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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for IP6K3 |
Gene summary |
Gene information | Gene symbol | IP6K3 | Gene ID | 117283 |
Gene name | inositol hexakisphosphate kinase 3 | |
Synonyms | IHPK3|INSP6K3 | |
Cytomap | 6p21.31 | |
Type of gene | protein-coding | |
Description | inositol hexakisphosphate kinase 3ATP:1D-myo-inositol-hexakisphosphate phosphotransferaseInsP6 kinase 3inositol hexaphosphate kinase 3 | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
IP6K3 | GO:0006468 | protein phosphorylation | 11502751 |
IP6K3 | GO:0032958 | inositol phosphate biosynthetic process | 11502751 |
IP6K3 | GO:0046488 | phosphatidylinositol metabolic process | 11502751 |
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Gene structures and expression levels for IP6K3 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
PG | UP | ENST00000451316.6 | IP6K3-202:protein_coding:IP6K3 | 1.263313e+01 | 1.233476e+00 | 2.128128e-05 | 8.773921e-04 |
CB | UP | ENST00000451316.6 | IP6K3-202:protein_coding:IP6K3 | 4.723690e+00 | 1.067278e+00 | 8.834342e-04 | 4.653182e-03 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for IP6K3 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_222011 | chr6 | 33735278:33735655:33746588:33746633:33746758:33746848 | 33746588:33746633 |
exon_skip_54623 | chr6 | 33735278:33735655:33739133:33739261:33746758:33746848 | 33739133:33739261 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for IP6K3 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000451316 | 33739133 | 33739261 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000451316 | 33739133 | 33739261 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000451316 | 33739133 | 33739261 | 3UTR-3UTR |
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Infer the effects of exon skipping event on protein functional features for IP6K3 |
p-ENSG00000161896_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in IP6K3 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Mayo | ENST00000451316 | 33739133 | 33739261 | hsa-miR-4493 | chr6:33739171-33739178 | 8mer-1a | chr6:33739162-33739179 | 163.00 | -25.70 |
Mayo | ENST00000451316 | 33739133 | 33739261 | hsa-miR-379-5p | chr6:33739244-33739251 | 8mer-1a | chr6:33739241-33739261 | 153.00 | -21.53 |
Mayo | ENST00000451316 | 33739133 | 33739261 | hsa-miR-3529-5p | chr6:33739244-33739251 | 8mer-1a | chr6:33739241-33739261 | 153.00 | -21.53 |
Mayo | ENST00000451316 | 33739133 | 33739261 | hsa-miR-324-3p | chr6:33739196-33739203 | 8mer-1a | chr6:33739178-33739203 | 155.00 | -25.37 |
Mayo | ENST00000451316 | 33739133 | 33739261 | hsa-miR-1227-3p | chr6:33739188-33739195 | 8mer-1a | chr6:33739178-33739203 | 155.00 | -25.37 |
Mayo | ENST00000451316 | 33739133 | 33739261 | hsa-miR-3691-3p | chr6:33739220-33739227 | 8mer-1a | chr6:33739216-33739238 | 153.00 | -28.42 |
Mayo | ENST00000451316 | 33739133 | 33739261 | hsa-miR-6509-3p | chr6:33739197-33739204 | 8mer-1a | chr6:33739183-33739204 | 145.00 | -18.08 |
MSBB | ENST00000451316 | 33739133 | 33739261 | hsa-miR-4493 | chr6:33739171-33739178 | 8mer-1a | chr6:33739162-33739179 | 163.00 | -25.70 |
MSBB | ENST00000451316 | 33739133 | 33739261 | hsa-miR-379-5p | chr6:33739244-33739251 | 8mer-1a | chr6:33739241-33739261 | 153.00 | -21.53 |
MSBB | ENST00000451316 | 33739133 | 33739261 | hsa-miR-3529-5p | chr6:33739244-33739251 | 8mer-1a | chr6:33739241-33739261 | 153.00 | -21.53 |
MSBB | ENST00000451316 | 33739133 | 33739261 | hsa-miR-324-3p | chr6:33739196-33739203 | 8mer-1a | chr6:33739178-33739203 | 155.00 | -25.37 |
MSBB | ENST00000451316 | 33739133 | 33739261 | hsa-miR-1227-3p | chr6:33739188-33739195 | 8mer-1a | chr6:33739178-33739203 | 155.00 | -25.37 |
MSBB | ENST00000451316 | 33739133 | 33739261 | hsa-miR-3691-3p | chr6:33739220-33739227 | 8mer-1a | chr6:33739216-33739238 | 153.00 | -28.42 |
MSBB | ENST00000451316 | 33739133 | 33739261 | hsa-miR-6509-3p | chr6:33739197-33739204 | 8mer-1a | chr6:33739183-33739204 | 145.00 | -18.08 |
ROSMAP | ENST00000451316 | 33739133 | 33739261 | hsa-miR-4493 | chr6:33739171-33739178 | 8mer-1a | chr6:33739162-33739179 | 163.00 | -25.70 |
ROSMAP | ENST00000451316 | 33739133 | 33739261 | hsa-miR-379-5p | chr6:33739244-33739251 | 8mer-1a | chr6:33739241-33739261 | 153.00 | -21.53 |
ROSMAP | ENST00000451316 | 33739133 | 33739261 | hsa-miR-3529-5p | chr6:33739244-33739251 | 8mer-1a | chr6:33739241-33739261 | 153.00 | -21.53 |
ROSMAP | ENST00000451316 | 33739133 | 33739261 | hsa-miR-324-3p | chr6:33739196-33739203 | 8mer-1a | chr6:33739178-33739203 | 155.00 | -25.37 |
ROSMAP | ENST00000451316 | 33739133 | 33739261 | hsa-miR-1227-3p | chr6:33739188-33739195 | 8mer-1a | chr6:33739178-33739203 | 155.00 | -25.37 |
ROSMAP | ENST00000451316 | 33739133 | 33739261 | hsa-miR-3691-3p | chr6:33739220-33739227 | 8mer-1a | chr6:33739216-33739238 | 153.00 | -28.42 |
ROSMAP | ENST00000451316 | 33739133 | 33739261 | hsa-miR-6509-3p | chr6:33739197-33739204 | 8mer-1a | chr6:33739183-33739204 | 145.00 | -18.08 |
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SNVs in the skipped exons for IP6K3 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for IP6K3 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for IP6K3 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for IP6K3 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for IP6K3 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for IP6K3 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |