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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for PDCD10 |
 Gene summary |
| Gene information | Gene symbol | PDCD10 | Gene ID | 11235 |
| Gene name | programmed cell death 10 | |
| Synonyms | CCM3|TFAR15 | |
| Cytomap | 3q26.1 | |
| Type of gene | protein-coding | |
| Description | programmed cell death protein 10TF-1 cell apoptosis-related protein 15apoptosis-related protein 15cerebral cavernous malformations 3 protein | |
| Modification date | 20200313 | |
| UniProtAcc | C9J363, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| PDCD10 | GO:0008284 | positive regulation of cell proliferation | 17360971|23541896 |
| PDCD10 | GO:0030335 | positive regulation of cell migration | 23541896 |
| PDCD10 | GO:0032874 | positive regulation of stress-activated MAPK cascade | 22652780 |
| PDCD10 | GO:0042542 | response to hydrogen peroxide | 22291017 |
| PDCD10 | GO:0043066 | negative regulation of apoptotic process | 17360971 |
| PDCD10 | GO:0043406 | positive regulation of MAP kinase activity | 17360971 |
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Gene structures and expression levels for PDCD10 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000114209
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for PDCD10 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_103346 | chr3 | 167720205:167720273:167725401:167725473:167734459:167734482 | 167725401:167725473 |
| exon_skip_124068 | chr3 | 167687223:167687316:167687615:167687693:167695596:167695701 | 167687615:167687693 |
| exon_skip_128291 | chr3 | 167687223:167687316:167687615:167687693:167695596:167695722 | 167687615:167687693 |
| exon_skip_143118 | chr3 | 167687223:167687316:167687615:167687693:167695596:167695720 | 167687615:167687693 |
| exon_skip_162812 | chr3 | 167725401:167725473:167734214:167734345:167734806:167734832 | 167734214:167734345 |
| exon_skip_169658 | chr3 | 167697040:167697126:167697851:167697978:167704842:167704895 | 167697851:167697978 |
| exon_skip_181337 | chr3 | 167720205:167720273:167734214:167734345:167734806:167734832 | 167734214:167734345 |
| exon_skip_209773 | chr3 | 167720205:167720273:167725401:167725473:167734214:167734345 | 167725401:167725473 |
| exon_skip_220634 | chr3 | 167697009:167697126:167697851:167697978:167704842:167704895 | 167697851:167697978 |
| exon_skip_247257 | chr3 | 167720205:167720273:167734214:167734246:167734806:167734851 | 167734214:167734246 |
| exon_skip_253170 | chr3 | 167720062:167720273:167725401:167725473:167734432:167734544 | 167725401:167725473 |
| exon_skip_274607 | chr3 | 167704842:167704895:167720062:167720273:167734806:167734832 | 167720062:167720273 |
| exon_skip_292852 | chr3 | 167720205:167720273:167725401:167725473:167734806:167734832 | 167725401:167725473 |
| exon_skip_292963 | chr3 | 167720205:167720273:167734214:167734246:167734806:167734832 | 167734214:167734246 |
| exon_skip_295172 | chr3 | 167720205:167720273:167725401:167725473:167734459:167734510 | 167725401:167725473 |
| exon_skip_31609 | chr3 | 167697040:167697126:167704842:167704895:167720062:167720098 | 167704842:167704895 |
| exon_skip_69439 | chr3 | 167687223:167687316:167687615:167687693:167695596:167695672 | 167687615:167687693 |
| exon_skip_73614 | chr3 | 167720205:167720273:167734214:167734350:167734806:167734832 | 167734214:167734350 |
| exon_skip_75123 | chr3 | 167720205:167720273:167725401:167725473:167734432:167734517 | 167725401:167725473 |
| exon_skip_81594 | chr3 | 167720205:167720273:167725401:167725473:167734214:167734246 | 167725401:167725473 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for PDCD10 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000497056 | 167720062 | 167720273 | 3UTR-3CDS |
| ENST00000473645 | 167725401 | 167725473 | 3UTR-3UTR |
| ENST00000470131 | 167734214 | 167734345 | 3UTR-3UTR |
| ENST00000392750 | 167687615 | 167687693 | Frame-shift |
| ENST00000461494 | 167687615 | 167687693 | Frame-shift |
| ENST00000470131 | 167687615 | 167687693 | Frame-shift |
| ENST00000473645 | 167687615 | 167687693 | Frame-shift |
| ENST00000497056 | 167687615 | 167687693 | Frame-shift |
| ENST00000392750 | 167704842 | 167704895 | In-frame |
| ENST00000461494 | 167704842 | 167704895 | In-frame |
| ENST00000470131 | 167704842 | 167704895 | In-frame |
| ENST00000473645 | 167704842 | 167704895 | In-frame |
| ENST00000497056 | 167704842 | 167704895 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000473645 | 167725401 | 167725473 | 3UTR-3UTR |
| ENST00000470131 | 167734214 | 167734345 | 3UTR-3UTR |
| ENST00000392750 | 167687615 | 167687693 | Frame-shift |
| ENST00000461494 | 167687615 | 167687693 | Frame-shift |
| ENST00000470131 | 167687615 | 167687693 | Frame-shift |
| ENST00000473645 | 167687615 | 167687693 | Frame-shift |
| ENST00000497056 | 167687615 | 167687693 | Frame-shift |
| ENST00000392750 | 167704842 | 167704895 | In-frame |
| ENST00000461494 | 167704842 | 167704895 | In-frame |
| ENST00000470131 | 167704842 | 167704895 | In-frame |
| ENST00000473645 | 167704842 | 167704895 | In-frame |
| ENST00000497056 | 167704842 | 167704895 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000473645 | 167725401 | 167725473 | 3UTR-3UTR |
| ENST00000470131 | 167734214 | 167734345 | 3UTR-3UTR |
| ENST00000392750 | 167687615 | 167687693 | Frame-shift |
| ENST00000461494 | 167687615 | 167687693 | Frame-shift |
| ENST00000470131 | 167687615 | 167687693 | Frame-shift |
| ENST00000473645 | 167687615 | 167687693 | Frame-shift |
| ENST00000497056 | 167687615 | 167687693 | Frame-shift |
| ENST00000392750 | 167704842 | 167704895 | In-frame |
| ENST00000461494 | 167704842 | 167704895 | In-frame |
| ENST00000470131 | 167704842 | 167704895 | In-frame |
| ENST00000473645 | 167704842 | 167704895 | In-frame |
| ENST00000497056 | 167704842 | 167704895 | In-frame |
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Infer the effects of exon skipping event on protein functional features for PDCD10 |
p-ENSG00000114209_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000392750 | 2084 | 212 | 167704842 | 167704895 | 515 | 567 | 32 | 49 |
| ENST00000461494 | 951 | 212 | 167704842 | 167704895 | 326 | 378 | 32 | 49 |
| ENST00000470131 | 1043 | 212 | 167704842 | 167704895 | 432 | 484 | 32 | 49 |
| ENST00000473645 | 1377 | 212 | 167704842 | 167704895 | 420 | 472 | 32 | 49 |
| ENST00000497056 | 1293 | 212 | 167704842 | 167704895 | 338 | 390 | 32 | 49 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000392750 | 2084 | 212 | 167704842 | 167704895 | 515 | 567 | 32 | 49 |
| ENST00000461494 | 951 | 212 | 167704842 | 167704895 | 326 | 378 | 32 | 49 |
| ENST00000470131 | 1043 | 212 | 167704842 | 167704895 | 432 | 484 | 32 | 49 |
| ENST00000473645 | 1377 | 212 | 167704842 | 167704895 | 420 | 472 | 32 | 49 |
| ENST00000497056 | 1293 | 212 | 167704842 | 167704895 | 338 | 390 | 32 | 49 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000392750 | 2084 | 212 | 167704842 | 167704895 | 515 | 567 | 32 | 49 |
| ENST00000461494 | 951 | 212 | 167704842 | 167704895 | 326 | 378 | 32 | 49 |
| ENST00000470131 | 1043 | 212 | 167704842 | 167704895 | 432 | 484 | 32 | 49 |
| ENST00000473645 | 1377 | 212 | 167704842 | 167704895 | 420 | 472 | 32 | 49 |
| ENST00000497056 | 1293 | 212 | 167704842 | 167704895 | 338 | 390 | 32 | 49 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9BUL8 | 32 | 49 | 1 | 212 | Chain | ID=PRO_0000187562;Note=Programmed cell death protein 10 |
| Q9BUL8 | 32 | 49 | 1 | 212 | Chain | ID=PRO_0000187562;Note=Programmed cell death protein 10 |
| Q9BUL8 | 32 | 49 | 1 | 212 | Chain | ID=PRO_0000187562;Note=Programmed cell death protein 10 |
| Q9BUL8 | 32 | 49 | 1 | 212 | Chain | ID=PRO_0000187562;Note=Programmed cell death protein 10 |
| Q9BUL8 | 32 | 49 | 1 | 212 | Chain | ID=PRO_0000187562;Note=Programmed cell death protein 10 |
| Q9BUL8 | 32 | 49 | 26 | 34 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GEH |
| Q9BUL8 | 32 | 49 | 26 | 34 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GEH |
| Q9BUL8 | 32 | 49 | 26 | 34 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GEH |
| Q9BUL8 | 32 | 49 | 26 | 34 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GEH |
| Q9BUL8 | 32 | 49 | 26 | 34 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GEH |
| Q9BUL8 | 32 | 49 | 38 | 54 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GEH |
| Q9BUL8 | 32 | 49 | 38 | 54 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GEH |
| Q9BUL8 | 32 | 49 | 38 | 54 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GEH |
| Q9BUL8 | 32 | 49 | 38 | 54 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GEH |
| Q9BUL8 | 32 | 49 | 38 | 54 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GEH |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9BUL8 | 32 | 49 | 1 | 212 | Chain | ID=PRO_0000187562;Note=Programmed cell death protein 10 |
| Q9BUL8 | 32 | 49 | 1 | 212 | Chain | ID=PRO_0000187562;Note=Programmed cell death protein 10 |
| Q9BUL8 | 32 | 49 | 1 | 212 | Chain | ID=PRO_0000187562;Note=Programmed cell death protein 10 |
| Q9BUL8 | 32 | 49 | 1 | 212 | Chain | ID=PRO_0000187562;Note=Programmed cell death protein 10 |
| Q9BUL8 | 32 | 49 | 1 | 212 | Chain | ID=PRO_0000187562;Note=Programmed cell death protein 10 |
| Q9BUL8 | 32 | 49 | 26 | 34 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GEH |
| Q9BUL8 | 32 | 49 | 26 | 34 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GEH |
| Q9BUL8 | 32 | 49 | 26 | 34 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GEH |
| Q9BUL8 | 32 | 49 | 26 | 34 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GEH |
| Q9BUL8 | 32 | 49 | 26 | 34 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GEH |
| Q9BUL8 | 32 | 49 | 38 | 54 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GEH |
| Q9BUL8 | 32 | 49 | 38 | 54 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GEH |
| Q9BUL8 | 32 | 49 | 38 | 54 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GEH |
| Q9BUL8 | 32 | 49 | 38 | 54 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GEH |
| Q9BUL8 | 32 | 49 | 38 | 54 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GEH |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9BUL8 | 32 | 49 | 1 | 212 | Chain | ID=PRO_0000187562;Note=Programmed cell death protein 10 |
| Q9BUL8 | 32 | 49 | 1 | 212 | Chain | ID=PRO_0000187562;Note=Programmed cell death protein 10 |
| Q9BUL8 | 32 | 49 | 1 | 212 | Chain | ID=PRO_0000187562;Note=Programmed cell death protein 10 |
| Q9BUL8 | 32 | 49 | 1 | 212 | Chain | ID=PRO_0000187562;Note=Programmed cell death protein 10 |
| Q9BUL8 | 32 | 49 | 1 | 212 | Chain | ID=PRO_0000187562;Note=Programmed cell death protein 10 |
| Q9BUL8 | 32 | 49 | 26 | 34 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GEH |
| Q9BUL8 | 32 | 49 | 26 | 34 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GEH |
| Q9BUL8 | 32 | 49 | 26 | 34 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GEH |
| Q9BUL8 | 32 | 49 | 26 | 34 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GEH |
| Q9BUL8 | 32 | 49 | 26 | 34 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GEH |
| Q9BUL8 | 32 | 49 | 38 | 54 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GEH |
| Q9BUL8 | 32 | 49 | 38 | 54 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GEH |
| Q9BUL8 | 32 | 49 | 38 | 54 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GEH |
| Q9BUL8 | 32 | 49 | 38 | 54 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GEH |
| Q9BUL8 | 32 | 49 | 38 | 54 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GEH |
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3'-UTR located exon skipping events that lost miRNA binding sites in PDCD10 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000470131 | 167734214 | 167734345 | hsa-miR-4428 | chr3:167734265-167734272 | 8mer-1a | chr3:167734262-167734283 | 150.00 | -21.33 |
| Mayo | ENST00000470131 | 167734214 | 167734345 | hsa-miR-5195-3p | chr3:167734289-167734296 | 8mer-1a | chr3:167734276-167734296 | 155.00 | -17.50 |
| Mayo | ENST00000470131 | 167734214 | 167734345 | hsa-miR-4521 | chr3:167734267-167734274 | 8mer-1a | chr3:167734262-167734283 | 150.00 | -21.33 |
| Mayo | ENST00000470131 | 167734214 | 167734345 | hsa-miR-663b | chr3:167734275-167734282 | 8mer-1a | chr3:167734262-167734283 | 150.00 | -21.33 |
| Mayo | ENST00000473645 | 167725401 | 167725473 | hsa-miR-4279 | chr3:167725464-167725471 | 8mer-1a | chr3:167725456-167725471 | 140.00 | -11.50 |
| Mayo | ENST00000473645 | 167725401 | 167725473 | hsa-miR-6831-3p | chr3:167725431-167725438 | 8mer-1a | chr3:167725423-167725443 | 163.00 | -20.77 |
| Mayo | ENST00000470131 | 167734214 | 167734345 | hsa-miR-584-3p | chr3:167734293-167734300 | 8mer-1a | chr3:167734290-167734315 | 149.00 | -26.67 |
| Mayo | ENST00000470131 | 167734214 | 167734345 | hsa-miR-145-5p | chr3:167734289-167734296 | 8mer-1a | chr3:167734276-167734296 | 155.00 | -17.50 |
| Mayo | ENST00000473645 | 167725401 | 167725473 | hsa-miR-6843-3p | chr3:167725450-167725457 | 8mer-1a | chr3:167725439-167725457 | 155.00 | -18.59 |
| Mayo | ENST00000473645 | 167725401 | 167725473 | hsa-miR-6848-3p | chr3:167725450-167725457 | 8mer-1a | chr3:167725439-167725457 | 155.00 | -18.59 |
| MSBB | ENST00000470131 | 167734214 | 167734345 | hsa-miR-4428 | chr3:167734265-167734272 | 8mer-1a | chr3:167734262-167734283 | 150.00 | -21.33 |
| MSBB | ENST00000470131 | 167734214 | 167734345 | hsa-miR-5195-3p | chr3:167734289-167734296 | 8mer-1a | chr3:167734276-167734296 | 155.00 | -17.50 |
| MSBB | ENST00000470131 | 167734214 | 167734345 | hsa-miR-4521 | chr3:167734267-167734274 | 8mer-1a | chr3:167734262-167734283 | 150.00 | -21.33 |
| MSBB | ENST00000470131 | 167734214 | 167734345 | hsa-miR-663b | chr3:167734275-167734282 | 8mer-1a | chr3:167734262-167734283 | 150.00 | -21.33 |
| MSBB | ENST00000473645 | 167725401 | 167725473 | hsa-miR-4279 | chr3:167725464-167725471 | 8mer-1a | chr3:167725456-167725471 | 140.00 | -11.50 |
| MSBB | ENST00000473645 | 167725401 | 167725473 | hsa-miR-6831-3p | chr3:167725431-167725438 | 8mer-1a | chr3:167725423-167725443 | 163.00 | -20.77 |
| MSBB | ENST00000470131 | 167734214 | 167734345 | hsa-miR-584-3p | chr3:167734293-167734300 | 8mer-1a | chr3:167734290-167734315 | 149.00 | -26.67 |
| MSBB | ENST00000470131 | 167734214 | 167734345 | hsa-miR-145-5p | chr3:167734289-167734296 | 8mer-1a | chr3:167734276-167734296 | 155.00 | -17.50 |
| MSBB | ENST00000473645 | 167725401 | 167725473 | hsa-miR-6843-3p | chr3:167725450-167725457 | 8mer-1a | chr3:167725439-167725457 | 155.00 | -18.59 |
| MSBB | ENST00000473645 | 167725401 | 167725473 | hsa-miR-6848-3p | chr3:167725450-167725457 | 8mer-1a | chr3:167725439-167725457 | 155.00 | -18.59 |
| ROSMAP | ENST00000470131 | 167734214 | 167734345 | hsa-miR-4428 | chr3:167734265-167734272 | 8mer-1a | chr3:167734262-167734283 | 150.00 | -21.33 |
| ROSMAP | ENST00000470131 | 167734214 | 167734345 | hsa-miR-5195-3p | chr3:167734289-167734296 | 8mer-1a | chr3:167734276-167734296 | 155.00 | -17.50 |
| ROSMAP | ENST00000470131 | 167734214 | 167734345 | hsa-miR-4521 | chr3:167734267-167734274 | 8mer-1a | chr3:167734262-167734283 | 150.00 | -21.33 |
| ROSMAP | ENST00000470131 | 167734214 | 167734345 | hsa-miR-663b | chr3:167734275-167734282 | 8mer-1a | chr3:167734262-167734283 | 150.00 | -21.33 |
| ROSMAP | ENST00000473645 | 167725401 | 167725473 | hsa-miR-4279 | chr3:167725464-167725471 | 8mer-1a | chr3:167725456-167725471 | 140.00 | -11.50 |
| ROSMAP | ENST00000473645 | 167725401 | 167725473 | hsa-miR-6831-3p | chr3:167725431-167725438 | 8mer-1a | chr3:167725423-167725443 | 163.00 | -20.77 |
| ROSMAP | ENST00000470131 | 167734214 | 167734345 | hsa-miR-584-3p | chr3:167734293-167734300 | 8mer-1a | chr3:167734290-167734315 | 149.00 | -26.67 |
| ROSMAP | ENST00000470131 | 167734214 | 167734345 | hsa-miR-145-5p | chr3:167734289-167734296 | 8mer-1a | chr3:167734276-167734296 | 155.00 | -17.50 |
| ROSMAP | ENST00000473645 | 167725401 | 167725473 | hsa-miR-6843-3p | chr3:167725450-167725457 | 8mer-1a | chr3:167725439-167725457 | 155.00 | -18.59 |
| ROSMAP | ENST00000473645 | 167725401 | 167725473 | hsa-miR-6848-3p | chr3:167725450-167725457 | 8mer-1a | chr3:167725439-167725457 | 155.00 | -18.59 |
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SNVs in the skipped exons for PDCD10 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for PDCD10 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PDCD10 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for PDCD10 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | RBM45 | exon_skip_292852 | 5.501304e-01 | 8.456756e-14 |
| CB | NUP42 | exon_skip_292852 | 5.011690e-01 | 2.306121e-11 |
| CB | PABPC4 | exon_skip_292852 | 4.469575e-01 | 4.410168e-09 |
| DLPFC | ELAVL4 | exon_skip_292852 | 4.062930e-01 | 2.386684e-14 |
| DLPFC | KHDRBS2 | exon_skip_292852 | 5.157621e-01 | 1.737178e-23 |
| DLPFC | EIF4B | exon_skip_292852 | 4.272276e-01 | 7.504341e-16 |
| HCC | PABPN1 | exon_skip_292852 | -4.943332e-01 | 3.623537e-18 |
| HCC | CNOT4 | exon_skip_292852 | -4.105981e-01 | 1.737382e-12 |
| HCC | QKI | exon_skip_292852 | -4.070213e-01 | 2.814519e-12 |
| HCC | FUBP1 | exon_skip_292852 | -4.403234e-01 | 2.507843e-14 |
| HCC | RBM45 | exon_skip_292852 | -4.271212e-01 | 1.734229e-13 |
| HCC | PTBP1 | exon_skip_292852 | -5.756900e-01 | 2.081135e-25 |
| HCC | PABPC4 | exon_skip_292852 | -4.196402e-01 | 5.000451e-13 |
| HCC | SRSF4 | exon_skip_292852 | -5.434837e-01 | 2.638229e-22 |
| IFG | EIF4B | exon_skip_292852 | 4.001655e-01 | 3.485725e-02 |
| PCC | PTBP1 | exon_skip_292852 | -5.372492e-01 | 2.511141e-17 |
| TC | ELAVL4 | exon_skip_292852 | 4.914234e-01 | 4.158646e-11 |
| TC | TIA1 | exon_skip_292852 | 4.082928e-01 | 8.346126e-08 |
| TC | MATR3 | exon_skip_292852 | 5.306824e-01 | 5.274992e-13 |
| TC | KHDRBS2 | exon_skip_292852 | 5.590011e-01 | 1.563732e-14 |
| TC | HNRNPA0 | exon_skip_292852 | 5.387456e-01 | 2.002695e-13 |
| TC | RBM45 | exon_skip_292852 | 4.259763e-01 | 1.956035e-08 |
| TC | PUF60 | exon_skip_292852 | 4.564020e-01 | 1.315148e-09 |
| TC | NUP42 | exon_skip_292852 | 5.284474e-01 | 6.868272e-13 |
| TC | RALYL | exon_skip_292852 | 4.876063e-01 | 6.177314e-11 |
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RelatedDrugs for PDCD10 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PDCD10 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
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