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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for CPNE4 |
 Gene summary |
| Gene information | Gene symbol | CPNE4 | Gene ID | 131034 |
| Gene name | copine 4 | |
| Synonyms | COPN4|CPN4 | |
| Cytomap | 3q22.1 | |
| Type of gene | protein-coding | |
| Description | copine-4copine 8copine IV | |
| Modification date | 20200320 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for CPNE4 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000196353
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
 |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PG | DOWN | ENST00000515418.1 | CPNE4-213:retained_intron:CPNE4 | 8.697922e+01 | -9.155478e-01 | 1.795121e-07 | 2.405154e-05 |
| PG | DOWN | ENST00000514999.5 | CPNE4-212:protein_coding:CPNE4 | 2.433784e+00 | -9.945127e-01 | 1.496717e-05 | 6.774395e-04 |
| PG | DOWN | ENST00000505957.1 | CPNE4-206:protein_coding:CPNE4 | 6.024720e+00 | -9.544169e-01 | 1.434813e-04 | 3.578598e-03 |
| TC | DOWN | ENST00000503204.1 | CPNE4-203:lncRNA:CPNE4 | 6.952299e+01 | -1.233075e+00 | 5.187741e-04 | 5.921791e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CPNE4 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_215631 | chr3 | 131669675:131669764:131685875:131685958:131696542:131696616 | 131685875:131685958 |
| exon_skip_258997 | chr3 | 131549947:131550080:131552440:131552491:131555497:131555551 | 131552440:131552491 |
| exon_skip_266837 | chr3 | 131905264:131905444:132034567:132035442:132037557:132037710 | 132034567:132035442 |
| exon_skip_267108 | chr3 | 131685875:131685958:131696542:131696616:131699909:131699980 | 131696542:131696616 |
| exon_skip_58902 | chr3 | 131581579:131581665:131587484:131587582:131669675:131669764 | 131587484:131587582 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for CPNE4 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000512055 | 132034567 | 132035442 | 3UTR-3UTR |
| ENST00000429747 | 131552440 | 131552491 | Frame-shift |
| ENST00000511604 | 131552440 | 131552491 | Frame-shift |
| ENST00000512055 | 131552440 | 131552491 | Frame-shift |
| ENST00000429747 | 131587484 | 131587582 | In-frame |
| ENST00000511604 | 131587484 | 131587582 | In-frame |
| ENST00000512055 | 131587484 | 131587582 | In-frame |
| ENST00000429747 | 131685875 | 131685958 | In-frame |
| ENST00000511604 | 131685875 | 131685958 | In-frame |
| ENST00000512055 | 131685875 | 131685958 | In-frame |
| ENST00000429747 | 131696542 | 131696616 | In-frame |
| ENST00000511604 | 131696542 | 131696616 | In-frame |
| ENST00000512055 | 131696542 | 131696616 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000512055 | 132034567 | 132035442 | 3UTR-3UTR |
| ENST00000429747 | 131685875 | 131685958 | In-frame |
| ENST00000511604 | 131685875 | 131685958 | In-frame |
| ENST00000512055 | 131685875 | 131685958 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000512055 | 132034567 | 132035442 | 3UTR-3UTR |
| ENST00000429747 | 131552440 | 131552491 | Frame-shift |
| ENST00000511604 | 131552440 | 131552491 | Frame-shift |
| ENST00000512055 | 131552440 | 131552491 | Frame-shift |
| ENST00000429747 | 131587484 | 131587582 | In-frame |
| ENST00000511604 | 131587484 | 131587582 | In-frame |
| ENST00000512055 | 131587484 | 131587582 | In-frame |
| ENST00000429747 | 131685875 | 131685958 | In-frame |
| ENST00000511604 | 131685875 | 131685958 | In-frame |
| ENST00000512055 | 131685875 | 131685958 | In-frame |
| ENST00000429747 | 131696542 | 131696616 | In-frame |
| ENST00000511604 | 131696542 | 131696616 | In-frame |
| ENST00000512055 | 131696542 | 131696616 | In-frame |
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Infer the effects of exon skipping event on protein functional features for CPNE4 |
p-ENSG00000196353_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000429747 | 4201 | 557 | 131696542 | 131696616 | 1310 | 1383 | 144 | 168 |
| ENST00000511604 | 2520 | 557 | 131696542 | 131696616 | 1010 | 1083 | 144 | 168 |
| ENST00000512055 | 5448 | 557 | 131696542 | 131696616 | 2560 | 2633 | 144 | 168 |
| ENST00000429747 | 4201 | 557 | 131685875 | 131685958 | 1385 | 1467 | 169 | 196 |
| ENST00000511604 | 2520 | 557 | 131685875 | 131685958 | 1085 | 1167 | 169 | 196 |
| ENST00000512055 | 5448 | 557 | 131685875 | 131685958 | 2635 | 2717 | 169 | 196 |
| ENST00000429747 | 4201 | 557 | 131587484 | 131587582 | 1559 | 1656 | 227 | 259 |
| ENST00000511604 | 2520 | 557 | 131587484 | 131587582 | 1259 | 1356 | 227 | 259 |
| ENST00000512055 | 5448 | 557 | 131587484 | 131587582 | 2809 | 2906 | 227 | 259 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000429747 | 4201 | 557 | 131685875 | 131685958 | 1385 | 1467 | 169 | 196 |
| ENST00000511604 | 2520 | 557 | 131685875 | 131685958 | 1085 | 1167 | 169 | 196 |
| ENST00000512055 | 5448 | 557 | 131685875 | 131685958 | 2635 | 2717 | 169 | 196 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000429747 | 4201 | 557 | 131696542 | 131696616 | 1310 | 1383 | 144 | 168 |
| ENST00000511604 | 2520 | 557 | 131696542 | 131696616 | 1010 | 1083 | 144 | 168 |
| ENST00000512055 | 5448 | 557 | 131696542 | 131696616 | 2560 | 2633 | 144 | 168 |
| ENST00000429747 | 4201 | 557 | 131685875 | 131685958 | 1385 | 1467 | 169 | 196 |
| ENST00000511604 | 2520 | 557 | 131685875 | 131685958 | 1085 | 1167 | 169 | 196 |
| ENST00000512055 | 5448 | 557 | 131685875 | 131685958 | 2635 | 2717 | 169 | 196 |
| ENST00000429747 | 4201 | 557 | 131587484 | 131587582 | 1559 | 1656 | 227 | 259 |
| ENST00000511604 | 2520 | 557 | 131587484 | 131587582 | 1259 | 1356 | 227 | 259 |
| ENST00000512055 | 5448 | 557 | 131587484 | 131587582 | 2809 | 2906 | 227 | 259 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q96A23 | 144 | 168 | 1 | 557 | Chain | ID=PRO_0000144841;Note=Copine-4 |
| Q96A23 | 144 | 168 | 1 | 557 | Chain | ID=PRO_0000144841;Note=Copine-4 |
| Q96A23 | 144 | 168 | 1 | 557 | Chain | ID=PRO_0000144841;Note=Copine-4 |
| Q96A23 | 144 | 168 | 141 | 246 | Domain | Note=C2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041 |
| Q96A23 | 144 | 168 | 141 | 246 | Domain | Note=C2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041 |
| Q96A23 | 144 | 168 | 141 | 246 | Domain | Note=C2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041 |
| Q96A23 | 169 | 196 | 1 | 557 | Chain | ID=PRO_0000144841;Note=Copine-4 |
| Q96A23 | 169 | 196 | 1 | 557 | Chain | ID=PRO_0000144841;Note=Copine-4 |
| Q96A23 | 169 | 196 | 1 | 557 | Chain | ID=PRO_0000144841;Note=Copine-4 |
| Q96A23 | 169 | 196 | 141 | 246 | Domain | Note=C2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041 |
| Q96A23 | 169 | 196 | 141 | 246 | Domain | Note=C2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041 |
| Q96A23 | 169 | 196 | 141 | 246 | Domain | Note=C2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041 |
| Q96A23 | 227 | 259 | 1 | 557 | Chain | ID=PRO_0000144841;Note=Copine-4 |
| Q96A23 | 227 | 259 | 1 | 557 | Chain | ID=PRO_0000144841;Note=Copine-4 |
| Q96A23 | 227 | 259 | 1 | 557 | Chain | ID=PRO_0000144841;Note=Copine-4 |
| Q96A23 | 227 | 259 | 141 | 246 | Domain | Note=C2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041 |
| Q96A23 | 227 | 259 | 141 | 246 | Domain | Note=C2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041 |
| Q96A23 | 227 | 259 | 141 | 246 | Domain | Note=C2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q96A23 | 169 | 196 | 1 | 557 | Chain | ID=PRO_0000144841;Note=Copine-4 |
| Q96A23 | 169 | 196 | 1 | 557 | Chain | ID=PRO_0000144841;Note=Copine-4 |
| Q96A23 | 169 | 196 | 1 | 557 | Chain | ID=PRO_0000144841;Note=Copine-4 |
| Q96A23 | 169 | 196 | 141 | 246 | Domain | Note=C2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041 |
| Q96A23 | 169 | 196 | 141 | 246 | Domain | Note=C2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041 |
| Q96A23 | 169 | 196 | 141 | 246 | Domain | Note=C2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q96A23 | 144 | 168 | 1 | 557 | Chain | ID=PRO_0000144841;Note=Copine-4 |
| Q96A23 | 144 | 168 | 1 | 557 | Chain | ID=PRO_0000144841;Note=Copine-4 |
| Q96A23 | 144 | 168 | 1 | 557 | Chain | ID=PRO_0000144841;Note=Copine-4 |
| Q96A23 | 144 | 168 | 141 | 246 | Domain | Note=C2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041 |
| Q96A23 | 144 | 168 | 141 | 246 | Domain | Note=C2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041 |
| Q96A23 | 144 | 168 | 141 | 246 | Domain | Note=C2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041 |
| Q96A23 | 169 | 196 | 1 | 557 | Chain | ID=PRO_0000144841;Note=Copine-4 |
| Q96A23 | 169 | 196 | 1 | 557 | Chain | ID=PRO_0000144841;Note=Copine-4 |
| Q96A23 | 169 | 196 | 1 | 557 | Chain | ID=PRO_0000144841;Note=Copine-4 |
| Q96A23 | 169 | 196 | 141 | 246 | Domain | Note=C2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041 |
| Q96A23 | 169 | 196 | 141 | 246 | Domain | Note=C2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041 |
| Q96A23 | 169 | 196 | 141 | 246 | Domain | Note=C2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041 |
| Q96A23 | 227 | 259 | 1 | 557 | Chain | ID=PRO_0000144841;Note=Copine-4 |
| Q96A23 | 227 | 259 | 1 | 557 | Chain | ID=PRO_0000144841;Note=Copine-4 |
| Q96A23 | 227 | 259 | 1 | 557 | Chain | ID=PRO_0000144841;Note=Copine-4 |
| Q96A23 | 227 | 259 | 141 | 246 | Domain | Note=C2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041 |
| Q96A23 | 227 | 259 | 141 | 246 | Domain | Note=C2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041 |
| Q96A23 | 227 | 259 | 141 | 246 | Domain | Note=C2 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041 |
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3'-UTR located exon skipping events that lost miRNA binding sites in CPNE4 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000512055 | 132034567 | 132035442 | hsa-miR-6727-3p | chr3:132035433-132035440 | 8mer-1a | chr3:132035423-132035442 | 149.00 | -18.56 |
| Mayo | ENST00000512055 | 132034567 | 132035442 | hsa-miR-6738-3p | chr3:132034942-132034949 | 8mer-1a | chr3:132034939-132034959 | 160.00 | -27.70 |
| Mayo | ENST00000512055 | 132034567 | 132035442 | hsa-miR-9-5p | chr3:132035333-132035340 | 8mer-1a | chr3:132035324-132035347 | 140.00 | -16.99 |
| Mayo | ENST00000512055 | 132034567 | 132035442 | hsa-miR-4677-3p | chr3:132034988-132034995 | 8mer-1a | chr3:132034971-132035000 | 151.00 | -24.43 |
| Mayo | ENST00000512055 | 132034567 | 132035442 | hsa-miR-4488 | chr3:132034625-132034632 | 8mer-1a | chr3:132034612-132034632 | 163.00 | -33.33 |
| Mayo | ENST00000512055 | 132034567 | 132035442 | hsa-miR-1237-5p | chr3:132034625-132034632 | 8mer-1a | chr3:132034612-132034632 | 163.00 | -33.33 |
| Mayo | ENST00000512055 | 132034567 | 132035442 | hsa-miR-6749-3p | chr3:132034922-132034929 | 8mer-1a | chr3:132034915-132034936 | 162.00 | -23.61 |
| Mayo | ENST00000512055 | 132034567 | 132035442 | hsa-miR-6756-3p | chr3:132034952-132034959 | 8mer-1a | chr3:132034939-132034959 | 160.00 | -27.70 |
| Mayo | ENST00000512055 | 132034567 | 132035442 | hsa-miR-4697-5p | chr3:132034625-132034632 | 8mer-1a | chr3:132034612-132034632 | 163.00 | -33.33 |
| Mayo | ENST00000512055 | 132034567 | 132035442 | hsa-miR-627-3p | chr3:132034892-132034899 | 8mer-1a | chr3:132034880-132034901 | 163.00 | -15.80 |
| Mayo | ENST00000512055 | 132034567 | 132035442 | hsa-miR-10393-5p | chr3:132034597-132034604 | 8mer-1a | chr3:132034580-132034604 | 164.00 | -19.71 |
| Mayo | ENST00000512055 | 132034567 | 132035442 | hsa-miR-3680-3p | chr3:132034635-132034642 | 8mer-1a | chr3:132034623-132034642 | 156.00 | -23.59 |
| Mayo | ENST00000512055 | 132034567 | 132035442 | hsa-miR-4722-3p | chr3:132035433-132035440 | 8mer-1a | chr3:132035423-132035442 | 149.00 | -18.56 |
| Mayo | ENST00000512055 | 132034567 | 132035442 | hsa-miR-4727-5p | chr3:132034941-132034948 | 8mer-1a | chr3:132034939-132034959 | 160.00 | -27.70 |
| Mayo | ENST00000512055 | 132034567 | 132035442 | hsa-miR-3065-3p | chr3:132034756-132034763 | 8mer-1a | chr3:132034756-132034777 | 160.00 | -21.36 |
| Mayo | ENST00000512055 | 132034567 | 132035442 | hsa-miR-1909-5p | chr3:132035326-132035333 | 8mer-1a | chr3:132035316-132035337 | 151.00 | -18.91 |
| Mayo | ENST00000512055 | 132034567 | 132035442 | hsa-miR-5589-5p | chr3:132035026-132035033 | 8mer-1a | chr3:132035015-132035038 | 150.00 | -31.20 |
| Mayo | ENST00000512055 | 132034567 | 132035442 | hsa-miR-498-3p | chr3:132035355-132035362 | 8mer-1a | chr3:132035351-132035371 | 154.00 | -13.82 |
| Mayo | ENST00000512055 | 132034567 | 132035442 | hsa-miR-6803-3p | chr3:132034918-132034925 | 8mer-1a | chr3:132034900-132034925 | 159.00 | -33.02 |
| Mayo | ENST00000512055 | 132034567 | 132035442 | hsa-miR-3127-3p | chr3:132034952-132034959 | 8mer-1a | chr3:132034939-132034959 | 160.00 | -27.70 |
| Mayo | ENST00000512055 | 132034567 | 132035442 | hsa-miR-6513-3p | chr3:132035224-132035231 | 8mer-1a | chr3:132035222-132035244 | 161.00 | -14.89 |
| Mayo | ENST00000512055 | 132034567 | 132035442 | hsa-miR-130b-5p | chr3:132034946-132034953 | 8mer-1a | chr3:132034939-132034959 | 160.00 | -27.70 |
| Mayo | ENST00000512055 | 132034567 | 132035442 | hsa-miR-6817-3p | chr3:132034992-132034999 | 8mer-1a | chr3:132034971-132035000 | 151.00 | -24.43 |
| Mayo | ENST00000512055 | 132034567 | 132035442 | hsa-miR-3667-3p | chr3:132034925-132034932 | 8mer-1a | chr3:132034923-132034943 | 170.00 | -27.33 |
| Mayo | ENST00000512055 | 132034567 | 132035442 | hsa-miR-6823-5p | chr3:132034787-132034794 | 8mer-1a | chr3:132034772-132034794 | 150.00 | -27.07 |
| Mayo | ENST00000512055 | 132034567 | 132035442 | hsa-miR-551b-5p | chr3:132035228-132035235 | 8mer-1a | chr3:132035222-132035244 | 161.00 | -14.89 |
| Mayo | ENST00000512055 | 132034567 | 132035442 | hsa-miR-7977 | chr3:132034747-132034754 | 8mer-1a | chr3:132034737-132034754 | 145.00 | -17.96 |
| Mayo | ENST00000512055 | 132034567 | 132035442 | hsa-miR-4468 | chr3:132035188-132035195 | 8mer-1a | chr3:132035182-132035201 | 169.00 | -23.72 |
| Mayo | ENST00000512055 | 132034567 | 132035442 | hsa-miR-3674 | chr3:132035412-132035419 | 8mer-1a | chr3:132035405-132035428 | 164.00 | -18.23 |
| Mayo | ENST00000512055 | 132034567 | 132035442 | hsa-miR-5708 | chr3:132035202-132035209 | 8mer-1a | chr3:132035193-132035217 | 153.00 | -24.49 |
| Mayo | ENST00000512055 | 132034567 | 132035442 | hsa-miR-6852-5p | chr3:132034628-132034635 | 8mer-1a | chr3:132034623-132034642 | 156.00 | -23.59 |
| Mayo | ENST00000512055 | 132034567 | 132035442 | hsa-miR-4767 | chr3:132035170-132035177 | 8mer-1a | chr3:132035160-132035179 | 168.00 | -39.53 |
| MSBB | ENST00000512055 | 132034567 | 132035442 | hsa-miR-6727-3p | chr3:132035433-132035440 | 8mer-1a | chr3:132035423-132035442 | 149.00 | -18.56 |
| MSBB | ENST00000512055 | 132034567 | 132035442 | hsa-miR-6738-3p | chr3:132034942-132034949 | 8mer-1a | chr3:132034939-132034959 | 160.00 | -27.70 |
| MSBB | ENST00000512055 | 132034567 | 132035442 | hsa-miR-9-5p | chr3:132035333-132035340 | 8mer-1a | chr3:132035324-132035347 | 140.00 | -16.99 |
| MSBB | ENST00000512055 | 132034567 | 132035442 | hsa-miR-4677-3p | chr3:132034988-132034995 | 8mer-1a | chr3:132034971-132035000 | 151.00 | -24.43 |
| MSBB | ENST00000512055 | 132034567 | 132035442 | hsa-miR-4488 | chr3:132034625-132034632 | 8mer-1a | chr3:132034612-132034632 | 163.00 | -33.33 |
| MSBB | ENST00000512055 | 132034567 | 132035442 | hsa-miR-1237-5p | chr3:132034625-132034632 | 8mer-1a | chr3:132034612-132034632 | 163.00 | -33.33 |
| MSBB | ENST00000512055 | 132034567 | 132035442 | hsa-miR-6749-3p | chr3:132034922-132034929 | 8mer-1a | chr3:132034915-132034936 | 162.00 | -23.61 |
| MSBB | ENST00000512055 | 132034567 | 132035442 | hsa-miR-6756-3p | chr3:132034952-132034959 | 8mer-1a | chr3:132034939-132034959 | 160.00 | -27.70 |
| MSBB | ENST00000512055 | 132034567 | 132035442 | hsa-miR-4697-5p | chr3:132034625-132034632 | 8mer-1a | chr3:132034612-132034632 | 163.00 | -33.33 |
| MSBB | ENST00000512055 | 132034567 | 132035442 | hsa-miR-627-3p | chr3:132034892-132034899 | 8mer-1a | chr3:132034880-132034901 | 163.00 | -15.80 |
| MSBB | ENST00000512055 | 132034567 | 132035442 | hsa-miR-10393-5p | chr3:132034597-132034604 | 8mer-1a | chr3:132034580-132034604 | 164.00 | -19.71 |
| MSBB | ENST00000512055 | 132034567 | 132035442 | hsa-miR-3680-3p | chr3:132034635-132034642 | 8mer-1a | chr3:132034623-132034642 | 156.00 | -23.59 |
| MSBB | ENST00000512055 | 132034567 | 132035442 | hsa-miR-4722-3p | chr3:132035433-132035440 | 8mer-1a | chr3:132035423-132035442 | 149.00 | -18.56 |
| MSBB | ENST00000512055 | 132034567 | 132035442 | hsa-miR-4727-5p | chr3:132034941-132034948 | 8mer-1a | chr3:132034939-132034959 | 160.00 | -27.70 |
| MSBB | ENST00000512055 | 132034567 | 132035442 | hsa-miR-3065-3p | chr3:132034756-132034763 | 8mer-1a | chr3:132034756-132034777 | 160.00 | -21.36 |
| MSBB | ENST00000512055 | 132034567 | 132035442 | hsa-miR-1909-5p | chr3:132035326-132035333 | 8mer-1a | chr3:132035316-132035337 | 151.00 | -18.91 |
| MSBB | ENST00000512055 | 132034567 | 132035442 | hsa-miR-5589-5p | chr3:132035026-132035033 | 8mer-1a | chr3:132035015-132035038 | 150.00 | -31.20 |
| MSBB | ENST00000512055 | 132034567 | 132035442 | hsa-miR-498-3p | chr3:132035355-132035362 | 8mer-1a | chr3:132035351-132035371 | 154.00 | -13.82 |
| MSBB | ENST00000512055 | 132034567 | 132035442 | hsa-miR-6803-3p | chr3:132034918-132034925 | 8mer-1a | chr3:132034900-132034925 | 159.00 | -33.02 |
| MSBB | ENST00000512055 | 132034567 | 132035442 | hsa-miR-3127-3p | chr3:132034952-132034959 | 8mer-1a | chr3:132034939-132034959 | 160.00 | -27.70 |
| MSBB | ENST00000512055 | 132034567 | 132035442 | hsa-miR-6513-3p | chr3:132035224-132035231 | 8mer-1a | chr3:132035222-132035244 | 161.00 | -14.89 |
| MSBB | ENST00000512055 | 132034567 | 132035442 | hsa-miR-130b-5p | chr3:132034946-132034953 | 8mer-1a | chr3:132034939-132034959 | 160.00 | -27.70 |
| MSBB | ENST00000512055 | 132034567 | 132035442 | hsa-miR-6817-3p | chr3:132034992-132034999 | 8mer-1a | chr3:132034971-132035000 | 151.00 | -24.43 |
| MSBB | ENST00000512055 | 132034567 | 132035442 | hsa-miR-3667-3p | chr3:132034925-132034932 | 8mer-1a | chr3:132034923-132034943 | 170.00 | -27.33 |
| MSBB | ENST00000512055 | 132034567 | 132035442 | hsa-miR-6823-5p | chr3:132034787-132034794 | 8mer-1a | chr3:132034772-132034794 | 150.00 | -27.07 |
| MSBB | ENST00000512055 | 132034567 | 132035442 | hsa-miR-551b-5p | chr3:132035228-132035235 | 8mer-1a | chr3:132035222-132035244 | 161.00 | -14.89 |
| MSBB | ENST00000512055 | 132034567 | 132035442 | hsa-miR-7977 | chr3:132034747-132034754 | 8mer-1a | chr3:132034737-132034754 | 145.00 | -17.96 |
| MSBB | ENST00000512055 | 132034567 | 132035442 | hsa-miR-4468 | chr3:132035188-132035195 | 8mer-1a | chr3:132035182-132035201 | 169.00 | -23.72 |
| MSBB | ENST00000512055 | 132034567 | 132035442 | hsa-miR-3674 | chr3:132035412-132035419 | 8mer-1a | chr3:132035405-132035428 | 164.00 | -18.23 |
| MSBB | ENST00000512055 | 132034567 | 132035442 | hsa-miR-5708 | chr3:132035202-132035209 | 8mer-1a | chr3:132035193-132035217 | 153.00 | -24.49 |
| MSBB | ENST00000512055 | 132034567 | 132035442 | hsa-miR-6852-5p | chr3:132034628-132034635 | 8mer-1a | chr3:132034623-132034642 | 156.00 | -23.59 |
| MSBB | ENST00000512055 | 132034567 | 132035442 | hsa-miR-4767 | chr3:132035170-132035177 | 8mer-1a | chr3:132035160-132035179 | 168.00 | -39.53 |
| ROSMAP | ENST00000512055 | 132034567 | 132035442 | hsa-miR-6727-3p | chr3:132035433-132035440 | 8mer-1a | chr3:132035423-132035442 | 149.00 | -18.56 |
| ROSMAP | ENST00000512055 | 132034567 | 132035442 | hsa-miR-6738-3p | chr3:132034942-132034949 | 8mer-1a | chr3:132034939-132034959 | 160.00 | -27.70 |
| ROSMAP | ENST00000512055 | 132034567 | 132035442 | hsa-miR-9-5p | chr3:132035333-132035340 | 8mer-1a | chr3:132035324-132035347 | 140.00 | -16.99 |
| ROSMAP | ENST00000512055 | 132034567 | 132035442 | hsa-miR-4677-3p | chr3:132034988-132034995 | 8mer-1a | chr3:132034971-132035000 | 151.00 | -24.43 |
| ROSMAP | ENST00000512055 | 132034567 | 132035442 | hsa-miR-4488 | chr3:132034625-132034632 | 8mer-1a | chr3:132034612-132034632 | 163.00 | -33.33 |
| ROSMAP | ENST00000512055 | 132034567 | 132035442 | hsa-miR-1237-5p | chr3:132034625-132034632 | 8mer-1a | chr3:132034612-132034632 | 163.00 | -33.33 |
| ROSMAP | ENST00000512055 | 132034567 | 132035442 | hsa-miR-6749-3p | chr3:132034922-132034929 | 8mer-1a | chr3:132034915-132034936 | 162.00 | -23.61 |
| ROSMAP | ENST00000512055 | 132034567 | 132035442 | hsa-miR-6756-3p | chr3:132034952-132034959 | 8mer-1a | chr3:132034939-132034959 | 160.00 | -27.70 |
| ROSMAP | ENST00000512055 | 132034567 | 132035442 | hsa-miR-4697-5p | chr3:132034625-132034632 | 8mer-1a | chr3:132034612-132034632 | 163.00 | -33.33 |
| ROSMAP | ENST00000512055 | 132034567 | 132035442 | hsa-miR-627-3p | chr3:132034892-132034899 | 8mer-1a | chr3:132034880-132034901 | 163.00 | -15.80 |
| ROSMAP | ENST00000512055 | 132034567 | 132035442 | hsa-miR-10393-5p | chr3:132034597-132034604 | 8mer-1a | chr3:132034580-132034604 | 164.00 | -19.71 |
| ROSMAP | ENST00000512055 | 132034567 | 132035442 | hsa-miR-3680-3p | chr3:132034635-132034642 | 8mer-1a | chr3:132034623-132034642 | 156.00 | -23.59 |
| ROSMAP | ENST00000512055 | 132034567 | 132035442 | hsa-miR-4722-3p | chr3:132035433-132035440 | 8mer-1a | chr3:132035423-132035442 | 149.00 | -18.56 |
| ROSMAP | ENST00000512055 | 132034567 | 132035442 | hsa-miR-4727-5p | chr3:132034941-132034948 | 8mer-1a | chr3:132034939-132034959 | 160.00 | -27.70 |
| ROSMAP | ENST00000512055 | 132034567 | 132035442 | hsa-miR-3065-3p | chr3:132034756-132034763 | 8mer-1a | chr3:132034756-132034777 | 160.00 | -21.36 |
| ROSMAP | ENST00000512055 | 132034567 | 132035442 | hsa-miR-1909-5p | chr3:132035326-132035333 | 8mer-1a | chr3:132035316-132035337 | 151.00 | -18.91 |
| ROSMAP | ENST00000512055 | 132034567 | 132035442 | hsa-miR-5589-5p | chr3:132035026-132035033 | 8mer-1a | chr3:132035015-132035038 | 150.00 | -31.20 |
| ROSMAP | ENST00000512055 | 132034567 | 132035442 | hsa-miR-498-3p | chr3:132035355-132035362 | 8mer-1a | chr3:132035351-132035371 | 154.00 | -13.82 |
| ROSMAP | ENST00000512055 | 132034567 | 132035442 | hsa-miR-6803-3p | chr3:132034918-132034925 | 8mer-1a | chr3:132034900-132034925 | 159.00 | -33.02 |
| ROSMAP | ENST00000512055 | 132034567 | 132035442 | hsa-miR-3127-3p | chr3:132034952-132034959 | 8mer-1a | chr3:132034939-132034959 | 160.00 | -27.70 |
| ROSMAP | ENST00000512055 | 132034567 | 132035442 | hsa-miR-6513-3p | chr3:132035224-132035231 | 8mer-1a | chr3:132035222-132035244 | 161.00 | -14.89 |
| ROSMAP | ENST00000512055 | 132034567 | 132035442 | hsa-miR-130b-5p | chr3:132034946-132034953 | 8mer-1a | chr3:132034939-132034959 | 160.00 | -27.70 |
| ROSMAP | ENST00000512055 | 132034567 | 132035442 | hsa-miR-6817-3p | chr3:132034992-132034999 | 8mer-1a | chr3:132034971-132035000 | 151.00 | -24.43 |
| ROSMAP | ENST00000512055 | 132034567 | 132035442 | hsa-miR-3667-3p | chr3:132034925-132034932 | 8mer-1a | chr3:132034923-132034943 | 170.00 | -27.33 |
| ROSMAP | ENST00000512055 | 132034567 | 132035442 | hsa-miR-6823-5p | chr3:132034787-132034794 | 8mer-1a | chr3:132034772-132034794 | 150.00 | -27.07 |
| ROSMAP | ENST00000512055 | 132034567 | 132035442 | hsa-miR-551b-5p | chr3:132035228-132035235 | 8mer-1a | chr3:132035222-132035244 | 161.00 | -14.89 |
| ROSMAP | ENST00000512055 | 132034567 | 132035442 | hsa-miR-7977 | chr3:132034747-132034754 | 8mer-1a | chr3:132034737-132034754 | 145.00 | -17.96 |
| ROSMAP | ENST00000512055 | 132034567 | 132035442 | hsa-miR-4468 | chr3:132035188-132035195 | 8mer-1a | chr3:132035182-132035201 | 169.00 | -23.72 |
| ROSMAP | ENST00000512055 | 132034567 | 132035442 | hsa-miR-3674 | chr3:132035412-132035419 | 8mer-1a | chr3:132035405-132035428 | 164.00 | -18.23 |
| ROSMAP | ENST00000512055 | 132034567 | 132035442 | hsa-miR-5708 | chr3:132035202-132035209 | 8mer-1a | chr3:132035193-132035217 | 153.00 | -24.49 |
| ROSMAP | ENST00000512055 | 132034567 | 132035442 | hsa-miR-6852-5p | chr3:132034628-132034635 | 8mer-1a | chr3:132034623-132034642 | 156.00 | -23.59 |
| ROSMAP | ENST00000512055 | 132034567 | 132035442 | hsa-miR-4767 | chr3:132035170-132035177 | 8mer-1a | chr3:132035160-132035179 | 168.00 | -39.53 |
Top |
SNVs in the skipped exons for CPNE4 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
Top |
AD stage-associated exon skippint events for CPNE4 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
Top |
Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CPNE4 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
Top |
Correlation with RNA binding proteins (RBPs) for CPNE4 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
Top |
RelatedDrugs for CPNE4 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for CPNE4 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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