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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for CMKLR1 |
Gene summary |
Gene information | Gene symbol | CMKLR1 | Gene ID | 1240 |
Gene name | chemerin chemokine-like receptor 1 | |
Synonyms | CHEMERINR|ChemR23|DEZ|RVER1 | |
Cytomap | 12q23.3 | |
Type of gene | protein-coding | |
Description | chemokine-like receptor 1G-protein coupled receptor ChemR23G-protein coupled receptor DEZchemerin receptorchemokine receptor-like 1orphan G-protein coupled receptor, Dezresolvin E1 receptor | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
CMKLR1 | GO:0006935 | chemotaxis | 14530373 |
CMKLR1 | GO:0007186 | G protein-coupled receptor signaling pathway | 14530373 |
CMKLR1 | GO:0032088 | negative regulation of NF-kappaB transcription factor activity | 15753205 |
CMKLR1 | GO:0050848 | regulation of calcium-mediated signaling | 14530373 |
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Gene structures and expression levels for CMKLR1 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CMKLR1 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_185107 | chr12 | 108293596:108293664:108329995:108330207:108339027:108339311 | 108329995:108330207 |
exon_skip_191536 | chr12 | 108293589:108293664:108329995:108330207:108339027:108339311 | 108329995:108330207 |
exon_skip_36442 | chr12 | 108291570:108292959:108293589:108293664:108329995:108330207 | 108293589:108293664 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for CMKLR1 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000550402 | 108293589 | 108293664 | 3UTR-3CDS |
ENST00000550402 | 108329995 | 108330207 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000550402 | 108293589 | 108293664 | 3UTR-3CDS |
ENST00000550402 | 108329995 | 108330207 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000550402 | 108329995 | 108330207 | 3UTR-3UTR |
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Infer the effects of exon skipping event on protein functional features for CMKLR1 |
p-ENSG00000174600_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in CMKLR1 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Mayo | ENST00000550402 | 108329995 | 108330207 | hsa-miR-1290 | chr12:108330177-108330184 | 8mer-1a | chr12:108330166-108330184 | 165.00 | -22.55 |
Mayo | ENST00000550402 | 108329995 | 108330207 | hsa-miR-1255b-2-3p | chr12:108330080-108330087 | 8mer-1a | chr12:108330065-108330087 | 174.00 | -19.82 |
Mayo | ENST00000550402 | 108329995 | 108330207 | hsa-miR-5587-5p | chr12:108330068-108330075 | 8mer-1a | chr12:108330065-108330087 | 174.00 | -19.82 |
Mayo | ENST00000550402 | 108329995 | 108330207 | hsa-miR-4530 | chr12:108330192-108330199 | 8mer-1a | chr12:108330182-108330199 | 153.00 | -18.54 |
Mayo | ENST00000550402 | 108329995 | 108330207 | hsa-miR-4772-3p | chr12:108330149-108330156 | 8mer-1a | chr12:108330143-108330165 | 169.00 | -24.16 |
Mayo | ENST00000550402 | 108329995 | 108330207 | hsa-miR-645 | chr12:108330110-108330117 | 8mer-1a | chr12:108330099-108330117 | 163.00 | -24.44 |
Mayo | ENST00000550402 | 108329995 | 108330207 | hsa-miR-6529-5p | chr12:108330116-108330123 | 8mer-1a | chr12:108330114-108330136 | 160.00 | -26.45 |
Mayo | ENST00000550402 | 108329995 | 108330207 | hsa-miR-4652-3p | chr12:108330074-108330081 | 8mer-1a | chr12:108330065-108330087 | 174.00 | -19.82 |
Mayo | ENST00000550402 | 108329995 | 108330207 | hsa-miR-766-3p | chr12:108330194-108330201 | 8mer-1a | chr12:108330180-108330201 | 150.00 | -14.52 |
MSBB | ENST00000550402 | 108329995 | 108330207 | hsa-miR-1290 | chr12:108330177-108330184 | 8mer-1a | chr12:108330166-108330184 | 165.00 | -22.55 |
MSBB | ENST00000550402 | 108329995 | 108330207 | hsa-miR-1255b-2-3p | chr12:108330080-108330087 | 8mer-1a | chr12:108330065-108330087 | 174.00 | -19.82 |
MSBB | ENST00000550402 | 108329995 | 108330207 | hsa-miR-5587-5p | chr12:108330068-108330075 | 8mer-1a | chr12:108330065-108330087 | 174.00 | -19.82 |
MSBB | ENST00000550402 | 108329995 | 108330207 | hsa-miR-4530 | chr12:108330192-108330199 | 8mer-1a | chr12:108330182-108330199 | 153.00 | -18.54 |
MSBB | ENST00000550402 | 108329995 | 108330207 | hsa-miR-4772-3p | chr12:108330149-108330156 | 8mer-1a | chr12:108330143-108330165 | 169.00 | -24.16 |
MSBB | ENST00000550402 | 108329995 | 108330207 | hsa-miR-645 | chr12:108330110-108330117 | 8mer-1a | chr12:108330099-108330117 | 163.00 | -24.44 |
MSBB | ENST00000550402 | 108329995 | 108330207 | hsa-miR-6529-5p | chr12:108330116-108330123 | 8mer-1a | chr12:108330114-108330136 | 160.00 | -26.45 |
MSBB | ENST00000550402 | 108329995 | 108330207 | hsa-miR-4652-3p | chr12:108330074-108330081 | 8mer-1a | chr12:108330065-108330087 | 174.00 | -19.82 |
MSBB | ENST00000550402 | 108329995 | 108330207 | hsa-miR-766-3p | chr12:108330194-108330201 | 8mer-1a | chr12:108330180-108330201 | 150.00 | -14.52 |
ROSMAP | ENST00000550402 | 108329995 | 108330207 | hsa-miR-1290 | chr12:108330177-108330184 | 8mer-1a | chr12:108330166-108330184 | 165.00 | -22.55 |
ROSMAP | ENST00000550402 | 108329995 | 108330207 | hsa-miR-1255b-2-3p | chr12:108330080-108330087 | 8mer-1a | chr12:108330065-108330087 | 174.00 | -19.82 |
ROSMAP | ENST00000550402 | 108329995 | 108330207 | hsa-miR-5587-5p | chr12:108330068-108330075 | 8mer-1a | chr12:108330065-108330087 | 174.00 | -19.82 |
ROSMAP | ENST00000550402 | 108329995 | 108330207 | hsa-miR-4530 | chr12:108330192-108330199 | 8mer-1a | chr12:108330182-108330199 | 153.00 | -18.54 |
ROSMAP | ENST00000550402 | 108329995 | 108330207 | hsa-miR-4772-3p | chr12:108330149-108330156 | 8mer-1a | chr12:108330143-108330165 | 169.00 | -24.16 |
ROSMAP | ENST00000550402 | 108329995 | 108330207 | hsa-miR-645 | chr12:108330110-108330117 | 8mer-1a | chr12:108330099-108330117 | 163.00 | -24.44 |
ROSMAP | ENST00000550402 | 108329995 | 108330207 | hsa-miR-6529-5p | chr12:108330116-108330123 | 8mer-1a | chr12:108330114-108330136 | 160.00 | -26.45 |
ROSMAP | ENST00000550402 | 108329995 | 108330207 | hsa-miR-4652-3p | chr12:108330074-108330081 | 8mer-1a | chr12:108330065-108330087 | 174.00 | -19.82 |
ROSMAP | ENST00000550402 | 108329995 | 108330207 | hsa-miR-766-3p | chr12:108330194-108330201 | 8mer-1a | chr12:108330180-108330201 | 150.00 | -14.52 |
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SNVs in the skipped exons for CMKLR1 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for CMKLR1 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CMKLR1 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for CMKLR1 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for CMKLR1 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CMKLR1 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |