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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for WIF1 |
 Gene summary |
| Gene information | Gene symbol | WIF1 | Gene ID | 11197 |
| Gene name | WNT inhibitory factor 1 | |
| Synonyms | WIF-1 | |
| Cytomap | 12q14.3 | |
| Type of gene | protein-coding | |
| Description | wnt inhibitory factor 1 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for WIF1 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000156076
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for WIF1 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_151930 | chr12 | 65062481:65062576:65066641:65066736:65067695:65067790 | 65066641:65066736 |
| exon_skip_273806 | chr12 | 65055118:65055213:65056031:65056126:65062481:65062576 | 65056031:65056126 |
| exon_skip_278342 | chr12 | 65055118:65055213:65056073:65056126:65062481:65062576 | 65056073:65056126 |
| exon_skip_286080 | chr12 | 65056073:65056126:65062481:65062576:65066641:65066659 | 65062481:65062576 |
| exon_skip_38991 | chr12 | 65051307:65051470:65055118:65055213:65056031:65056126 | 65055118:65055213 |
| exon_skip_67609 | chr12 | 65056097:65056126:65062481:65062576:65066641:65066659 | 65062481:65062576 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for WIF1 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000286574 | 65055118 | 65055213 | In-frame |
| ENST00000286574 | 65056031 | 65056126 | In-frame |
| ENST00000286574 | 65062481 | 65062576 | In-frame |
| ENST00000286574 | 65066641 | 65066736 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000286574 | 65056031 | 65056126 | In-frame |
| ENST00000286574 | 65062481 | 65062576 | In-frame |
| ENST00000286574 | 65066641 | 65066736 | In-frame |
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Infer the effects of exon skipping event on protein functional features for WIF1 |
p-ENSG00000156076_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000286574 | 2255 | 379 | 65066641 | 65066736 | 1010 | 1104 | 211 | 243 |
| ENST00000286574 | 2255 | 379 | 65062481 | 65062576 | 1106 | 1200 | 243 | 275 |
| ENST00000286574 | 2255 | 379 | 65056031 | 65056126 | 1202 | 1296 | 275 | 307 |
| ENST00000286574 | 2255 | 379 | 65055118 | 65055213 | 1298 | 1392 | 307 | 339 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000286574 | 2255 | 379 | 65066641 | 65066736 | 1010 | 1104 | 211 | 243 |
| ENST00000286574 | 2255 | 379 | 65062481 | 65062576 | 1106 | 1200 | 243 | 275 |
| ENST00000286574 | 2255 | 379 | 65056031 | 65056126 | 1202 | 1296 | 275 | 307 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9Y5W5 | 211 | 243 | 29 | 379 | Chain | ID=PRO_0000007775;Note=Wnt inhibitory factor 1 |
| Q9Y5W5 | 211 | 243 | 214 | 224 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q9Y5W5 | 211 | 243 | 218 | 230 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q9Y5W5 | 211 | 243 | 232 | 241 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q9Y5W5 | 211 | 243 | 211 | 242 | Domain | Note=EGF-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 |
| Q9Y5W5 | 211 | 243 | 243 | 271 | Domain | Note=EGF-like 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 |
| Q9Y5W5 | 243 | 275 | 29 | 379 | Chain | ID=PRO_0000007775;Note=Wnt inhibitory factor 1 |
| Q9Y5W5 | 243 | 275 | 246 | 256 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q9Y5W5 | 243 | 275 | 250 | 262 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q9Y5W5 | 243 | 275 | 243 | 271 | Domain | Note=EGF-like 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 |
| Q9Y5W5 | 243 | 275 | 274 | 306 | Domain | Note=EGF-like 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 |
| Q9Y5W5 | 243 | 275 | 245 | 245 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9Y5W5 | 275 | 307 | 29 | 379 | Chain | ID=PRO_0000007775;Note=Wnt inhibitory factor 1 |
| Q9Y5W5 | 275 | 307 | 278 | 288 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q9Y5W5 | 275 | 307 | 282 | 294 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q9Y5W5 | 275 | 307 | 296 | 305 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q9Y5W5 | 275 | 307 | 274 | 306 | Domain | Note=EGF-like 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 |
| Q9Y5W5 | 275 | 307 | 307 | 338 | Domain | Note=EGF-like 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 |
| Q9Y5W5 | 307 | 339 | 29 | 379 | Chain | ID=PRO_0000007775;Note=Wnt inhibitory factor 1 |
| Q9Y5W5 | 307 | 339 | 310 | 320 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q9Y5W5 | 307 | 339 | 314 | 326 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q9Y5W5 | 307 | 339 | 328 | 337 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q9Y5W5 | 307 | 339 | 307 | 338 | Domain | Note=EGF-like 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9Y5W5 | 211 | 243 | 29 | 379 | Chain | ID=PRO_0000007775;Note=Wnt inhibitory factor 1 |
| Q9Y5W5 | 211 | 243 | 214 | 224 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q9Y5W5 | 211 | 243 | 218 | 230 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q9Y5W5 | 211 | 243 | 232 | 241 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q9Y5W5 | 211 | 243 | 211 | 242 | Domain | Note=EGF-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 |
| Q9Y5W5 | 211 | 243 | 243 | 271 | Domain | Note=EGF-like 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 |
| Q9Y5W5 | 243 | 275 | 29 | 379 | Chain | ID=PRO_0000007775;Note=Wnt inhibitory factor 1 |
| Q9Y5W5 | 243 | 275 | 246 | 256 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q9Y5W5 | 243 | 275 | 250 | 262 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q9Y5W5 | 243 | 275 | 243 | 271 | Domain | Note=EGF-like 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 |
| Q9Y5W5 | 243 | 275 | 274 | 306 | Domain | Note=EGF-like 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 |
| Q9Y5W5 | 243 | 275 | 245 | 245 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9Y5W5 | 275 | 307 | 29 | 379 | Chain | ID=PRO_0000007775;Note=Wnt inhibitory factor 1 |
| Q9Y5W5 | 275 | 307 | 278 | 288 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q9Y5W5 | 275 | 307 | 282 | 294 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q9Y5W5 | 275 | 307 | 296 | 305 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q9Y5W5 | 275 | 307 | 274 | 306 | Domain | Note=EGF-like 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 |
| Q9Y5W5 | 275 | 307 | 307 | 338 | Domain | Note=EGF-like 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 |
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3'-UTR located exon skipping events that lost miRNA binding sites in WIF1 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for WIF1 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for WIF1 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for WIF1 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for WIF1 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for WIF1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for WIF1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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