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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for WDR31 |
 Gene summary |
| Gene information | Gene symbol | WDR31 | Gene ID | 114987 |
| Gene name | WD repeat domain 31 | |
| Synonyms | - | |
| Cytomap | 9q32 | |
| Type of gene | protein-coding | |
| Description | WD repeat-containing protein 31 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for WDR31 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000148225
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for WDR31 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_172451 | chr9 | 113332009:113332050:113336288:113336440:113340217:113340254 | 113336288:113336440 |
| exon_skip_177004 | chr9 | 113323011:113323155:113328881:113328955:113330984:113331113 | 113328881:113328955 |
| exon_skip_214899 | chr9 | 113328881:113328955:113330984:113331116:113331978:113332050 | 113330984:113331116 |
| exon_skip_226382 | chr9 | 113331978:113332050:113336288:113336440:113340217:113340254 | 113336288:113336440 |
| exon_skip_295686 | chr9 | 113328881:113328955:113330984:113331113:113331907:113332050 | 113330984:113331113 |
| exon_skip_6 | chr9 | 113328881:113328955:113330984:113331116:113331907:113332050 | 113330984:113331116 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for WDR31 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000374193 | 113336288 | 113336440 | 3UTR-3UTR |
| ENST00000374193 | 113330984 | 113331116 | Frame-shift |
| ENST00000374193 | 113328881 | 113328955 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000374193 | 113336288 | 113336440 | 3UTR-3UTR |
| ENST00000374193 | 113330984 | 113331116 | Frame-shift |
| ENST00000374193 | 113328881 | 113328955 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000374193 | 113336288 | 113336440 | 3UTR-3UTR |
| ENST00000374193 | 113330984 | 113331116 | Frame-shift |
| ENST00000374193 | 113328881 | 113328955 | In-frame |
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Infer the effects of exon skipping event on protein functional features for WDR31 |
p-ENSG00000148225_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000374193 | 4895 | 367 | 113328881 | 113328955 | 497 | 570 | 83 | 107 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000374193 | 4895 | 367 | 113328881 | 113328955 | 497 | 570 | 83 | 107 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000374193 | 4895 | 367 | 113328881 | 113328955 | 497 | 570 | 83 | 107 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8NA23 | 83 | 107 | 1 | 367 | Chain | ID=PRO_0000051380;Note=WD repeat-containing protein 31 |
| Q8NA23 | 83 | 107 | 53 | 90 | Repeat | Note=WD 1 |
| Q8NA23 | 83 | 107 | 94 | 132 | Repeat | Note=WD 2 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8NA23 | 83 | 107 | 1 | 367 | Chain | ID=PRO_0000051380;Note=WD repeat-containing protein 31 |
| Q8NA23 | 83 | 107 | 53 | 90 | Repeat | Note=WD 1 |
| Q8NA23 | 83 | 107 | 94 | 132 | Repeat | Note=WD 2 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8NA23 | 83 | 107 | 1 | 367 | Chain | ID=PRO_0000051380;Note=WD repeat-containing protein 31 |
| Q8NA23 | 83 | 107 | 53 | 90 | Repeat | Note=WD 1 |
| Q8NA23 | 83 | 107 | 94 | 132 | Repeat | Note=WD 2 |
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3'-UTR located exon skipping events that lost miRNA binding sites in WDR31 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000374193 | 113336288 | 113336440 | hsa-miR-4632-5p | chr9:113336317-113336324 | 8mer-1a | chr9:113336299-113336324 | 158.00 | -24.77 |
| Mayo | ENST00000374193 | 113336288 | 113336440 | hsa-miR-5585-3p | chr9:113336322-113336329 | 8mer-1a | chr9:113336314-113336335 | 150.00 | -9.31 |
| Mayo | ENST00000374193 | 113336288 | 113336440 | hsa-miR-6735-5p | chr9:113336317-113336324 | 8mer-1a | chr9:113336299-113336324 | 158.00 | -24.77 |
| Mayo | ENST00000374193 | 113336288 | 113336440 | hsa-miR-3156-3p | chr9:113336392-113336399 | 8mer-1a | chr9:113336386-113336407 | 150.00 | -16.70 |
| Mayo | ENST00000374193 | 113336288 | 113336440 | hsa-miR-6879-5p | chr9:113336317-113336324 | 8mer-1a | chr9:113336299-113336324 | 158.00 | -24.77 |
| Mayo | ENST00000374193 | 113336288 | 113336440 | hsa-miR-4301 | chr9:113336391-113336398 | 8mer-1a | chr9:113336386-113336407 | 150.00 | -16.70 |
| Mayo | ENST00000374193 | 113336288 | 113336440 | hsa-miR-5693 | chr9:113336400-113336407 | 8mer-1a | chr9:113336399-113336422 | 156.00 | -13.11 |
| Mayo | ENST00000374193 | 113336288 | 113336440 | hsa-miR-7843-5p | chr9:113336317-113336324 | 8mer-1a | chr9:113336299-113336324 | 158.00 | -24.77 |
| Mayo | ENST00000374193 | 113336288 | 113336440 | hsa-miR-4436b-3p | chr9:113336317-113336324 | 8mer-1a | chr9:113336299-113336324 | 158.00 | -24.77 |
| MSBB | ENST00000374193 | 113336288 | 113336440 | hsa-miR-4632-5p | chr9:113336317-113336324 | 8mer-1a | chr9:113336299-113336324 | 158.00 | -24.77 |
| MSBB | ENST00000374193 | 113336288 | 113336440 | hsa-miR-5585-3p | chr9:113336322-113336329 | 8mer-1a | chr9:113336314-113336335 | 150.00 | -9.31 |
| MSBB | ENST00000374193 | 113336288 | 113336440 | hsa-miR-6735-5p | chr9:113336317-113336324 | 8mer-1a | chr9:113336299-113336324 | 158.00 | -24.77 |
| MSBB | ENST00000374193 | 113336288 | 113336440 | hsa-miR-3156-3p | chr9:113336392-113336399 | 8mer-1a | chr9:113336386-113336407 | 150.00 | -16.70 |
| MSBB | ENST00000374193 | 113336288 | 113336440 | hsa-miR-6879-5p | chr9:113336317-113336324 | 8mer-1a | chr9:113336299-113336324 | 158.00 | -24.77 |
| MSBB | ENST00000374193 | 113336288 | 113336440 | hsa-miR-4301 | chr9:113336391-113336398 | 8mer-1a | chr9:113336386-113336407 | 150.00 | -16.70 |
| MSBB | ENST00000374193 | 113336288 | 113336440 | hsa-miR-5693 | chr9:113336400-113336407 | 8mer-1a | chr9:113336399-113336422 | 156.00 | -13.11 |
| MSBB | ENST00000374193 | 113336288 | 113336440 | hsa-miR-7843-5p | chr9:113336317-113336324 | 8mer-1a | chr9:113336299-113336324 | 158.00 | -24.77 |
| MSBB | ENST00000374193 | 113336288 | 113336440 | hsa-miR-4436b-3p | chr9:113336317-113336324 | 8mer-1a | chr9:113336299-113336324 | 158.00 | -24.77 |
| ROSMAP | ENST00000374193 | 113336288 | 113336440 | hsa-miR-4632-5p | chr9:113336317-113336324 | 8mer-1a | chr9:113336299-113336324 | 158.00 | -24.77 |
| ROSMAP | ENST00000374193 | 113336288 | 113336440 | hsa-miR-5585-3p | chr9:113336322-113336329 | 8mer-1a | chr9:113336314-113336335 | 150.00 | -9.31 |
| ROSMAP | ENST00000374193 | 113336288 | 113336440 | hsa-miR-6735-5p | chr9:113336317-113336324 | 8mer-1a | chr9:113336299-113336324 | 158.00 | -24.77 |
| ROSMAP | ENST00000374193 | 113336288 | 113336440 | hsa-miR-3156-3p | chr9:113336392-113336399 | 8mer-1a | chr9:113336386-113336407 | 150.00 | -16.70 |
| ROSMAP | ENST00000374193 | 113336288 | 113336440 | hsa-miR-6879-5p | chr9:113336317-113336324 | 8mer-1a | chr9:113336299-113336324 | 158.00 | -24.77 |
| ROSMAP | ENST00000374193 | 113336288 | 113336440 | hsa-miR-4301 | chr9:113336391-113336398 | 8mer-1a | chr9:113336386-113336407 | 150.00 | -16.70 |
| ROSMAP | ENST00000374193 | 113336288 | 113336440 | hsa-miR-5693 | chr9:113336400-113336407 | 8mer-1a | chr9:113336399-113336422 | 156.00 | -13.11 |
| ROSMAP | ENST00000374193 | 113336288 | 113336440 | hsa-miR-7843-5p | chr9:113336317-113336324 | 8mer-1a | chr9:113336299-113336324 | 158.00 | -24.77 |
| ROSMAP | ENST00000374193 | 113336288 | 113336440 | hsa-miR-4436b-3p | chr9:113336317-113336324 | 8mer-1a | chr9:113336299-113336324 | 158.00 | -24.77 |
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SNVs in the skipped exons for WDR31 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for WDR31 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for WDR31 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
| HCC | exon_skip_226382 | rs10817477 | chr9:113313517 | 4.260812e-13 | 2.218958e-10 |
| HCC | exon_skip_226382 | rs2296076 | chr9:113316991 | 4.260812e-13 | 2.218958e-10 |
| HCC | exon_skip_226382 | rs2296075 | chr9:113317151 | 4.260812e-13 | 2.218958e-10 |
| HCC | exon_skip_226382 | rs2418249 | chr9:113291760 | 4.208417e-12 | 1.854092e-09 |
| HCC | exon_skip_226382 | rs10981725 | chr9:113301466 | 4.208417e-12 | 1.854092e-09 |
| HCC | exon_skip_226382 | rs16932806 | chr9:113338088 | 2.858621e-11 | 1.101499e-08 |
| HCC | exon_skip_226382 | rs10981714 | chr9:113286697 | 1.920279e-10 | 6.432745e-08 |
| HCC | exon_skip_226382 | rs7860625 | chr9:113302807 | 2.756719e-06 | 4.062844e-04 |
| HCC | exon_skip_226382 | rs4979232 | chr9:113286594 | 1.196003e-04 | 1.069297e-02 |
| HCC | exon_skip_226382 | rs2296073 | chr9:113299348 | 7.502408e-04 | 4.666523e-02 |
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Correlation with RNA binding proteins (RBPs) for WDR31 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for WDR31 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for WDR31 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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