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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for WDR17 |
 Gene summary |
| Gene information | Gene symbol | WDR17 | Gene ID | 116966 |
| Gene name | WD repeat domain 17 | |
| Synonyms | - | |
| Cytomap | 4q34.2 | |
| Type of gene | protein-coding | |
| Description | WD repeat-containing protein 17epididymis secretory sperm binding protein | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for WDR17 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000150627
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PG | DOWN | ENST00000508773.1 | WDR17-206:retained_intron:WDR17 | 2.196847e+00 | -9.501214e-01 | 5.190275e-03 | 4.685807e-02 |
| CB | UP | ENST00000513261.1 | WDR17-208:nonsense_mediated_decay:WDR17 | 6.706578e+00 | 1.070166e+00 | 9.079971e-11 | 5.841090e-09 |
| CB | UP | ENST00000505894.2 | WDR17-203:protein_coding:WDR17 | 2.738591e+00 | 1.658745e+00 | 2.381759e-03 | 1.064921e-02 |
| TC | UP | ENST00000505894.2 | WDR17-203:protein_coding:WDR17 | 1.603165e+00 | 1.496345e+00 | 8.054859e-03 | 4.778113e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for WDR17 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_107130 | chr4 | 176141983:176142069:176145995:176146159:176148133:176148335 | 176145995:176146159 |
| exon_skip_144044 | chr4 | 176142033:176142069:176145995:176146159:176148133:176148335 | 176145995:176146159 |
| exon_skip_17187 | chr4 | 176141983:176142069:176145995:176146159:176148133:176148212 | 176145995:176146159 |
| exon_skip_184848 | chr4 | 176163154:176163293:176166124:176166144:176168672:176168783 | 176166124:176166144 |
| exon_skip_188893 | chr4 | 176111575:176111703:176115796:176115979:176119867:176120097 | 176115796:176115979 |
| exon_skip_228361 | chr4 | 176135108:176135276:176137520:176137611:176139892:176139974 | 176137520:176137611 |
| exon_skip_247720 | chr4 | 176065834:176066079:176096463:176096585:176111575:176111703 | 176096463:176096585 |
| exon_skip_272239 | chr4 | 176172375:176172516:176173267:176173369:176174617:176174718 | 176173267:176173369 |
| exon_skip_36556 | chr4 | 176142009:176142069:176145995:176146159:176148133:176148335 | 176145995:176146159 |
| exon_skip_37468 | chr4 | 176141983:176142069:176145995:176146159:176148133:176148271 | 176145995:176146159 |
| exon_skip_45188 | chr4 | 176149807:176149956:176150043:176150173:176150468:176150593 | 176150043:176150173 |
| exon_skip_57600 | chr4 | 176151812:176151967:176156079:176156143:176159994:176160126 | 176156079:176156143 |
| exon_skip_82941 | chr4 | 176139892:176139974:176141983:176142069:176145995:176146159 | 176141983:176142069 |
| exon_skip_89114 | chr4 | 176162075:176162174:176163154:176163293:176168672:176168783 | 176163154:176163293 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for WDR17 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000280190 | 176096463 | 176096585 | 5CDS-5UTR |
| ENST00000280190 | 176115796 | 176115979 | Frame-shift |
| ENST00000280190 | 176150043 | 176150173 | Frame-shift |
| ENST00000280190 | 176141983 | 176142069 | In-frame |
| ENST00000280190 | 176145995 | 176146159 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000280190 | 176096463 | 176096585 | 5CDS-5UTR |
| ENST00000280190 | 176115796 | 176115979 | Frame-shift |
| ENST00000280190 | 176156079 | 176156143 | Frame-shift |
| ENST00000280190 | 176173267 | 176173369 | Frame-shift |
| ENST00000280190 | 176141983 | 176142069 | In-frame |
| ENST00000280190 | 176145995 | 176146159 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000280190 | 176096463 | 176096585 | 5CDS-5UTR |
| ENST00000280190 | 176115796 | 176115979 | Frame-shift |
| ENST00000280190 | 176137520 | 176137611 | Frame-shift |
| ENST00000280190 | 176141983 | 176142069 | In-frame |
| ENST00000280190 | 176145995 | 176146159 | In-frame |
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Infer the effects of exon skipping event on protein functional features for WDR17 |
p-ENSG00000150627_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000280190 | 4722 | 1322 | 176141983 | 176142069 | 1672 | 1757 | 505 | 533 |
| ENST00000280190 | 4722 | 1322 | 176145995 | 176146159 | 1759 | 1922 | 534 | 588 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000280190 | 4722 | 1322 | 176141983 | 176142069 | 1672 | 1757 | 505 | 533 |
| ENST00000280190 | 4722 | 1322 | 176145995 | 176146159 | 1759 | 1922 | 534 | 588 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000280190 | 4722 | 1322 | 176141983 | 176142069 | 1672 | 1757 | 505 | 533 |
| ENST00000280190 | 4722 | 1322 | 176145995 | 176146159 | 1759 | 1922 | 534 | 588 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8IZU2 | 505 | 533 | 1 | 1322 | Chain | ID=PRO_0000051364;Note=WD repeat-containing protein 17 |
| Q8IZU2 | 505 | 533 | 478 | 518 | Repeat | Note=WD 8 |
| Q8IZU2 | 505 | 533 | 519 | 559 | Repeat | Note=WD 9 |
| Q8IZU2 | 534 | 588 | 1 | 1322 | Chain | ID=PRO_0000051364;Note=WD repeat-containing protein 17 |
| Q8IZU2 | 534 | 588 | 519 | 559 | Repeat | Note=WD 9 |
| Q8IZU2 | 534 | 588 | 564 | 604 | Repeat | Note=WD 10 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8IZU2 | 505 | 533 | 1 | 1322 | Chain | ID=PRO_0000051364;Note=WD repeat-containing protein 17 |
| Q8IZU2 | 505 | 533 | 478 | 518 | Repeat | Note=WD 8 |
| Q8IZU2 | 505 | 533 | 519 | 559 | Repeat | Note=WD 9 |
| Q8IZU2 | 534 | 588 | 1 | 1322 | Chain | ID=PRO_0000051364;Note=WD repeat-containing protein 17 |
| Q8IZU2 | 534 | 588 | 519 | 559 | Repeat | Note=WD 9 |
| Q8IZU2 | 534 | 588 | 564 | 604 | Repeat | Note=WD 10 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8IZU2 | 505 | 533 | 1 | 1322 | Chain | ID=PRO_0000051364;Note=WD repeat-containing protein 17 |
| Q8IZU2 | 505 | 533 | 478 | 518 | Repeat | Note=WD 8 |
| Q8IZU2 | 505 | 533 | 519 | 559 | Repeat | Note=WD 9 |
| Q8IZU2 | 534 | 588 | 1 | 1322 | Chain | ID=PRO_0000051364;Note=WD repeat-containing protein 17 |
| Q8IZU2 | 534 | 588 | 519 | 559 | Repeat | Note=WD 9 |
| Q8IZU2 | 534 | 588 | 564 | 604 | Repeat | Note=WD 10 |
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3'-UTR located exon skipping events that lost miRNA binding sites in WDR17 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for WDR17 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for WDR17 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for WDR17 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for WDR17 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | DAZAP1 | exon_skip_188893 | -4.435458e-01 | 3.108912e-07 |
| CB | RBM6 | exon_skip_188893 | -5.896866e-01 | 8.912818e-13 |
| CB | PCBP4 | exon_skip_188893 | 4.879073e-01 | 1.196289e-08 |
| CB | FUBP3 | exon_skip_188893 | 4.172334e-01 | 1.744656e-06 |
| CB | HNRNPDL | exon_skip_188893 | 5.451829e-01 | 8.430481e-11 |
| CB | NUP42 | exon_skip_188893 | 5.744051e-01 | 4.592461e-12 |
| CB | PABPC4 | exon_skip_188893 | 4.111140e-01 | 2.552963e-06 |
| CB | ZNF638 | exon_skip_37468 | -4.202323e-01 | 2.930758e-06 |
| CB | UNK | exon_skip_37468 | 4.827348e-01 | 4.666166e-08 |
| CB | NUP42 | exon_skip_37468 | 4.679504e-01 | 1.340158e-07 |
| CB | RALYL | exon_skip_184848 | 4.964448e-01 | 5.924941e-10 |
| FL | RALYL | exon_skip_184848 | 4.419082e-01 | 1.739624e-10 |
| IFG | RBM5 | exon_skip_247720 | -4.692744e-01 | 1.795394e-02 |
| IFG | G3BP2 | exon_skip_247720 | 4.411488e-01 | 2.728229e-02 |
| IFG | ELAVL4 | exon_skip_188893 | -5.541973e-01 | 2.704238e-03 |
| IFG | KHDRBS2 | exon_skip_188893 | -4.767322e-01 | 1.193218e-02 |
| IFG | KHDRBS3 | exon_skip_188893 | -4.271300e-01 | 2.627585e-02 |
| IFG | RALYL | exon_skip_188893 | -5.747118e-01 | 1.715799e-03 |
| IFG | NOVA1 | exon_skip_188893 | -5.568849e-01 | 2.551949e-03 |
| IFG | TARDBP | exon_skip_184848 | -5.640205e-01 | 1.771970e-03 |
| IFG | PCBP2 | exon_skip_184848 | -4.237701e-01 | 2.462487e-02 |
| PCC | RALYL | exon_skip_184848 | 4.968502e-01 | 3.550886e-13 |
| PG | RBM24 | exon_skip_184848 | 4.977030e-01 | 1.199846e-11 |
| PG | RALYL | exon_skip_184848 | 6.452638e-01 | 1.097906e-20 |
| STG | FUBP3 | exon_skip_188893 | 4.720726e-01 | 2.174467e-05 |
| STG | RALYL | exon_skip_184848 | 4.520348e-01 | 2.890147e-05 |
| TC | RBM6 | exon_skip_188893 | -4.169242e-01 | 4.355494e-06 |
| TC | RBM24 | exon_skip_184848 | 7.657822e-01 | 4.112514e-26 |
| TC | RALYL | exon_skip_184848 | 8.563744e-01 | 2.882587e-38 |
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RelatedDrugs for WDR17 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for WDR17 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
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