 Gene summary |
| Gene information | Gene symbol | BTBD16 |
Gene ID | 118663 | | Gene name | BTB domain containing 16 |
| Synonyms | C10orf87 |
| Cytomap | 10q26.13 |
| Type of gene | protein-coding |
| Description | BTB/POZ domain-containing protein 16 |
| Modification date | 20200313 |
| UniProtAcc | Q32M84, |
| Context | |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
ENSG00000138152
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
***cutpoints = c(0, 0.0001, 0.001, 0.01, 1), symbols = c("****", "***", "**", "ns")
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| CB | DOWN | 9.046601e+00 | -1.167589e+00 | 1.615635e-05 | 1.152272e-04 |
| TC | DOWN | 6.541777e+01 | -8.944060e-01 | 1.931363e-06 | 3.407485e-05 |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | DOWN | ENST00000260723.5 | BTBD16-201:protein_coding:BTBD16 | 5.776329e+00 | -1.418045e+00 | 1.826375e-06 | 2.503067e-05 |
| CB | DOWN | ENST00000495370.2 | BTBD16-202:lncRNA:BTBD16 | 3.069368e+00 | -1.223908e+00 | 1.179849e-04 | 8.519042e-04 |
| TC | DOWN | ENST00000260723.5 | BTBD16-201:protein_coding:BTBD16 | 3.857152e+01 | -1.207109e+00 | 6.622428e-10 | 9.367919e-08 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_121654 | chr10 | 122332436:122332513:122334881:122334979:122336494:122336622 | 122334881:122334979 |
| exon_skip_184815 | chr10 | 122331967:122332258:122332436:122332513:122334881:122334979 | 122332436:122332513 |
| exon_skip_238745 | chr10 | 122299004:122299134:122307189:122307308:122329480:122329571 | 122307189:122307308 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000260723 | 122307189 | 122307308 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000260723 | 122307189 | 122307308 | In-frame |
| ENST00000260723 | 122334881 | 122334979 | In-frame |
p-ENSG00000138152_img4.png
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| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000260723 | 1866 | 506 | 122307189 | 122307308 | 1044 | 1162 | 264 | 303 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000260723 | 1866 | 506 | 122307189 | 122307308 | 1044 | 1162 | 264 | 303 |
| ENST00000260723 | 1866 | 506 | 122334881 | 122334979 | 1417 | 1514 | 388 | 421 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q32M84 | 264 | 303 | 1 | 506 | Chain | ID=PRO_0000247121;Note=BTB/POZ domain-containing protein 16 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q32M84 | 264 | 303 | 1 | 506 | Chain | ID=PRO_0000247121;Note=BTB/POZ domain-containing protein 16 |
| Q32M84 | 388 | 421 | 1 | 506 | Chain | ID=PRO_0000247121;Note=BTB/POZ domain-containing protein 16 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Diseases associated with this gene.
(DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
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