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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for CREB1 |
 Gene summary |
| Gene information | Gene symbol | CREB1 | Gene ID | 1385 |
| Gene name | cAMP responsive element binding protein 1 | |
| Synonyms | CREB|CREB-1 | |
| Cytomap | 2q33.3 | |
| Type of gene | protein-coding | |
| Description | cyclic AMP-responsive element-binding protein 1active transcription factor CREBcAMP-response element-binding protein-1cyclic adenosine 3',5'-monophosphate response element binding proteincyclic adenosine 3',5'-monophosphate response element-binding pr | |
| Modification date | 20200315 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| CREB1 | GO:0006468 | protein phosphorylation | 8798441 |
| CREB1 | GO:0010033 | response to organic substance | 8798441 |
| CREB1 | GO:0010944 | negative regulation of transcription by competitive promoter binding | 19861239 |
| CREB1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 1655749|8798441|19861239 |
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Gene structures and expression levels for CREB1 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000118260
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000494094.5 | CREB1-216:retained_intron:CREB1 | 7.055604e+00 | 1.957720e+00 | 1.136594e-05 | 1.173789e-04 |
| CB | UP | ENST00000464407.1 | CREB1-214:retained_intron:CREB1 | 2.442922e+00 | 8.868619e-01 | 1.288870e-05 | 1.305258e-04 |
| CB | UP | ENST00000421139.5 | CREB1-204:protein_coding:CREB1 | 5.263275e+00 | 9.890248e-01 | 1.480308e-04 | 1.034469e-03 |
| CB | UP | ENST00000448277.5 | CREB1-209:protein_coding:CREB1 | 6.682015e+00 | 2.398791e+00 | 4.835649e-03 | 1.914136e-02 |
| CB | UP | ENST00000430624.5 | CREB1-205:protein_coding:CREB1 | 3.862482e+00 | 2.489011e+00 | 4.849196e-03 | 1.918774e-02 |
| TC | UP | ENST00000448277.5 | CREB1-209:protein_coding:CREB1 | 1.053468e+01 | 1.090151e+00 | 3.440470e-03 | 2.530788e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CREB1 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_121386 | chr2 | 207570179:207570321:207575272:207575454:207577505:207577631 | 207575272:207575454 |
| exon_skip_202231 | chr2 | 207560314:207560372:207561119:207561160:207567463:207567556 | 207561119:207561160 |
| exon_skip_3001 | chr2 | 207530104:207530134:207555628:207555749:207560226:207560348 | 207555628:207555749 |
| exon_skip_35371 | chr2 | 207576636:207576693:207577110:207577224:207577505:207577655 | 207577110:207577224 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for CREB1 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000432329 | 207555628 | 207555749 | 5CDS-5UTR |
| ENST00000432329 | 207561119 | 207561160 | In-frame |
| ENST00000432329 | 207575272 | 207575454 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000432329 | 207555628 | 207555749 | 5CDS-5UTR |
| ENST00000432329 | 207561119 | 207561160 | In-frame |
| ENST00000432329 | 207575272 | 207575454 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000432329 | 207555628 | 207555749 | 5CDS-5UTR |
| ENST00000432329 | 207561119 | 207561160 | In-frame |
| ENST00000432329 | 207575272 | 207575454 | In-frame |
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Infer the effects of exon skipping event on protein functional features for CREB1 |
p-ENSG00000118260_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000432329 | 7667 | 341 | 207561119 | 207561160 | 514 | 554 | 87 | 101 |
| ENST00000432329 | 7667 | 341 | 207575272 | 207575454 | 800 | 981 | 183 | 243 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000432329 | 7667 | 341 | 207561119 | 207561160 | 514 | 554 | 87 | 101 |
| ENST00000432329 | 7667 | 341 | 207575272 | 207575454 | 800 | 981 | 183 | 243 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000432329 | 7667 | 341 | 207561119 | 207561160 | 514 | 554 | 87 | 101 |
| ENST00000432329 | 7667 | 341 | 207575272 | 207575454 | 800 | 981 | 183 | 243 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P16220 | 87 | 101 | 88 | 101 | Alternative sequence | ID=VSP_000596;Note=In isoform CREB-B. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:1831258,ECO:0000303|PubMed:2974179;Dbxref=PMID:1831258,PMID:2974179 |
| P16220 | 87 | 101 | 1 | 341 | Chain | ID=PRO_0000076597;Note=Cyclic AMP-responsive element-binding protein 1 |
| P16220 | 87 | 101 | 101 | 160 | Domain | Note=KID;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00312 |
| P16220 | 183 | 243 | 162 | 272 | Alternative sequence | ID=VSP_043914;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15579595;Dbxref=PMID:15579595 |
| P16220 | 183 | 243 | 1 | 341 | Chain | ID=PRO_0000076597;Note=Cyclic AMP-responsive element-binding protein 1 |
| P16220 | 183 | 243 | 184 | 184 | Sequence conflict | Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P16220 | 183 | 243 | 188 | 188 | Sequence conflict | Note=G->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P16220 | 183 | 243 | 195 | 195 | Sequence conflict | Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P16220 | 183 | 243 | 210 | 210 | Sequence conflict | Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P16220 | 87 | 101 | 88 | 101 | Alternative sequence | ID=VSP_000596;Note=In isoform CREB-B. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:1831258,ECO:0000303|PubMed:2974179;Dbxref=PMID:1831258,PMID:2974179 |
| P16220 | 87 | 101 | 1 | 341 | Chain | ID=PRO_0000076597;Note=Cyclic AMP-responsive element-binding protein 1 |
| P16220 | 87 | 101 | 101 | 160 | Domain | Note=KID;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00312 |
| P16220 | 183 | 243 | 162 | 272 | Alternative sequence | ID=VSP_043914;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15579595;Dbxref=PMID:15579595 |
| P16220 | 183 | 243 | 1 | 341 | Chain | ID=PRO_0000076597;Note=Cyclic AMP-responsive element-binding protein 1 |
| P16220 | 183 | 243 | 184 | 184 | Sequence conflict | Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P16220 | 183 | 243 | 188 | 188 | Sequence conflict | Note=G->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P16220 | 183 | 243 | 195 | 195 | Sequence conflict | Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P16220 | 183 | 243 | 210 | 210 | Sequence conflict | Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P16220 | 87 | 101 | 88 | 101 | Alternative sequence | ID=VSP_000596;Note=In isoform CREB-B. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:1831258,ECO:0000303|PubMed:2974179;Dbxref=PMID:1831258,PMID:2974179 |
| P16220 | 87 | 101 | 1 | 341 | Chain | ID=PRO_0000076597;Note=Cyclic AMP-responsive element-binding protein 1 |
| P16220 | 87 | 101 | 101 | 160 | Domain | Note=KID;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00312 |
| P16220 | 183 | 243 | 162 | 272 | Alternative sequence | ID=VSP_043914;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15579595;Dbxref=PMID:15579595 |
| P16220 | 183 | 243 | 1 | 341 | Chain | ID=PRO_0000076597;Note=Cyclic AMP-responsive element-binding protein 1 |
| P16220 | 183 | 243 | 184 | 184 | Sequence conflict | Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P16220 | 183 | 243 | 188 | 188 | Sequence conflict | Note=G->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P16220 | 183 | 243 | 195 | 195 | Sequence conflict | Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P16220 | 183 | 243 | 210 | 210 | Sequence conflict | Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
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3'-UTR located exon skipping events that lost miRNA binding sites in CREB1 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for CREB1 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for CREB1 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CREB1 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for CREB1 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for CREB1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| P16220 | approved|vet_approved | DB01183 | Naloxone | small molecule | P16220 |
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RelatedDiseases for CREB1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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