![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | Open reading frame (ORF) annotation in the exon skipping event |
![]() | |
![]() | 3'-UTR located exon skipping events lost miRNA binding sites |
![]() | |
![]() | |
![]() | Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
![]() | |
![]() | |
![]() |
Gene summary for COX7B |
![]() |
Gene information | Gene symbol | COX7B | Gene ID | 1349 |
Gene name | cytochrome c oxidase subunit 7B | |
Synonyms | APLCC|LSDMCA2 | |
Cytomap | Xq21.1 | |
Type of gene | protein-coding | |
Description | cytochrome c oxidase subunit 7B, mitochondrialcytochrome c oxidase polypeptide VIIbcytochrome c oxidase subunit VIIbcytochrome-c oxidase chain VIIb | |
Modification date | 20200328 | |
UniProtAcc | ||
Context |
![]() |
Gene | GO ID | GO term | PubMed ID |
Top |
Gene structures and expression levels for COX7B |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
![]() |
![]() |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
![]() |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
![]() |
Top |
Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for COX7B |
![]() |
![]() |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_109629 | chrX | 77901744:77901867:77902643:77902767:77905184:77905385 | 77902643:77902767 |
exon_skip_20750 | chrX | 77899485:77899593:77902650:77902767:77905184:77905385 | 77902650:77902767 |
exon_skip_34529 | chrX | 77899485:77899593:77902643:77902767:77905184:77905385 | 77902643:77902767 |
![]() |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
exon_skip_202589 | Mayo_TC | 2.340000e-01 | 4.075342e-01 | -1.735342e-01 | 8.729184e-03 |
Top |
Open reading frame (ORF) annotation in the exon skipping event for COX7B |
![]() |
ENST | Start of skipped exon | End of skipped exon | ORF |
![]() |
ENST | Start of skipped exon | End of skipped exon | ORF |
![]() |
ENST | Start of skipped exon | End of skipped exon | ORF |
Top |
Infer the effects of exon skipping event on protein functional features for COX7B |
p-ENSG00000131174_img4.png![]() |
![]() |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
![]() |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
![]() |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
![]() |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
![]() |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
![]() |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Top |
3'-UTR located exon skipping events that lost miRNA binding sites in COX7B |
![]() |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Top |
SNVs in the skipped exons for COX7B |
![]() |
![]() |
![]() |
![]() |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
![]() |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
Top |
AD stage-associated exon skippint events for COX7B |
![]() |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
Top |
Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for COX7B |
![]() |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
Top |
Correlation with RNA binding proteins (RBPs) for COX7B |
![]() |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
CB | RBM45 | exon_skip_202589 | 4.108848e-01 | 6.123820e-07 |
IFG | PABPN1L | exon_skip_20750 | 5.926420e-01 | 4.639002e-03 |
IFG | KHSRP | exon_skip_20750 | 5.472342e-01 | 1.024369e-02 |
IFG | PTBP1 | exon_skip_20750 | 4.503115e-01 | 4.051398e-02 |
IFG | PABPC1 | exon_skip_20750 | 6.888267e-01 | 5.542014e-04 |
Top |
RelatedDrugs for COX7B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
P24311 | approved | DB02659 | Cholic Acid | small molecule | P24311 |
Top |
RelatedDiseases for COX7B |
![]() (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |