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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for CHRM3 |
 Gene summary |
| Gene information | Gene symbol | CHRM3 | Gene ID | 1131 |
| Gene name | cholinergic receptor muscarinic 3 | |
| Synonyms | EGBRS|HM3|PBS | |
| Cytomap | 1q43 | |
| Type of gene | protein-coding | |
| Description | muscarinic acetylcholine receptor M3acetylcholine receptor, muscarinic 3m3 muscarinic receptor | |
| Modification date | 20200327 | |
| UniProtAcc | ||
| Context | - 30090216(Polymorphisms in the Cholinergic Receptors Muscarinic CHRM2 and CHRM3) Genes and Alzheimer's Disease) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for CHRM3 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000133019
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CHRM3 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_102130 | chr1 | 239718796:239718899:239826853:239827081:239827252:239827371 | 239826853:239827081 |
| exon_skip_159936 | chr1 | 239492709:239492807:239545641:239545749:239632224:239632286 | 239545641:239545749 |
| exon_skip_236499 | chr1 | 239678186:239678288:239718796:239718899:239826853:239827081 | 239718796:239718899 |
| exon_skip_278165 | chr1 | 239678186:239678288:239827252:239827378:239907433:239907780 | 239827252:239827378 |
| exon_skip_55522 | chr1 | 239545641:239545749:239632224:239632286:239678186:239678288 | 239632224:239632286 |
| exon_skip_57136 | chr1 | 239386920:239387227:239492709:239492807:239545641:239545749 | 239492709:239492807 |
| exon_skip_96790 | chr1 | 239718796:239718899:239826853:239827081:239827252:239827378 | 239826853:239827081 |
| exon_skip_99483 | chr1 | 239678186:239678288:239827252:239827378:239907433:239907620 | 239827252:239827378 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for CHRM3 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000255380 | 239827252 | 239827378 | 5UTR-5UTR |
| ENST00000615928 | 239827252 | 239827378 | 5UTR-5UTR |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000255380 | 239827252 | 239827378 | 5UTR-5UTR |
| ENST00000615928 | 239827252 | 239827378 | 5UTR-5UTR |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000255380 | 239827252 | 239827378 | 5UTR-5UTR |
| ENST00000615928 | 239827252 | 239827378 | 5UTR-5UTR |
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Infer the effects of exon skipping event on protein functional features for CHRM3 |
p-ENSG00000133019_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in CHRM3 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for CHRM3 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for CHRM3 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CHRM3 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for CHRM3 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| IFG | IGF2BP2 | exon_skip_55522 | 4.406452e-01 | 2.142232e-02 |
| IFG | ILF2 | exon_skip_278165 | -4.054466e-01 | 3.589254e-02 |
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RelatedDrugs for CHRM3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| P20309 | approved | DB00185 | Cevimeline | small molecule | P20309 |
| P20309 | approved|investigational | DB00193 | Tramadol | small molecule | P20309 |
| P20309 | approved | DB00202 | Succinylcholine | small molecule | P20309 |
| P20309 | approved | DB00246 | Ziprasidone | small molecule | P20309 |
| P20309 | approved | DB00280 | Disopyramide | small molecule | P20309 |
| P20309 | approved | DB00332 | Ipratropium | small molecule | P20309 |
| P20309 | approved|investigational | DB00334 | Olanzapine | small molecule | P20309 |
| P20309 | approved | DB00340 | Metixene | small molecule | P20309 |
| P20309 | approved|withdrawn | DB00342 | Terfenadine | small molecule | P20309 |
| P20309 | approved | DB00363 | Clozapine | small molecule | P20309 |
| P20309 | approved | DB00376 | Trihexyphenidyl | small molecule | P20309 |
| P20309 | approved | DB00383 | Oxyphencyclimine | small molecule | P20309 |
| P20309 | approved | DB00387 | Procyclidine | small molecule | P20309 |
| P20309 | approved | DB00408 | Loxapine | small molecule | P20309 |
| P20309 | approved | DB00411 | Carbamoylcholine | small molecule | P20309 |
| P20309 | approved|vet_approved | DB00420 | Promazine | small molecule | P20309 |
| P20309 | approved | DB00424 | Hyoscyamine | small molecule | P20309 |
| P20309 | approved | DB00434 | Cyproheptadine | small molecule | P20309 |
| P20309 | approved | DB00458 | Imipramine | small molecule | P20309 |
| P20309 | approved|investigational|vet_approved | DB00477 | Chlorpromazine | small molecule | P20309 |
| P20309 | approved|investigational | DB00496 | Darifenacin | small molecule | P20309 |
| P20309 | approved | DB00540 | Nortriptyline | small molecule | P20309 |
| P20309 | approved|vet_approved | DB00572 | Atropine | small molecule | P20309 |
| P20309 | approved|vet_approved | DB00599 | Thiopental | small molecule | P20309 |
| P20309 | approved|investigational | DB00622 | Nicardipine | small molecule | P20309 |
| P20309 | approved|investigational | DB00715 | Paroxetine | small molecule | P20309 |
| P20309 | approved | DB00725 | Homatropine methylbromide | small molecule | P20309 |
| P20309 | approved|investigational | DB00747 | Scopolamine | small molecule | P20309 |
| P20309 | approved | DB00777 | Propiomazine | small molecule | P20309 |
| P20309 | approved|investigational | DB00809 | Tropicamide | small molecule | P20309 |
| P20309 | approved | DB00835 | Brompheniramine | small molecule | P20309 |
| P20309 | approved|investigational | DB00934 | Maprotiline | small molecule | P20309 |
| P20309 | approved|investigational|vet_approved | DB00986 | Glycopyrronium | small molecule | P20309 |
| P20309 | approved | DB01019 | Bethanechol | small molecule | P20309 |
| P20309 | approved|investigational | DB01036 | Tolterodine | small molecule | P20309 |
| P20309 | approved|investigational | DB01062 | Oxybutynin | small molecule | P20309 |
| P20309 | approved|investigational | DB01069 | Promethazine | small molecule | P20309 |
| P20309 | approved|investigational | DB01085 | Pilocarpine | small molecule | P20309 |
| P20309 | approved|investigational | DB01142 | Doxepin | small molecule | P20309 |
| P20309 | approved|investigational | DB01151 | Desipramine | small molecule | P20309 |
| P20309 | approved | DB01224 | Quetiapine | small molecule | P20309 |
| P20309 | approved | DB01226 | Mivacurium | small molecule | P20309 |
| P20309 | approved|investigational | DB01238 | Aripiprazole | small molecule | P20309 |
| P20309 | approved | DB01337 | Pancuronium | small molecule | P20309 |
| P20309 | approved | DB01338 | Pipecuronium | small molecule | P20309 |
| P20309 | approved|investigational | DB01403 | Methotrimeprazine | small molecule | P20309 |
| P20309 | approved | DB01409 | Tiotropium | small molecule | P20309 |
| P20309 | approved | DB01591 | Solifenacin | small molecule | P20309 |
| P20309 | approved|vet_approved | DB01625 | Isopropamide | small molecule | P20309 |
| P20309 | approved|investigational | DB03128 | Acetylcholine | small molecule | P20309 |
| P20309 | approved | DB04843 | Mepenzolate | small molecule | P20309 |
| P20309 | approved | DB06153 | Pizotifen | small molecule | P20309 |
| P20309 | approved | DB06702 | Fesoterodine | small molecule | P20309 |
| P20309 | approved | DB06787 | Hexocyclium | small molecule | P20309 |
| P20309 | approved | DB08897 | Aclidinium | small molecule | P20309 |
| P20309 | approved | DB09076 | Umeclidinium | small molecule | P20309 |
| P20309 | approved | DB09089 | Trimebutine | small molecule | P20309 |
| P20309 | approved | DB09167 | Dosulepin | small molecule | P20309 |
| P20309 | approved|investigational|vet_approved | DB09300 | Butylscopolamine | small molecule | P20309 |
| P20309 | approved | DB11181 | Homatropine | small molecule | P20309 |
| P20309 | approved | DB11235 | Thonzylamine | small molecule | P20309 |
| P20309 | approved|investigational | DB12278 | Propiverine | small molecule | P20309 |
| P20309 | approved|vet_approved|withdrawn | DB13720 | Diphemanil | small molecule | P20309 |
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RelatedDiseases for CHRM3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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