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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for TPRA1 |
Gene summary |
Gene information | Gene symbol | TPRA1 | Gene ID | 131601 |
Gene name | transmembrane protein adipocyte associated 1 | |
Synonyms | GPR175|TMEM227|TPRA40 | |
Cytomap | 3q21.3 | |
Type of gene | protein-coding | |
Description | transmembrane protein adipocyte-associated 1G protein-coupled receptor 175integral membrane protein GPR175seven transmembrane domain orphan receptortransmembrane domain protein regulated in adipocytes 40 kDatransmembrane protein 227transmembrane pro | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for TPRA1 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
CB | DOWN | ENST00000450633.6 | TPRA1-204:protein_coding:TPRA1 | 4.632485e+02 | -9.340355e-01 | 2.302951e-13 | 4.421185e-11 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TPRA1 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_111541 | chr3 | 127575185:127575265:127575403:127575505:127575940:127575995 | 127575403:127575505 |
exon_skip_115008 | chr3 | 127576821:127576893:127576990:127577076:127579740:127579872 | 127576990:127577076 |
exon_skip_140046 | chr3 | 127575185:127575265:127575749:127575809:127575940:127575995 | 127575749:127575809 |
exon_skip_150215 | chr3 | 127575185:127575265:127575403:127575505:127575749:127575809 | 127575403:127575505 |
exon_skip_162849 | chr3 | 127580022:127580163:127590410:127590592:127590883:127591095 | 127590410:127590592 |
exon_skip_180980 | chr3 | 127575403:127575505:127575749:127575809:127575940:127575995 | 127575749:127575809 |
exon_skip_189493 | chr3 | 127576617:127576696:127576821:127576893:127576990:127577076 | 127576821:127576893 |
exon_skip_237819 | chr3 | 127575403:127575505:127575749:127575809:127575940:127576050 | 127575749:127575809 |
exon_skip_246474 | chr3 | 127575185:127575265:127575749:127575809:127575940:127576050 | 127575749:127575809 |
exon_skip_266756 | chr3 | 127575185:127575265:127575403:127575505:127575940:127576050 | 127575403:127575505 |
exon_skip_28574 | chr3 | 127575749:127575809:127575940:127576050:127576617:127576696 | 127575940:127576050 |
exon_skip_37132 | chr3 | 127576821:127576893:127576990:127577076:127579740:127579805 | 127576990:127577076 |
exon_skip_87957 | chr3 | 127580022:127580163:127588070:127588160:127590410:127590592 | 127588070:127588160 |
exon_skip_99824 | chr3 | 127576990:127577076:127579740:127579872:127580022:127580163 | 127579740:127579872 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
exon_skip_237819 | Mayo_CB | 5.713415e-01 | 7.337662e-01 | -1.624248e-01 | 6.310622e-08 |
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Open reading frame (ORF) annotation in the exon skipping event for TPRA1 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000489960 | 127590410 | 127590592 | 3UTR-3UTR |
ENST00000355552 | 127575403 | 127575505 | Frame-shift |
ENST00000450633 | 127575403 | 127575505 | Frame-shift |
ENST00000489960 | 127575403 | 127575505 | Frame-shift |
ENST00000355552 | 127575749 | 127575809 | Frame-shift |
ENST00000450633 | 127575749 | 127575809 | Frame-shift |
ENST00000489960 | 127575749 | 127575809 | Frame-shift |
ENST00000355552 | 127576821 | 127576893 | Frame-shift |
ENST00000450633 | 127576821 | 127576893 | Frame-shift |
ENST00000489960 | 127576821 | 127576893 | Frame-shift |
ENST00000355552 | 127575940 | 127576050 | In-frame |
ENST00000450633 | 127575940 | 127576050 | In-frame |
ENST00000489960 | 127575940 | 127576050 | In-frame |
ENST00000355552 | 127576990 | 127577076 | In-frame |
ENST00000450633 | 127576990 | 127577076 | In-frame |
ENST00000489960 | 127576990 | 127577076 | In-frame |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000355552 | 127575749 | 127575809 | Frame-shift |
ENST00000450633 | 127575749 | 127575809 | Frame-shift |
ENST00000489960 | 127575749 | 127575809 | Frame-shift |
ENST00000355552 | 127576821 | 127576893 | Frame-shift |
ENST00000450633 | 127576821 | 127576893 | Frame-shift |
ENST00000489960 | 127576821 | 127576893 | Frame-shift |
ENST00000355552 | 127575940 | 127576050 | In-frame |
ENST00000450633 | 127575940 | 127576050 | In-frame |
ENST00000489960 | 127575940 | 127576050 | In-frame |
ENST00000355552 | 127576990 | 127577076 | In-frame |
ENST00000450633 | 127576990 | 127577076 | In-frame |
ENST00000489960 | 127576990 | 127577076 | In-frame |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000489960 | 127590410 | 127590592 | 3UTR-3UTR |
ENST00000355552 | 127575403 | 127575505 | Frame-shift |
ENST00000450633 | 127575403 | 127575505 | Frame-shift |
ENST00000489960 | 127575403 | 127575505 | Frame-shift |
ENST00000355552 | 127575749 | 127575809 | Frame-shift |
ENST00000450633 | 127575749 | 127575809 | Frame-shift |
ENST00000489960 | 127575749 | 127575809 | Frame-shift |
ENST00000355552 | 127576821 | 127576893 | Frame-shift |
ENST00000450633 | 127576821 | 127576893 | Frame-shift |
ENST00000489960 | 127576821 | 127576893 | Frame-shift |
ENST00000355552 | 127579740 | 127579872 | Frame-shift |
ENST00000450633 | 127579740 | 127579872 | Frame-shift |
ENST00000489960 | 127579740 | 127579872 | Frame-shift |
ENST00000355552 | 127575940 | 127576050 | In-frame |
ENST00000450633 | 127575940 | 127576050 | In-frame |
ENST00000489960 | 127575940 | 127576050 | In-frame |
ENST00000355552 | 127576990 | 127577076 | In-frame |
ENST00000450633 | 127576990 | 127577076 | In-frame |
ENST00000489960 | 127576990 | 127577076 | In-frame |
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Infer the effects of exon skipping event on protein functional features for TPRA1 |
p-ENSG00000163870_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000355552 | 1950 | 373 | 127576990 | 127577076 | 636 | 721 | 86 | 114 |
ENST00000450633 | 1882 | 373 | 127576990 | 127577076 | 550 | 635 | 86 | 114 |
ENST00000489960 | 1920 | 373 | 127576990 | 127577076 | 665 | 750 | 86 | 114 |
ENST00000355552 | 1950 | 373 | 127575940 | 127576050 | 876 | 985 | 166 | 202 |
ENST00000450633 | 1882 | 373 | 127575940 | 127576050 | 790 | 899 | 166 | 202 |
ENST00000489960 | 1920 | 373 | 127575940 | 127576050 | 905 | 1014 | 166 | 202 |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000355552 | 1950 | 373 | 127576990 | 127577076 | 636 | 721 | 86 | 114 |
ENST00000450633 | 1882 | 373 | 127576990 | 127577076 | 550 | 635 | 86 | 114 |
ENST00000489960 | 1920 | 373 | 127576990 | 127577076 | 665 | 750 | 86 | 114 |
ENST00000355552 | 1950 | 373 | 127575940 | 127576050 | 876 | 985 | 166 | 202 |
ENST00000450633 | 1882 | 373 | 127575940 | 127576050 | 790 | 899 | 166 | 202 |
ENST00000489960 | 1920 | 373 | 127575940 | 127576050 | 905 | 1014 | 166 | 202 |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000355552 | 1950 | 373 | 127576990 | 127577076 | 636 | 721 | 86 | 114 |
ENST00000450633 | 1882 | 373 | 127576990 | 127577076 | 550 | 635 | 86 | 114 |
ENST00000489960 | 1920 | 373 | 127576990 | 127577076 | 665 | 750 | 86 | 114 |
ENST00000355552 | 1950 | 373 | 127575940 | 127576050 | 876 | 985 | 166 | 202 |
ENST00000450633 | 1882 | 373 | 127575940 | 127576050 | 790 | 899 | 166 | 202 |
ENST00000489960 | 1920 | 373 | 127575940 | 127576050 | 905 | 1014 | 166 | 202 |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q86W33 | 86 | 114 | 1 | 373 | Chain | ID=PRO_0000076099;Note=Transmembrane protein adipocyte-associated 1 |
Q86W33 | 86 | 114 | 1 | 373 | Chain | ID=PRO_0000076099;Note=Transmembrane protein adipocyte-associated 1 |
Q86W33 | 86 | 114 | 1 | 373 | Chain | ID=PRO_0000076099;Note=Transmembrane protein adipocyte-associated 1 |
Q86W33 | 86 | 114 | 76 | 96 | Transmembrane | Note=Helical%3B Name%3D2;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
Q86W33 | 86 | 114 | 76 | 96 | Transmembrane | Note=Helical%3B Name%3D2;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
Q86W33 | 86 | 114 | 76 | 96 | Transmembrane | Note=Helical%3B Name%3D2;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
Q86W33 | 166 | 202 | 1 | 373 | Chain | ID=PRO_0000076099;Note=Transmembrane protein adipocyte-associated 1 |
Q86W33 | 166 | 202 | 1 | 373 | Chain | ID=PRO_0000076099;Note=Transmembrane protein adipocyte-associated 1 |
Q86W33 | 166 | 202 | 1 | 373 | Chain | ID=PRO_0000076099;Note=Transmembrane protein adipocyte-associated 1 |
Q86W33 | 166 | 202 | 151 | 171 | Transmembrane | Note=Helical%3B Name%3D4;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
Q86W33 | 166 | 202 | 151 | 171 | Transmembrane | Note=Helical%3B Name%3D4;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
Q86W33 | 166 | 202 | 151 | 171 | Transmembrane | Note=Helical%3B Name%3D4;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
Q86W33 | 166 | 202 | 192 | 212 | Transmembrane | Note=Helical%3B Name%3D5;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
Q86W33 | 166 | 202 | 192 | 212 | Transmembrane | Note=Helical%3B Name%3D5;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
Q86W33 | 166 | 202 | 192 | 212 | Transmembrane | Note=Helical%3B Name%3D5;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q86W33 | 86 | 114 | 1 | 373 | Chain | ID=PRO_0000076099;Note=Transmembrane protein adipocyte-associated 1 |
Q86W33 | 86 | 114 | 1 | 373 | Chain | ID=PRO_0000076099;Note=Transmembrane protein adipocyte-associated 1 |
Q86W33 | 86 | 114 | 1 | 373 | Chain | ID=PRO_0000076099;Note=Transmembrane protein adipocyte-associated 1 |
Q86W33 | 86 | 114 | 76 | 96 | Transmembrane | Note=Helical%3B Name%3D2;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
Q86W33 | 86 | 114 | 76 | 96 | Transmembrane | Note=Helical%3B Name%3D2;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
Q86W33 | 86 | 114 | 76 | 96 | Transmembrane | Note=Helical%3B Name%3D2;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
Q86W33 | 166 | 202 | 1 | 373 | Chain | ID=PRO_0000076099;Note=Transmembrane protein adipocyte-associated 1 |
Q86W33 | 166 | 202 | 1 | 373 | Chain | ID=PRO_0000076099;Note=Transmembrane protein adipocyte-associated 1 |
Q86W33 | 166 | 202 | 1 | 373 | Chain | ID=PRO_0000076099;Note=Transmembrane protein adipocyte-associated 1 |
Q86W33 | 166 | 202 | 151 | 171 | Transmembrane | Note=Helical%3B Name%3D4;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
Q86W33 | 166 | 202 | 151 | 171 | Transmembrane | Note=Helical%3B Name%3D4;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
Q86W33 | 166 | 202 | 151 | 171 | Transmembrane | Note=Helical%3B Name%3D4;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
Q86W33 | 166 | 202 | 192 | 212 | Transmembrane | Note=Helical%3B Name%3D5;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
Q86W33 | 166 | 202 | 192 | 212 | Transmembrane | Note=Helical%3B Name%3D5;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
Q86W33 | 166 | 202 | 192 | 212 | Transmembrane | Note=Helical%3B Name%3D5;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q86W33 | 86 | 114 | 1 | 373 | Chain | ID=PRO_0000076099;Note=Transmembrane protein adipocyte-associated 1 |
Q86W33 | 86 | 114 | 1 | 373 | Chain | ID=PRO_0000076099;Note=Transmembrane protein adipocyte-associated 1 |
Q86W33 | 86 | 114 | 1 | 373 | Chain | ID=PRO_0000076099;Note=Transmembrane protein adipocyte-associated 1 |
Q86W33 | 86 | 114 | 76 | 96 | Transmembrane | Note=Helical%3B Name%3D2;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
Q86W33 | 86 | 114 | 76 | 96 | Transmembrane | Note=Helical%3B Name%3D2;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
Q86W33 | 86 | 114 | 76 | 96 | Transmembrane | Note=Helical%3B Name%3D2;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
Q86W33 | 166 | 202 | 1 | 373 | Chain | ID=PRO_0000076099;Note=Transmembrane protein adipocyte-associated 1 |
Q86W33 | 166 | 202 | 1 | 373 | Chain | ID=PRO_0000076099;Note=Transmembrane protein adipocyte-associated 1 |
Q86W33 | 166 | 202 | 1 | 373 | Chain | ID=PRO_0000076099;Note=Transmembrane protein adipocyte-associated 1 |
Q86W33 | 166 | 202 | 151 | 171 | Transmembrane | Note=Helical%3B Name%3D4;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
Q86W33 | 166 | 202 | 151 | 171 | Transmembrane | Note=Helical%3B Name%3D4;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
Q86W33 | 166 | 202 | 151 | 171 | Transmembrane | Note=Helical%3B Name%3D4;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
Q86W33 | 166 | 202 | 192 | 212 | Transmembrane | Note=Helical%3B Name%3D5;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
Q86W33 | 166 | 202 | 192 | 212 | Transmembrane | Note=Helical%3B Name%3D5;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
Q86W33 | 166 | 202 | 192 | 212 | Transmembrane | Note=Helical%3B Name%3D5;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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3'-UTR located exon skipping events that lost miRNA binding sites in TPRA1 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Mayo | ENST00000489960 | 127590410 | 127590592 | hsa-miR-1287-5p | chr3:127590488-127590495 | 8mer-1a | chr3:127590480-127590501 | 166.00 | -27.17 |
Mayo | ENST00000489960 | 127590410 | 127590592 | hsa-miR-1292-3p | chr3:127590565-127590572 | 8mer-1a | chr3:127590555-127590572 | 147.00 | -26.18 |
Mayo | ENST00000489960 | 127590410 | 127590592 | hsa-miR-4467 | chr3:127590466-127590473 | 8mer-1a | chr3:127590450-127590473 | 153.00 | -35.39 |
Mayo | ENST00000489960 | 127590410 | 127590592 | hsa-miR-10400-5p | chr3:127590466-127590473 | 8mer-1a | chr3:127590450-127590473 | 153.00 | -35.39 |
ROSMAP | ENST00000489960 | 127590410 | 127590592 | hsa-miR-1287-5p | chr3:127590488-127590495 | 8mer-1a | chr3:127590480-127590501 | 166.00 | -27.17 |
ROSMAP | ENST00000489960 | 127590410 | 127590592 | hsa-miR-1292-3p | chr3:127590565-127590572 | 8mer-1a | chr3:127590555-127590572 | 147.00 | -26.18 |
ROSMAP | ENST00000489960 | 127590410 | 127590592 | hsa-miR-4467 | chr3:127590466-127590473 | 8mer-1a | chr3:127590450-127590473 | 153.00 | -35.39 |
ROSMAP | ENST00000489960 | 127590410 | 127590592 | hsa-miR-10400-5p | chr3:127590466-127590473 | 8mer-1a | chr3:127590450-127590473 | 153.00 | -35.39 |
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SNVs in the skipped exons for TPRA1 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for TPRA1 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TPRA1 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
CB | exon_skip_28574 | rs2304551 | chr3:127669307 | 1.990335e-04 | 2.982139e-02 |
PCC | exon_skip_180980 | rs893293 | chr3:127604987 | 4.419974e-05 | 8.951103e-03 |
DLPFC | exon_skip_237819 | rs893293 | chr3:127604987 | 8.121550e-04 | 4.716267e-02 |
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Correlation with RNA binding proteins (RBPs) for TPRA1 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
CB | RBM6 | exon_skip_237819 | -4.896601e-01 | 5.747096e-11 |
CB | PCBP4 | exon_skip_237819 | 6.025009e-01 | 4.397687e-17 |
CB | RBM6 | exon_skip_115008 | -4.541609e-01 | 1.823040e-09 |
CB | RBM3 | exon_skip_115008 | 4.449476e-01 | 4.199070e-09 |
CB | FUS | exon_skip_115008 | 4.214875e-01 | 3.151742e-08 |
IFG | RBM6 | exon_skip_237819 | -4.675313e-01 | 3.765248e-02 |
IFG | RBM5 | exon_skip_237819 | -5.344300e-01 | 1.520172e-02 |
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RelatedDrugs for TPRA1 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TPRA1 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |