipped exons.

Cancer type

Sample

ESID

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

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AD stage-associated exon skippint events for ATF2

Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).

AD stage info

Cohort

Tissue

SE id

Coefficient

P-value

Chromosome

Strand

E1 start

E1 end

Skipped start

Skipped end

E2 start

E2 end

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ATF2

sQTL information located at the skipped exons.

Tissue type

Exon skip ID

SNP id

Location

P-value

FDR

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Correlation with RNA binding proteins (RBPs) for ATF2

Correlated RBP and related information.

Tissue type	RBP name	Exon skip ID	Correlation coeifficient	P-value
CB	PCBP4	exon_skip_151067	4.118211e-01	1.492258e-07
FL	KHDRBS3	exon_skip_203682	4.057524e-01	4.374035e-09
HCC	SFPQ	exon_skip_203682	-4.980862e-01	2.464046e-18
HCC	RBM5	exon_skip_203682	-5.373719e-01	1.326745e-21
HCC	KHDRBS3	exon_skip_203682	-5.192601e-01	4.813927e-20
PG	KHDRBS2	exon_skip_203682	4.235843e-01	6.831065e-10
STG	KHDRBS2	exon_skip_203682	5.037280e-01	5.649050e-07
STG	KHDRBS3	exon_skip_203682	4.266490e-01	3.397478e-05
TC	ILF2	exon_skip_203682	4.115756e-01	8.552088e-08
TC	KHDRBS2	exon_skip_203682	6.528694e-01	1.946644e-20
TC	KHDRBS3	exon_skip_203682	5.512094e-01	7.395736e-14
TC	NOVA1	exon_skip_203682	6.056879e-01	4.320333e-17

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RelatedDrugs for ATF2

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for ATF2

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	3'-UTR located exon skipping events lost miRNA binding sites
	SNVs in the skipped exons with depth of coverage
	AD stage-associated exon skipping events
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Correlation with RNA binding proteins (RBPs)
	Related drugs with this gene
	Related diseases with this gene

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Gene summary for ATF2

Gene structures and expression levels for ATF2

Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ATF2

Open reading frame (ORF) annotation in the exon skipping event for ATF2

Infer the effects of exon skipping event on protein functional features for ATF2

3'-UTR located exon skipping events that lost miRNA binding sites in ATF2

SNVs in the skipped exons for ATF2

AD stage-associated exon skippint events for ATF2

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ATF2

Correlation with RNA binding proteins (RBPs) for ATF2

RelatedDrugs for ATF2

RelatedDiseases for ATF2