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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for TRIM9 |
 Gene summary |
| Gene information | Gene symbol | TRIM9 | Gene ID | 114088 |
| Gene name | tripartite motif containing 9 | |
| Synonyms | RNF91|SPRING | |
| Cytomap | 14q22.1 | |
| Type of gene | protein-coding | |
| Description | E3 ubiquitin-protein ligase TRIM9RING finger protein 91RING-type E3 ubiquitin transferase TRIM9SNAP-25-interacting RING finger proteinhomolog of rat RING finger Springtripartite motif-containing protein 9 | |
| Modification date | 20200313 | |
| UniProtAcc | Q9C026, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TRIM9 | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 20085810 |
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Gene structures and expression levels for TRIM9 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000100505
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TRIM9 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_150551 | chr14 | 50982942:50982965:50983380:50983421:50985956:50986144 | 50983380:50983421 |
| exon_skip_16819 | chr14 | 50998050:50998188:51000683:51000828:51009080:51009233 | 51000683:51000828 |
| exon_skip_200672 | chr14 | 50981854:50982103:50982942:50982965:50983380:50983421 | 50982942:50982965 |
| exon_skip_211139 | chr14 | 50981955:50982103:50998050:50998188:51000683:51000828 | 50998050:50998188 |
| exon_skip_218845 | chr14 | 50998050:50998188:51000683:51000840:51009080:51009233 | 51000683:51000840 |
| exon_skip_22771 | chr14 | 50981955:50982103:50982942:50982965:50983380:50983421 | 50982942:50982965 |
| exon_skip_242594 | chr14 | 50981854:50982103:50998050:50998188:51000683:51000828 | 50998050:50998188 |
| exon_skip_250654 | chr14 | 51009080:51009233:51010384:51010494:51022835:51022957 | 51010384:51010494 |
| exon_skip_268360 | chr14 | 50983380:50983421:50985956:50986144:50998050:50998188 | 50985956:50986144 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_33566 | MSBB_PG | 1.634821e-01 | 3.089583e-01 | -1.454762e-01 | 3.864317e-02 |
| exon_skip_251437 | Mayo_CB | 2.991358e-01 | 1.730000e-01 | 1.261358e-01 | 5.942001e-04 |
| exon_skip_92108 | Mayo_CB | 3.001235e-01 | 1.758571e-01 | 1.242663e-01 | 7.942062e-04 |
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Open reading frame (ORF) annotation in the exon skipping event for TRIM9 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000298355 | 50998050 | 50998188 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000298355 | 50998050 | 50998188 | Frame-shift |
| ENST00000298355 | 51000683 | 51000840 | Frame-shift |
| ENST00000298355 | 51010384 | 51010494 | In-frame |
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Infer the effects of exon skipping event on protein functional features for TRIM9 |
p-ENSG00000100505_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000298355 | 5301 | 710 | 51010384 | 51010494 | 2164 | 2273 | 347 | 383 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9C026 | 347 | 383 | 1 | 710 | Chain | ID=PRO_0000056208;Note=E3 ubiquitin-protein ligase TRIM9 |
| Q9C026 | 347 | 383 | 374 | 432 | Domain | Note=COS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00586 |
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3'-UTR located exon skipping events that lost miRNA binding sites in TRIM9 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for TRIM9 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for TRIM9 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TRIM9 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for TRIM9 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | TARDBP | exon_skip_251437 | 4.810920e-01 | 4.035568e-10 |
| CB | ELAVL1 | exon_skip_251437 | 4.998645e-01 | 6.388906e-11 |
| CB | FUBP1 | exon_skip_251437 | 4.846946e-01 | 2.857737e-10 |
| CB | KHSRP | exon_skip_251437 | 4.728901e-01 | 8.723926e-10 |
| CB | HNRNPC | exon_skip_251437 | 5.018812e-01 | 5.206064e-11 |
| CB | RBMS3 | exon_skip_113132 | -4.026604e-01 | 3.251892e-07 |
| CB | PCBP2 | exon_skip_272421 | 4.290102e-01 | 2.835018e-08 |
| CB | RALYL | exon_skip_272421 | 5.096446e-01 | 1.474519e-11 |
| CB | EWSR1 | exon_skip_272421 | 4.037278e-01 | 2.079948e-07 |
| CB | SRSF9 | exon_skip_272421 | 4.271281e-01 | 3.307224e-08 |
| CB | SRSF2 | exon_skip_223581 | 4.249190e-01 | 3.958017e-08 |
| CB | PCBP2 | exon_skip_223581 | 4.631983e-01 | 1.457653e-09 |
| CB | HNRNPA0 | exon_skip_223581 | 4.676544e-01 | 9.659398e-10 |
| CB | NUP42 | exon_skip_223581 | 4.898021e-01 | 1.142021e-10 |
| CB | RALYL | exon_skip_223581 | 5.794930e-01 | 3.435247e-15 |
| CB | SRSF9 | exon_skip_223581 | 4.978922e-01 | 5.036014e-11 |
| CB | RBM4 | exon_skip_94314 | -4.420774e-01 | 1.658118e-08 |
| CB | CNOT4 | exon_skip_150551 | -5.289266e-01 | 1.497624e-12 |
| CB | RBM45 | exon_skip_150551 | 6.547182e-01 | 2.465191e-20 |
| CB | CNOT4 | exon_skip_8525 | -4.621565e-01 | 3.360895e-09 |
| CB | RBM3 | exon_skip_8525 | 4.769608e-01 | 8.871855e-10 |
| CB | PCBP1 | exon_skip_8525 | -4.180348e-01 | 1.246026e-07 |
| CB | PCBP4 | exon_skip_8525 | 5.614600e-01 | 1.142791e-13 |
| CB | TRA2A | exon_skip_8525 | -5.247921e-01 | 7.559781e-12 |
| CB | RBM45 | exon_skip_8525 | 6.358326e-01 | 3.884791e-18 |
| FL | SRSF2 | exon_skip_33566 | 4.729597e-01 | 5.007622e-11 |
| FL | RBM3 | exon_skip_33566 | 4.674955e-01 | 8.900733e-11 |
| FL | HNRNPK | exon_skip_33566 | 4.368804e-01 | 1.862939e-09 |
| FL | KHDRBS3 | exon_skip_33566 | 4.920222e-01 | 6.205833e-12 |
| FL | RBM24 | exon_skip_33566 | 4.993849e-01 | 2.674697e-12 |
| FL | HNRNPA0 | exon_skip_33566 | 5.074027e-01 | 1.045106e-12 |
| FL | RALYL | exon_skip_33566 | 5.253428e-01 | 1.165254e-13 |
| FL | HNRNPL | exon_skip_33566 | 4.818670e-01 | 1.918033e-11 |
| FL | EIF4B | exon_skip_33566 | 4.219781e-01 | 7.365284e-09 |
| HCC | DAZAP1 | exon_skip_33566 | -4.785526e-01 | 6.446910e-17 |
| HCC | PABPN1 | exon_skip_33566 | -4.548333e-01 | 3.050992e-15 |
| HCC | RBM6 | exon_skip_33566 | -5.349007e-01 | 1.849971e-21 |
| HCC | CNOT4 | exon_skip_33566 | -4.072286e-01 | 3.002496e-12 |
| HCC | TRNAU1AP | exon_skip_33566 | -4.230675e-01 | 3.414525e-13 |
| HCC | UNK | exon_skip_33566 | -4.394219e-01 | 3.200239e-14 |
| HCC | PCBP2 | exon_skip_33566 | -4.083582e-01 | 2.580939e-12 |
| HCC | KHDRBS3 | exon_skip_33566 | -4.962818e-01 | 2.949133e-18 |
| HCC | RBM45 | exon_skip_33566 | -4.743135e-01 | 1.313204e-16 |
| HCC | PTBP1 | exon_skip_33566 | -6.152734e-01 | 1.279585e-29 |
| HCC | RBM41 | exon_skip_33566 | -4.029858e-01 | 5.273125e-12 |
| PCC | RBM6 | exon_skip_33566 | -5.109183e-01 | 2.317900e-15 |
| PCC | TRNAU1AP | exon_skip_33566 | -4.013278e-01 | 1.572201e-09 |
| PCC | PCBP4 | exon_skip_33566 | -4.910277e-01 | 3.834434e-14 |
| PCC | PTBP1 | exon_skip_33566 | -6.811818e-01 | 5.485046e-30 |
| PG | SRSF2 | exon_skip_33566 | 5.101052e-01 | 5.578923e-12 |
| PG | PABPN1 | exon_skip_33566 | 4.701565e-01 | 3.547897e-10 |
| PG | ELAVL1 | exon_skip_33566 | 4.789562e-01 | 1.487559e-10 |
| PG | CNOT4 | exon_skip_33566 | 5.043300e-01 | 1.051736e-11 |
| PG | RBM3 | exon_skip_33566 | 5.414319e-01 | 1.442084e-13 |
| PG | MBNL1 | exon_skip_33566 | 5.149140e-01 | 3.260572e-12 |
| PG | IGF2BP2 | exon_skip_33566 | -4.012455e-01 | 1.454246e-07 |
| PG | TRNAU1AP | exon_skip_33566 | 4.253923e-01 | 2.054800e-08 |
| PG | PCBP1 | exon_skip_33566 | 5.482446e-01 | 6.187831e-14 |
| PG | HNRNPK | exon_skip_33566 | 6.053054e-01 | 2.285934e-17 |
| PG | KHDRBS2 | exon_skip_33566 | 6.011864e-01 | 4.265609e-17 |
| PG | KHDRBS3 | exon_skip_33566 | 6.498863e-01 | 1.434945e-20 |
| PG | RBM24 | exon_skip_33566 | 6.610213e-01 | 1.868707e-21 |
| PG | HNRNPA0 | exon_skip_33566 | 6.314763e-01 | 3.485071e-19 |
| PG | RBM45 | exon_skip_33566 | 4.405208e-01 | 5.562931e-09 |
| PG | PUF60 | exon_skip_33566 | 4.468275e-01 | 3.165307e-09 |
| PG | HNRNPD | exon_skip_33566 | 5.475326e-01 | 6.765975e-14 |
| PG | NUP42 | exon_skip_33566 | 5.426093e-01 | 1.247599e-13 |
| PG | RALYL | exon_skip_33566 | 7.187224e-01 | 1.013423e-26 |
| PG | HNRNPL | exon_skip_33566 | 5.804053e-01 | 8.695228e-16 |
| PG | RBM23 | exon_skip_33566 | 4.639349e-01 | 6.463643e-10 |
| PG | EWSR1 | exon_skip_33566 | 5.250509e-01 | 1.021980e-12 |
| PG | SRSF9 | exon_skip_33566 | 4.194528e-01 | 3.373324e-08 |
| PG | SRSF5 | exon_skip_33566 | 5.341222e-01 | 3.500704e-13 |
| PG | EIF4B | exon_skip_33566 | 4.679922e-01 | 4.377114e-10 |
| TC | SRSF2 | exon_skip_223581 | 5.393277e-01 | 2.222233e-13 |
| TC | RBM3 | exon_skip_223581 | 4.052664e-01 | 1.164086e-07 |
| TC | KHDRBS2 | exon_skip_223581 | 8.289470e-01 | 1.849607e-41 |
| TC | KHDRBS3 | exon_skip_223581 | 7.055756e-01 | 2.940093e-25 |
| TC | RBM24 | exon_skip_223581 | 7.630143e-01 | 1.464183e-31 |
| TC | HNRNPA0 | exon_skip_223581 | 6.544924e-01 | 8.278110e-21 |
| TC | RBM45 | exon_skip_223581 | 5.379374e-01 | 2.629032e-13 |
| TC | HNRNPD | exon_skip_223581 | 5.765704e-01 | 1.819470e-15 |
| TC | NUP42 | exon_skip_223581 | 7.120049e-01 | 6.919476e-26 |
| TC | RALYL | exon_skip_223581 | 8.384004e-01 | 3.160858e-43 |
| TC | PTBP1 | exon_skip_223581 | -4.107294e-01 | 7.554807e-08 |
| TC | PTBP3 | exon_skip_223581 | 4.168068e-01 | 4.627830e-08 |
| TC | HNRNPL | exon_skip_223581 | 4.268388e-01 | 2.016916e-08 |
| TC | EWSR1 | exon_skip_223581 | 4.387772e-01 | 7.242320e-09 |
| TC | SRSF5 | exon_skip_223581 | 4.913515e-01 | 4.825374e-11 |
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RelatedDrugs for TRIM9 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TRIM9 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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