ExonSkipAD: functional annotation of exon skipping event in human

Gene summary for MRPL55

Gene summary

Gene information	Gene symbol	MRPL55
	Gene ID	128308
	Gene name	mitochondrial ribosomal protein L55
	Synonyms	AAVG5835\|L55nt\|MRP-L55\|PRO19675
	Cytomap	1q42.13
	Type of gene	protein-coding
	Description	39S ribosomal protein L55, mitochondrialL55mtmitochondrial large ribosomal subunit protein bL31mmitochondrial large ribosomal subunit protein mL55
	Modification date	20200313
	UniProtAcc	A0A024R3U3, A0A087X2A2, A0A0A0MST4, A0A0G2JMK5, Q7Z7F7, X6R631, X6RIW1,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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Gene structures and expression levels for MRPL55

Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

ENSG00000162910

Differentially expressed gene analysis across multiple brain tissues between AD and control.

Tissue type

DEG direction

Base mean exp.

log2FC(AD/control)

P-value

Adj. p-value

Differentially expressed isoform analysis across multiple brain tissues between AD and control.

Tissue type	DEG direction	ENST	Transcript info.	Base mean exp.	log2FC(AD/control)	P-value	Adjc. p-value
CB	DOWN	ENST00000336520.8	MRPL55-203:protein_coding:MRPL55	3.153655e+01	-8.502000e-01	5.139400e-08	1.207089e-06
CB	DOWN	ENST00000295008.8	MRPL55-201:protein_coding:MRPL55	1.269123e+01	-1.311380e+00	3.424353e-05	2.983953e-04

Landscape of isoform expressions across multiple brain tissues between AD and control.

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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for MRPL55

Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).

All exon skipping events in AD cohorts.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon
exon_skip_109274	chr1	228107668:228107869:228107977:228108084:228108235:228108318	228107977:228108084
exon_skip_122456	chr1	228108437:228108474:228108955:228109021:228109149:228109278	228108955:228109021
exon_skip_149793	chr1	228108247:228108321:228108437:228109021:228109149:228109278	228108437:228109021
exon_skip_166373	chr1	228108290:228108318:228108955:228109021:228109261:228109290	228108955:228109021
exon_skip_174063	chr1	228108290:228108318:228108437:228108474:228109261:228109290	228108437:228108474
exon_skip_204208	chr1	228108437:228108474:228108955:228109021:228109261:228109290	228108955:228109021
exon_skip_204595	chr1	228108247:228108321:228108437:228108474:228108955:228109016	228108437:228108474
exon_skip_20770	chr1	228108290:228108318:228108437:228108474:228109149:228109278	228108437:228108474
exon_skip_209675	chr1	228107824:228107869:228108235:228108318:228109149:228109278	228108235:228108318
exon_skip_211560	chr1	228107824:228107869:228107977:228108137:228108235:228108318	228107977:228108137
exon_skip_229641	chr1	228108290:228108318:228108441:228108508:228109149:228109278	228108441:228108508
exon_skip_232571	chr1	228108290:228108318:228108441:228108508:228109149:228109280	228108441:228108508
exon_skip_237564	chr1	228108290:228108318:228108437:228109021:228109149:228109278	228108437:228109021
exon_skip_266217	chr1	228108290:228108318:228108437:228108474:228108955:228109016	228108437:228108474
exon_skip_267368	chr1	228107824:228107869:228108235:228108321:228108955:228109016	228108235:228108321
exon_skip_294593	chr1	228108290:228108318:228108437:228109021:228109261:228109290	228108437:228109021
exon_skip_34010	chr1	228108290:228108318:228108955:228109021:228109149:228109278	228108955:228109021
exon_skip_43684	chr1	228107824:228107869:228107977:228108084:228108235:228108318	228107977:228108084
exon_skip_54760	chr1	228107824:228107869:228108235:228108318:228109261:228109290	228108235:228108318
exon_skip_62211	chr1	228107824:228107869:228108235:228108318:228108955:228109016	228108235:228108318
exon_skip_97054	chr1	228108290:228108318:228108437:228108508:228108955:228109016	228108437:228108508

Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.

Exon skipping information

Tissue type

Avg(PSIs) in AD

Avg(PSIs) in control

Difference (PSI)

Adj. p-value

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Open reading frame (ORF) annotation in the exon skipping event for MRPL55

Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000295008	228108235	228108318	3UTR-3CDS
ENST00000336520	228108235	228108318	3UTR-3CDS
ENST00000348259	228108235	228108318	3UTR-3CDS
ENST00000366741	228108235	228108318	3UTR-3CDS
ENST00000366742	228108235	228108321	3UTR-3CDS
ENST00000366746	228108235	228108318	3UTR-3CDS
ENST00000336300	228108437	228108474	3UTR-3UTR
ENST00000366736	228108437	228108508	3UTR-3UTR
ENST00000366739	228108437	228108474	3UTR-3UTR
ENST00000366740	228108437	228108474	3UTR-3UTR
ENST00000366747	228108437	228108474	3UTR-3UTR
ENST00000391867	228108437	228108474	3UTR-3UTR
ENST00000366744	228108441	228108508	3UTR-3UTR
ENST00000295008	228108955	228109021	3UTR-3UTR
ENST00000336520	228108955	228109021	3UTR-3UTR
ENST00000391867	228108955	228109021	3UTR-3UTR

Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000348259	228108235	228108318	3UTR-3CDS
ENST00000366746	228108235	228108318	3UTR-3CDS
ENST00000336300	228108437	228108474	3UTR-3UTR
ENST00000366739	228108437	228108474	3UTR-3UTR
ENST00000366740	228108437	228108474	3UTR-3UTR
ENST00000366747	228108437	228108474	3UTR-3UTR
ENST00000391867	228108437	228108474	3UTR-3UTR
ENST00000366744	228108441	228108508	3UTR-3UTR
ENST00000295008	228108955	228109021	3UTR-3UTR
ENST00000336520	228108955	228109021	3UTR-3UTR
ENST00000391867	228108955	228109021	3UTR-3UTR

Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000295008	228108235	228108318	3UTR-3CDS
ENST00000336520	228108235	228108318	3UTR-3CDS
ENST00000348259	228108235	228108318	3UTR-3CDS
ENST00000366741	228108235	228108318	3UTR-3CDS
ENST00000366742	228108235	228108321	3UTR-3CDS
ENST00000366746	228108235	228108318	3UTR-3CDS
ENST00000336300	228108437	228108474	3UTR-3UTR
ENST00000366736	228108437	228108508	3UTR-3UTR
ENST00000366739	228108437	228108474	3UTR-3UTR
ENST00000366740	228108437	228108474	3UTR-3UTR
ENST00000366747	228108437	228108474	3UTR-3UTR
ENST00000391867	228108437	228108474	3UTR-3UTR
ENST00000366744	228108441	228108508	3UTR-3UTR
ENST00000295008	228108955	228109021	3UTR-3UTR
ENST00000336520	228108955	228109021	3UTR-3UTR
ENST00000391867	228108955	228109021	3UTR-3UTR

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Infer the effects of exon skipping event on protein functional features for MRPL55

p-ENSG00000162910_img4.png
boxplot

Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.

ENST

Length of mRNA

Length of AA seq.

Genomic start

Genomic end

mRNA start

mRNA end

AA start

AA end

Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.

ENST

Length of mRNA

Length of AA seq.

Genomic start

Genomic end

mRNA start

mRNA end

AA start

AA end

Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.

ENST

Length of mRNA

Length of AA seq.

Genomic start

Genomic end

mRNA start

mRNA end

AA start

AA end

Lost protein functional features of individual exon skipping events in ROSMAP.

UniProt acc.

Start of exon skipping (AA)

End of exon skipping (AA)

Protein feature start (AA)

Protein feature end (AA)

Category of protein feature

Description of feature

Lost protein functional features of individual exon skipping events in MSBB.

UniProt acc.

Start of exon skipping (AA)

End of exon skipping (AA)

Protein feature start (AA)

Protein feature end (AA)

Category of protein feature

Description of feature

Lost protein functional features of individual exon skipping events in Mayo.

UniProt acc.

Start of exon skipping (AA)

End of exon skipping (AA)

Protein feature start (AA)

Protein feature end (AA)

Category of protein feature

Description of feature

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3'-UTR located exon skipping events that lost miRNA binding sites in MRPL55

3'-UTR exon skipping evnets lost miRNA binding.

Tissue type	ENST	Exon skip start	Exon skip end	microRNA	Binding site by TargetScan	Binding type by TargetScan	Bdinding site by miRanda	Score of miRanda	Energy by miRanda
Mayo	ENST00000391867	228108437	228108474	hsa-miR-4251	chr1:228108462-228108469	8mer-1a	chr1:228108460-228108480	149.00	-23.34
Mayo	ENST00000366736	228108437	228108508	hsa-miR-4251	chr1:228108462-228108469	8mer-1a	chr1:228108460-228108480	149.00	-23.34
Mayo	ENST00000366744	228108441	228108508	hsa-miR-4251	chr1:228108462-228108469	8mer-1a	chr1:228108460-228108480	149.00	-23.34
Mayo	ENST00000391867	228108955	228109021	hsa-miR-6165	chr1:228109012-228109019	8mer-1a	chr1:228109001-228109019	165.00	-26.48
Mayo	ENST00000366736	228108437	228108508	hsa-miR-3140-3p	chr1:228108490-228108497	8mer-1a	chr1:228108476-228108497	156.00	-15.04
Mayo	ENST00000366744	228108441	228108508	hsa-miR-3140-3p	chr1:228108490-228108497	8mer-1a	chr1:228108476-228108497	156.00	-15.04
Mayo	ENST00000366736	228108437	228108508	hsa-miR-3148	chr1:228108484-228108491	8mer-1a	chr1:228108476-228108497	156.00	-15.04
Mayo	ENST00000366744	228108441	228108508	hsa-miR-3148	chr1:228108484-228108491	8mer-1a	chr1:228108476-228108497	156.00	-15.04
Mayo	ENST00000391867	228108955	228109021	hsa-miR-3690	chr1:228108976-228108983	8mer-1a	chr1:228108965-228108987	153.00	-25.61
MSBB	ENST00000391867	228108437	228108474	hsa-miR-4251	chr1:228108462-228108469	8mer-1a	chr1:228108460-228108480	149.00	-23.34
MSBB	ENST00000366744	228108441	228108508	hsa-miR-4251	chr1:228108462-228108469	8mer-1a	chr1:228108460-228108480	149.00	-23.34
MSBB	ENST00000391867	228108955	228109021	hsa-miR-6165	chr1:228109012-228109019	8mer-1a	chr1:228109001-228109019	165.00	-26.48
MSBB	ENST00000366744	228108441	228108508	hsa-miR-3140-3p	chr1:228108490-228108497	8mer-1a	chr1:228108476-228108497	156.00	-15.04
MSBB	ENST00000366744	228108441	228108508	hsa-miR-3148	chr1:228108484-228108491	8mer-1a	chr1:228108476-228108497	156.00	-15.04
MSBB	ENST00000391867	228108955	228109021	hsa-miR-3690	chr1:228108976-228108983	8mer-1a	chr1:228108965-228108987	153.00	-25.61
ROSMAP	ENST00000391867	228108437	228108474	hsa-miR-4251	chr1:228108462-228108469	8mer-1a	chr1:228108460-228108480	149.00	-23.34
ROSMAP	ENST00000366736	228108437	228108508	hsa-miR-4251	chr1:228108462-228108469	8mer-1a	chr1:228108460-228108480	149.00	-23.34
ROSMAP	ENST00000366744	228108441	228108508	hsa-miR-4251	chr1:228108462-228108469	8mer-1a	chr1:228108460-228108480	149.00	-23.34
ROSMAP	ENST00000391867	228108955	228109021	hsa-miR-6165	chr1:228109012-228109019	8mer-1a	chr1:228109001-228109019	165.00	-26.48
ROSMAP	ENST00000366736	228108437	228108508	hsa-miR-3140-3p	chr1:228108490-228108497	8mer-1a	chr1:228108476-228108497	156.00	-15.04
ROSMAP	ENST00000366744	228108441	228108508	hsa-miR-3140-3p	chr1:228108490-228108497	8mer-1a	chr1:228108476-228108497	156.00	-15.04
ROSMAP	ENST00000366736	228108437	228108508	hsa-miR-3148	chr1:228108484-228108491	8mer-1a	chr1:228108476-228108497	156.00	-15.04
ROSMAP	ENST00000366744	228108441	228108508	hsa-miR-3148	chr1:228108484-228108491	8mer-1a	chr1:228108476-228108497	156.00	-15.04
ROSMAP	ENST00000391867	228108955	228109021	hsa-miR-3690	chr1:228108976-228108983	8mer-1a	chr1:228108965-228108987	153.00	-25.61

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SNVs in the skipped exons for MRPL55

- Differential PSIs between mutated versus non-mutated samples.

- Depth of Coverage in the skipped exon of the mutated samples.

- Sashimi plot in the skipped exon of the mutated samples.

- Non-synonymous mutations located in the skipped exons.

Cancer type

Sample

ESID

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

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AD stage-associated exon skippint events for MRPL55

Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).

AD stage info

Cohort

Tissue

SE id

Coefficient

P-value

Chromosome

Strand

E1 start

E1 end

Skipped start

Skipped end

E2 start

E2 end

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MRPL55

sQTL information located at the skipped exons.

Tissue type	Exon skip ID	SNP id	Location	P-value	FDR
CB	exon_skip_34010	rs849749	chr1:228109044	8.627590e-08	4.199356e-05
CB	exon_skip_237564	rs849749	chr1:228109044	1.519551e-07	6.947033e-05
CB	exon_skip_237564	rs1059778	chr1:228184361	3.475902e-05	7.250765e-03
CB	exon_skip_237564	rs1745423	chr1:228036452	6.514876e-05	1.231602e-02
TC	exon_skip_34010	rs849749	chr1:228109044	2.317822e-14	5.195412e-11
TC	exon_skip_237564	rs849749	chr1:228109044	7.397924e-12	9.340768e-09
TC	exon_skip_34010	rs1059778	chr1:228184361	2.860306e-09	1.894296e-06
TC	exon_skip_294593	rs849749	chr1:228109044	7.730571e-08	3.537162e-05
TC	exon_skip_166373	rs849749	chr1:228109044	7.730571e-08	3.537162e-05
TC	exon_skip_237564	rs1059778	chr1:228184361	3.949374e-07	1.475424e-04
TC	exon_skip_34010	rs1745423	chr1:228036452	1.315672e-06	4.331165e-04
TC	exon_skip_34010	rs12142165	chr1:228195501	5.366315e-06	1.474583e-03
TC	exon_skip_294593	rs1059778	chr1:228184361	6.898807e-06	1.810882e-03
TC	exon_skip_166373	rs1059778	chr1:228184361	6.898807e-06	1.810882e-03
TC	exon_skip_237564	rs1745423	chr1:228036452	2.710988e-05	5.598612e-03
HCC	exon_skip_34010	rs849749	chr1:228109044	1.757261e-12	8.167729e-10
HCC	exon_skip_34010	rs822725	chr1:228095176	6.278830e-11	2.295687e-08
HCC	exon_skip_34010	rs766972	chr1:228057123	2.669131e-10	8.767553e-08
HCC	exon_skip_34010	rs1059778	chr1:228184361	2.131778e-08	4.891619e-06
HCC	exon_skip_34010	rs7537636	chr1:228125323	2.347641e-07	4.371280e-05
HCC	exon_skip_34010	rs17623766	chr1:228201455	3.309012e-07	5.961336e-05
HCC	exon_skip_34010	rs10753445	chr1:228190871	3.652013e-07	6.512315e-05
HCC	exon_skip_34010	rs4653917	chr1:228184053	3.681356e-07	6.559040e-05
HCC	exon_skip_237564	rs849749	chr1:228109044	6.164664e-07	1.061233e-04
HCC	exon_skip_34010	rs2185544	chr1:228186551	8.029695e-07	1.340105e-04
HCC	exon_skip_34010	rs1745423	chr1:228036452	2.413192e-06	3.621142e-04
HCC	exon_skip_34010	rs708124	chr1:228033070	2.606277e-06	3.876461e-04
HCC	exon_skip_34010	rs2313600	chr1:228200699	4.450073e-06	6.178905e-04
HCC	exon_skip_237564	rs822725	chr1:228095176	7.840798e-06	1.018698e-03
HCC	exon_skip_237564	rs766972	chr1:228057123	9.935440e-06	1.244739e-03
HCC	exon_skip_237564	rs708124	chr1:228033070	5.143233e-04	3.468991e-02
PCC	exon_skip_34010	rs7537636	chr1:228125323	3.276218e-10	2.817712e-07
PCC	exon_skip_34010	rs10753445	chr1:228190871	3.276218e-10	2.817712e-07
PCC	exon_skip_34010	rs849749	chr1:228109044	6.442992e-10	5.151980e-07
PCC	exon_skip_34010	rs2185544	chr1:228186551	7.128009e-10	5.630011e-07
PCC	exon_skip_34010	rs766972	chr1:228057123	7.135625e-10	5.630011e-07
PCC	exon_skip_34010	rs1059778	chr1:228184361	9.420551e-10	6.917318e-07
PCC	exon_skip_34010	rs822725	chr1:228095176	1.331381e-09	9.411735e-07
PCC	exon_skip_237564	rs849749	chr1:228109044	7.507239e-09	4.536764e-06
PCC	exon_skip_237564	rs1059778	chr1:228184361	1.238949e-08	7.206587e-06
PCC	exon_skip_237564	rs7537636	chr1:228125323	3.349366e-08	1.775788e-05
PCC	exon_skip_237564	rs10753445	chr1:228190871	3.349366e-08	1.775788e-05
PCC	exon_skip_34010	rs4653917	chr1:228184053	3.385929e-08	1.792390e-05
PCC	exon_skip_237564	rs766972	chr1:228057123	4.375567e-08	2.265468e-05
PCC	exon_skip_34010	rs17623766	chr1:228201455	4.876731e-08	2.477844e-05
PCC	exon_skip_237564	rs2185544	chr1:228186551	6.172928e-08	3.090447e-05
PCC	exon_skip_237564	rs822725	chr1:228095176	9.709265e-08	4.656083e-05
PCC	exon_skip_237564	rs4653917	chr1:228184053	1.389882e-07	6.203416e-05
PCC	exon_skip_34010	rs708124	chr1:228033070	2.924358e-07	1.197234e-04
PCC	exon_skip_34010	rs2313600	chr1:228200699	2.939646e-07	1.202051e-04
PCC	exon_skip_237564	rs17623766	chr1:228201455	2.955160e-07	1.204069e-04
PCC	exon_skip_237564	rs708124	chr1:228033070	1.515029e-06	4.903237e-04
PCC	exon_skip_34010	rs1745423	chr1:228036452	2.291480e-06	7.048674e-04
PCC	exon_skip_237564	rs2313600	chr1:228200699	2.774350e-06	8.382955e-04
PCC	exon_skip_237564	rs1745423	chr1:228036452	5.620137e-06	1.537553e-03
PCC	exon_skip_166373	rs849749	chr1:228109044	2.318794e-05	5.246713e-03
PCC	exon_skip_166373	rs822725	chr1:228095176	2.349381e-05	5.307447e-03
PCC	exon_skip_294593	rs849749	chr1:228109044	2.976056e-05	6.445099e-03
PCC	exon_skip_294593	rs822725	chr1:228095176	2.999684e-05	6.470667e-03
PCC	exon_skip_166373	rs766972	chr1:228057123	5.148357e-05	1.014928e-02
PCC	exon_skip_294593	rs766972	chr1:228057123	6.556569e-05	1.249218e-02
DLPFC	exon_skip_34010	rs1059778	chr1:228184361	5.190011e-14	2.842475e-11
DLPFC	exon_skip_34010	rs4653917	chr1:228184053	1.038831e-13	5.405903e-11
DLPFC	exon_skip_34010	rs849749	chr1:228109044	1.225106e-13	6.296781e-11
DLPFC	exon_skip_34010	rs17623766	chr1:228201455	1.836488e-13	9.130133e-11
DLPFC	exon_skip_34010	rs7537636	chr1:228125323	1.555728e-12	6.681035e-10
DLPFC	exon_skip_34010	rs2313600	chr1:228200699	1.555841e-12	6.681035e-10
DLPFC	exon_skip_34010	rs10753445	chr1:228190871	1.928012e-12	8.132850e-10
DLPFC	exon_skip_34010	rs822725	chr1:228095176	8.412516e-12	3.268028e-09
DLPFC	exon_skip_34010	rs2185544	chr1:228186551	9.235709e-12	3.546576e-09
DLPFC	exon_skip_34010	rs766972	chr1:228057123	3.383815e-11	1.177589e-08
DLPFC	exon_skip_237564	rs849749	chr1:228109044	5.508518e-11	1.870243e-08
DLPFC	exon_skip_237564	rs4653917	chr1:228184053	2.430827e-10	7.396223e-08
DLPFC	exon_skip_237564	rs17623766	chr1:228201455	3.178799e-10	9.602101e-08
DLPFC	exon_skip_34010	rs1745423	chr1:228036452	5.366591e-10	1.550954e-07
DLPFC	exon_skip_237564	rs2313600	chr1:228200699	2.176708e-09	5.681309e-07
DLPFC	exon_skip_237564	rs822725	chr1:228095176	2.383853e-09	6.154651e-07
DLPFC	exon_skip_237564	rs1059778	chr1:228184361	4.689103e-09	1.158701e-06
DLPFC	exon_skip_237564	rs766972	chr1:228057123	6.194538e-09	1.484583e-06
DLPFC	exon_skip_166373	rs849749	chr1:228109044	1.232735e-08	2.816959e-06
DLPFC	exon_skip_34010	rs708124	chr1:228033070	1.723534e-08	3.838725e-06
DLPFC	exon_skip_237564	rs7537636	chr1:228125323	2.039657e-08	4.477141e-06
DLPFC	exon_skip_237564	rs10753445	chr1:228190871	2.101394e-08	4.600566e-06
DLPFC	exon_skip_166373	rs2313600	chr1:228200699	1.256714e-07	2.286767e-05
DLPFC	exon_skip_237564	rs2185544	chr1:228186551	1.473376e-07	2.635087e-05
DLPFC	exon_skip_166373	rs4653917	chr1:228184053	2.050204e-07	3.524569e-05
DLPFC	exon_skip_166373	rs822725	chr1:228095176	2.060006e-07	3.536583e-05
DLPFC	exon_skip_166373	rs1059778	chr1:228184361	2.678859e-07	4.501857e-05
DLPFC	exon_skip_166373	rs17623766	chr1:228201455	3.880509e-07	6.319258e-05
DLPFC	exon_skip_237564	rs708124	chr1:228033070	4.077852e-07	6.594160e-05
DLPFC	exon_skip_166373	rs766972	chr1:228057123	5.750545e-07	8.919436e-05
DLPFC	exon_skip_294593	rs849749	chr1:228109044	9.104218e-07	1.365167e-04
DLPFC	exon_skip_237564	rs1745423	chr1:228036452	1.032259e-06	1.519221e-04
DLPFC	exon_skip_166373	rs7537636	chr1:228125323	1.130720e-06	1.639573e-04
DLPFC	exon_skip_166373	rs10753445	chr1:228190871	1.222846e-06	1.751869e-04
DLPFC	exon_skip_166373	rs2185544	chr1:228186551	2.742867e-06	3.585107e-04
DLPFC	exon_skip_294593	rs822725	chr1:228095176	5.318232e-06	6.409621e-04
DLPFC	exon_skip_294593	rs2313600	chr1:228200699	5.378555e-06	6.463669e-04
DLPFC	exon_skip_166373	rs1745423	chr1:228036452	6.542648e-06	7.723700e-04
DLPFC	exon_skip_166373	rs708124	chr1:228033070	7.644815e-06	8.843579e-04
DLPFC	exon_skip_294593	rs4653917	chr1:228184053	1.263791e-05	1.383404e-03
DLPFC	exon_skip_294593	rs766972	chr1:228057123	1.359867e-05	1.472172e-03
DLPFC	exon_skip_294593	rs1059778	chr1:228184361	1.852312e-05	1.937481e-03
DLPFC	exon_skip_294593	rs17623766	chr1:228201455	2.129473e-05	2.189007e-03
DLPFC	exon_skip_294593	rs7537636	chr1:228125323	3.889240e-05	3.706049e-03
DLPFC	exon_skip_294593	rs10753445	chr1:228190871	4.148816e-05	3.928745e-03
DLPFC	exon_skip_294593	rs2185544	chr1:228186551	7.172354e-05	6.350066e-03
DLPFC	exon_skip_294593	rs708124	chr1:228033070	7.830003e-05	6.840728e-03
DLPFC	exon_skip_294593	rs1745423	chr1:228036452	1.059634e-04	8.890225e-03

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Correlation with RNA binding proteins (RBPs) for MRPL55

Correlated RBP and related information.

Tissue type	RBP name	Exon skip ID	Correlation coeifficient	P-value
CB	HNRNPDL	exon_skip_237564	4.267892e-01	2.025345e-08
IFG	BOLL	exon_skip_237564	4.036809e-01	4.084405e-02
IFG	RBM24	exon_skip_237564	-4.675251e-01	1.602680e-02
IFG	ENOX1	exon_skip_237564	-4.416060e-01	2.391166e-02
IFG	RALYL	exon_skip_237564	-4.226235e-01	3.148228e-02

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RelatedDrugs for MRPL55

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for MRPL55

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	3'-UTR located exon skipping events lost miRNA binding sites
	SNVs in the skipped exons with depth of coverage
	AD stage-associated exon skipping events
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Correlation with RNA binding proteins (RBPs)
	Related drugs with this gene
	Related diseases with this gene

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Gene summary for MRPL55

Gene structures and expression levels for MRPL55

Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for MRPL55

Open reading frame (ORF) annotation in the exon skipping event for MRPL55

Infer the effects of exon skipping event on protein functional features for MRPL55

3'-UTR located exon skipping events that lost miRNA binding sites in MRPL55

SNVs in the skipped exons for MRPL55

AD stage-associated exon skippint events for MRPL55

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MRPL55

Correlation with RNA binding proteins (RBPs) for MRPL55

RelatedDrugs for MRPL55

RelatedDiseases for MRPL55