|
Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for CR2 |
Gene summary |
Gene information | Gene symbol | CR2 | Gene ID | 1380 |
Gene name | complement C3d receptor 2 | |
Synonyms | C3DR|CD21|CR|CVID7|SLEB9 | |
Cytomap | 1q32.2 | |
Type of gene | protein-coding | |
Description | complement receptor type 2EBV receptorcomplement component (3d/Epstein Barr virus) receptor 2complement component 3d receptor 2 | |
Modification date | 20200313 | |
UniProtAcc | ||
Context | - 29202042(Relative Impact of Complement Receptors CD21/35 (Cr2/1) on Scrapie Pathogenesis in Mice) |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
CR2 | GO:0030183 | B cell differentiation | 2995485 |
CR2 | GO:0042100 | B cell proliferation | 2995485 |
Top |
Gene structures and expression levels for CR2 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
PCC | UP | ENST00000400888.2 | CCR2-202:protein_coding:CCR2 | 1.818239e+00 | 1.100089e+00 | 1.032175e-03 | 2.606358e-02 |
STG | UP | ENST00000318507.7 | CXCR2-201:protein_coding:CXCR2 | 7.315958e+00 | 1.435134e+00 | 4.233962e-05 | 6.707591e-03 |
PG | UP | ENST00000400888.2 | CCR2-202:protein_coding:CCR2 | 3.098441e+00 | 1.046583e+00 | 2.814601e-04 | 5.851768e-03 |
PG | UP | ENST00000556856.1 | FLVCR2-213:protein_coding:FLVCR2 | 1.389532e+00 | 1.518905e+00 | 1.969736e-03 | 2.359391e-02 |
CB | DOWN | ENST00000537045.5 | DGCR2-205:protein_coding:DGCR2 | 9.643959e+02 | -1.587423e+00 | 2.052818e-12 | 2.699368e-10 |
CB | DOWN | ENST00000456090.2 | SMCR2-201:lncRNA:SMCR2 | 9.659735e-01 | -1.296764e+00 | 5.949296e-05 | 4.770430e-04 |
CB | UP | ENST00000318507.7 | CXCR2-201:protein_coding:CXCR2 | 8.032552e+00 | 8.101238e-01 | 3.383609e-03 | 1.424767e-02 |
CB | UP | ENST00000445291.5 | DECR2-206:nonsense_mediated_decay:DECR2 | 7.315358e+00 | 9.685456e-01 | 4.729724e-03 | 1.879908e-02 |
CB | UP | ENST00000400888.2 | CCR2-202:protein_coding:CCR2 | 1.497049e+00 | 8.163488e-01 | 8.774348e-03 | 3.122603e-02 |
TC | DOWN | ENST00000537045.5 | DGCR2-205:protein_coding:DGCR2 | 1.246574e+03 | -8.853778e-01 | 1.761568e-05 | 4.055469e-04 |
TC | UP | ENST00000445132.2 | CCR2-204:protein_coding:CCR2 | 1.980249e+00 | 1.237072e+00 | 6.941940e-05 | 1.210138e-03 |
TC | UP | ENST00000318507.7 | CXCR2-201:protein_coding:CXCR2 | 2.430967e+01 | 9.817172e-01 | 2.896561e-04 | 3.739809e-03 |
TC | UP | ENST00000400888.2 | CCR2-202:protein_coding:CCR2 | 4.386327e+00 | 8.931753e-01 | 1.151552e-03 | 1.102970e-02 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
Top |
Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CR2 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_234155 | chr1 | 207472772:207473179:207473545:207473721:207473801:207473885 | 207473545:207473721 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
Top |
Open reading frame (ORF) annotation in the exon skipping event for CR2 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Top |
Infer the effects of exon skipping event on protein functional features for CR2 |
p-ENSG00000117322_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Top |
3'-UTR located exon skipping events that lost miRNA binding sites in CR2 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Top |
SNVs in the skipped exons for CR2 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
Top |
AD stage-associated exon skippint events for CR2 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
Top |
Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CR2 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
Top |
Correlation with RNA binding proteins (RBPs) for CR2 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
Top |
RelatedDrugs for CR2 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for CR2 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |