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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for CNTNAP5 |
 Gene summary |
| Gene information | Gene symbol | CNTNAP5 | Gene ID | 129684 |
| Gene name | contactin associated protein family member 5 | |
| Synonyms | caspr5 | |
| Cytomap | 2q14.3 | |
| Type of gene | protein-coding | |
| Description | contactin-associated protein-like 5cell recognition molecule Caspr5contactin associated protein like 5 | |
| Modification date | 20200313 | |
| UniProtAcc | Q8WYK1, | |
| Context | - 29090003(Structure and function of the contactin-associated protein family in myelinated axons and their relationship with nerve diseases) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for CNTNAP5 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000155052
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CNTNAP5 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_104843 | chr2 | 124025287:124025732:124221705:124221809:124242200:124242393 | 124221705:124221809 |
| exon_skip_158832 | chr2 | 124772799:124773017:124789902:124790141:124798096:124798320 | 124789902:124790141 |
| exon_skip_2371 | chr2 | 124789902:124790141:124798096:124798320:124865306:124865436 | 124798096:124798320 |
| exon_skip_38545 | chr2 | 124524303:124524452:124527285:124527456:124563217:124563323 | 124527285:124527456 |
| exon_skip_65781 | chr2 | 124446753:124446937:124474739:124474879:124504292:124504556 | 124474739:124474879 |
| exon_skip_82087 | chr2 | 124609801:124609920:124647758:124647958:124747229:124747385 | 124647758:124647958 |
| exon_skip_8516 | chr2 | 124647758:124647958:124747229:124747385:124763672:124763799 | 124747229:124747385 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for CNTNAP5 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000431078 | 124527285 | 124527456 | Frame-shift |
| ENST00000431078 | 124747229 | 124747385 | Frame-shift |
| ENST00000431078 | 124221705 | 124221809 | In-frame |
| ENST00000431078 | 124474739 | 124474879 | In-frame |
| ENST00000431078 | 124647758 | 124647958 | In-frame |
| ENST00000431078 | 124789902 | 124790141 | In-frame |
| ENST00000431078 | 124798096 | 124798320 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000431078 | 124527285 | 124527456 | Frame-shift |
| ENST00000431078 | 124747229 | 124747385 | Frame-shift |
| ENST00000431078 | 124221705 | 124221809 | In-frame |
| ENST00000431078 | 124647758 | 124647958 | In-frame |
| ENST00000431078 | 124789902 | 124790141 | In-frame |
| ENST00000431078 | 124798096 | 124798320 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000431078 | 124527285 | 124527456 | Frame-shift |
| ENST00000431078 | 124221705 | 124221809 | In-frame |
| ENST00000431078 | 124647758 | 124647958 | In-frame |
| ENST00000431078 | 124789902 | 124790141 | In-frame |
| ENST00000431078 | 124798096 | 124798320 | In-frame |
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Infer the effects of exon skipping event on protein functional features for CNTNAP5 |
p-ENSG00000155052_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000431078 | 5301 | 1306 | 124221705 | 124221809 | 448 | 551 | 28 | 62 |
| ENST00000431078 | 5301 | 1306 | 124474739 | 124474879 | 1284 | 1423 | 306 | 353 |
| ENST00000431078 | 5301 | 1306 | 124647758 | 124647958 | 2239 | 2438 | 625 | 691 |
| ENST00000431078 | 5301 | 1306 | 124789902 | 124790141 | 3115 | 3353 | 917 | 996 |
| ENST00000431078 | 5301 | 1306 | 124798096 | 124798320 | 3355 | 3578 | 997 | 1071 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000431078 | 5301 | 1306 | 124221705 | 124221809 | 448 | 551 | 28 | 62 |
| ENST00000431078 | 5301 | 1306 | 124647758 | 124647958 | 2239 | 2438 | 625 | 691 |
| ENST00000431078 | 5301 | 1306 | 124789902 | 124790141 | 3115 | 3353 | 917 | 996 |
| ENST00000431078 | 5301 | 1306 | 124798096 | 124798320 | 3355 | 3578 | 997 | 1071 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000431078 | 5301 | 1306 | 124221705 | 124221809 | 448 | 551 | 28 | 62 |
| ENST00000431078 | 5301 | 1306 | 124647758 | 124647958 | 2239 | 2438 | 625 | 691 |
| ENST00000431078 | 5301 | 1306 | 124789902 | 124790141 | 3115 | 3353 | 917 | 996 |
| ENST00000431078 | 5301 | 1306 | 124798096 | 124798320 | 3355 | 3578 | 997 | 1071 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8WYK1 | 28 | 62 | 25 | 1306 | Chain | ID=PRO_0000317377;Note=Contactin-associated protein-like 5 |
| Q8WYK1 | 28 | 62 | 44 | 47 | Compositional bias | Note=Poly-Ser |
| Q8WYK1 | 28 | 62 | 30 | 174 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q8WYK1 | 28 | 62 | 30 | 174 | Domain | Note=F5/8 type C;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00081 |
| Q8WYK1 | 28 | 62 | 25 | 1237 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8WYK1 | 306 | 353 | 25 | 1306 | Chain | ID=PRO_0000317377;Note=Contactin-associated protein-like 5 |
| Q8WYK1 | 306 | 353 | 329 | 360 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q8WYK1 | 306 | 353 | 180 | 360 | Domain | Note=Laminin G-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00122 |
| Q8WYK1 | 306 | 353 | 353 | 353 | Sequence conflict | Note=T->TV;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q8WYK1 | 306 | 353 | 25 | 1237 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8WYK1 | 625 | 691 | 25 | 1306 | Chain | ID=PRO_0000317377;Note=Contactin-associated protein-like 5 |
| Q8WYK1 | 625 | 691 | 584 | 790 | Domain | Note=Fibrinogen C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00739 |
| Q8WYK1 | 625 | 691 | 25 | 1237 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8WYK1 | 917 | 996 | 25 | 1306 | Chain | ID=PRO_0000317377;Note=Contactin-associated protein-like 5 |
| Q8WYK1 | 917 | 996 | 929 | 956 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q8WYK1 | 917 | 996 | 960 | 973 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q8WYK1 | 917 | 996 | 967 | 982 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q8WYK1 | 917 | 996 | 984 | 994 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q8WYK1 | 917 | 996 | 791 | 956 | Domain | Note=Laminin G-like 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00122 |
| Q8WYK1 | 917 | 996 | 957 | 995 | Domain | Note=EGF-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 |
| Q8WYK1 | 917 | 996 | 957 | 962 | Sequence conflict | Note=PGHCSS->SIKKLK;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q8WYK1 | 917 | 996 | 25 | 1237 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8WYK1 | 997 | 1071 | 25 | 1306 | Chain | ID=PRO_0000317377;Note=Contactin-associated protein-like 5 |
| Q8WYK1 | 997 | 1071 | 1013 | 1199 | Domain | Note=Laminin G-like 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00122 |
| Q8WYK1 | 997 | 1071 | 25 | 1237 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8WYK1 | 28 | 62 | 25 | 1306 | Chain | ID=PRO_0000317377;Note=Contactin-associated protein-like 5 |
| Q8WYK1 | 28 | 62 | 44 | 47 | Compositional bias | Note=Poly-Ser |
| Q8WYK1 | 28 | 62 | 30 | 174 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q8WYK1 | 28 | 62 | 30 | 174 | Domain | Note=F5/8 type C;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00081 |
| Q8WYK1 | 28 | 62 | 25 | 1237 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8WYK1 | 625 | 691 | 25 | 1306 | Chain | ID=PRO_0000317377;Note=Contactin-associated protein-like 5 |
| Q8WYK1 | 625 | 691 | 584 | 790 | Domain | Note=Fibrinogen C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00739 |
| Q8WYK1 | 625 | 691 | 25 | 1237 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8WYK1 | 917 | 996 | 25 | 1306 | Chain | ID=PRO_0000317377;Note=Contactin-associated protein-like 5 |
| Q8WYK1 | 917 | 996 | 929 | 956 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q8WYK1 | 917 | 996 | 960 | 973 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q8WYK1 | 917 | 996 | 967 | 982 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q8WYK1 | 917 | 996 | 984 | 994 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q8WYK1 | 917 | 996 | 791 | 956 | Domain | Note=Laminin G-like 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00122 |
| Q8WYK1 | 917 | 996 | 957 | 995 | Domain | Note=EGF-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 |
| Q8WYK1 | 917 | 996 | 957 | 962 | Sequence conflict | Note=PGHCSS->SIKKLK;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q8WYK1 | 917 | 996 | 25 | 1237 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8WYK1 | 997 | 1071 | 25 | 1306 | Chain | ID=PRO_0000317377;Note=Contactin-associated protein-like 5 |
| Q8WYK1 | 997 | 1071 | 1013 | 1199 | Domain | Note=Laminin G-like 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00122 |
| Q8WYK1 | 997 | 1071 | 25 | 1237 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8WYK1 | 28 | 62 | 25 | 1306 | Chain | ID=PRO_0000317377;Note=Contactin-associated protein-like 5 |
| Q8WYK1 | 28 | 62 | 44 | 47 | Compositional bias | Note=Poly-Ser |
| Q8WYK1 | 28 | 62 | 30 | 174 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q8WYK1 | 28 | 62 | 30 | 174 | Domain | Note=F5/8 type C;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00081 |
| Q8WYK1 | 28 | 62 | 25 | 1237 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8WYK1 | 625 | 691 | 25 | 1306 | Chain | ID=PRO_0000317377;Note=Contactin-associated protein-like 5 |
| Q8WYK1 | 625 | 691 | 584 | 790 | Domain | Note=Fibrinogen C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00739 |
| Q8WYK1 | 625 | 691 | 25 | 1237 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8WYK1 | 917 | 996 | 25 | 1306 | Chain | ID=PRO_0000317377;Note=Contactin-associated protein-like 5 |
| Q8WYK1 | 917 | 996 | 929 | 956 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q8WYK1 | 917 | 996 | 960 | 973 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q8WYK1 | 917 | 996 | 967 | 982 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q8WYK1 | 917 | 996 | 984 | 994 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q8WYK1 | 917 | 996 | 791 | 956 | Domain | Note=Laminin G-like 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00122 |
| Q8WYK1 | 917 | 996 | 957 | 995 | Domain | Note=EGF-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 |
| Q8WYK1 | 917 | 996 | 957 | 962 | Sequence conflict | Note=PGHCSS->SIKKLK;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q8WYK1 | 917 | 996 | 25 | 1237 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8WYK1 | 997 | 1071 | 25 | 1306 | Chain | ID=PRO_0000317377;Note=Contactin-associated protein-like 5 |
| Q8WYK1 | 997 | 1071 | 1013 | 1199 | Domain | Note=Laminin G-like 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00122 |
| Q8WYK1 | 997 | 1071 | 25 | 1237 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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3'-UTR located exon skipping events that lost miRNA binding sites in CNTNAP5 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for CNTNAP5 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for CNTNAP5 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CNTNAP5 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for CNTNAP5 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for CNTNAP5 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CNTNAP5 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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