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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for TATDN3 |
 Gene summary |
| Gene information | Gene symbol | TATDN3 | Gene ID | 128387 |
| Gene name | TatD DNase domain containing 3 | |
| Synonyms | - | |
| Cytomap | 1q32.3 | |
| Type of gene | protein-coding | |
| Description | putative deoxyribonuclease TATDN3 | |
| Modification date | 20200313 | |
| UniProtAcc | E9PP81, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for TATDN3 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000203705
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | DOWN | ENST00000525574.5 | TATDN3-206:nonsense_mediated_decay:TATDN3 | 6.103406e+01 | -9.094107e-01 | 7.253033e-03 | 2.671343e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TATDN3 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_114573 | chr1 | 212807747:212807848:212812251:212812328:212815013:212815175 | 212812251:212812328 |
| exon_skip_125492 | chr1 | 212804619:212804651:212807736:212807848:212812227:212812328 | 212807736:212807848 |
| exon_skip_129762 | chr1 | 212796517:212796590:212797112:212797196:212804320:212804429 | 212797112:212797196 |
| exon_skip_131889 | chr1 | 212807747:212807848:212812227:212812328:212815013:212815175 | 212812227:212812328 |
| exon_skip_142888 | chr1 | 212807736:212807848:212812227:212812328:212815047:212815597 | 212812227:212812328 |
| exon_skip_14433 | chr1 | 212804619:212804651:212807736:212807848:212812248:212812282 | 212807736:212807848 |
| exon_skip_175238 | chr1 | 212796517:212796590:212797112:212797196:212802701:212802751 | 212797112:212797196 |
| exon_skip_187646 | chr1 | 212804320:212804429:212804596:212804651:212807736:212807848 | 212804596:212804651 |
| exon_skip_203731 | chr1 | 212807736:212807848:212812251:212812328:212815013:212815175 | 212812251:212812328 |
| exon_skip_242677 | chr1 | 212796517:212796590:212802701:212802763:212804320:212804429 | 212802701:212802763 |
| exon_skip_250571 | chr1 | 212804330:212804429:212804596:212804651:212807736:212807848 | 212804596:212804651 |
| exon_skip_291382 | chr1 | 212807736:212807848:212812227:212812328:212815013:212815175 | 212812227:212812328 |
| exon_skip_53162 | chr1 | 212807736:212807848:212812248:212812328:212815013:212815175 | 212812248:212812328 |
| exon_skip_6152 | chr1 | 212804619:212804651:212807736:212807848:212812251:212812328 | 212807736:212807848 |
| exon_skip_70595 | chr1 | 212802701:212802763:212804320:212804429:212804596:212804651 | 212804320:212804429 |
| exon_skip_81063 | chr1 | 212804596:212804651:212807736:212807848:212812251:212812328 | 212807736:212807848 |
| exon_skip_89549 | chr1 | 212797112:212797196:212802701:212802763:212804320:212804429 | 212802701:212802763 |
| exon_skip_95336 | chr1 | 212797112:212797196:212807736:212807848:212812248:212812282 | 212807736:212807848 |
| exon_skip_99720 | chr1 | 212807747:212807848:212812248:212812328:212815013:212815175 | 212812248:212812328 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for TATDN3 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000366974 | 212797112 | 212797196 | Frame-shift |
| ENST00000366974 | 212804320 | 212804429 | Frame-shift |
| ENST00000366974 | 212804596 | 212804651 | Frame-shift |
| ENST00000366974 | 212807736 | 212807848 | Frame-shift |
| ENST00000366974 | 212802701 | 212802763 | In-frame |
| ENST00000366974 | 212812248 | 212812328 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000366974 | 212797112 | 212797196 | Frame-shift |
| ENST00000366974 | 212804320 | 212804429 | Frame-shift |
| ENST00000366974 | 212804596 | 212804651 | Frame-shift |
| ENST00000366974 | 212807736 | 212807848 | Frame-shift |
| ENST00000366974 | 212802701 | 212802763 | In-frame |
| ENST00000366974 | 212812248 | 212812328 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000366974 | 212797112 | 212797196 | Frame-shift |
| ENST00000366974 | 212804320 | 212804429 | Frame-shift |
| ENST00000366974 | 212804596 | 212804651 | Frame-shift |
| ENST00000366974 | 212807736 | 212807848 | Frame-shift |
| ENST00000366974 | 212802701 | 212802763 | In-frame |
| ENST00000366974 | 212812248 | 212812328 | In-frame |
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Infer the effects of exon skipping event on protein functional features for TATDN3 |
p-ENSG00000203705_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000366974 | 2406 | 274 | 212802701 | 212802763 | 354 | 415 | 86 | 107 |
| ENST00000366974 | 2406 | 274 | 212812248 | 212812328 | 696 | 775 | 200 | 227 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000366974 | 2406 | 274 | 212802701 | 212802763 | 354 | 415 | 86 | 107 |
| ENST00000366974 | 2406 | 274 | 212812248 | 212812328 | 696 | 775 | 200 | 227 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000366974 | 2406 | 274 | 212802701 | 212802763 | 354 | 415 | 86 | 107 |
| ENST00000366974 | 2406 | 274 | 212812248 | 212812328 | 696 | 775 | 200 | 227 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q17R31 | 86 | 107 | 87 | 107 | Alternative sequence | ID=VSP_045263;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q17R31 | 86 | 107 | 103 | 109 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y1H |
| Q17R31 | 86 | 107 | 1 | 274 | Chain | ID=PRO_0000313595;Note=Putative deoxyribonuclease TATDN3 |
| Q17R31 | 86 | 107 | 85 | 98 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y1H |
| Q17R31 | 86 | 107 | 99 | 101 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y1H |
| Q17R31 | 86 | 107 | 107 | 107 | Metal binding | Note=Divalent metal cation 1 |
| Q17R31 | 86 | 107 | 107 | 107 | Metal binding | Note=Divalent metal cation 2 |
| Q17R31 | 86 | 107 | 86 | 86 | Sequence conflict | Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q17R31 | 200 | 227 | 200 | 200 | Alternative sequence | ID=VSP_044448;Note=In isoform 3 and isoform 5. Q->QLLSLFSK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q17R31 | 200 | 227 | 201 | 201 | Alternative sequence | ID=VSP_030048;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q17R31 | 200 | 227 | 213 | 215 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y1H |
| Q17R31 | 200 | 227 | 1 | 274 | Chain | ID=PRO_0000313595;Note=Putative deoxyribonuclease TATDN3 |
| Q17R31 | 200 | 227 | 199 | 207 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y1H |
| Q17R31 | 200 | 227 | 210 | 212 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y1H |
| Q17R31 | 200 | 227 | 218 | 218 | Metal binding | Note=Divalent metal cation 1 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q17R31 | 86 | 107 | 87 | 107 | Alternative sequence | ID=VSP_045263;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q17R31 | 86 | 107 | 103 | 109 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y1H |
| Q17R31 | 86 | 107 | 1 | 274 | Chain | ID=PRO_0000313595;Note=Putative deoxyribonuclease TATDN3 |
| Q17R31 | 86 | 107 | 85 | 98 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y1H |
| Q17R31 | 86 | 107 | 99 | 101 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y1H |
| Q17R31 | 86 | 107 | 107 | 107 | Metal binding | Note=Divalent metal cation 1 |
| Q17R31 | 86 | 107 | 107 | 107 | Metal binding | Note=Divalent metal cation 2 |
| Q17R31 | 86 | 107 | 86 | 86 | Sequence conflict | Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q17R31 | 200 | 227 | 200 | 200 | Alternative sequence | ID=VSP_044448;Note=In isoform 3 and isoform 5. Q->QLLSLFSK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q17R31 | 200 | 227 | 201 | 201 | Alternative sequence | ID=VSP_030048;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q17R31 | 200 | 227 | 213 | 215 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y1H |
| Q17R31 | 200 | 227 | 1 | 274 | Chain | ID=PRO_0000313595;Note=Putative deoxyribonuclease TATDN3 |
| Q17R31 | 200 | 227 | 199 | 207 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y1H |
| Q17R31 | 200 | 227 | 210 | 212 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y1H |
| Q17R31 | 200 | 227 | 218 | 218 | Metal binding | Note=Divalent metal cation 1 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q17R31 | 86 | 107 | 87 | 107 | Alternative sequence | ID=VSP_045263;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q17R31 | 86 | 107 | 103 | 109 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y1H |
| Q17R31 | 86 | 107 | 1 | 274 | Chain | ID=PRO_0000313595;Note=Putative deoxyribonuclease TATDN3 |
| Q17R31 | 86 | 107 | 85 | 98 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y1H |
| Q17R31 | 86 | 107 | 99 | 101 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y1H |
| Q17R31 | 86 | 107 | 107 | 107 | Metal binding | Note=Divalent metal cation 1 |
| Q17R31 | 86 | 107 | 107 | 107 | Metal binding | Note=Divalent metal cation 2 |
| Q17R31 | 86 | 107 | 86 | 86 | Sequence conflict | Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q17R31 | 200 | 227 | 200 | 200 | Alternative sequence | ID=VSP_044448;Note=In isoform 3 and isoform 5. Q->QLLSLFSK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q17R31 | 200 | 227 | 201 | 201 | Alternative sequence | ID=VSP_030048;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q17R31 | 200 | 227 | 213 | 215 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y1H |
| Q17R31 | 200 | 227 | 1 | 274 | Chain | ID=PRO_0000313595;Note=Putative deoxyribonuclease TATDN3 |
| Q17R31 | 200 | 227 | 199 | 207 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y1H |
| Q17R31 | 200 | 227 | 210 | 212 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y1H |
| Q17R31 | 200 | 227 | 218 | 218 | Metal binding | Note=Divalent metal cation 1 |
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3'-UTR located exon skipping events that lost miRNA binding sites in TATDN3 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for TATDN3 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for TATDN3 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TATDN3 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for TATDN3 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | SAMD4A | exon_skip_250571 | -5.515367e-01 | 1.485277e-13 |
| CB | TRA2A | exon_skip_250571 | -6.663577e-01 | 5.442079e-21 |
| TC | NOVA1 | exon_skip_250571 | 4.353876e-01 | 8.729138e-09 |
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RelatedDrugs for TATDN3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TATDN3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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