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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for SUPT16H |
 Gene summary |
| Gene information | Gene symbol | SUPT16H | Gene ID | 11198 |
| Gene name | SPT16 homolog, facilitates chromatin remodeling subunit | |
| Synonyms | CDC68|FACTP140|SPT16|SPT16/CDC68 | |
| Cytomap | 14q11.2 | |
| Type of gene | protein-coding | |
| Description | FACT complex subunit SPT16FACT 140 kDa subunitchromatin-specific transcription elongation factor 140 kDa subunitfacilitates chromatin remodeling 140 kDa subunitfacilitates chromatin transcription complex subunit SPT16hSPT16suppressor of Ty 16 homolo | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for SUPT16H |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000092201
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| HCC | UP | ENST00000557394.5 | SUPT16H-207:retained_intron:SUPT16H | 3.611016e+01 | 1.386670e+00 | 3.487258e-06 | 6.569398e-04 |
| PG | UP | ENST00000557652.1 | SUPT16H-208:nonsense_mediated_decay:SUPT16H | 5.218012e+00 | 1.121811e+00 | 1.165138e-03 | 1.630125e-02 |
| CB | DOWN | ENST00000557394.5 | SUPT16H-207:retained_intron:SUPT16H | 1.419503e+03 | -9.297805e-01 | 3.090578e-11 | 2.414334e-09 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for SUPT16H |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_130835 | chr14 | 21353703:21353832:21354411:21354540:21357197:21357366 | 21354411:21354540 |
| exon_skip_140855 | chr14 | 21351479:21352818:21353488:21353565:21353703:21353832 | 21353488:21353565 |
| exon_skip_159923 | chr14 | 21371874:21372044:21373338:21373430:21383862:21383946 | 21373338:21373430 |
| exon_skip_175591 | chr14 | 21371874:21372044:21372469:21372717:21373338:21373426 | 21372469:21372717 |
| exon_skip_183176 | chr14 | 21365070:21365143:21366439:21366529:21368269:21368441 | 21366439:21366529 |
| exon_skip_194189 | chr14 | 21357927:21358002:21358315:21358427:21359484:21359609 | 21358315:21358427 |
| exon_skip_212029 | chr14 | 21370336:21370488:21371874:21371970:21373338:21373430 | 21371874:21371970 |
| exon_skip_229248 | chr14 | 21371874:21372044:21372469:21372717:21373338:21373361 | 21372469:21372717 |
| exon_skip_73139 | chr14 | 21370336:21370488:21371874:21372044:21373338:21373430 | 21371874:21372044 |
| exon_skip_81072 | chr14 | 21371874:21372044:21372469:21372717:21373338:21373430 | 21372469:21372717 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for SUPT16H |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000216297 | 21366439 | 21366529 | Frame-shift |
| ENST00000216297 | 21371874 | 21372044 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000216297 | 21354411 | 21354540 | Frame-shift |
| ENST00000216297 | 21358315 | 21358427 | Frame-shift |
| ENST00000216297 | 21366439 | 21366529 | Frame-shift |
| ENST00000216297 | 21353488 | 21353565 | In-frame |
| ENST00000216297 | 21371874 | 21372044 | In-frame |
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Infer the effects of exon skipping event on protein functional features for SUPT16H |
p-ENSG00000092201_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000216297 | 4701 | 1047 | 21371874 | 21372044 | 499 | 668 | 53 | 109 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000216297 | 4701 | 1047 | 21371874 | 21372044 | 499 | 668 | 53 | 109 |
| ENST00000216297 | 4701 | 1047 | 21353488 | 21353565 | 3260 | 3336 | 973 | 999 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9Y5B9 | 53 | 109 | 62 | 68 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E5B |
| Q9Y5B9 | 53 | 109 | 73 | 77 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E5B |
| Q9Y5B9 | 53 | 109 | 103 | 107 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E5B |
| Q9Y5B9 | 53 | 109 | 2 | 1047 | Chain | ID=PRO_0000245169;Note=FACT complex subunit SPT16 |
| Q9Y5B9 | 53 | 109 | 48 | 57 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E5B |
| Q9Y5B9 | 53 | 109 | 79 | 89 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E5B |
| Q9Y5B9 | 53 | 109 | 95 | 99 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E5B |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9Y5B9 | 53 | 109 | 62 | 68 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E5B |
| Q9Y5B9 | 53 | 109 | 73 | 77 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E5B |
| Q9Y5B9 | 53 | 109 | 103 | 107 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E5B |
| Q9Y5B9 | 53 | 109 | 2 | 1047 | Chain | ID=PRO_0000245169;Note=FACT complex subunit SPT16 |
| Q9Y5B9 | 53 | 109 | 48 | 57 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E5B |
| Q9Y5B9 | 53 | 109 | 79 | 89 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E5B |
| Q9Y5B9 | 53 | 109 | 95 | 99 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5E5B |
| Q9Y5B9 | 973 | 999 | 2 | 1047 | Chain | ID=PRO_0000245169;Note=FACT complex subunit SPT16 |
| Q9Y5B9 | 973 | 999 | 926 | 1011 | Compositional bias | Note=Glu-rich (acidic) |
| Q9Y5B9 | 973 | 999 | 979 | 979 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692;Dbxref=PMID:17081983,PMID:20068231,PMID:21406692 |
| Q9Y5B9 | 973 | 999 | 982 | 982 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:20068231,PMID:21406692,PMID |
| Q9Y5B9 | 973 | 999 | 986 | 986 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692 |
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3'-UTR located exon skipping events that lost miRNA binding sites in SUPT16H |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for SUPT16H |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for SUPT16H |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SUPT16H |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for SUPT16H |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for SUPT16H |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SUPT16H |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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