Home Download Statistics Landscape Help Contact

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	3'-UTR located exon skipping events lost miRNA binding sites
	SNVs in the skipped exons with depth of coverage
	AD stage-associated exon skipping events
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Correlation with RNA binding proteins (RBPs)
	Related drugs with this gene
	Related diseases with this gene

Gene summary for CR1

Gene summary

Gene information	Gene symbol	CR1
	Gene ID	1378
	Gene name	complement C3b/C4b receptor 1 (Knops blood group)
	Synonyms	C3BR|C4BR|CD35|KN
	Cytomap	1q32.2
	Type of gene	protein-coding
	Description	complement receptor type 1C3-binding proteinC3b/C4b receptorCD35 antigenKnops blood group antigencomplement component (3b/4b) receptor 1 (Knops blood group)complement receptor 1
	Modification date	20200313
	UniProtAcc	A0A2S1GUW1, A0A2S1GUW8, A0A346RCT4, A0A346RD54, A0A346RD63, A0A346RD80, A0A346RD82, E9PDY4, E9PQN4, H0YE06, P17927, Q5SBJ5, Q5SBJ6, Q5SBJ7, Q5SBJ8, Q5SBJ9, Q5SBK0, Q5SBK1, Q5SBK2, Q5SBK3, Q5SBK4, Q5SBK5, Q5SBK6, Q5SR44, Q9HB98, Q9HB99, Q9HC54, Q9HC55, V6EYC3,
	Context	- 24794147(CR1 in Alzheimer's Disease)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
CR1	GO:0045957	negative regulation of complement activation, alternative pathway	10531307
CR1	GO:0045959	negative regulation of complement activation, classical pathway	6910481|10531307
CR1	GO:1900004	negative regulation of serine-type endopeptidase activity	6910481
CR1	GO:1900005	positive regulation of serine-type endopeptidase activity	2972794

Top

Gene structures and expression levels for CR1

Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

ENSG00000203710

Differentially expressed gene analysis across multiple brain tissues between AD and control.

***cutpoints = c(0, 0.0001, 0.001, 0.01, 1), symbols = c("****", "***", "**", "ns")

Tissue type	DEG direction	Base mean exp.	log2FC(AD/control)	P-value	Adj. p-value
PG	UP	9.452554e+01	9.066660e-01	6.104997e-10	6.545164e-08

Differentially expressed isoform analysis across multiple brain tissues between AD and control.

Tissue type	DEG direction	ENST	Transcript info.	Base mean exp.	log2FC(AD/control)	P-value	Adjc. p-value
DLPFC	UP	ENST00000295683.3	CXCR1-201:protein_coding:CXCR1	5.303254e+00	8.015512e-01	3.340877e-04	1.592855e-02
PCC	UP	ENST00000585274.1	ASPSCR1-221:retained_intron:ASPSCR1	1.898671e+00	1.148046e+00	7.266413e-04	2.093908e-02
PCC	UP	ENST00000578361.5	ASPSCR1-206:retained_intron:ASPSCR1	1.702151e+00	2.133637e+00	2.928852e-03	4.951123e-02
STG	UP	ENST00000342435.9	PLSCR1-201:protein_coding:PLSCR1	4.385255e+01	1.126288e+00	5.906251e-04	2.944078e-02
PG	UP	ENST00000400960.7	CR1-206:protein_coding:CR1	2.047929e+01	9.178915e-01	1.860471e-07	2.481698e-05
PG	UP	ENST00000434033.5	CR1-207:retained_intron:CR1	1.118652e+01	1.352490e+00	6.042254e-06	3.459249e-04
PG	UP	ENST00000578361.5	ASPSCR1-206:retained_intron:ASPSCR1	1.567746e+00	1.113082e+00	3.504598e-03	3.560170e-02
PG	UP	ENST00000367049.8	CR1-201:protein_coding:CR1	2.284583e+01	1.298068e+00	4.506731e-03	4.247412e-02
CB	DOWN	ENST00000578361.5	ASPSCR1-206:retained_intron:ASPSCR1	1.249324e+01	-2.026956e+00	6.468244e-11	4.385744e-09
CB	DOWN	ENST00000399220.2	CX3CR1-202:protein_coding:CX3CR1	1.239996e+02	-1.390626e+00	1.619086e-09	6.488007e-08
CB	DOWN	ENST00000583744.1	ASPSCR1-218:protein_coding:ASPSCR1	8.477749e+00	-2.160129e+00	1.028872e-06	1.533742e-05
CB	DOWN	ENST00000524332.1	DECR1-219:retained_intron:DECR1	9.468744e+00	-1.082076e+00	2.764903e-06	3.559473e-05
CB	DOWN	ENST00000585274.1	ASPSCR1-221:retained_intron:ASPSCR1	1.619125e+01	-1.056015e+00	5.986669e-06	6.825230e-05
CB	UP	ENST00000478267.5	PLSCR1-210:nonsense_mediated_decay:PLSCR1	1.006000e+01	9.777130e-01	4.888489e-05	4.034446e-04
CB	DOWN	ENST00000493432.5	PLSCR1-218:nonsense_mediated_decay:PLSCR1	2.920331e+00	-4.850115e+00	1.183556e-04	8.541210e-04
CB	UP	ENST00000295683.3	CXCR1-201:protein_coding:CXCR1	8.014530e+00	9.561555e-01	2.987928e-04	1.867236e-03
CB	UP	ENST00000462666.5	PLSCR1-203:protein_coding:PLSCR1	1.934487e+00	1.481648e+00	2.411307e-03	1.076363e-02
CB	UP	ENST00000494568.5	PLSCR1-219:retained_intron:PLSCR1	1.395011e+00	1.457484e+00	4.029154e-03	1.646277e-02
TC	DOWN	ENST00000399220.2	CX3CR1-202:protein_coding:CX3CR1	4.322740e+02	-1.009459e+00	1.064301e-06	4.223919e-05
TC	UP	ENST00000487389.5	PLSCR1-214:protein_coding:PLSCR1	5.066525e+01	1.132351e+00	1.244221e-06	4.776115e-05
TC	UP	ENST00000472349.1	PLSCR1-208:protein_coding:PLSCR1	9.685566e+00	8.850616e-01	4.295105e-06	1.319084e-04
TC	DOWN	ENST00000585274.1	ASPSCR1-221:retained_intron:ASPSCR1	1.155711e+01	-1.070617e+00	1.543216e-05	3.664400e-04
TC	DOWN	ENST00000578361.5	ASPSCR1-206:retained_intron:ASPSCR1	8.237331e+00	-1.725787e+00	4.755624e-05	8.933013e-04
TC	UP	ENST00000295683.3	CXCR1-201:protein_coding:CXCR1	2.338835e+01	1.065917e+00	5.829013e-05	1.053496e-03
TC	DOWN	ENST00000524332.1	DECR1-219:retained_intron:DECR1	7.448006e+00	-8.107225e-01	1.075312e-04	1.709020e-03
TC	DOWN	ENST00000358309.3	CX3CR1-201:protein_coding:CX3CR1	8.679408e+01	-1.416131e+00	9.997113e-04	9.901094e-03
TC	UP	ENST00000462666.5	PLSCR1-203:protein_coding:PLSCR1	5.223531e+00	1.160374e+00	2.494042e-03	1.985017e-02
TC	DOWN	ENST00000581608.5	ASPSCR1-210:retained_intron:ASPSCR1	9.575729e+00	-1.639784e+00	7.693032e-03	4.613807e-02

Landscape of isoform expressions across multiple brain tissues between AD and control.

Top

Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CR1

Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).

All exon skipping events in AD cohorts.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon
exon_skip_11336	chr1	207558538:207558623:207560739:207561137:207563864:207564040	207560739:207561137
exon_skip_232688	chr1	207528716:207528801:207532180:207532398:207533409:207533588	207532180:207532398
exon_skip_32989	chr1	207550735:207550953:207551964:207552143:207552752:207552851	207551964:207552143
exon_skip_47316	chr1	207532180:207532398:207533409:207533588:207534197:207534296	207533409:207533588
exon_skip_81839	chr1	207564132:207564234:207565838:207565923:207567824:207568042	207565838:207565923

Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.

Exon skipping information

Tissue type

Avg(PSIs) in AD

Avg(PSIs) in control

Difference (PSI)

Adj. p-value

Top

Open reading frame (ORF) annotation in the exon skipping event for CR1

Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000367051	207565838	207565923	Frame-shift
ENST00000367053	207565838	207565923	Frame-shift
ENST00000400960	207565838	207565923	Frame-shift
ENST00000367053	207532180	207532398	In-frame
ENST00000400960	207532180	207532398	In-frame
ENST00000367053	207533409	207533588	In-frame
ENST00000400960	207533409	207533588	In-frame
ENST00000367051	207560739	207561137	In-frame

Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000367051	207565838	207565923	Frame-shift
ENST00000367053	207565838	207565923	Frame-shift
ENST00000400960	207565838	207565923	Frame-shift
ENST00000367053	207532180	207532398	In-frame
ENST00000400960	207532180	207532398	In-frame
ENST00000367053	207533409	207533588	In-frame
ENST00000400960	207533409	207533588	In-frame
ENST00000367051	207551964	207552143	In-frame
ENST00000367051	207560739	207561137	In-frame

Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.

ENST

Start of skipped exon

End of skipped exon

ORF

Top

Infer the effects of exon skipping event on protein functional features for CR1

p-ENSG00000203710_img4.png

Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000367051	6965	2039	207560739	207561137	514	911	163	295
ENST00000367053	6965	2039	207532180	207532398	1279	1496	418	490
ENST00000367053	6965	2039	207532180	207532398	1279	1496	418	490
ENST00000367053	6965	2039	207532180	207532398	1279	1496	418	490
ENST00000367053	6965	2039	207532180	207532398	1279	1496	418	490
ENST00000400960	8614	2039	207532180	207532398	1375	1592	418	490
ENST00000400960	8614	2039	207532180	207532398	1375	1592	418	490
ENST00000400960	8614	2039	207532180	207532398	1375	1592	418	490
ENST00000400960	8614	2039	207532180	207532398	1375	1592	418	490
ENST00000367053	6965	2039	207533409	207533588	1498	1676	491	550
ENST00000400960	8614	2039	207533409	207533588	1594	1772	491	550
ENST00000367051	6965	2039	207560739	207561137	1864	2261	613	745
ENST00000367051	6965	2039	207560739	207561137	1864	2261	613	745
ENST00000367053	6965	2039	207533409	207533588	2848	3026	941	1000
ENST00000400960	8614	2039	207533409	207533588	2944	3122	941	1000

Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000367051	6965	2039	207560739	207561137	514	911	163	295
ENST00000367053	6965	2039	207532180	207532398	1279	1496	418	490
ENST00000367053	6965	2039	207532180	207532398	1279	1496	418	490
ENST00000367053	6965	2039	207532180	207532398	1279	1496	418	490
ENST00000367053	6965	2039	207532180	207532398	1279	1496	418	490
ENST00000400960	8614	2039	207532180	207532398	1375	1592	418	490
ENST00000400960	8614	2039	207532180	207532398	1375	1592	418	490
ENST00000400960	8614	2039	207532180	207532398	1375	1592	418	490
ENST00000400960	8614	2039	207532180	207532398	1375	1592	418	490
ENST00000367051	6965	2039	207551964	207552143	1498	1676	491	550
ENST00000367053	6965	2039	207533409	207533588	1498	1676	491	550
ENST00000400960	8614	2039	207533409	207533588	1594	1772	491	550
ENST00000367051	6965	2039	207560739	207561137	1864	2261	613	745
ENST00000367051	6965	2039	207560739	207561137	1864	2261	613	745
ENST00000367051	6965	2039	207551964	207552143	2848	3026	941	1000
ENST00000367053	6965	2039	207533409	207533588	2848	3026	941	1000
ENST00000400960	8614	2039	207533409	207533588	2944	3122	941	1000

Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.

ENST

Length of mRNA

Length of AA seq.

Genomic start

Genomic end

mRNA start

mRNA end

AA start

AA end

Lost protein functional features of individual exon skipping events in ROSMAP.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P17927	163	295	161	163	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MCY
P17927	163	295	173	175	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MCY
P17927	163	295	180	183	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MCY
P17927	163	295	190	192	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MCY
P17927	163	295	197	201	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MCY
P17927	163	295	212	215	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MCY
P17927	163	295	219	223	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MCY
P17927	163	295	225	228	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MCY
P17927	163	295	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
P17927	163	295	166	215	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	163	295	195	232	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	163	295	238	280	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	163	295	266	293	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	163	295	102	163	Domain	Note=Sushi 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	163	295	164	234	Domain	Note=Sushi 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	163	295	236	295	Domain	Note=Sushi 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	163	295	295	355	Domain	Note=Sushi 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	163	295	252	252	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	163	295	173	173	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	163	295	173	173	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	163	295	42	1971	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	418	490	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
P17927	418	490	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
P17927	418	490	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
P17927	418	490	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
P17927	418	490	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
P17927	418	490	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
P17927	418	490	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
P17927	418	490	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
P17927	418	490	421	470	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	421	470	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	421	470	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	421	470	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	421	470	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	421	470	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	421	470	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	421	470	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	450	487	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	450	487	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	450	487	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	450	487	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	450	487	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	450	487	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	450	487	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	450	487	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	356	418	Domain	Note=Sushi 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	356	418	Domain	Note=Sushi 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	356	418	Domain	Note=Sushi 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	356	418	Domain	Note=Sushi 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	356	418	Domain	Note=Sushi 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	356	418	Domain	Note=Sushi 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	356	418	Domain	Note=Sushi 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	356	418	Domain	Note=Sushi 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	419	489	Domain	Note=Sushi 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	419	489	Domain	Note=Sushi 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	419	489	Domain	Note=Sushi 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	419	489	Domain	Note=Sushi 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	419	489	Domain	Note=Sushi 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	419	489	Domain	Note=Sushi 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	419	489	Domain	Note=Sushi 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	419	489	Domain	Note=Sushi 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	447	447	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	418	490	447	447	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	418	490	447	447	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	418	490	447	447	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	418	490	447	447	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	418	490	447	447	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	418	490	447	447	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	418	490	447	447	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	418	490	445	445	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	418	490	445	445	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	418	490	445	445	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	418	490	445	445	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	418	490	445	445	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	418	490	445	445	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	418	490	445	445	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	418	490	445	445	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	418	490	445	445	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	418	490	445	445	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	418	490	445	445	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	418	490	445	445	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	418	490	445	445	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	418	490	445	445	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	418	490	445	445	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	418	490	445	445	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	418	490	445	445	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	418	490	445	445	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	418	490	445	445	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	418	490	445	445	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	418	490	445	445	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	418	490	445	445	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	418	490	445	445	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	418	490	445	445	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	418	490	42	1971	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	418	490	42	1971	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	418	490	42	1971	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	418	490	42	1971	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	418	490	42	1971	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	418	490	42	1971	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	418	490	42	1971	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	418	490	42	1971	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	491	550	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
P17927	491	550	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
P17927	491	550	493	536	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	491	550	493	536	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	491	550	523	549	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	491	550	523	549	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	491	550	491	551	Domain	Note=Sushi 8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	491	550	491	551	Domain	Note=Sushi 8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	491	550	509	509	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	491	550	509	509	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	491	550	42	1971	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	491	550	42	1971	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	613	745	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
P17927	613	745	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
P17927	613	745	616	665	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	613	745	616	665	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	613	745	645	682	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	613	745	645	682	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	613	745	688	730	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	613	745	688	730	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	613	745	716	743	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	613	745	716	743	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	613	745	552	613	Domain	Note=Sushi 9;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	613	745	552	613	Domain	Note=Sushi 9;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	613	745	614	684	Domain	Note=Sushi 10;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	613	745	614	684	Domain	Note=Sushi 10;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	613	745	686	745	Domain	Note=Sushi 11;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	613	745	686	745	Domain	Note=Sushi 11;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	613	745	745	805	Domain	Note=Sushi 12;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	613	745	745	805	Domain	Note=Sushi 12;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	613	745	702	702	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	613	745	702	702	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	613	745	42	1971	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	613	745	42	1971	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	941	1000	950	954	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FO9
P17927	941	1000	950	954	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FO9
P17927	941	1000	961	963	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FO9
P17927	941	1000	961	963	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FO9
P17927	941	1000	971	973	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FO9
P17927	941	1000	971	973	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FO9
P17927	941	1000	977	979	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GKN
P17927	941	1000	977	979	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GKN
P17927	941	1000	982	986	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GKN
P17927	941	1000	982	986	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GKN
P17927	941	1000	988	990	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FO9
P17927	941	1000	988	990	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FO9
P17927	941	1000	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
P17927	941	1000	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
P17927	941	1000	943	986	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	941	1000	943	986	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	941	1000	973	999	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	941	1000	973	999	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	941	1000	941	1001	Domain	Note=Sushi 15;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	941	1000	941	1001	Domain	Note=Sushi 15;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	941	1000	959	959	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	941	1000	959	959	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	941	1000	42	1971	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	941	1000	42	1971	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255

Lost protein functional features of individual exon skipping events in MSBB.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P17927	163	295	161	163	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MCY
P17927	163	295	173	175	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MCY
P17927	163	295	180	183	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MCY
P17927	163	295	190	192	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MCY
P17927	163	295	197	201	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MCY
P17927	163	295	212	215	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MCY
P17927	163	295	219	223	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MCY
P17927	163	295	225	228	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2MCY
P17927	163	295	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
P17927	163	295	166	215	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	163	295	195	232	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	163	295	238	280	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	163	295	266	293	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	163	295	102	163	Domain	Note=Sushi 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	163	295	164	234	Domain	Note=Sushi 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	163	295	236	295	Domain	Note=Sushi 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	163	295	295	355	Domain	Note=Sushi 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	163	295	252	252	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	163	295	173	173	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	163	295	173	173	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	163	295	42	1971	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	418	490	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
P17927	418	490	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
P17927	418	490	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
P17927	418	490	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
P17927	418	490	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
P17927	418	490	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
P17927	418	490	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
P17927	418	490	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
P17927	418	490	421	470	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	421	470	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	421	470	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	421	470	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	421	470	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	421	470	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	421	470	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	421	470	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	450	487	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	450	487	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	450	487	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	450	487	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	450	487	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	450	487	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	450	487	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	450	487	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	356	418	Domain	Note=Sushi 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	356	418	Domain	Note=Sushi 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	356	418	Domain	Note=Sushi 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	356	418	Domain	Note=Sushi 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	356	418	Domain	Note=Sushi 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	356	418	Domain	Note=Sushi 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	356	418	Domain	Note=Sushi 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	356	418	Domain	Note=Sushi 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	419	489	Domain	Note=Sushi 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	419	489	Domain	Note=Sushi 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	419	489	Domain	Note=Sushi 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	419	489	Domain	Note=Sushi 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	419	489	Domain	Note=Sushi 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	419	489	Domain	Note=Sushi 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	419	489	Domain	Note=Sushi 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	419	489	Domain	Note=Sushi 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	418	490	447	447	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	418	490	447	447	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	418	490	447	447	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	418	490	447	447	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	418	490	447	447	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	418	490	447	447	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	418	490	447	447	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	418	490	447	447	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	418	490	445	445	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	418	490	445	445	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	418	490	445	445	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	418	490	445	445	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	418	490	445	445	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	418	490	445	445	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	418	490	445	445	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	418	490	445	445	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	418	490	445	445	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	418	490	445	445	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	418	490	445	445	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	418	490	445	445	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	418	490	445	445	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	418	490	445	445	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	418	490	445	445	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	418	490	445	445	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	418	490	445	445	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	418	490	445	445	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	418	490	445	445	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	418	490	445	445	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	418	490	445	445	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	418	490	445	445	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	418	490	445	445	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	418	490	445	445	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P17927	418	490	42	1971	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	418	490	42	1971	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	418	490	42	1971	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	418	490	42	1971	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	418	490	42	1971	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	418	490	42	1971	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	418	490	42	1971	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	418	490	42	1971	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	491	550	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
P17927	491	550	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
P17927	491	550	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
P17927	491	550	493	536	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	491	550	493	536	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	491	550	493	536	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	491	550	523	549	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	491	550	523	549	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	491	550	523	549	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	491	550	491	551	Domain	Note=Sushi 8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	491	550	491	551	Domain	Note=Sushi 8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	491	550	491	551	Domain	Note=Sushi 8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	491	550	509	509	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	491	550	509	509	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	491	550	509	509	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	491	550	42	1971	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	491	550	42	1971	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	491	550	42	1971	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	613	745	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
P17927	613	745	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
P17927	613	745	616	665	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	613	745	616	665	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	613	745	645	682	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	613	745	645	682	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	613	745	688	730	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	613	745	688	730	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	613	745	716	743	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	613	745	716	743	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	613	745	552	613	Domain	Note=Sushi 9;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	613	745	552	613	Domain	Note=Sushi 9;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	613	745	614	684	Domain	Note=Sushi 10;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	613	745	614	684	Domain	Note=Sushi 10;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	613	745	686	745	Domain	Note=Sushi 11;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	613	745	686	745	Domain	Note=Sushi 11;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	613	745	745	805	Domain	Note=Sushi 12;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	613	745	745	805	Domain	Note=Sushi 12;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	613	745	702	702	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	613	745	702	702	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	613	745	42	1971	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	613	745	42	1971	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	941	1000	950	954	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FO9
P17927	941	1000	950	954	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FO9
P17927	941	1000	950	954	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FO9
P17927	941	1000	961	963	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FO9
P17927	941	1000	961	963	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FO9
P17927	941	1000	961	963	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FO9
P17927	941	1000	971	973	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FO9
P17927	941	1000	971	973	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FO9
P17927	941	1000	971	973	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FO9
P17927	941	1000	977	979	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GKN
P17927	941	1000	977	979	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GKN
P17927	941	1000	977	979	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GKN
P17927	941	1000	982	986	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GKN
P17927	941	1000	982	986	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GKN
P17927	941	1000	982	986	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1GKN
P17927	941	1000	988	990	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FO9
P17927	941	1000	988	990	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FO9
P17927	941	1000	988	990	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FO9
P17927	941	1000	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
P17927	941	1000	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
P17927	941	1000	42	2039	Chain	ID=PRO_0000006009;Note=Complement receptor type 1
P17927	941	1000	943	986	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	941	1000	943	986	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	941	1000	943	986	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	941	1000	973	999	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	941	1000	973	999	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	941	1000	973	999	Disulfide bond	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	941	1000	941	1001	Domain	Note=Sushi 15;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	941	1000	941	1001	Domain	Note=Sushi 15;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	941	1000	941	1001	Domain	Note=Sushi 15;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00302
P17927	941	1000	959	959	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	941	1000	959	959	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	941	1000	959	959	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	941	1000	42	1971	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	941	1000	42	1971	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P17927	941	1000	42	1971	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255

Lost protein functional features of individual exon skipping events in Mayo.

UniProt acc.

Start of exon skipping (AA)

End of exon skipping (AA)

Protein feature start (AA)

Protein feature end (AA)

Category of protein feature

Description of feature

Top

3'-UTR located exon skipping events that lost miRNA binding sites in CR1

3'-UTR exon skipping evnets lost miRNA binding.

Tissue type

ENST

Exon skip start

Exon skip end

microRNA

Binding site by TargetScan

Binding type by TargetScan

Bdinding site by miRanda

Score of miRanda

Energy by miRanda

Top

SNVs in the skipped exons for CR1

- Differential PSIs between mutated versus non-mutated samples.

- Depth of Coverage in the skipped exon of the mutated samples.

- Sashimi plot in the skipped exon of the mutated samples.

- Non-synonymous mutations located in the skipped exons.

Cancer type

Sample

ESID

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

Top

AD stage-associated exon skippint events for CR1

Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).

AD stage info

Cohort

Tissue

SE id

Coefficient

P-value

Chromosome

Strand

E1 start

E1 end

Skipped start

Skipped end

E2 start

E2 end

Top

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CR1

sQTL information located at the skipped exons.

Tissue type

Exon skip ID

SNP id

Location

P-value

FDR

Top

Correlation with RNA binding proteins (RBPs) for CR1

Correlated RBP and related information.

Tissue type

RBP name

Exon skip ID

Correlation coeifficient

P-value

Top

RelatedDrugs for CR1

Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

RelatedDiseases for CR1

Diseases associated with this gene. (DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth) Web File Viewing | Emergency Information |Site Policies