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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for SLC38A10 |
 Gene summary |
| Gene information | Gene symbol | SLC38A10 | Gene ID | 124565 |
| Gene name | solute carrier family 38 member 10 | |
| Synonyms | PP1744 | |
| Cytomap | 17q25.3 | |
| Type of gene | protein-coding | |
| Description | putative sodium-coupled neutral amino acid transporter 10 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for SLC38A10 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000157637
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for SLC38A10 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_119013 | chr17 | 81260361:81260394:81270918:81271024:81272516:81272627 | 81270918:81271024 |
| exon_skip_169547 | chr17 | 81253073:81253240:81260238:81260394:81270918:81271024 | 81260238:81260394 |
| exon_skip_178034 | chr17 | 81270918:81271024:81272516:81272627:81275969:81276151 | 81272516:81272627 |
| exon_skip_222070 | chr17 | 81282189:81282332:81283409:81283502:81284850:81284895 | 81283409:81283502 |
| exon_skip_241998 | chr17 | 81246885:81247061:81251493:81251612:81252195:81252272 | 81251493:81251612 |
| exon_skip_278317 | chr17 | 81246885:81247061:81250070:81250093:81251493:81251612 | 81250070:81250093 |
| exon_skip_32435 | chr17 | 81275969:81276151:81277031:81277133:81280609:81280733 | 81277031:81277133 |
| exon_skip_43622 | chr17 | 81283409:81283502:81284850:81284895:81289691:81289808 | 81284850:81284895 |
| exon_skip_61743 | chr17 | 81284850:81284895:81289691:81289808:81294823:81294914 | 81289691:81289808 |
| exon_skip_73195 | chr17 | 81260361:81260394:81270918:81271024:81275969:81276151 | 81270918:81271024 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_278317 | ROSMAP_DLPFC | 4.644444e-01 | 5.762617e-01 | -1.118172e-01 | 3.080559e-03 |
| exon_skip_278317 | Mayo_TC | 3.693902e-01 | 4.984722e-01 | -1.290820e-01 | 7.676183e-06 |
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Open reading frame (ORF) annotation in the exon skipping event for SLC38A10 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000374759 | 81272516 | 81272627 | Frame-shift |
| ENST00000374759 | 81277031 | 81277133 | Frame-shift |
| ENST00000374759 | 81283409 | 81283502 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000374759 | 81272516 | 81272627 | Frame-shift |
| ENST00000374759 | 81277031 | 81277133 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000374759 | 81260238 | 81260394 | Frame-shift |
| ENST00000374759 | 81270918 | 81271024 | Frame-shift |
| ENST00000374759 | 81272516 | 81272627 | Frame-shift |
| ENST00000374759 | 81277031 | 81277133 | Frame-shift |
| ENST00000374759 | 81283409 | 81283502 | Frame-shift |
| ENST00000374759 | 81284850 | 81284895 | Frame-shift |
| ENST00000374759 | 81251493 | 81251612 | In-frame |
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Infer the effects of exon skipping event on protein functional features for SLC38A10 |
p-ENSG00000157637_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000374759 | 4317 | 1119 | 81251493 | 81251612 | 2330 | 2448 | 648 | 688 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9HBR0 | 648 | 688 | 1 | 1119 | Chain | ID=PRO_0000318975;Note=Putative sodium-coupled neutral amino acid transporter 10 |
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3'-UTR located exon skipping events that lost miRNA binding sites in SLC38A10 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for SLC38A10 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for SLC38A10 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SLC38A10 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for SLC38A10 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| DLPFC | KHDRBS2 | exon_skip_278317 | 5.777698e-01 | 9.352460e-28 |
| DLPFC | KHDRBS3 | exon_skip_278317 | 4.295417e-01 | 1.016194e-14 |
| HCC | MSI1 | exon_skip_278317 | -5.350614e-01 | 4.979804e-21 |
| HCC | RBM47 | exon_skip_278317 | -4.823923e-01 | 7.510166e-17 |
| IFG | ESRP1 | exon_skip_178034 | -4.744996e-01 | 1.654932e-02 |
| PCC | MSI1 | exon_skip_278317 | -4.702655e-01 | 2.413576e-12 |
| PCC | RBM47 | exon_skip_278317 | -4.503574e-01 | 2.486629e-11 |
| TC | SRSF2 | exon_skip_278317 | 4.536284e-01 | 3.458405e-09 |
| TC | MSI1 | exon_skip_278317 | -5.926857e-01 | 5.609924e-16 |
| TC | KHDRBS2 | exon_skip_278317 | 5.414517e-01 | 4.150792e-13 |
| TC | KHDRBS3 | exon_skip_278317 | 4.608015e-01 | 1.814337e-09 |
| TC | HNRNPD | exon_skip_278317 | 4.476513e-01 | 5.853661e-09 |
| TC | NUP42 | exon_skip_278317 | 5.178748e-01 | 6.064177e-12 |
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RelatedDrugs for SLC38A10 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SLC38A10 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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