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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for MAP4K5 |
 Gene summary |
| Gene information | Gene symbol | MAP4K5 | Gene ID | 11183 |
| Gene name | mitogen-activated protein kinase kinase kinase kinase 5 | |
| Synonyms | GCKR|KHS|KHS1|MAPKKKK5 | |
| Cytomap | 14q22.1 | |
| Type of gene | protein-coding | |
| Description | mitogen-activated protein kinase kinase kinase kinase 5MAPK/ERK kinase kinase kinase 5MEK kinase kinase 5MEKKK 5germinal center kinase-relatedkinase homologous to SPS1/STE20 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| MAP4K5 | GO:0006468 | protein phosphorylation | 9038372 |
| MAP4K5 | GO:0035556 | intracellular signal transduction | 9038372 |
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Gene structures and expression levels for MAP4K5 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000012983
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PG | UP | ENST00000554091.5 | MAP4K5-203:nonsense_mediated_decay:MAP4K5 | 1.129002e+01 | 1.552861e+00 | 3.057746e-04 | 6.215878e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for MAP4K5 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_101938 | chr14 | 50462693:50462781:50464052:50464133:50466583:50466645 | 50464052:50464133 |
| exon_skip_134677 | chr14 | 50423123:50423176:50425907:50425977:50428662:50428754 | 50425907:50425977 |
| exon_skip_136835 | chr14 | 50486104:50486194:50504800:50504857:50531942:50532087 | 50504800:50504857 |
| exon_skip_146115 | chr14 | 50443939:50444036:50445041:50445194:50446079:50446121 | 50445041:50445194 |
| exon_skip_149149 | chr14 | 50443939:50444036:50445041:50445194:50446079:50446120 | 50445041:50445194 |
| exon_skip_153096 | chr14 | 50423121:50423176:50425907:50425977:50428662:50428754 | 50425907:50425977 |
| exon_skip_155594 | chr14 | 50476274:50476306:50482361:50482416:50485578:50485642 | 50482361:50482416 |
| exon_skip_176093 | chr14 | 50418525:50420106:50423121:50423176:50425907:50425977 | 50423121:50423176 |
| exon_skip_19325 | chr14 | 50434964:50435065:50437476:50437534:50437894:50438008 | 50437476:50437534 |
| exon_skip_198543 | chr14 | 50445041:50445194:50446079:50446121:50447414:50447481 | 50446079:50446121 |
| exon_skip_205475 | chr14 | 50434394:50434571:50434962:50435065:50437476:50437534 | 50434962:50435065 |
| exon_skip_222859 | chr14 | 50434394:50434571:50434962:50435065:50437476:50437496 | 50434962:50435065 |
| exon_skip_275557 | chr14 | 50440362:50440441:50442732:50442816:50443729:50443770 | 50442732:50442816 |
| exon_skip_27589 | chr14 | 50428662:50428754:50429192:50429260:50434394:50434571 | 50429192:50429260 |
| exon_skip_56302 | chr14 | 50425907:50425977:50428662:50428754:50429192:50429256 | 50428662:50428754 |
| exon_skip_68754 | chr14 | 50448774:50448832:50456516:50456594:50462665:50462781 | 50456516:50456594 |
| exon_skip_83027 | chr14 | 50442732:50442816:50443729:50443770:50443939:50444036 | 50443729:50443770 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for MAP4K5 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000013125 | 50423121 | 50423176 | Frame-shift |
| ENST00000013125 | 50425907 | 50425977 | Frame-shift |
| ENST00000013125 | 50434962 | 50435065 | Frame-shift |
| ENST00000013125 | 50437476 | 50437534 | Frame-shift |
| ENST00000013125 | 50442732 | 50442816 | Frame-shift |
| ENST00000013125 | 50445041 | 50445194 | Frame-shift |
| ENST00000013125 | 50456516 | 50456594 | Frame-shift |
| ENST00000013125 | 50504800 | 50504857 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000013125 | 50423121 | 50423176 | Frame-shift |
| ENST00000013125 | 50425907 | 50425977 | Frame-shift |
| ENST00000013125 | 50434962 | 50435065 | Frame-shift |
| ENST00000013125 | 50445041 | 50445194 | Frame-shift |
| ENST00000013125 | 50456516 | 50456594 | Frame-shift |
| ENST00000013125 | 50504800 | 50504857 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000013125 | 50423121 | 50423176 | Frame-shift |
| ENST00000013125 | 50425907 | 50425977 | Frame-shift |
| ENST00000013125 | 50434962 | 50435065 | Frame-shift |
| ENST00000013125 | 50437476 | 50437534 | Frame-shift |
| ENST00000013125 | 50442732 | 50442816 | Frame-shift |
| ENST00000013125 | 50445041 | 50445194 | Frame-shift |
| ENST00000013125 | 50446079 | 50446121 | Frame-shift |
| ENST00000013125 | 50456516 | 50456594 | Frame-shift |
| ENST00000013125 | 50464052 | 50464133 | Frame-shift |
| ENST00000013125 | 50482361 | 50482416 | Frame-shift |
| ENST00000013125 | 50504800 | 50504857 | Frame-shift |
| ENST00000013125 | 50428662 | 50428754 | In-frame |
| ENST00000013125 | 50429192 | 50429260 | In-frame |
| ENST00000013125 | 50443729 | 50443770 | In-frame |
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Infer the effects of exon skipping event on protein functional features for MAP4K5 |
p-ENSG00000012983_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000013125 | 4371 | 846 | 50443729 | 50443770 | 1757 | 1797 | 479 | 492 |
| ENST00000013125 | 4371 | 846 | 50429192 | 50429260 | 2484 | 2551 | 721 | 744 |
| ENST00000013125 | 4371 | 846 | 50428662 | 50428754 | 2553 | 2644 | 744 | 775 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9Y4K4 | 479 | 492 | 1 | 846 | Chain | ID=PRO_0000086282;Note=Mitogen-activated protein kinase kinase kinase kinase 5 |
| Q9Y4K4 | 721 | 744 | 1 | 846 | Chain | ID=PRO_0000086282;Note=Mitogen-activated protein kinase kinase kinase kinase 5 |
| Q9Y4K4 | 721 | 744 | 506 | 819 | Domain | Note=CNH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00795 |
| Q9Y4K4 | 744 | 775 | 1 | 846 | Chain | ID=PRO_0000086282;Note=Mitogen-activated protein kinase kinase kinase kinase 5 |
| Q9Y4K4 | 744 | 775 | 506 | 819 | Domain | Note=CNH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00795 |
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3'-UTR located exon skipping events that lost miRNA binding sites in MAP4K5 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for MAP4K5 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for MAP4K5 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MAP4K5 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for MAP4K5 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for MAP4K5 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Q9Y4K4 | approved|investigational | DB12010 | Fostamatinib | small molecule | Q9Y4K4 |
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RelatedDiseases for MAP4K5 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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