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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for KAT7 |
 Gene summary |
| Gene information | Gene symbol | KAT7 | Gene ID | 11143 |
| Gene name | lysine acetyltransferase 7 | |
| Synonyms | HBO1|HBOA|MYST2|ZC2HC7 | |
| Cytomap | 17q21.33 | |
| Type of gene | protein-coding | |
| Description | histone acetyltransferase KAT7K(lysine) acetyltransferase 7MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2MYST histone acetyltransferase 2histone acetyltransferase MYST2histone acetyltransferase binding to ORC1 | |
| Modification date | 20200327 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| KAT7 | GO:0006260 | DNA replication | 16387653 |
| KAT7 | GO:0018393 | internal peptidyl-lysine acetylation | 26221039 |
| KAT7 | GO:0031098 | stress-activated protein kinase signaling cascade | 21856198 |
| KAT7 | GO:0043966 | histone H3 acetylation | 16387653 |
| KAT7 | GO:0043981 | histone H4-K5 acetylation | 16387653 |
| KAT7 | GO:0043982 | histone H4-K8 acetylation | 16387653 |
| KAT7 | GO:0043983 | histone H4-K12 acetylation | 16387653 |
| KAT7 | GO:0043984 | histone H4-K16 acetylation | 16387653 |
| KAT7 | GO:1900182 | positive regulation of protein localization to nucleus | 24739512 |
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Gene structures and expression levels for KAT7 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000136504
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for KAT7 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_120759 | chr17 | 49798319:49798558:49805363:49805445:49809119:49809208 | 49805363:49805445 |
| exon_skip_141606 | chr17 | 49805363:49805445:49811476:49811574:49815803:49815896 | 49811476:49811574 |
| exon_skip_151334 | chr17 | 49821685:49821790:49823202:49823295:49826000:49826146 | 49823202:49823295 |
| exon_skip_153076 | chr17 | 49791938:49792033:49796750:49796926:49805363:49805445 | 49796750:49796926 |
| exon_skip_262482 | chr17 | 49805363:49805445:49809119:49809208:49811476:49811574 | 49809119:49809208 |
| exon_skip_31788 | chr17 | 49791886:49792033:49796750:49796926:49805363:49805445 | 49796750:49796926 |
| exon_skip_37403 | chr17 | 49796750:49796926:49798319:49798558:49805363:49805445 | 49798319:49798558 |
| exon_skip_86451 | chr17 | 49815803:49815913:49817820:49818011:49821337:49821426 | 49817820:49818011 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |