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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for LILRB1 |
 Gene summary |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| LILRB1 | GO:0001915 | negative regulation of T cell mediated cytotoxicity | 21213105 |
| LILRB1 | GO:0002230 | positive regulation of defense response to virus by host | 18398485 |
| LILRB1 | GO:0002309 | T cell proliferation involved in immune response | 18094328 |
| LILRB1 | GO:0002740 | negative regulation of cytokine secretion involved in immune response | 18094328 |
| LILRB1 | GO:0002774 | Fc receptor mediated inhibitory signaling pathway | 9842885 |
| LILRB1 | GO:0007165 | signal transduction | 18802077 |
| LILRB1 | GO:0009615 | response to virus | 9285411|17869268|18094328 |
| LILRB1 | GO:0010628 | positive regulation of gene expression | 18094328 |
| LILRB1 | GO:0014063 | negative regulation of serotonin secretion | 11907092 |
| LILRB1 | GO:0032609 | interferon-gamma production | 11907092 |
| LILRB1 | GO:0032689 | negative regulation of interferon-gamma production | 17869268 |
| LILRB1 | GO:0032945 | negative regulation of mononuclear cell proliferation | 21551166 |
| LILRB1 | GO:0035548 | negative regulation of interferon-beta secretion | 21213105 |
| LILRB1 | GO:0042130 | negative regulation of T cell proliferation | 15585844 |
| LILRB1 | GO:0042536 | negative regulation of tumor necrosis factor biosynthetic process | 18684926 |
| LILRB1 | GO:0043065 | positive regulation of apoptotic process | 21551166 |
| LILRB1 | GO:0045077 | negative regulation of interferon-gamma biosynthetic process | 18684926 |
| LILRB1 | GO:0045786 | negative regulation of cell cycle | 21551166 |
| LILRB1 | GO:0045806 | negative regulation of endocytosis | 18094328 |
| LILRB1 | GO:0045953 | negative regulation of natural killer cell mediated cytotoxicity | 12874224|18398485 |
| LILRB1 | GO:0046636 | negative regulation of alpha-beta T cell activation | 21213105 |
| LILRB1 | GO:0051607 | defense response to virus | 15585844 |
| LILRB1 | GO:0051926 | negative regulation of calcium ion transport | 9842885 |
| LILRB1 | GO:0060907 | positive regulation of macrophage cytokine production | 19304799 |
| LILRB1 | GO:0072643 | interferon-gamma secretion | 15585844 |
| LILRB1 | GO:2000669 | negative regulation of dendritic cell apoptotic process | 18094328 |
| LILRB1 | GO:2001180 | negative regulation of interleukin-10 secretion | 18094328 |
| LILRB1 | GO:2001183 | negative regulation of interleukin-12 secretion | 18094328 |
| LILRB1 | GO:2001186 | negative regulation of CD8-positive, alpha-beta T cell activation | 21213105 |
| LILRB1 | GO:2001189 | negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell | 18094328 |
| LILRB1 | GO:2001193 | positive regulation of gamma-delta T cell activation involved in immune response | 21233315 |
| LILRB1 | GO:2001202 | negative regulation of transforming growth factor-beta secretion | 18094328 |
| LILRB1 | GO:2001205 | negative regulation of osteoclast development | 18802077 |
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Gene structures and expression levels for LILRB1 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000104972
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PG | UP | ENST00000396315.5 | LILRB1-202:protein_coding:LILRB1 | 1.563007e+00 | 1.825910e+00 | 3.143635e-03 | 3.289640e-02 |
| CB | DOWN | ENST00000396332.8 | LILRB1-206:protein_coding:LILRB1 | 1.037354e+00 | -2.014798e+00 | 1.543823e-02 | 4.937400e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for LILRB1 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_132816 | chr19 | 54634641:54634763:54635104:54635179:54635259:54635296 | 54635104:54635179 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for LILRB1 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for LILRB1 |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in LILRB1 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for LILRB1 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for LILRB1 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for LILRB1 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for LILRB1 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for LILRB1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LILRB1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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