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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for TRIOBP |
 Gene summary |
| Gene information | Gene symbol | TRIOBP | Gene ID | 11078 |
| Gene name | TRIO and F-actin binding protein | |
| Synonyms | DFNB28|HRIHFB2122|TAP68|TARA|dJ37E16.4 | |
| Cytomap | 22q13.1 | |
| Type of gene | protein-coding | |
| Description | TRIO and F-actin-binding proteinprotein Taratara-like proteintrio-associated repeat on actin | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context | - 30089789(Protein misassembly and aggregation as potential convergence points for non-genetic causes of chronic mental illness) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TRIOBP | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading | 11148140 |
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Gene structures and expression levels for TRIOBP |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000100106
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PG | UP | ENST00000331103.5 | TRIOBP-201:retained_intron:TRIOBP | 1.561800e+00 | 8.890641e-01 | 1.237569e-03 | 1.702988e-02 |
| TC | UP | ENST00000452519.5 | TRIOBP-209:protein_coding:TRIOBP | 1.097712e+00 | 8.470929e-01 | 1.823464e-03 | 1.564747e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TRIOBP |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_10876 | chr22 | 37710427:37710566:37713210:37713411:37715763:37715934 | 37713210:37713411 |
| exon_skip_172635 | chr22 | 37733298:37733412:37734399:37735442:37738642:37738719 | 37734399:37735442 |
| exon_skip_208422 | chr22 | 37751772:37751828:37754877:37754984:37755101:37755190 | 37754877:37754984 |
| exon_skip_231898 | chr22 | 37751772:37751828:37754877:37754984:37755101:37755153 | 37754877:37754984 |
| exon_skip_47915 | chr22 | 37738642:37738719:37740895:37741032:37751772:37751828 | 37740895:37741032 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for TRIOBP |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000644935 | 37713210 | 37713411 | Frame-shift |
| ENST00000644935 | 37734399 | 37735442 | In-frame |
| ENST00000644935 | 37740895 | 37741032 | In-frame |
| ENST00000644935 | 37754877 | 37754984 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000644935 | 37754877 | 37754984 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000644935 | 37713210 | 37713411 | Frame-shift |
| ENST00000644935 | 37734399 | 37735442 | In-frame |
| ENST00000644935 | 37740895 | 37741032 | In-frame |
| ENST00000644935 | 37754877 | 37754984 | In-frame |
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Infer the effects of exon skipping event on protein functional features for TRIOBP |
p-ENSG00000100106_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000644935 | 10102 | 2365 | 37734399 | 37735442 | 4275 | 5317 | 1354 | 1702 |
| ENST00000644935 | 10102 | 2365 | 37740895 | 37741032 | 5397 | 5533 | 1728 | 1774 |
| ENST00000644935 | 10102 | 2365 | 37754877 | 37754984 | 5592 | 5698 | 1793 | 1829 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000644935 | 10102 | 2365 | 37754877 | 37754984 | 5592 | 5698 | 1793 | 1829 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000644935 | 10102 | 2365 | 37734399 | 37735442 | 4275 | 5317 | 1354 | 1702 |
| ENST00000644935 | 10102 | 2365 | 37740895 | 37741032 | 5397 | 5533 | 1728 | 1774 |
| ENST00000644935 | 10102 | 2365 | 37754877 | 37754984 | 5592 | 5698 | 1793 | 1829 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9H2D6 | 1354 | 1702 | 1 | 1772 | Alternative sequence | ID=VSP_017711;Note=In isoform 1. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11148140,ECO:0000303|PubMed:15489334;Dbxref=PMID:11148140,PMID:15489334 |
| Q9H2D6 | 1354 | 1702 | 62 | 1774 | Alternative sequence | ID=VSP_047499;Note=In isoform 6 and isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q9H2D6 | 1354 | 1702 | 1317 | 2365 | Alternative sequence | ID=VSP_017713;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16385457;Dbxref=PMID:16385457 |
| Q9H2D6 | 1354 | 1702 | 1317 | 1355 | Alternative sequence | ID=VSP_017714;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16385458;Dbxref=PMID:16385458 |
| Q9H2D6 | 1354 | 1702 | 1 | 2365 | Chain | ID=PRO_0000072433;Note=TRIO and F-actin-binding protein |
| Q9H2D6 | 1354 | 1702 | 1372 | 1372 | Natural variant | ID=VAR_051413;Note=E->D;Dbxref=dbSNP:rs8140207 |
| Q9H2D6 | 1354 | 1702 | 1377 | 1377 | Natural variant | ID=VAR_051414;Note=W->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11258795,ECO:0000269|PubMed:16385458;Dbxref=dbSNP:rs8140958,PMID:11258795,PMID:16385458 |
| Q9H2D6 | 1354 | 1702 | 1421 | 1421 | Sequence conflict | Note=R->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9H2D6 | 1354 | 1702 | 1689 | 1689 | Sequence conflict | Note=S->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9H2D6 | 1728 | 1774 | 1 | 1772 | Alternative sequence | ID=VSP_017711;Note=In isoform 1. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11148140,ECO:0000303|PubMed:15489334;Dbxref=PMID:11148140,PMID:15489334 |
| Q9H2D6 | 1728 | 1774 | 62 | 1774 | Alternative sequence | ID=VSP_047499;Note=In isoform 6 and isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q9H2D6 | 1728 | 1774 | 1317 | 2365 | Alternative sequence | ID=VSP_017713;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16385457;Dbxref=PMID:16385457 |
| Q9H2D6 | 1728 | 1774 | 1729 | 1774 | Alternative sequence | ID=VSP_017715;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16385458;Dbxref=PMID:16385458 |
| Q9H2D6 | 1728 | 1774 | 1773 | 1774 | Alternative sequence | ID=VSP_017716;Note=In isoform 1. RR->MT;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11148140,ECO:0000303|PubMed:15489334;Dbxref=PMID:11148140,PMID:15489334 |
| Q9H2D6 | 1728 | 1774 | 1 | 2365 | Chain | ID=PRO_0000072433;Note=TRIO and F-actin-binding protein |
| Q9H2D6 | 1793 | 1829 | 1317 | 2365 | Alternative sequence | ID=VSP_017713;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16385457;Dbxref=PMID:16385457 |
| Q9H2D6 | 1793 | 1829 | 1794 | 1806 | Alternative sequence | ID=VSP_017717;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16385458;Dbxref=PMID:16385458 |
| Q9H2D6 | 1793 | 1829 | 1 | 2365 | Chain | ID=PRO_0000072433;Note=TRIO and F-actin-binding protein |
| Q9H2D6 | 1793 | 1829 | 1778 | 1887 | Domain | Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145 |
| Q9H2D6 | 1793 | 1829 | 1796 | 1796 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9H2D6 | 1793 | 1829 | 1317 | 2365 | Alternative sequence | ID=VSP_017713;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16385457;Dbxref=PMID:16385457 |
| Q9H2D6 | 1793 | 1829 | 1794 | 1806 | Alternative sequence | ID=VSP_017717;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16385458;Dbxref=PMID:16385458 |
| Q9H2D6 | 1793 | 1829 | 1 | 2365 | Chain | ID=PRO_0000072433;Note=TRIO and F-actin-binding protein |
| Q9H2D6 | 1793 | 1829 | 1778 | 1887 | Domain | Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145 |
| Q9H2D6 | 1793 | 1829 | 1796 | 1796 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9H2D6 | 1354 | 1702 | 1 | 1772 | Alternative sequence | ID=VSP_017711;Note=In isoform 1. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11148140,ECO:0000303|PubMed:15489334;Dbxref=PMID:11148140,PMID:15489334 |
| Q9H2D6 | 1354 | 1702 | 62 | 1774 | Alternative sequence | ID=VSP_047499;Note=In isoform 6 and isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q9H2D6 | 1354 | 1702 | 1317 | 2365 | Alternative sequence | ID=VSP_017713;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16385457;Dbxref=PMID:16385457 |
| Q9H2D6 | 1354 | 1702 | 1317 | 1355 | Alternative sequence | ID=VSP_017714;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16385458;Dbxref=PMID:16385458 |
| Q9H2D6 | 1354 | 1702 | 1 | 2365 | Chain | ID=PRO_0000072433;Note=TRIO and F-actin-binding protein |
| Q9H2D6 | 1354 | 1702 | 1372 | 1372 | Natural variant | ID=VAR_051413;Note=E->D;Dbxref=dbSNP:rs8140207 |
| Q9H2D6 | 1354 | 1702 | 1377 | 1377 | Natural variant | ID=VAR_051414;Note=W->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11258795,ECO:0000269|PubMed:16385458;Dbxref=dbSNP:rs8140958,PMID:11258795,PMID:16385458 |
| Q9H2D6 | 1354 | 1702 | 1421 | 1421 | Sequence conflict | Note=R->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9H2D6 | 1354 | 1702 | 1689 | 1689 | Sequence conflict | Note=S->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9H2D6 | 1728 | 1774 | 1 | 1772 | Alternative sequence | ID=VSP_017711;Note=In isoform 1. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11148140,ECO:0000303|PubMed:15489334;Dbxref=PMID:11148140,PMID:15489334 |
| Q9H2D6 | 1728 | 1774 | 62 | 1774 | Alternative sequence | ID=VSP_047499;Note=In isoform 6 and isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q9H2D6 | 1728 | 1774 | 1317 | 2365 | Alternative sequence | ID=VSP_017713;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16385457;Dbxref=PMID:16385457 |
| Q9H2D6 | 1728 | 1774 | 1729 | 1774 | Alternative sequence | ID=VSP_017715;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16385458;Dbxref=PMID:16385458 |
| Q9H2D6 | 1728 | 1774 | 1773 | 1774 | Alternative sequence | ID=VSP_017716;Note=In isoform 1. RR->MT;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11148140,ECO:0000303|PubMed:15489334;Dbxref=PMID:11148140,PMID:15489334 |
| Q9H2D6 | 1728 | 1774 | 1 | 2365 | Chain | ID=PRO_0000072433;Note=TRIO and F-actin-binding protein |
| Q9H2D6 | 1793 | 1829 | 1317 | 2365 | Alternative sequence | ID=VSP_017713;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16385457;Dbxref=PMID:16385457 |
| Q9H2D6 | 1793 | 1829 | 1794 | 1806 | Alternative sequence | ID=VSP_017717;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16385458;Dbxref=PMID:16385458 |
| Q9H2D6 | 1793 | 1829 | 1 | 2365 | Chain | ID=PRO_0000072433;Note=TRIO and F-actin-binding protein |
| Q9H2D6 | 1793 | 1829 | 1778 | 1887 | Domain | Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145 |
| Q9H2D6 | 1793 | 1829 | 1796 | 1796 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569 |
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3'-UTR located exon skipping events that lost miRNA binding sites in TRIOBP |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for TRIOBP |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for TRIOBP |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TRIOBP |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for TRIOBP |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for TRIOBP |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TRIOBP |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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