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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for OSBPL10 |
Gene summary |
Gene information | Gene symbol | OSBPL10 | Gene ID | 114884 |
Gene name | oxysterol binding protein like 10 | |
Synonyms | ORP10|OSBP9 | |
Cytomap | 3p23 | |
Type of gene | protein-coding | |
Description | oxysterol-binding protein-related protein 10ORP-10OSBP-related protein 10 | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for OSBPL10 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
CB | UP | ENST00000467955.5 | OSBPL10-211:lncRNA:OSBPL10 | 5.367299e-01 | 1.332429e+00 | 1.368172e-02 | 4.476867e-02 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for OSBPL10 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_186456 | chr3 | 31876435:31876512:31879430:31879553:31879655:31879830 | 31879430:31879553 |
exon_skip_291748 | chr3 | 31748014:31748120:31830040:31830231:31876433:31876512 | 31830040:31830231 |
exon_skip_293024 | chr3 | 31876435:31876512:31879655:31879830:31980899:31980946 | 31879655:31879830 |
exon_skip_52162 | chr3 | 31747933:31748120:31830040:31830231:31876433:31876512 | 31830040:31830231 |
exon_skip_7495 | chr3 | 31683969:31684114:31702359:31702508:31733257:31733411 | 31702359:31702508 |
exon_skip_91893 | chr3 | 31702376:31702508:31733257:31733411:31747910:31748120 | 31733257:31733411 |
exon_skip_96626 | chr3 | 31747910:31748120:31797755:31797841:31830040:31830105 | 31797755:31797841 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for OSBPL10 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000396556 | 31733257 | 31733411 | Frame-shift |
ENST00000396556 | 31702359 | 31702508 | In-frame |
ENST00000396556 | 31830040 | 31830231 | In-frame |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000396556 | 31830040 | 31830231 | In-frame |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000396556 | 31830040 | 31830231 | In-frame |
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Infer the effects of exon skipping event on protein functional features for OSBPL10 |
p-ENSG00000144645_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000396556 | 6617 | 764 | 31830040 | 31830231 | 661 | 851 | 179 | 242 |
ENST00000396556 | 6617 | 764 | 31702359 | 31702508 | 1219 | 1367 | 365 | 414 |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000396556 | 6617 | 764 | 31830040 | 31830231 | 661 | 851 | 179 | 242 |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000396556 | 6617 | 764 | 31830040 | 31830231 | 661 | 851 | 179 | 242 |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q9BXB5 | 179 | 242 | 180 | 243 | Alternative sequence | ID=VSP_042930;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
Q9BXB5 | 179 | 242 | 1 | 764 | Chain | ID=PRO_0000100380;Note=Oxysterol-binding protein-related protein 10 |
Q9BXB5 | 179 | 242 | 196 | 196 | Modified residue | Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648 |
Q9BXB5 | 179 | 242 | 201 | 201 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648 |
Q9BXB5 | 179 | 242 | 209 | 209 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:21406692,PMID:23186163 |
Q9BXB5 | 179 | 242 | 223 | 223 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163 |
Q9BXB5 | 365 | 414 | 1 | 764 | Chain | ID=PRO_0000100380;Note=Oxysterol-binding protein-related protein 10 |
Q9BXB5 | 365 | 414 | 413 | 418 | Region | Note=Phosphatidylinositol 4-phosphate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q02201 |
Q9BXB5 | 365 | 414 | 413 | 418 | Region | Note=Phosphatidylserine binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q02201 |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q9BXB5 | 179 | 242 | 180 | 243 | Alternative sequence | ID=VSP_042930;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
Q9BXB5 | 179 | 242 | 1 | 764 | Chain | ID=PRO_0000100380;Note=Oxysterol-binding protein-related protein 10 |
Q9BXB5 | 179 | 242 | 196 | 196 | Modified residue | Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648 |
Q9BXB5 | 179 | 242 | 201 | 201 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648 |
Q9BXB5 | 179 | 242 | 209 | 209 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:21406692,PMID:23186163 |
Q9BXB5 | 179 | 242 | 223 | 223 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163 |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q9BXB5 | 179 | 242 | 180 | 243 | Alternative sequence | ID=VSP_042930;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
Q9BXB5 | 179 | 242 | 1 | 764 | Chain | ID=PRO_0000100380;Note=Oxysterol-binding protein-related protein 10 |
Q9BXB5 | 179 | 242 | 196 | 196 | Modified residue | Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648 |
Q9BXB5 | 179 | 242 | 201 | 201 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648 |
Q9BXB5 | 179 | 242 | 209 | 209 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:21406692,PMID:23186163 |
Q9BXB5 | 179 | 242 | 223 | 223 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163 |
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3'-UTR located exon skipping events that lost miRNA binding sites in OSBPL10 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for OSBPL10 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for OSBPL10 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for OSBPL10 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
HCC | exon_skip_291748 | rs7646594 | chr3:31808326 | 1.858269e-04 | 1.526346e-02 |
PCC | exon_skip_291748 | rs11719924 | chr3:31904939 | 1.877800e-05 | 4.370524e-03 |
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Correlation with RNA binding proteins (RBPs) for OSBPL10 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for OSBPL10 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for OSBPL10 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |