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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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3'-UTR located exon skipping events lost miRNA binding sites

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SNVs in the skipped exons with depth of coverage

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AD stage-associated exon skipping events

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Correlation with RNA binding proteins (RBPs)

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Related drugs with this gene

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Related diseases with this gene

Gene summary for ICA1L

check button Gene summary
Gene informationGene symbol

ICA1L

Gene ID

130026

Gene nameislet cell autoantigen 1 like
SynonymsALS2CR14|ALS2CR15
Cytomap

2q33.2

Type of geneprotein-coding
Descriptionislet cell autoantigen 1-like proteinIca69-related proteinamyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 14amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 15amyotrophic lateral sclerosis 2 chromosomal r
Modification date20200313
UniProtAcc

C9J0T2,

C9J101,

C9J1M7,

C9J5Z0,

C9J9Z8,

C9JAQ4,

C9JDK6,

C9JDM8,

C9JEN4,

C9JEP0,

C9JP49,

C9JRB6,

F8WBK1,

F8WBQ1,

Q8NDH6,

Q96Q33,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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Gene structures and expression levels for ICA1L

check buttonSkipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

ENSG00000163596
check button Differentially expressed gene analysis across multiple brain tissues between AD and control.
Tissue typeDEG directionBase mean exp.log2FC(AD/control)P-valueAdj. p-value

check button Differentially expressed isoform analysis across multiple brain tissues between AD and control.
gencode gene structure
Tissue typeDEG directionENSTTranscript info.Base mean exp.log2FC(AD/control)P-valueAdjc. p-value
CBUPENST00000418208.5ICA1L-206:protein_coding:ICA1L9.509261e+001.228953e+002.115349e-101.188480e-08

check button Landscape of isoform expressions across multiple brain tissues between AD and control.
gencode gene structure

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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ICA1L

check button Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).
boxplot

check button All exon skipping events in AD cohorts.
Exon skip IDchrExons involved in exon skippingSkipped exon
exon_skip_111589chr2202815911:202816009:202817418:202817543:202819701:202819899202817418:202817543
exon_skip_12326chr2202819887:202819899:202821358:202821481:202825695:202825748202821358:202821481
exon_skip_135767chr2202819887:202819899:202821358:202821481:202825695:202825746202821358:202821481
exon_skip_164463chr2202821427:202821481:202825695:202825767:202828848:202829016202825695:202825767
exon_skip_165966chr2202788990:202789087:202796890:202796964:202811746:202811789202796890:202796964
exon_skip_167707chr2202828848:202829016:202870530:202870656:202871619:202871985202870530:202870656
exon_skip_168032chr2202869536:202869605:202870530:202870656:202871619:202871735202870530:202870656
exon_skip_173948chr2202779070:202779648:202785918:202786007:202788830:202789087202785918:202786007
exon_skip_178854chr2202869536:202869605:202870530:202870656:202871619:202871642202870530:202870656
exon_skip_185000chr2202869536:202869605:202870530:202870656:202870930:202871046202870530:202870656
exon_skip_192190chr2202828848:202829016:202860147:202860244:202869536:202869605202860147:202860244
exon_skip_254637chr2202785918:202786007:202788830:202789087:202796890:202796964202788830:202789087
exon_skip_258933chr2202828848:202829016:202869536:202869605:202871619:202871985202869536:202869605
exon_skip_275178chr2202828848:202829016:202869536:202869605:202870530:202870656202869536:202869605
exon_skip_4220chr2202821427:202821481:202825695:202825748:202828848:202829016202825695:202825748
exon_skip_44678chr2202796890:202796964:202811746:202811789:202814702:202814784202811746:202811789
exon_skip_45327chr2202869536:202869605:202870530:202870656:202871191:202871246202870530:202870656
exon_skip_47783chr2202811746:202811789:202814702:202814784:202815911:202816009202814702:202814784
exon_skip_90318chr2202828848:202829016:202870530:202870656:202870930:202871046202870530:202870656

check button Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.
psi tcga
Exon skipping informationTissue typeAvg(PSIs) in ADAvg(PSIs) in controlDifference (PSI)Adj. p-value
exon_skip_135767Mayo_CB7.502597e-018.820000e-01-1.317403e-011.178869e-08


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Open reading frame (ORF) annotation in the exon skipping event for ICA1L

check button Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000003922372028705302028706563UTR-3UTR
ENST00000358299202811746202811789Frame-shift
ENST00000392237202811746202811789Frame-shift
ENST00000617388202811746202811789Frame-shift
ENST00000358299202821358202821481Frame-shift
ENST00000392237202821358202821481Frame-shift
ENST00000617388202821358202821481Frame-shift
ENST00000358299202825695202825767Frame-shift
ENST00000392237202825695202825767Frame-shift
ENST00000617388202825695202825767Frame-shift
ENST00000358299202785918202786007In-frame
ENST00000392237202785918202786007In-frame
ENST00000617388202785918202786007In-frame
ENST00000358299202788830202789087In-frame
ENST00000392237202788830202789087In-frame
ENST00000617388202788830202789087In-frame
ENST00000358299202796890202796964In-frame
ENST00000392237202796890202796964In-frame
ENST00000617388202796890202796964In-frame
ENST00000358299202817418202817543In-frame
ENST00000392237202817418202817543In-frame
ENST00000617388202817418202817543In-frame

check button Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000003922372028705302028706563UTR-3UTR
ENST00000358299202811746202811789Frame-shift
ENST00000392237202811746202811789Frame-shift
ENST00000617388202811746202811789Frame-shift
ENST00000358299202821358202821481Frame-shift
ENST00000392237202821358202821481Frame-shift
ENST00000617388202821358202821481Frame-shift
ENST00000358299202825695202825767Frame-shift
ENST00000392237202825695202825767Frame-shift
ENST00000617388202825695202825767Frame-shift
ENST00000358299202785918202786007In-frame
ENST00000392237202785918202786007In-frame
ENST00000617388202785918202786007In-frame
ENST00000358299202788830202789087In-frame
ENST00000392237202788830202789087In-frame
ENST00000617388202788830202789087In-frame
ENST00000358299202796890202796964In-frame
ENST00000392237202796890202796964In-frame
ENST00000617388202796890202796964In-frame

check button Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000003922372028705302028706563UTR-3UTR
ENST00000358299202811746202811789Frame-shift
ENST00000392237202811746202811789Frame-shift
ENST00000617388202811746202811789Frame-shift
ENST00000358299202814702202814784Frame-shift
ENST00000392237202814702202814784Frame-shift
ENST00000617388202814702202814784Frame-shift
ENST00000358299202821358202821481Frame-shift
ENST00000392237202821358202821481Frame-shift
ENST00000617388202821358202821481Frame-shift
ENST00000358299202825695202825767Frame-shift
ENST00000392237202825695202825767Frame-shift
ENST00000617388202825695202825767Frame-shift
ENST00000358299202785918202786007In-frame
ENST00000392237202785918202786007In-frame
ENST00000617388202785918202786007In-frame
ENST00000358299202788830202789087In-frame
ENST00000392237202788830202789087In-frame
ENST00000617388202788830202789087In-frame
ENST00000358299202796890202796964In-frame
ENST00000392237202796890202796964In-frame
ENST00000617388202796890202796964In-frame

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Infer the effects of exon skipping event on protein functional features for ICA1L

p-ENSG00000163596_img4.png
boxplot

check button Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST0000035829934744822028174182028175439331057186227
ENST000003922375190482202817418202817543717841186227
ENST0000061738881684822028174182028175438781002186227
ENST00000358299347448220279689020279696412851358303328
ENST00000392237519048220279689020279696410691142303328
ENST00000617388816848220279689020279696412301303303328
ENST00000358299347448220278883020278908713601616328414
ENST00000392237519048220278883020278908711441400328414
ENST00000617388816848220278883020278908713051561328414
ENST00000358299347448220278591820278600716181706414444
ENST00000392237519048220278591820278600714021490414444
ENST00000617388816848220278591820278600715631651414444

check button Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST00000358299347448220279689020279696412851358303328
ENST00000392237519048220279689020279696410691142303328
ENST00000617388816848220279689020279696412301303303328
ENST00000358299347448220278883020278908713601616328414
ENST00000392237519048220278883020278908711441400328414
ENST00000617388816848220278883020278908713051561328414
ENST00000358299347448220278591820278600716181706414444
ENST00000392237519048220278591820278600714021490414444
ENST00000617388816848220278591820278600715631651414444

check button Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST00000358299347448220279689020279696412851358303328
ENST00000392237519048220279689020279696410691142303328
ENST00000617388816848220279689020279696412301303303328
ENST00000358299347448220278883020278908713601616328414
ENST00000392237519048220278883020278908711441400328414
ENST00000617388816848220278883020278908713051561328414
ENST00000358299347448220278591820278600716181706414444
ENST00000392237519048220278591820278600714021490414444
ENST00000617388816848220278591820278600715631651414444

check button Lost protein functional features of individual exon skipping events in ROSMAP.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
Q8NDH6186227188482Alternative sequenceID=VSP_017107;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q8NDH6186227188482Alternative sequenceID=VSP_017107;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q8NDH6186227188482Alternative sequenceID=VSP_017107;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q8NDH61862271482ChainID=PRO_0000076175;Note=Islet cell autoantigen 1-like protein
Q8NDH61862271482ChainID=PRO_0000076175;Note=Islet cell autoantigen 1-like protein
Q8NDH61862271482ChainID=PRO_0000076175;Note=Islet cell autoantigen 1-like protein
Q8NDH618622744247DomainNote=AH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00294
Q8NDH618622744247DomainNote=AH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00294
Q8NDH618622744247DomainNote=AH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00294
Q8NDH6303328188482Alternative sequenceID=VSP_017107;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q8NDH6303328188482Alternative sequenceID=VSP_017107;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q8NDH6303328188482Alternative sequenceID=VSP_017107;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q8NDH63033281482ChainID=PRO_0000076175;Note=Islet cell autoantigen 1-like protein
Q8NDH63033281482ChainID=PRO_0000076175;Note=Islet cell autoantigen 1-like protein
Q8NDH63033281482ChainID=PRO_0000076175;Note=Islet cell autoantigen 1-like protein
Q8NDH6328414188482Alternative sequenceID=VSP_017107;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q8NDH6328414188482Alternative sequenceID=VSP_017107;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q8NDH6328414188482Alternative sequenceID=VSP_017107;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q8NDH63284141482ChainID=PRO_0000076175;Note=Islet cell autoantigen 1-like protein
Q8NDH63284141482ChainID=PRO_0000076175;Note=Islet cell autoantigen 1-like protein
Q8NDH63284141482ChainID=PRO_0000076175;Note=Islet cell autoantigen 1-like protein
Q8NDH6328414334334Sequence conflictNote=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NDH6328414334334Sequence conflictNote=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NDH6328414334334Sequence conflictNote=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NDH6414444188482Alternative sequenceID=VSP_017107;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q8NDH6414444188482Alternative sequenceID=VSP_017107;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q8NDH6414444188482Alternative sequenceID=VSP_017107;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q8NDH64144441482ChainID=PRO_0000076175;Note=Islet cell autoantigen 1-like protein
Q8NDH64144441482ChainID=PRO_0000076175;Note=Islet cell autoantigen 1-like protein
Q8NDH64144441482ChainID=PRO_0000076175;Note=Islet cell autoantigen 1-like protein

check button Lost protein functional features of individual exon skipping events in MSBB.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
Q8NDH6303328188482Alternative sequenceID=VSP_017107;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q8NDH6303328188482Alternative sequenceID=VSP_017107;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q8NDH6303328188482Alternative sequenceID=VSP_017107;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q8NDH63033281482ChainID=PRO_0000076175;Note=Islet cell autoantigen 1-like protein
Q8NDH63033281482ChainID=PRO_0000076175;Note=Islet cell autoantigen 1-like protein
Q8NDH63033281482ChainID=PRO_0000076175;Note=Islet cell autoantigen 1-like protein
Q8NDH6328414188482Alternative sequenceID=VSP_017107;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q8NDH6328414188482Alternative sequenceID=VSP_017107;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q8NDH6328414188482Alternative sequenceID=VSP_017107;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q8NDH63284141482ChainID=PRO_0000076175;Note=Islet cell autoantigen 1-like protein
Q8NDH63284141482ChainID=PRO_0000076175;Note=Islet cell autoantigen 1-like protein
Q8NDH63284141482ChainID=PRO_0000076175;Note=Islet cell autoantigen 1-like protein
Q8NDH6328414334334Sequence conflictNote=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NDH6328414334334Sequence conflictNote=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NDH6328414334334Sequence conflictNote=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NDH6414444188482Alternative sequenceID=VSP_017107;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q8NDH6414444188482Alternative sequenceID=VSP_017107;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q8NDH6414444188482Alternative sequenceID=VSP_017107;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q8NDH64144441482ChainID=PRO_0000076175;Note=Islet cell autoantigen 1-like protein
Q8NDH64144441482ChainID=PRO_0000076175;Note=Islet cell autoantigen 1-like protein
Q8NDH64144441482ChainID=PRO_0000076175;Note=Islet cell autoantigen 1-like protein

check button Lost protein functional features of individual exon skipping events in Mayo.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
Q8NDH6303328188482Alternative sequenceID=VSP_017107;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q8NDH6303328188482Alternative sequenceID=VSP_017107;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q8NDH6303328188482Alternative sequenceID=VSP_017107;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q8NDH63033281482ChainID=PRO_0000076175;Note=Islet cell autoantigen 1-like protein
Q8NDH63033281482ChainID=PRO_0000076175;Note=Islet cell autoantigen 1-like protein
Q8NDH63033281482ChainID=PRO_0000076175;Note=Islet cell autoantigen 1-like protein
Q8NDH6328414188482Alternative sequenceID=VSP_017107;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q8NDH6328414188482Alternative sequenceID=VSP_017107;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q8NDH6328414188482Alternative sequenceID=VSP_017107;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q8NDH63284141482ChainID=PRO_0000076175;Note=Islet cell autoantigen 1-like protein
Q8NDH63284141482ChainID=PRO_0000076175;Note=Islet cell autoantigen 1-like protein
Q8NDH63284141482ChainID=PRO_0000076175;Note=Islet cell autoantigen 1-like protein
Q8NDH6328414334334Sequence conflictNote=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NDH6328414334334Sequence conflictNote=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NDH6328414334334Sequence conflictNote=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NDH6414444188482Alternative sequenceID=VSP_017107;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q8NDH6414444188482Alternative sequenceID=VSP_017107;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q8NDH6414444188482Alternative sequenceID=VSP_017107;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q8NDH64144441482ChainID=PRO_0000076175;Note=Islet cell autoantigen 1-like protein
Q8NDH64144441482ChainID=PRO_0000076175;Note=Islet cell autoantigen 1-like protein
Q8NDH64144441482ChainID=PRO_0000076175;Note=Islet cell autoantigen 1-like protein


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3'-UTR located exon skipping events that lost miRNA binding sites in ICA1L

check button 3'-UTR exon skipping evnets lost miRNA binding.
Tissue typeENSTExon skip startExon skip endmicroRNABinding site by TargetScanBinding type by TargetScanBdinding site by miRandaScore of miRandaEnergy by miRanda
MayoENST00000392237202870530202870656hsa-miR-16-1-3pchr2:202870608-2028706158mer-1achr2:202870594-202870615145.00-9.19
MayoENST00000392237202870530202870656hsa-miR-193b-3pchr2:202870549-2028705568mer-1achr2:202870532-202870556150.00-19.89
MayoENST00000392237202870530202870656hsa-miR-193a-3pchr2:202870549-2028705568mer-1achr2:202870532-202870556150.00-19.89
MayoENST00000392237202870530202870656hsa-miR-449b-3pchr2:202870593-2028706008mer-1achr2:202870582-202870606151.00-18.09
MSBBENST00000392237202870530202870656hsa-miR-16-1-3pchr2:202870608-2028706158mer-1achr2:202870594-202870615145.00-9.19
MSBBENST00000392237202870530202870656hsa-miR-193b-3pchr2:202870549-2028705568mer-1achr2:202870532-202870556150.00-19.89
MSBBENST00000392237202870530202870656hsa-miR-193a-3pchr2:202870549-2028705568mer-1achr2:202870532-202870556150.00-19.89
MSBBENST00000392237202870530202870656hsa-miR-449b-3pchr2:202870593-2028706008mer-1achr2:202870582-202870606151.00-18.09
ROSMAPENST00000392237202870530202870656hsa-miR-16-1-3pchr2:202870608-2028706158mer-1achr2:202870594-202870615145.00-9.19
ROSMAPENST00000392237202870530202870656hsa-miR-193b-3pchr2:202870549-2028705568mer-1achr2:202870532-202870556150.00-19.89
ROSMAPENST00000392237202870530202870656hsa-miR-193a-3pchr2:202870549-2028705568mer-1achr2:202870532-202870556150.00-19.89
ROSMAPENST00000392237202870530202870656hsa-miR-449b-3pchr2:202870593-2028706008mer-1achr2:202870582-202870606151.00-18.09

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SNVs in the skipped exons for ICA1L

check button - Differential PSIs between mutated versus non-mutated samples.

check button - Depth of Coverage in the skipped exon of the mutated samples.

check button - Sashimi plot in the skipped exon of the mutated samples.

check button - Non-synonymous mutations located in the skipped exons.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange

check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange

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AD stage-associated exon skippint events for ICA1L

check button Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).
AD stage infoCohortTissueSE idCoefficient P-valueChromosomeStrandE1 startE1 endSkipped startSkipped endE2 startE2 end

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ICA1L

check button sQTL information located at the skipped exons.
Tissue typeExon skip IDSNP idLocationP-valueFDR
PCCexon_skip_12326rs6725887chr2:2028811625.498480e-051.077109e-02

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Correlation with RNA binding proteins (RBPs) for ICA1L

check button Correlated RBP and related information.
Tissue typeRBP nameExon skip IDCorrelation coeifficientP-value
CBTRA2Aexon_skip_165966-4.578887e-012.665167e-09
CBZNF638exon_skip_135767-4.246292e-013.885891e-07
CBSAMD4Aexon_skip_135767-4.803966e-015.564544e-09
CBTRA2Aexon_skip_135767-4.684077e-011.479589e-08
CBFUBP1exon_skip_135767-4.397657e-011.321663e-07
IFGTRA2Aexon_skip_165966-4.177122e-012.698156e-02
IFGPABPC4exon_skip_165966-4.130250e-012.892793e-02

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RelatedDrugs for ICA1L

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
UniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ICA1L

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource