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![]() | Open reading frame (ORF) annotation in the exon skipping event |
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![]() | 3'-UTR located exon skipping events lost miRNA binding sites |
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![]() | Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for CLTB |
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Gene information | Gene symbol | CLTB | Gene ID | 1212 |
Gene name | clathrin light chain B | |
Synonyms | LCB | |
Cytomap | 5q35.2 | |
Type of gene | protein-coding | |
Description | clathrin light chain Bclathrin, light chain (Lcb)clathrin, light polypeptide (Lcb) | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
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Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for CLTB |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
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Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CLTB |
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Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_114161 | chr5 | 176397944:176398047:176406157:176406708:176410257:176410303 | 176406157:176406708 |
exon_skip_18645 | chr5 | 176392933:176392945:176396479:176396532:176397607:176397718 | 176396479:176396532 |
exon_skip_19562 | chr5 | 176392920:176392945:176396479:176396532:176397607:176397718 | 176396479:176396532 |
exon_skip_204228 | chr5 | 176397944:176398047:176410257:176410303:176416177:176416261 | 176410257:176410303 |
exon_skip_243105 | chr5 | 176392737:176392945:176396479:176396532:176397607:176397718 | 176396479:176396532 |
exon_skip_253605 | chr5 | 176392649:176392945:176396479:176396532:176397607:176397718 | 176396479:176396532 |
exon_skip_79872 | chr5 | 176392649:176392945:176396479:176396532:176397607:176397692 | 176396479:176396532 |
exon_skip_83118 | chr5 | 176392882:176392945:176396479:176396532:176397607:176397718 | 176396479:176396532 |
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Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
exon_skip_253605 | MSBB_STG | 6.282609e-01 | 7.570833e-01 | -1.288225e-01 | 8.042774e-03 |
exon_skip_253605 | MSBB_PG | 4.980142e-01 | 6.555172e-01 | -1.575031e-01 | 4.383290e-04 |
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Open reading frame (ORF) annotation in the exon skipping event for CLTB |
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ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000310418 | 176396479 | 176396532 | In-frame |
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ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000310418 | 176396479 | 176396532 | In-frame |
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ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000310418 | 176396479 | 176396532 | In-frame |
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Infer the effects of exon skipping event on protein functional features for CLTB |
p-ENSG00000175416_img4.png![]() |
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ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000310418 | 1232 | 229 | 176396479 | 176396532 | 671 | 723 | 155 | 172 |
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ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000310418 | 1232 | 229 | 176396479 | 176396532 | 671 | 723 | 155 | 172 |
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ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000310418 | 1232 | 229 | 176396479 | 176396532 | 671 | 723 | 155 | 172 |
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UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
P09497 | 155 | 172 | 156 | 173 | Alternative sequence | ID=VSP_001098;Note=In isoform Non-brain. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2,ECO:0000303|Ref.3;Dbxref=PMID:15489334 |
P09497 | 155 | 172 | 1 | 229 | Chain | ID=PRO_0000205771;Note=Clathrin light chain B |
P09497 | 155 | 172 | 93 | 155 | Region | Note=Involved in binding clathrin heavy chain |
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UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
P09497 | 155 | 172 | 156 | 173 | Alternative sequence | ID=VSP_001098;Note=In isoform Non-brain. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2,ECO:0000303|Ref.3;Dbxref=PMID:15489334 |
P09497 | 155 | 172 | 1 | 229 | Chain | ID=PRO_0000205771;Note=Clathrin light chain B |
P09497 | 155 | 172 | 93 | 155 | Region | Note=Involved in binding clathrin heavy chain |
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UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
P09497 | 155 | 172 | 156 | 173 | Alternative sequence | ID=VSP_001098;Note=In isoform Non-brain. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.2,ECO:0000303|Ref.3;Dbxref=PMID:15489334 |
P09497 | 155 | 172 | 1 | 229 | Chain | ID=PRO_0000205771;Note=Clathrin light chain B |
P09497 | 155 | 172 | 93 | 155 | Region | Note=Involved in binding clathrin heavy chain |
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3'-UTR located exon skipping events that lost miRNA binding sites in CLTB |
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Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for CLTB |
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Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for CLTB |
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AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
CDR | MSBB | STG | exon_skip_253605 | -4.149593e-01 | 3.540000e-05 | chr5 | - | 176392649 | 176392945 | 176396479 | 176396532 | 176397607 | 176397718 |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CLTB |
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Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
PCC | exon_skip_79872 | rs11749216 | chr5:176464098 | 2.560087e-04 | 3.630051e-02 |
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Correlation with RNA binding proteins (RBPs) for CLTB |
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Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
CB | SRSF2 | exon_skip_83118 | 5.277319e-01 | 8.822293e-13 |
CB | SRSF11 | exon_skip_83118 | 4.986493e-01 | 2.244790e-11 |
CB | NOVA1 | exon_skip_83118 | 5.051080e-01 | 1.123056e-11 |
DLPFC | SRSF2 | exon_skip_19562 | 7.452911e-01 | 2.571165e-44 |
DLPFC | SRSF11 | exon_skip_19562 | -5.154134e-01 | 6.835524e-18 |
DLPFC | MBNL1 | exon_skip_19562 | 6.345688e-01 | 8.680776e-29 |
DLPFC | SRSF5 | exon_skip_19562 | 7.287436e-01 | 1.641243e-41 |
DLPFC | NOVA1 | exon_skip_19562 | 7.956799e-01 | 2.166647e-54 |
DLPFC | RBM4 | exon_skip_19562 | 4.293311e-01 | 2.558077e-12 |
FL | SRSF2 | exon_skip_253605 | 5.400279e-01 | 2.203705e-16 |
FL | NOVA1 | exon_skip_253605 | 4.264405e-01 | 3.746114e-10 |
HCC | ZNF326 | exon_skip_243105 | -5.855426e-01 | 1.611136e-26 |
HCC | SRSF11 | exon_skip_243105 | -4.741547e-01 | 1.041493e-16 |
HCC | RBM4 | exon_skip_243105 | -4.531871e-01 | 3.122801e-15 |
PCC | ZNF326 | exon_skip_79872 | -4.640183e-01 | 7.060004e-13 |
PG | SRSF2 | exon_skip_253605 | 5.256776e-01 | 1.556798e-15 |
PG | SRSF11 | exon_skip_253605 | 4.797550e-01 | 7.521297e-13 |
PG | MBNL1 | exon_skip_253605 | 5.171236e-01 | 5.286667e-15 |
PG | SRSF5 | exon_skip_253605 | 4.545503e-01 | 1.540558e-11 |
PG | NOVA1 | exon_skip_253605 | 6.423765e-01 | 1.513000e-24 |
PG | RBM4 | exon_skip_253605 | 5.029008e-01 | 3.747377e-14 |
STG | SRSF2 | exon_skip_253605 | 5.571640e-01 | 6.617310e-09 |
STG | SRSF11 | exon_skip_253605 | 4.636021e-01 | 2.869615e-06 |
STG | MBNL1 | exon_skip_253605 | 5.036860e-01 | 2.653563e-07 |
STG | NOVA1 | exon_skip_253605 | 6.269327e-01 | 1.781149e-11 |
STG | RBM4 | exon_skip_253605 | 5.006234e-01 | 3.217757e-07 |
TC | SRSF2 | exon_skip_18645 | 4.738637e-01 | 2.467424e-10 |
TC | MBNL1 | exon_skip_18645 | 4.118089e-01 | 6.296120e-08 |
TC | NOVA1 | exon_skip_18645 | 6.787684e-01 | 6.025551e-23 |
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RelatedDrugs for CLTB |
![]() (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CLTB |
![]() (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |