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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for ADCYAP1R1 |
 Gene summary |
| Gene information | Gene symbol | ADCYAP1R1 | Gene ID | 117 |
| Gene name | ADCYAP receptor type I | |
| Synonyms | PAC1|PAC1R|PACAPR|PACAPRI | |
| Cytomap | 7p14.3 | |
| Type of gene | protein-coding | |
| Description | pituitary adenylate cyclase-activating polypeptide type I receptorPACAP receptor 1PACAP type I receptorPACAP-R1adenylate cyclase activating polypeptide 1 (pituitary) receptor type Ipituitary adenylate cyclase activating polypeptide 1 receptor type I | |
| Modification date | 20200313 | |
| UniProtAcc | A0A090N8F8, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for ADCYAP1R1 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000078549
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| STG | UP | ENST00000409363.5 | ADCYAP1R1-203:protein_coding:ADCYAP1R1 | 3.442536e+01 | 1.059643e+00 | 1.795486e-04 | 1.551138e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ADCYAP1R1 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_10553 | chr7 | 31080613:31080633:31081713:31081754:31084141:31084250 | 31081713:31081754 |
| exon_skip_106576 | chr7 | 31077991:31078098:31080613:31080633:31081713:31081754 | 31080613:31080633 |
| exon_skip_113854 | chr7 | 31092644:31092735:31095667:31095750:31103237:31103271 | 31095667:31095750 |
| exon_skip_115048 | chr7 | 31095667:31095750:31100127:31100210:31103237:31103319 | 31100127:31100210 |
| exon_skip_129325 | chr7 | 31092689:31092735:31095667:31095750:31100127:31100210 | 31095667:31095750 |
| exon_skip_136806 | chr7 | 31092644:31092735:31095667:31095750:31100127:31100210 | 31095667:31095750 |
| exon_skip_141697 | chr7 | 31084141:31084250:31084737:31084834:31085310:31085442 | 31084737:31084834 |
| exon_skip_154687 | chr7 | 31086384:31086537:31086943:31087003:31087627:31087696 | 31086943:31087003 |
| exon_skip_218834 | chr7 | 31092644:31092735:31100127:31100210:31103237:31103366 | 31100127:31100210 |
| exon_skip_225508 | chr7 | 31103237:31103366:31104868:31104909:31106496:31106709 | 31104868:31104909 |
| exon_skip_227883 | chr7 | 31092644:31092735:31095667:31095750:31103237:31103366 | 31095667:31095750 |
| exon_skip_235090 | chr7 | 31092689:31092735:31100127:31100210:31103237:31103366 | 31100127:31100210 |
| exon_skip_236151 | chr7 | 31092689:31092735:31095667:31095750:31103237:31103366 | 31095667:31095750 |
| exon_skip_261930 | chr7 | 31100130:31100210:31103237:31103366:31104868:31104899 | 31103237:31103366 |
| exon_skip_268671 | chr7 | 31092644:31092735:31100127:31100210:31103237:31103319 | 31100127:31100210 |
| exon_skip_271537 | chr7 | 31095667:31095750:31100127:31100210:31103237:31103271 | 31100127:31100210 |
| exon_skip_27154 | chr7 | 31092644:31092735:31095667:31095750:31103237:31103319 | 31095667:31095750 |
| exon_skip_284984 | chr7 | 31092689:31092735:31103237:31103366:31104868:31104899 | 31103237:31103366 |
| exon_skip_29516 | chr7 | 31095667:31095750:31100127:31100210:31103237:31103366 | 31100127:31100210 |
| exon_skip_44386 | chr7 | 31092644:31092735:31103237:31103366:31104868:31104899 | 31103237:31103366 |
| exon_skip_64044 | chr7 | 31064831:31064936:31077991:31078098:31084141:31084250 | 31077991:31078098 |
| exon_skip_66232 | chr7 | 31092705:31092735:31095667:31095750:31100127:31100210 | 31095667:31095750 |
| exon_skip_7752 | chr7 | 31052527:31052678:31063194:31063315:31064831:31064936 | 31063194:31063315 |
| exon_skip_84281 | chr7 | 31092644:31092735:31100127:31100210:31103237:31103271 | 31100127:31100210 |
| exon_skip_87430 | chr7 | 31084737:31084834:31085310:31085442:31086384:31086537 | 31085310:31085442 |
| exon_skip_95176 | chr7 | 31064831:31064936:31077991:31078098:31084141:31084210 | 31077991:31078098 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_218834 | MSBB_PG | 1.565541e-01 | 2.691379e-01 | -1.125839e-01 | 2.376720e-06 |
| exon_skip_251070 | Mayo_CB | 2.785185e-01 | 1.506154e-01 | 1.279031e-01 | 1.514523e-04 |
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Open reading frame (ORF) annotation in the exon skipping event for ADCYAP1R1 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000304166 | 31084737 | 31084834 | Frame-shift |
| ENST00000304166 | 31103237 | 31103366 | Frame-shift |
| ENST00000304166 | 31080613 | 31080633 | In-frame |
| ENST00000304166 | 31081713 | 31081754 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000304166 | 31103237 | 31103366 | Frame-shift |
| ENST00000304166 | 31080613 | 31080633 | In-frame |
| ENST00000304166 | 31081713 | 31081754 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000304166 | 31084737 | 31084834 | Frame-shift |
| ENST00000304166 | 31085310 | 31085442 | Frame-shift |
| ENST00000304166 | 31086943 | 31087003 | Frame-shift |
| ENST00000304166 | 31103237 | 31103366 | Frame-shift |
| ENST00000304166 | 31080613 | 31080633 | In-frame |
| ENST00000304166 | 31081713 | 31081754 | In-frame |
| ENST00000304166 | 31104868 | 31104909 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ADCYAP1R1 |
p-ENSG00000078549_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000304166 | 6504 | 468 | 31081713 | 31081754 | 577 | 617 | 96 | 109 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000304166 | 6504 | 468 | 31081713 | 31081754 | 577 | 617 | 96 | 109 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000304166 | 6504 | 468 | 31081713 | 31081754 | 577 | 617 | 96 | 109 |
| ENST00000304166 | 6504 | 468 | 31104868 | 31104909 | 1467 | 1507 | 392 | 406 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P41586 | 96 | 109 | 89 | 109 | Alternative sequence | ID=VSP_042670;Note=In isoform S%2C isoform S-HOP1 and isoform VS. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P41586 | 96 | 109 | 21 | 468 | Chain | ID=PRO_0000012841;Note=Pituitary adenylate cyclase-activating polypeptide type I receptor |
| P41586 | 96 | 109 | 54 | 118 | Disulfide bond | . |
| P41586 | 96 | 109 | 77 | 134 | Disulfide bond | . |
| P41586 | 96 | 109 | 21 | 155 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P41586 | 96 | 109 | 89 | 109 | Alternative sequence | ID=VSP_042670;Note=In isoform S%2C isoform S-HOP1 and isoform VS. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P41586 | 96 | 109 | 21 | 468 | Chain | ID=PRO_0000012841;Note=Pituitary adenylate cyclase-activating polypeptide type I receptor |
| P41586 | 96 | 109 | 54 | 118 | Disulfide bond | . |
| P41586 | 96 | 109 | 77 | 134 | Disulfide bond | . |
| P41586 | 96 | 109 | 21 | 155 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P41586 | 96 | 109 | 89 | 109 | Alternative sequence | ID=VSP_042670;Note=In isoform S%2C isoform S-HOP1 and isoform VS. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P41586 | 96 | 109 | 21 | 468 | Chain | ID=PRO_0000012841;Note=Pituitary adenylate cyclase-activating polypeptide type I receptor |
| P41586 | 96 | 109 | 54 | 118 | Disulfide bond | . |
| P41586 | 96 | 109 | 77 | 134 | Disulfide bond | . |
| P41586 | 96 | 109 | 21 | 155 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P41586 | 392 | 406 | 21 | 468 | Chain | ID=PRO_0000012841;Note=Pituitary adenylate cyclase-activating polypeptide type I receptor |
| P41586 | 392 | 406 | 406 | 468 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P41586 | 392 | 406 | 386 | 405 | Transmembrane | Note=Helical%3B Name%3D7;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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3'-UTR located exon skipping events that lost miRNA binding sites in ADCYAP1R1 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for ADCYAP1R1 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ADCYAP1R1 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ADCYAP1R1 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
| PCC | exon_skip_64044 | rs17159800 | chr7:31004297 | 1.020253e-05 | 2.588077e-03 |
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Correlation with RNA binding proteins (RBPs) for ADCYAP1R1 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | HNRNPF | exon_skip_251070 | 5.591474e-01 | 2.213938e-13 |
| CB | NOVA1 | exon_skip_268671 | 4.086309e-01 | 9.811309e-08 |
| CB | RBM6 | exon_skip_295922 | -4.450588e-01 | 1.154604e-08 |
| CB | CNOT4 | exon_skip_295922 | -4.370032e-01 | 2.256268e-08 |
| CB | PCBP4 | exon_skip_295922 | 5.765093e-01 | 1.163120e-14 |
| CB | NUP42 | exon_skip_295922 | 5.121529e-01 | 2.098725e-11 |
| CB | SRSF4 | exon_skip_295922 | -4.067865e-01 | 2.396940e-07 |
| CB | RBM4 | exon_skip_295922 | -5.973464e-01 | 7.099844e-16 |
| CB | NOVA1 | exon_skip_278525 | 4.424945e-01 | 5.840742e-09 |
| CB | CNOT4 | exon_skip_44386 | -5.443440e-01 | 2.058579e-13 |
| CB | PCBP4 | exon_skip_44386 | 5.080244e-01 | 1.291274e-11 |
| CB | HNRNPL | exon_skip_44386 | -4.033336e-01 | 1.783271e-07 |
| CB | RBM23 | exon_skip_44386 | -5.113665e-01 | 9.002967e-12 |
| CB | SRSF4 | exon_skip_44386 | -5.478254e-01 | 1.348124e-13 |
| DLPFC | SRSF11 | exon_skip_218834 | -4.086799e-01 | 4.964779e-14 |
| FL | SRSF2 | exon_skip_218834 | 5.591294e-01 | 1.632944e-17 |
| FL | SRSF11 | exon_skip_218834 | 4.389390e-01 | 1.231189e-10 |
| FL | MBNL1 | exon_skip_218834 | 5.364132e-01 | 5.353669e-16 |
| FL | HNRNPL | exon_skip_218834 | 5.223162e-01 | 4.106073e-15 |
| FL | NOVA1 | exon_skip_218834 | 5.514315e-01 | 5.489226e-17 |
| FL | RBM4 | exon_skip_218834 | 4.317152e-01 | 2.655164e-10 |
| PCC | RBM6 | exon_skip_84281 | -4.776961e-01 | 1.343954e-13 |
| PG | HNRNPL | exon_skip_218834 | 4.216460e-01 | 2.759799e-10 |
| PG | NOVA1 | exon_skip_218834 | 4.683289e-01 | 1.260101e-12 |
| PG | RBM4 | exon_skip_218834 | 4.693219e-01 | 1.113426e-12 |
| STG | SRSF11 | exon_skip_218834 | 4.061859e-01 | 7.832673e-05 |
| STG | NOVA1 | exon_skip_218834 | 5.159481e-01 | 2.282097e-07 |
| TC | SRSF2 | exon_skip_235090 | 5.076701e-01 | 8.498287e-12 |
| TC | SRSF11 | exon_skip_235090 | 4.220266e-01 | 3.014193e-08 |
| TC | MBNL1 | exon_skip_235090 | 4.348936e-01 | 1.015001e-08 |
| TC | HNRNPL | exon_skip_235090 | 4.825214e-01 | 1.189405e-10 |
| TC | SRSF5 | exon_skip_235090 | 4.592696e-01 | 1.135477e-09 |
| TC | NOVA1 | exon_skip_235090 | 6.222011e-01 | 2.057436e-18 |
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RelatedDrugs for ADCYAP1R1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ADCYAP1R1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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