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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for DRAM2 |
 Gene summary |
| Gene information | Gene symbol | DRAM2 | Gene ID | 128338 |
| Gene name | DNA damage regulated autophagy modulator 2 | |
| Synonyms | CORD21|PRO180|TMEM77|WWFQ154 | |
| Cytomap | 1p13.3 | |
| Type of gene | protein-coding | |
| Description | DNA damage-regulated autophagy modulator protein 2damage regulated autophagy modulator 2transmembrane protein 77 | |
| Modification date | 20200320 | |
| UniProtAcc | Q6UX65, S4R2Z2, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| DRAM2 | GO:0010506 | regulation of autophagy | 19895784 |
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Gene structures and expression levels for DRAM2 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000156171
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000462092.5 | DRAM2-203:lncRNA:DRAM2 | 2.547711e+01 | 9.016433e-01 | 9.867437e-03 | 3.437721e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for DRAM2 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_107487 | chr1 | 111120645:111120693:111126227:111126294:111131424:111131568 | 111126227:111126294 |
| exon_skip_107810 | chr1 | 111120552:111120693:111124742:111124881:111126227:111126294 | 111124742:111124881 |
| exon_skip_114923 | chr1 | 111124742:111124881:111126227:111126294:111131424:111131567 | 111126227:111126294 |
| exon_skip_161892 | chr1 | 111131424:111131568:111137523:111137586:111140038:111140062 | 111137523:111137586 |
| exon_skip_18822 | chr1 | 111124742:111124881:111126227:111126294:111131424:111131568 | 111126227:111126294 |
| exon_skip_193390 | chr1 | 111120552:111120693:111126227:111126294:111131424:111131568 | 111126227:111126294 |
| exon_skip_197837 | chr1 | 111120516:111120693:111122616:111122643:111126227:111126294 | 111122616:111122643 |
| exon_skip_209491 | chr1 | 111137523:111137586:111139588:111139711:111140038:111140062 | 111139588:111139711 |
| exon_skip_227706 | chr1 | 111131424:111131568:111137523:111137586:111139501:111139520 | 111137523:111137586 |
| exon_skip_228248 | chr1 | 111119877:111119959:111120516:111120693:111124742:111124881 | 111120516:111120693 |
| exon_skip_231174 | chr1 | 111120670:111120693:111122616:111122643:111126227:111126294 | 111122616:111122643 |
| exon_skip_247552 | chr1 | 111120670:111120693:111124742:111124881:111126227:111126294 | 111124742:111124881 |
| exon_skip_253340 | chr1 | 111120670:111120693:111126227:111126294:111131424:111131568 | 111126227:111126294 |
| exon_skip_288400 | chr1 | 111137523:111137586:111139066:111139123:111139501:111139520 | 111139066:111139123 |
| exon_skip_294552 | chr1 | 111119877:111119959:111120516:111120693:111126227:111126294 | 111120516:111120693 |
| exon_skip_90273 | chr1 | 111137523:111137586:111139501:111139666:111140038:111140062 | 111139501:111139666 |
| exon_skip_95775 | chr1 | 111120552:111120693:111122616:111122643:111126227:111126294 | 111122616:111122643 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for DRAM2 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000539140 | 111137523 | 111137586 | 3UTR-3UTR |
| ENST00000286692 | 111120516 | 111120693 | Frame-shift |
| ENST00000539140 | 111120516 | 111120693 | Frame-shift |
| ENST00000286692 | 111124742 | 111124881 | Frame-shift |
| ENST00000539140 | 111124742 | 111124881 | Frame-shift |
| ENST00000286692 | 111126227 | 111126294 | Frame-shift |
| ENST00000539140 | 111126227 | 111126294 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000286692 | 111124742 | 111124881 | Frame-shift |
| ENST00000539140 | 111124742 | 111124881 | Frame-shift |
| ENST00000286692 | 111126227 | 111126294 | Frame-shift |
| ENST00000539140 | 111126227 | 111126294 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000539140 | 111137523 | 111137586 | 3UTR-3UTR |
| ENST00000286692 | 111124742 | 111124881 | Frame-shift |
| ENST00000539140 | 111124742 | 111124881 | Frame-shift |
| ENST00000286692 | 111126227 | 111126294 | Frame-shift |
| ENST00000539140 | 111126227 | 111126294 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for DRAM2 |
p-ENSG00000156171_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in DRAM2 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for DRAM2 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for DRAM2 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for DRAM2 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
| CB | exon_skip_90273 | rs2297703 | chr1:111188536 | 3.748003e-27 | 1.058086e-22 |
| CB | exon_skip_90273 | rs9970286 | chr1:111194776 | 8.533856e-13 | 1.320090e-09 |
| CB | exon_skip_90273 | rs11102208 | chr1:111068116 | 6.211553e-11 | 6.638093e-08 |
| TC | exon_skip_90273 | rs2297703 | chr1:111188536 | 8.999241e-21 | 6.190671e-17 |
| TC | exon_skip_90273 | rs9970286 | chr1:111194776 | 6.379824e-14 | 1.298711e-10 |
| TC | exon_skip_90273 | rs11102208 | chr1:111068116 | 1.907932e-11 | 2.162619e-08 |
| HCC | exon_skip_90273 | rs2297703 | chr1:111188536 | 2.435305e-35 | 3.353857e-31 |
| HCC | exon_skip_90273 | rs1467830 | chr1:111112300 | 1.902301e-31 | 1.571888e-27 |
| HCC | exon_skip_90273 | rs9970286 | chr1:111194776 | 1.073249e-14 | 7.075815e-12 |
| HCC | exon_skip_90273 | rs11102208 | chr1:111068116 | 6.235208e-12 | 2.671076e-09 |
| HCC | exon_skip_90273 | rs7551294 | chr1:111060588 | 8.264322e-11 | 2.926664e-08 |
| HCC | exon_skip_90273 | rs1777134 | chr1:111042757 | 9.228761e-10 | 2.767430e-07 |
| HCC | exon_skip_90273 | rs1782839 | chr1:111042526 | 4.303253e-09 | 1.135640e-06 |
| HCC | exon_skip_90273 | rs325923 | chr1:111148891 | 1.813281e-08 | 4.243226e-06 |
| HCC | exon_skip_90273 | rs325929 | chr1:111137593 | 1.375146e-07 | 2.684162e-05 |
| HCC | exon_skip_90273 | rs680025 | chr1:111162175 | 5.818880e-05 | 5.752955e-03 |
| HCC | exon_skip_90273 | rs679407 | chr1:111162301 | 5.818880e-05 | 5.752955e-03 |
| HCC | exon_skip_90273 | rs641379 | chr1:111185663 | 7.160295e-05 | 6.899396e-03 |
| HCC | exon_skip_90273 | rs325926 | chr1:111155992 | 1.411151e-04 | 1.221133e-02 |
| HCC | exon_skip_90273 | rs608881 | chr1:111188279 | 1.650512e-04 | 1.388204e-02 |
| PCC | exon_skip_90273 | rs2297703 | chr1:111188536 | 6.599233e-14 | 1.435186e-10 |
| PCC | exon_skip_90273 | rs1467830 | chr1:111112300 | 1.422903e-09 | 9.996623e-07 |
| PCC | exon_skip_90273 | rs9970286 | chr1:111194776 | 5.179481e-09 | 3.209586e-06 |
| PCC | exon_skip_90273 | rs11102208 | chr1:111068116 | 1.727251e-06 | 5.522026e-04 |
| PCC | exon_skip_90273 | rs7551294 | chr1:111060588 | 9.842552e-06 | 2.506365e-03 |
| PCC | exon_skip_90273 | rs1782839 | chr1:111042526 | 6.137230e-05 | 1.184565e-02 |
| PCC | exon_skip_90273 | rs1777134 | chr1:111042757 | 6.213344e-05 | 1.197226e-02 |
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Correlation with RNA binding proteins (RBPs) for DRAM2 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | TRA2A | exon_skip_253340 | -4.079754e-01 | 1.246924e-07 |
| CB | FUBP1 | exon_skip_253340 | -4.010390e-01 | 2.124017e-07 |
| CB | NUP42 | exon_skip_253340 | 4.687233e-01 | 6.780325e-10 |
| HCC | KHDRBS2 | exon_skip_247552 | -4.003494e-01 | 8.147465e-12 |
| HCC | PTBP1 | exon_skip_247552 | 4.655962e-01 | 6.226801e-16 |
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RelatedDrugs for DRAM2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DRAM2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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